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Product Info
How to Use
Customer Reviews
Product Info

What is Tresaderm?

Tresaderm is used in pets to treat certain acute or chronic bacterial, fungal and inflammatory skin disorders, as well as otitis externa (ear inflammation). Tresaderm requires a prescription from your veterinarian. Tresaderm requires refrigeration and must be kept at refrigerator temperatures at all times. To ensure proper temperature, it requires overnight shipping at an additional cost.


Cats and Dogs


  • Successfully fights bacterial infections of the skin and ears
  • Also treats inflamed skin and ears
  • Drops make ear application easy
  • Results in a week or less

How does Tresaderm work?

Each 15 ml dropper of Tresaderm solution contains thiabendazole and dexamethasone neomycin sulfate. Thiabendazole is a fungicide and parasiticide that kills or inhibits fungi and parasites. Dexamethasone neomycin sulfate is a potent anti-inflammatory.


For topical use on the skin or ears only. Do not get in eyes.

Brand Name:

Tresaderm (Merial)

Generic Name:

Thiabendazole, dexamethasone, neomycin sulfate

What is the most important information I should know about Tresaderm?

Tresaderm is a prescription medicine FDA approved for veterinary use in dogs and cats. Tresaderm is available as a dermatologic solution in a 15ml dropper bottle for use in the ear(s) or to apply topically to the skin. Each ml of solution contains 40mg thiabendazole, 1mg dexamethasone, and neomycin sulfate equivalent to 3.2mg of neomycin. Prior to use the affected area should be cleaned. Application and use of Tresaderm should be limited to a period of not longer than one week. Do not use in the eyes.

What should I discuss with my veterinarian before giving Tresaderm to my pet?

Tell your veterinarian if your pet is pregnant. Do not use Tresaderm if the pet is allergic to any of the individual ingredients. 

How should Tresaderm be used?

Use this medication exactly as directed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. The administration of Tresaderm depends on the severity of the condition and the extent of the lesions. The typical dose for the ear is 5-15 drops instilled into the ear twice a day. To treat skin disorders affecting other than the ear, the surface of the lesion should be well moistened with Tresaderm, usually 2-4 drops per square inch, twice a day. Store Tresaderm in the refrigerator. Do not freeze. Tresaderm should not be used for more than one week. Do not use Tresaderm in the eyes. Do not use Tresaderm on pregnant animals. Keep out of the reach of children or pets. 

What are the possible side effects of Tresaderm?

Side effects associated with this medication are related to the individual ingredients. Side effects following the use of injected or oral corticosteroids include increased thirst and urination, vomiting, diarrhea and Cushing's syndrome following prolonged or repeated steroid therapy. Discontinue use and contact the veterinarian if sensitivity to neomycin, which may cause redness, irritation and swelling, occurs. Continue the medication and talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What happens if I miss giving a dose of Tresaderm?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet or Tresaderm?

An overdose of this medication is unlikely. If an overdose is suspected, seek emergency veterinary medical treatment.

What should I avoid while using Tresaderm on my pet?

Do not use this medication in pets allergic to it or any of the individual ingredients. Discontinue use of this medication and contact the veterinarian if hearing loss is noted during treatment.

What other drugs will affect Tresaderm?

Before using Tresaderm, tell your veterinarian if your pet is using other antibiotic, antifungal or corticosteroid medications either topically or by mouth. Talk to the veterinarian or pharmacist before giving any prescription or over the counter medicines.

How to Use
  • Tresaderm Dermatologic Solution is a prescription medication used on dogs and cats as an aid in the treatment of certain acute or chronic bacterial, fungal, and inflammatory skin disorders as well as otitis externa (ear infections).
  • Tresaderm is used topically on the skin or in the ears depending on the type of infection being treated.
  • Keep Tresaderm in the refrigerator when not being used.

Prior to use, the affected area should be cleaned. Application and use of Tresaderm should be limited to a period of not longer than one week. Do not use Tresaderm in the eyes.

Dogs/Cats: (for use in the ears)
All weights
The usual dose for the ear is 5-15 drops placed into the ear twice daily
Dogs/Cats: (for use topically on the skin)
All weights
The usual dose to treat skin disorders affecting other than in the ear is 2 to 4 drops per square inch twice daily
Do not use!

Store Tresaderm in the refrigerator. Do not freeze.

