Credelio Quattro (lotilaner + praziquantel) Chewable Tablets for Dogs

What is Credelio Quattro 6-in-1 Parasite Protection Chewable Tablet for Dogs ?

Credelio Quattro / Credelio Quattro-CA1 (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) offers the broadest parasite coverage of its kind*, targeting 7 types of parasites§ in one flavored chewable tablet. It covers ticks, fleas, heartworm disease, New World screwworm larvae, and three intestinal worms that can be passed to humans: roundworms, hookworms, and tapeworms.

Along with broader parasite coverage than other chewable brands of its kind*, Credelio Quattro works fast where it counts. Thanks to lotilaner, one of the four active ingredients, it kills >99% of fleas within 8 hours of administration and remains effective for an entire month [3]. 

Crafted for sensitive dogs, Credelio Quattro / Credelio Quattro-CA1 comes in a tasty beef-flavored chewable that's meat allergen-free [9]. It's easy to give –– with successful administration to 98% of dogs in a U.S. field study [1] –– and easy to fit into your dog's routine. Best of all, Credelio Quattro / Credelio Quattro-CA1 can be prescribed to dogs and puppies at least 8 weeks old and weighing at least 3.3 lbs. Your veterinarian will prescribe the right dose for your dog.

*Based on label comparison of the number of parasite types covered in a chewable that targets ticks.

§Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.

[1] Elanco Animal Health. Data on file. REF-29599
[3] Cavalleri D et al. Parasit Vectors 2017;10(1):529
[9] Elanco Animal Health. Data on file. REF-26782

Suitable for:

Dogs and Puppies( from 8 weeks of age & older and weighing 3.3 lbs or greater)

Benefits:

• 7-IN-1 PARASITE COVERAGE: Credelio Quattro/Credelio Quattro-CA1 helps bring peace of mind with the broadest parasite coverage of its kind* available to dogs, targeting 7 types of parasites in one chewable tablet
• COVERS MORE* THAN FLEAS & TICKS: This flea and tick treatment is the first and only chewable* for dogs that covers ticks, fleas, heartworm disease, New World screwworm larvae, and 3 intestinal worms that can be passed to humans — roundworms, hookworms and tapeworms
• KILLS TICKS** & FLEAS FAST: This tick and flea chewable begins to kill ticks*** and fleas within 4 hours, so there can be one less thing to come between you and your pet
• TASTY & EASY TO GIVE: This FDA-approved parasite coverage comes in a flavored chewable tablet, with successful administration to 98% of dogs in a U.S. field study [1]
• Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.
• PRESCRIPTION REQUIRED: Credelio Quattro / Credelio Quattro-CA1 is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.

How does Credelio Quattro work?

This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly***. In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs. * Based on label comparison of the number of parasite types covered in a chewable that covers ticks ** Amblyomma americanum (lone star tick) *** Elanco Animal Health. Data on file. † Uncinaria stenocephala †† Based on the time to statistical significance vs. control in a study on Day 21 and Day 28 for reinfestations. The study compared Credelio (lotilaner)—not Credelio Quattro, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner). ††† Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative speed of kill provided by lotilaner (Credelio), sarolaner (Simparica Trio), and afoxolaner (NexGard) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 2024 Jul 20;17(1):313.

Caution:

 Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Lyme disease infections as a direct result of killing black-legged ticks. 

Credelio Quattro-CA1 is conditionally approved for the treatment of infestations caused by New World screwworm (NWS) larvae in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

IMPORTANT SAFETY INFORMATION: Lotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro/Credelio Quattro-CA1 administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. 

Credelio Quattro-CA1 is conditionally approved by the FDA pending a full demonstration of effectiveness under application number 141-619. If you suspect that your dog is infested with NWS larvae, seek veterinary care immediately for treatment to include removal of larvae and appropriate wound care. 

For complete safety information, please see the Credelio Quattro/Credelio Quattro-CA1 product label or ask your veterinarian.: Lotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro/Credelio Quattro-CA1 administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. 

Credelio Quattro-CA1 is conditionally approved by the FDA pending a full demonstration of effectiveness under application number 141-619. If you suspect that your dog is infested with NWS larvae, seek veterinary care immediately for treatment to include removal of larvae and appropriate wound care. 

For complete safety information, please see the Credelio Quattro/Credelio Quattro-CA1 product label or ask your veterinarian.

How should I store this product?

Store at 15-25 °C (59-77 °F). Excursions permitted between 5 and 40 °C (41 and 104 °F).

What is the most important information I should know about Credelio Quattro?

Credelio Quattro is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum , Taenia pisiformis , and Echinococcus granulosus) infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

How should Credelio Quattro be given/administered?

Credelio Quattro is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Credelio Quattro must be administered with food (see Clinical Pharmacology). Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule.

*Based on label comparison of the number of parasite types covered in a chewable that targets ticks
**I. ricinus, A. americanum, and I. scapularis [3,4]
***Ixodes ricinus
[1] Elanco Animal Health. Data on file. REF-29599
[3] Reif KE et al. Parasit Vectors 2024;17(1):313
[4] Elanco Animal Health. Data on file. REF-29173