What is Mometavet® (gentamicin sulfate, mometasone furoate anhydrous, and clotrimazole otic suspension)?

Mometavet™ Otic Suspension is indicated for treatment of otitis externa in dogs caused by susceptible strains of yeast and bacteria. Mometavet™ is available in 7.5 gm, 15 gm, and 30 gm dropper bottles and requires a prescription from your veterinarian.

Suitable For:

• Dogs with Otitis Externa

Benefits:

• Triple combination steroid, antibacterial and antifungal treatment that works to combat painful canine ear infections
• Each gram contains: gentamicin sulfate equal to 3 mg gentamicin base; mometasone furoate anhydrous equal to 1 mg mometasone; and 10 mg clotrimazole, in a mineral oil-based system containing plasticized hydrocarbon gel
• Administered just once a day for seven days
• Mometavet™ has been proven effective in reducing discomfort, redness, swelling, exudate and odor, as well as the treatment of otitis externa
• Once a day treatment

How does Mometavet® (gentamicin sulfate, mometasone furoate anhydrous, and clotrimazole otic suspension) work?

Mometavet® Otic Suspension is indicated for the treatment of otitis externa in dogs caused by susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Pseudomonas spp. [including P. aeruginosa], coagulase-positive staphylococci, Enterococcus faecalis, Proteus mirabilis, and beta-hemolytic streptococci). Each gram of Mometavet Otic Suspension contains gentamicin sulfate, equivalent to 3 mg gentamicin base; mometasone furoate anhydrous equivalent to 1 mg mometasone; and 10 mg clotrimazole, in a mineral oil-based system containing a plasticized hydrocarbon gel. Pharmacology:
'Gentamicin-Mometasone-Clotrimazole': By virtue of its three active ingredients, gentamicin, mometasone, and clotrimazole otic suspension has antibacterial, anti-inflammatory, and antifungal activity. In clinical field trials, gentamicin, mometasone, and clotrimazole otic suspension was effective in the treatment of otitis externa associated with bacteria and Malassezia pachydermatis. Gentamicin, mometasone, and clotrimazole otic suspension reduced discomfort, redness, swelling, exudate, and odor

Generic Name:

Gentamicin sulfate, USP; Mometasone furoate anhydrous; and Clotrimazole, USP, Otic suspension for dogs.

What is the most important thing I should know about Mometavet®?

Mometavet® requires a prescription from your veterinarian, and is for otic use in dogs only. It's available in 7.5 gm, 15 gm, and 30 gm dropper bottles. Each gram of Mometavet® contains Gentamicin Sulfate, USP, equivalent to 3 mg gentamicin base, Mometasone Furoate Monohydrate, equivalent to 1 mg mometasone, and Clotrimazole, USP 10 mg, all in a mineral oil-based system containing a plasticized hydrocarbon gel.

What should I discuss with my veterinarian before giving Mometavet® to my pet?

Tell your veterinarian if your pet is pregnant, breeding, or lactating. Tell your veterinarian if your dog is hypersensitive to any of the ingredients in Mometavet® or is currently taking other medications, including prescription and over-the-counter medicines and supplements.

How should Mometavet® be applied to my pet?

The external ear canal should be thoroughly cleaned and dried before treatment. Verify that the eardrum is intact. For dogs weighing less than 30 lbs, instill 4 drops from the 7.5 g bottles, 15 g bottles, and 30 g bottles (2 drops from the 215 g bottle) of Mometavet Otic Suspension once daily into the ear canal. For dogs weighing 30 lbs or more, instill 8 drops from the 7.5 g bottles, 15 g bottles, and 30 g bottles (4 drops from the 215 g bottle) once daily into the ear canal. Therapy should continue for 7 consecutive days.

What are the potential side effects of Mometavet®?

ADVERSE REACTIONS: Gentamicin: While aminoglycosides are absorbed poorly from skin, intoxication may occur when aminoglycosides are applied topically for prolonged periods of time to large wounds, burns, or any denuded skin, particularly if there is renal insufficiency. All aminoglycosides have the potential to produce reversible and irreversible vestibular, cochlear, and renal toxicity.
Mometasone: ALP (SAP) and ALT (SGPT) enzyme elevations, weight loss, anorexia, polydipsia, polyuria, neutrophilia, and lymphopenia have occurred following the use of parenteral, high-dose, and/or prolonged or systemic synthetic corticosteroids in dogs. Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.
Clotrimazole: The following have been reported occasionally in humans in connection with the use of clotrimazole: erythema, stinging, blistering, peeling, edema, pruritus, urticaria, and general irritation of the skin not present before therapy. Gentamicin sulfate, mometasone furoate anhydrous, and clotrimazole otic suspension: In field studies following once-daily treatment with gentamicin, mometasone, and clotrimazole otic suspension, ataxia, proprioceptive deficits, and increased water consumption were observed in less than 1% of 164 dogs. In a field study following twice-daily treatment with gentamicin, mometasone, and clotrimazole otic suspension, inflammation of the pinna and diarrhea were observed in less than 1% of 141 dogs.

What happens if I miss giving a dose of Mometavet® to my pet?

Give your dog the missed dose as soon as you remember. However, if it is close to the next dose, skip the missed dose and resume the regular dosing schedule. Do not give your dog a double dose.

What happens if I overdose my pet on Mometavet®?

If an overdose is suspected, contact your veterinarian. Overdosage may produce adverse immunosuppressive effects.

What should I avoid while giving Mometavet® to my pet?

Corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs that received corticosteroids during pregnancy. Field and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.

What other drugs will affect Mometavet®?

If hypersensitivity to any of the components occurs, treatment should be discontinued and appropriate therapy instituted. Concomitant use of drugs known to induce ototoxicity should be avoided. Do not use in dogs with known perforation of eardrums.

Cautions:

As with all drugs, side effects may occur. Mometavet^® Otic Suspension should be discontinued if hypersensitivity to any component occurs. Concomitant use of drugs known to induce ototoxicity should be avoided. Do not use in dogs with known perforation of eardrums. If hearing or vestibular dysfunction is noted during treatment, discontinue use immediately and flush the ear canal with a non-ototoxic solution. Refer to the prescribing information for complete details or visit www.dechra-us.com.

Warnings:

The use of these components has been associated with deafness or partial hearing loss in a small number of sensitive dogs (e.g, geriatric). The hearing deficit is usually temporary. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Mometavet Otic Suspension immediately and flush the ear canal thoroughly with a non-toxic solution.

Storage: 

Do not store above 25°C (77°F). Shake the bottles well before use.