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Apoquel

Apoquel (oclacitinib) Tablets for Dogs

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About this product

What is Apoquel Tablets for Dogs?

Apoquel is a prescription medication that treats and controls itching and inflammation in dogs caused by allergic conditions such as flea allergy, food allergy, contact allergy, and atopic dermatitis. It provides fast relief, with onset of action within 4 hours and effective itch control within 24 hours. Apoquel requires a prescription from your veterinarian and is sold per tablet in multiple strengths, including 3.6 mg, 5.4 mg, and 16 mg.

Suitable for:

  • Dogs (Over 12 months old and 6.6 lbs, with Itching & Inflammation from Allergies)

Benefits:

  • Begins working within 4 hours and effectively controls itching within 24 hours to stop your dog from scratching, licking, and chewing quickly!
  • Safe for short term and long term usage in dogs 12 months and older.
  • Can be used along with many other common medications, including parasiticides, antibiotics, vaccines, NSAIDs, and other allergen-specific immunotherapy (allergy shots or drops).
  • Not a steroid, antihistamine, or cyclosporine — targets itch at its source with minimal impact on immune function.
  • Controls pruritus associated with allergic dermatitis and atopic dermatitis.

How does Apoquel Tablets for Dogs work?

Apoquel for Dogs is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel for Dogs works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel for Dogs in dogs under 12 months of age or those with serious infections. Apoquel may increase the risk of serious infections and can worsen existing parasitic infestations or pre-existing cancers. Consider the risks and benefits in dogs with a history of these conditions. New benign and malignant tumors have been observed in clinical studies and post-approval. Apoquel has not been evaluated with certain medications, including corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. The most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications, including parasiticides, antibiotics, and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel Tablets for Dogs?

Apoquel for Dogs is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel Tablets for Dogs to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel Tablets for Dogs be given?

The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. See Dosage Chart.

What are the potential side effects of Apoquel Tablets for Dogs?

Common side effects of Apoquel tablets may include increased susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, weight loss, anorexia, ear infections, new cutaneous or subcutaneous lumps or dermal masses, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel Tablets for Dogs?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel Tablets for Dogs?

Contact your veterinarian immediately to seek medical attention.

What should I avoid while giving Apoquel Tablets for Dogs to my pet?

Apoquel for Dogs should not be given to dogs younger than 12 months or those with serious infections. Apoquel for Dogs is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel for Dogs has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel for Dogs should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel Tablets for Dogs?

Talk to your veterinarian before giving any prescription or over the counter medications.

See more

Apoquel Tablets for Dogs Directions:

  • Administer Apoquel orally twice a day for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.

Tip:

Apoquel for Dogs may be administered with or without food.

Apoquel Tablets for Dogs Dosage Chart:

Apoquel for Dogs Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg twice daily for up to 14 days
Apoquel for Dogs Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg tablet once daily
15-19.9 lbs One 3.6 mg tablet once daily
20-29.9 lbs One 5.4 mg tablet once daily
30-44.9 lbs 1/2 of a 16 mg tablet once daily
45-59.9 lbs Two 5.4 mg tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg tablets once daily
130-175.9 lbs Two 16 mg once daily
Apoquel for Dogs Dosage for Cats:
Cats
Do not use!
Apoquel for Dogs Dosage for Horses:
Horses
Do not use!

Apoquel Tablets for Dogs Ingredients:

Apoquel for Dogs 3.6 mg tablet
Active Ingredient Amount
Oclacitinib maleate 3.6 mg

 

Apoquel for Dogs 5.4 mg tablet
Active Ingredient Amount
Oclacitinib maleate 5.4 mg

Apoquel for Dogs 16 mg tablet
Active Ingredient Amount
Oclacitinib maleate 16 mg
Product Details
plus minus

What is Apoquel Tablets for Dogs?

Apoquel is a prescription medication that treats and controls itching and inflammation in dogs caused by allergic conditions such as flea allergy, food allergy, contact allergy, and atopic dermatitis. It provides fast relief, with onset of action within 4 hours and effective itch control within 24 hours. Apoquel requires a prescription from your veterinarian and is sold per tablet in multiple strengths, including 3.6 mg, 5.4 mg, and 16 mg.

Suitable for:

  • Dogs (Over 12 months old and 6.6 lbs, with Itching & Inflammation from Allergies)

Benefits:

  • Begins working within 4 hours and effectively controls itching within 24 hours to stop your dog from scratching, licking, and chewing quickly!
  • Safe for short term and long term usage in dogs 12 months and older.
  • Can be used along with many other common medications, including parasiticides, antibiotics, vaccines, NSAIDs, and other allergen-specific immunotherapy (allergy shots or drops).
  • Not a steroid, antihistamine, or cyclosporine — targets itch at its source with minimal impact on immune function.
  • Controls pruritus associated with allergic dermatitis and atopic dermatitis.

