Apoquel

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Apoquel
5.4 mg (sold per tablet)
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What is Apoquel?

Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours. Apoquel requires a prescription from your veterinarian, and is sold per tablet.

Suitable For:

Dogs over 12 months in age and weighing more than 6.6 lbs.

Benefits:

  • Provides onset of relief within 4 hours
  • Effectively controls itch within 24 hours
  • Safe for short term and long term usage
  • Can be used along with many other common medications, including parasiticides, antibiotics, and vaccines
  • Uniquely targeted to stop the itch with minimal negative impact on immune function
  • Controls pruritus associated with allergic dermatitis and controls atopic dermatitis
  • Sold per tablet

How does Apoquel work?

Apoquel is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions.  New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval.  Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel?

Apoquel is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel be given?

The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is ½ of a 3.6 mg tablet twice daily. The dosage for dogs 10-14.9 lbs is ½ of a 5.4 mg tablet twice daily. The dosage for dogs 15-19.9 lbs is one 3.6 mg tablet twice daily. The dosage for dogs 20-29.9 lbs is one 5.4 mg tablet twice daily. The dosage for dogs 30-44.9 lbs is ½ of a 16 mg tablet twice daily. The dosage for dogs 45-59.9 lbs is two 5.4 mg tablets twice daily. The dosage dogs 60-89.9 lbs is one 16 mg tablet twice daily. The dosage dogs 90-129.9 lbs is 1½ 16 mg tablets twice daily. The dosage for dogs 130-175.9 lbs is two 16 mg tablets daily.

What are the potential side effects of Apoquel?

Apoquel may increase susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, anorexia, new cutaneous or subcutaneous lumps, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel?

Contact your veterinarian immediately.

What should I avoid while giving Apoquel to my pet?

Apoquel should not be given to dogs younger than 12 months or those with serious infections. Apoquel is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel?

Talk to your veterinarian before giving any prescription or over the counter medications.

Apoquel Directions:

  • Administer to your dog orally twice daily for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.
Tip:

Apoquel may be administered with or without food

Apoquel Dosage:

Apoquel Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg twice daily for up to 14 days
Apoquel Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg tablet once daily
15-19.9 lbs One 3.6 mg tablet once daily
20-29.9 lbs One 5.4 mg tablet once daily
30-44.9 lbs 1/2 of a 16 mg tablet once daily
45-59.9 lbs Two 5.4 mg tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg tablets once daily
130-175.9 lbs Two 16 mg once daily
Apoquel Dosage for Cats:
Cats
Do not use!
Apoquel Dosage for Horses:
Horses
Do not use!

Apoquel Ingredients:

Apoquel 3.6 mg tablet
Active IngredientAmount
Oclacitinib maleate3.6 mg
Apoquel 5.4 mg tablet
Active IngredientAmount
Oclacitinib maleate5.4 mg
Apoquel 16 mg tablet
Active IngredientAmount
Oclacitinib maleate16 mg

What is Apoquel?

Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours. Apoquel requires a prescription from your veterinarian, and is sold per tablet.

Suitable For:

Dogs over 12 months in age and weighing more than 6.6 lbs.

Benefits:

  • Provides onset of relief within 4 hours
  • Effectively controls itch within 24 hours
  • Safe for short term and long term usage
  • Can be used along with many other common medications, including parasiticides, antibiotics, and vaccines
  • Uniquely targeted to stop the itch with minimal negative impact on immune function
  • Controls pruritus associated with allergic dermatitis and controls atopic dermatitis
  • Sold per tablet

How does Apoquel work?

Apoquel is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions.  New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval.  Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel?

Apoquel is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel be given?