Active Ingredients (per mL)
40 mg
1 mg
Neomycin (from neomycin sulfate)
3.2 mg
Other Ingredients: Glycerin, propylene glycol, purified water, hypophosphorous acid, about 8.5% ethyl alcohol and about 0.5% benzyl alcohol.
Customer Reviews
Tresaderm is rated 3.4 out of 5 by 38.
Rated 5 out of 5 by from Our Lab had chronic ear infections and we used every med for treatment. The most effective one used before getting Tresaderm was pricey and in a metal tube which was difficult to squeeze last bit out. It was also greasy leaving her ears messy. Tresaderm is just as effective but much simpler to apply and not goopy
Date published: 2015-01-16
Rated 4 out of 5 by from It Works! I used it on my teddy bear ( that's the type of dog I have) for an ear infection and having ear mites and after going bizirc scratching her ears she's more relaxed now and free from the constant scratching
Date published: 2013-11-26
Rated 5 out of 5 by from Worked!! The only way your cat would have went deaf is if it wasn't treated in enough time for the ear infection. I read that if an infection is left alone for a while it will cause your animal to go deaf so I don't hardly believe that this product caused your cat to go deaf. I'm using it on my Beagle now and it works perfect. He doesn't feel any discomfort now and isn't messing with his floppy ears anymore. :)
Date published: 2013-09-07
Rated 4 out of 5 by from Works Great! This product was used for my male tuxedo cat. He gets ear infections pretty quickly. This product was very quick and very effective. Love it! Only wish it came in a bigger bottle. It runs out quickly.
Date published: 2013-02-09
Rated 5 out of 5 by from Worked quickly with no problems I took my 13 week old Persian kitten, Owen, to the vet for a wellness exam and booster shots. Owen had not been cared for properly in his previous home, so among ear mites and ear infections, he was also infested with fleas, had tapeworms, and an upper respiratory infection. Our vet prescribed Tresaderm for the ear infections (5 drops 2x daily for 10 days). We saw improvement after only a few days. A week later when I took him back for a follow-up on the URI, the vet said his ears looked good and the mites were gone. I was a little concerned about using this product on Owen after reading some of the reviews, but it worked well and didn't cause Owen any ill effects, other than making the fur around his ears a little sticky/greasy and the "trauma" of being wrapped in a towel #so he couldn't shred our hands and arms# while we put cold medicine in his ears.
Date published: 2012-12-23
Rated 1 out of 5 by from Tresaderm made my cat deaf My kitty is around 10yrs(+?) old . I rescued her, so I dunno for sure. She had ear infection for months. Tresaderm worked to rid her of ear infection after a week of treatment. But it made her deaf.
Date published: 2012-06-05
Rated 1 out of 5 by from Made my dog deaf. My miniature schnauzer had infected ears, so my Vet prescribed Tresaderm drops twice a day for a week. At the end of the week the infection had cleared up, but my dog was completely deaf. When my Vet checked him again there was no debris in the ears causing the deafness. He said that he had probably suffered nerve deafness as a result of the Tresaderm or old age. Although my schnauzer is 10 years old, his hearing was extremely good until this treatment and he always heard if someone came to the door or drove up the driveway. I relied on him to be my ears. Now he can't hear anything, and it's very sad. This product healed my dog's infection but made him completely deaf.
Date published: 2012-04-11
Rated 5 out of 5 by from Works for My Teddy My Multipoo has had frequent ear infections in just his one ear and I took him to the vet and had to pay for the visit and the meds. This way I order the meds and save myself the visit cause I have dealt with this infection before and had seen a vet I felt good about doing it this way....I still think that it is better to see the vet if it is a new problem... Thanks Carol
Date published: 2012-03-30
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Mine is one month expired can we still use 

Asked by: Penny123
Any date after expiration is not recommended to take.
Answered by: Ben B
Date published: 2017-02-21

Do I need a rx for trasaderm

Asked by: Herley12
Yes, Tresaderm does require a prescription.
Answered by: 1800Petmeds Pharmacist
Date published: 2017-01-12

I did .not see Refrigerate 11/17 until today. Did it harm, work and is it spoiled?

Asked by: Rosemarie
This medication should remain refrigerated. Continued use is not recommended if not stored at these conditions.
Answered by: S Duesler PharmD MBA
Date published: 2016-12-31

Is it 100% necessary to clean the area before using the tresaderm? 

Asked by: ffaiith
Yes, you should clean the area before applying the drops to ensure the medication gets absorbed properly.
Answered by: Christine
Date published: 2016-10-14

Is there a minimum age or weight when using Tresaderm for ear mites?

Asked by: MHegwood
No, there is not a minimum age or weight for Tresaderm Antibiotic. However, if you have any concerns speak with your veterinarian. They will need to authorize this prescription.
Answered by: Christine
Date published: 2016-10-11

Is this harmful if your dog consumes thus by mouth

Asked by: Jenny38
Tresaderm is intended for external use only. Consult your veterinarian if your pet ingests orally.
Answered by: Lisa M
Date published: 2017-01-04

Is Tresaderm safe to use if the eardrum is ruptured?

Asked by: Anonymous
only a veterinarian can decide that.
Answered by: Linda petmeds pharmacist
Date published: 2017-01-27

Can you use Tresederm if the kitten had Ivermectin 2 weeks ago?

Asked by: Anonymous
Please consult you veterinarian, as both Tresaderm and Ivermectin containing products require a prescription.
Answered by: S Duesler PharmD MBA
Date published: 2016-07-15
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