How does Apoquel Tablets for Dogs work?

Apoquel for Dogs is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel for Dogs works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel for Dogs in dogs under 12 months of age or those with serious infections. Apoquel may increase the risk of serious infections and can worsen existing parasitic infestations or pre-existing cancers. Consider the risks and benefits in dogs with a history of these conditions. New benign and malignant tumors have been observed in clinical studies and post-approval. Apoquel has not been evaluated with certain medications, including corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. The most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications, including parasiticides, antibiotics, and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel Tablets for Dogs?

Apoquel for Dogs is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel Tablets for Dogs to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel Tablets for Dogs be given?

The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. See Dosage Chart.

What are the potential side effects of Apoquel Tablets for Dogs?

Common side effects of Apoquel tablets may include increased susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, weight loss, anorexia, ear infections, new cutaneous or subcutaneous lumps or dermal masses, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel Tablets for Dogs?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel Tablets for Dogs?

Contact your veterinarian immediately to seek medical attention.

What should I avoid while giving Apoquel Tablets for Dogs to my pet?

Apoquel for Dogs should not be given to dogs younger than 12 months or those with serious infections. Apoquel for Dogs is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel for Dogs has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel for Dogs should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel Tablets for Dogs?

Talk to your veterinarian before giving any prescription or over the counter medications.

See more
How to use
plus minus

Apoquel Tablets for Dogs Directions:

  • Administer Apoquel orally twice a day for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.

Tip:

Apoquel for Dogs may be administered with or without food.

Apoquel Tablets for Dogs Dosage Chart:

Apoquel for Dogs Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg twice daily for up to 14 days
Apoquel for Dogs Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg tablet once daily
15-19.9 lbs One 3.6 mg tablet once daily
20-29.9 lbs One 5.4 mg tablet once daily
30-44.9 lbs 1/2 of a 16 mg tablet once daily
45-59.9 lbs Two 5.4 mg tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg tablets once daily
130-175.9 lbs Two 16 mg once daily
Apoquel for Dogs Dosage for Cats:
Cats
Do not use!
Apoquel for Dogs Dosage for Horses:
Horses
Do not use!
Ingredients
plus minus

Apoquel Tablets for Dogs Ingredients:

Apoquel for Dogs 3.6 mg tablet
Active Ingredient Amount
Oclacitinib maleate 3.6 mg

 

Apoquel for Dogs 5.4 mg tablet
Active Ingredient Amount
Oclacitinib maleate 5.4 mg

Apoquel for Dogs 16 mg tablet
Active Ingredient Amount
Oclacitinib maleate 16 mg
Q&A
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Apoquel-11700.webp

Fast-Acting Allergic Itch Relief For Your Dog

Apoquel Tablet is the #1 prescribed oral medication for allergic itch in dogs.1 Unlike other allergic itch treatments, such as steroids, antihistamines, and at-home remedies, Apoquel works at the underling cause of itch to provide fast relief.

lifestyle-product-image
apoquel-11700-banner-2.webp

Prescribed for over 15 million dogs5 and is #1 in pet owner and vet satisfaction.*,6,7

Safe to use for long-term maintenance or short-term therapy4,8 in dogs 12 months of age and older.

Why Does Apoquel
Lead The Pack?

Apoquel Chewable stops allergic itch right at the source.9

  • bullet points icon

    Antihistamines offer little or no benefit in treating flare-ups in a majority of dogs with allergic itch.10

  • bullet points icon

    Steroids may offer relief but may not be a good option if your dog requires long-term treatment.

  • bullet points icon

    Home remedies, such as, topicals, may provide some temporary relief but don’t treat the underlying cause of allergic itch.

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Indications
Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
*Vets, n=250; pet owners, n=491.
REFERENCES
  1. Kynetec - PetTrak, US Pruritus Factored National. MAT Canine Pruritus, Total Unique Patients on Apoquel. Dec. 2023, Zoetis Inc.
  2. Gadeyne C, Little P, King VL, Edwards N, Davis K, Stegemann MR. Efficacy of oclacitinib (Apoquel®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol.
2014;25(6):512-518,e86. doi:10.1111/vde.12166.
  3. Data on file: Study Report A161C-US-21-C02, Zoetis Inc.
  4. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.
  5. Kynetec PetTrak – GAH-284: Unique Patient Count Since Launch Custom Report: Apoquel: January 2014 – February 2024.
  6. Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 17, 2022, Zoetis Inc.
  7. Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc.
  8. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.
  9. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101.
  10. Olivry T, DeBoer DJ, Favrot C, et al. for the International Committee on Allergic Diseases of Animals. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res. 2015;11:210. doi: 10.1186/s12917-015-0514-6.