The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is ½ of a 3.6 mg tablet twice daily. The dosage for dogs 10-14.9 lbs is ½ of a 5.4 mg tablet twice daily. The dosage for dogs 15-19.9 lbs is one 3.6 mg tablet twice daily. The dosage for dogs 20-29.9 lbs is one 5.4 mg tablet twice daily. The dosage for dogs 30-44.9 lbs is ½ of a 16 mg tablet twice daily. The dosage for dogs 45-59.9 lbs is two 5.4 mg tablets twice daily. The dosage dogs 60-89.9 lbs is one 16 mg tablet twice daily. The dosage dogs 90-129.9 lbs is 1½ 16 mg tablets twice daily. The dosage for dogs 130-175.9 lbs is two 16 mg tablets daily.

What are the potential side effects of Apoquel?

Apoquel may increase susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, anorexia, new cutaneous or subcutaneous lumps, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel?

Contact your veterinarian immediately.

What should I avoid while giving Apoquel to my pet?

Apoquel should not be given to dogs younger than 12 months or those with serious infections. Apoquel is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel?

Talk to your veterinarian before giving any prescription or over the counter medications.

Apoquel Directions:

  • Administer to your dog orally twice daily for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.
Tip:

Apoquel may be administered with or without food

Apoquel Dosage:

Apoquel Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg twice daily for up to 14 days
Apoquel Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg tablet once daily
15-19.9 lbs One 3.6 mg tablet once daily
20-29.9 lbs One 5.4 mg tablet once daily
30-44.9 lbs 1/2 of a 16 mg tablet once daily
45-59.9 lbs Two 5.4 mg tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg tablets once daily
130-175.9 lbs Two 16 mg once daily
Apoquel Dosage for Cats:
Cats
Do not use!
Apoquel Dosage for Horses:
Horses
Do not use!

Apoquel Ingredients:

Apoquel 3.6 mg tablet
Active IngredientAmount
Oclacitinib maleate3.6 mg
Apoquel 5.4 mg tablet
Active IngredientAmount
Oclacitinib maleate5.4 mg
Apoquel 16 mg tablet
Active IngredientAmount
Oclacitinib maleate16 mg
LEARN MORE ABOUT

Fast-Acting Allergic Itch Relief For Your Dog

Apoquel Tablet is the #1 prescribed oral medication for allergic itch in dogs.1 Unlike other allergic itch treatments, such as steroids, antihistamines, and at-home remedies, Apoquel works at the underling cause of itch to provide fast relief.


Relief You Can Count On

Apoquel Tablet starts relieving
allergic dog itch within 4 hours2
and effectively controls it
within 24 hours.3,4

Prescribed for over 15 million dogs5 and is #1 in pet owner and vet satisfaction.*,6,7

Safe to use for long-term maintenance or short-term therapy4,8 in dogs 12 months of age and older.

Why Does Apoquel Lead The Pack?

Apoquel Chewable stops allergic itch right at the source.9

  • Antihistamines offer little or no benefit in treating flare-ups in a majority of dogs with allergic itch.10
  • Steroids may offer relief but may not be a good option if your dog requires long-term treatment
  • Home remedies, such as, topicals, may provide some temporary relief but don’t treat the underlying cause of allergic itch.
Indications
Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
*Vets, n=250; pet owners, n=491.

REFERENCES
1. Kynetec - PetTrak, US Pruritus Factored National. MAT Canine Pruritus, Total Unique Patients on Apoquel. Dec. 2023, Zoetis Inc. 2. Gadeyne C, Little P, King VL, Edwards N, Davis K, Stegemann MR. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol.
2014;25(6):512-518,e86. doi:10.1111/vde.12166.
3. Data on file: Study Report A161C-US-21-C02, Zoetis Inc.
4. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.
5. Kynetec PetTrak – GAH-284: Unique Patient Count Since Launch Custom Report: Apoquel: January 2014 – February 2024.
6. Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 17, 2022, Zoetis Inc.
7. Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc.
8. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.
9. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101.
10. Olivry T, DeBoer DJ, Favrot C, et al. for the International Committee on Allergic Diseases of Animals. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res. 2015;11:210. doi: 10.1186/s12917-015-0514-6.

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