Proin ER (phenylpropanolamine hydrochloride extended-release) Urinary Incontinence Chewable Tablets for Dogs

What is Proin ER (phenylpropanolamine hydrochloride extended-release)?

Proin ER (phenylpropanolamine hydrochloride extended‑release tablets) is an FDA‑approved, once‑daily medication for controlling urinary incontinence in dogs caused by urethral sphincter hypotonus. Its extended‑release technology increases urethral sphincter tone and provides steady absorption throughout the day to help prevent urinary leakage. The liver‑flavored tablets are given with food in a single daily dose and offer the same proven efficacy as traditional Proin in a convenient extended‑release form. Proin ER requires a prescription from your veterinarian.

Suitable for:

• Dogs (Over 10 lbs, with Urinary Incontinence)

Benefits:

• Helps control your dog’s urinary incontinence, reducing leaking and wet spots so your pet can stay comfortable at home.
• Convenient once‑daily tablet that can be given with or without food.
• All‑day effectiveness with patented extended‑release technology that provides steady support between doses.
• Delicious, enticing flavor designed to encourage voluntary consumption and reduce the stress of daily dosing.
• Weight‑based dosing options ensure accurate, veterinarian‑guided dosing for dogs 10 lbs and over.

How does Proin ER (phenylpropanolamine hydrochloride extended-release) work?

Phenylpropanolamine is a sympathomimetic alpha‑adrenergic agonist that increases urethral sphincter tone to help prevent urinary leakage. The extended‑release formulation provides controlled, steady absorption over the day to maintain therapeutic effect.

Caution:

Not for human use. Consult a physician in case of accidental ingestion by humans. Keep Proin ER in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.

How should I store this product?

Store in a cool, dry place at a controlled room temperature 20-25°C (68-77°F), excursions permitted between 15-40°C (59-104°F). Keep PROIN ER in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Keep out of reach of children.

What is the most important information I should know about Proin ER (phenylpropanolamine hydrochloride extended-release)?

Proin ER is indicated for the control of urinary incontinence due to urethral sphincter hypotonus in dogs. It requires a prescription from your veterinarian. Proin ER provides the same proven efficacy as Proin in extended-release tablets. The patented extended-release technology provides a controlled release mechanism that achieves steady absorption.

What should I discuss with my veterinarian before giving Proin ER (phenylpropanolamine hydrochloride extended-release) to my pet?

Discuss if your dog has any underlying heart conditions or high blood pressure, as this drug can significantly increase blood pressure. Let your vet know if your dog has any kidney issues or diabetes. You should also mention if your dog is pregnant or nursing, as this medication can affect blood flow to the uterus.

How should Proin ER (phenylpropanolamine hydrochloride extended-release)?

Proin ER should be given orally once daily with food. Tablets must be swallowed whole; you must not split or crush them, as this destroys the extended-release properties. Give Proin ER exactly as directed by your veterinarian. If you do not understand the directions, ask the pharmacist or veterinarian to explain them to you.

What are the potential side effects of Proin ER (phenylpropanolamine hydrochloride extended-release)?

The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. Contact your veterinarian if you notice restlessness, irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water.

What happens if I miss giving a dose of Proin ER (phenylpropanolamine hydrochloride extended-release)?

If you forget to give your dog a dose, then resume dosing at the next scheduled dose.

What happens if I overdose my pet on Proin ER (phenylpropanolamine hydrochloride extended-release)?

Contact your veterinarian immediately or the nearest vet hospital. You can also contact ASPCA 24/7 Poison Control Hotline at 888-426-4435 or the Pet Poison Helpline at 855-764-7661. Signs of overdose can include: extreme agitation, arrhythmias, high fever, hypersalivation, panting, and dangerously high blood pressure.

What special precautions are there?

This medication may cause increased thirst, so you must provide your dog with ample fresh water at all times. Owners should also monitor for signs of restlessness or irritability.

What should I avoid while giving Proin ER (phenylpropanolamine hydrochloride extended-release) to my pet?

Avoid alternating Proin ER™ with Proin Chewable Tablets, as the safety of interchangeable use has not been studied. Do not use this product in dogs weighing less than 10 pounds, as they cannot be safely dosed.

What other drugs will affect Proin ER (phenylpropanolamine hydrochloride extended-release)?

Caution should be used if your dog is receiving other sympathomimetic drugs, tricyclic antidepressants, or MAOIs, as this can increase toxicity. Using this medication with certain gaseous anesthetics can also increase the risk of heart arrhythmias.