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Simparica

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Simparica?

Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly and requires a prescription from your veterinarian.

For:

Dogs (6+ months of age, weighing 2.8+ lbs)

Benefits:

  • Each tablet provides a full month of protection against fleas and ticks
  • Tasty, liver-flavored chewable tablet is easy to administer
  • Chewable tablets can be given directly to your dog or broken up and mixed with food
  • Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs

How does Simparica work?

Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Simparica is administered once a month directly by mouth or can be crumbled and mixed with food. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

Cautions:

Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age weighing less than 2.8 lbs. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

Brand Name

Simparica (Zoetis)

Generic Name

Sarolaner (sar-oh-lan-ur)

What is the most important thing I should know about Simparica?

Simparica is used for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] in dogs over 6 months of age weighing 2.8 lbs and over. Simparica is available as a liver-flavored, chewable tablet. Simparica requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica to my pet?

Tell your veterinarian if your pet is breeding, pregnant, or lactating.

How Simparica should be given?

Simparica should be administered orally, once every month, at the minimum dosage of 0.91 mg/lb (2 mg/kg) sarolaner. Dogs weighing 2.8 to 5.5 lbs should be given one 5 mg Simparica chewable tablet monthly. Dogs weighing 5.6 to 11.0 lbs should be given one 10 mg Simparica chewable tablet monthly. Dogs weighing 11.1 to 22.0 lbs should be given one 20 mg Simparica chewable tablet monthly. Dogs weighing 22.1 to 44.0 lbs should be given one 40 mg Simparica chewable tablet monthly. Dogs weighing 44.1 to 88.0 lbs should be given one 80 mg Simparica chewable tablet monthly. Dogs weighing 88.1 to 132.0 lbs should be given one 120 mg Simparica chewable tablet monthly. Dogs weighing more than 132.0 lbs should be given appropriate combination of Simparica tablets monthly. Care should be taken that your dog consumes the complete dose, and treated pets should be observed for a few minutes to ensure that part of the dose is not lost or refused.

For flea treatment and prevention: Treatment may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

For tick treatment and control: Treatment with Simparica can begin at any time of the year.

What are the potential side effects of Simparica?

The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.

What happens if I miss giving a dose of Simparica?

If a dose is missed, administer Simparica and resume a monthly dosing schedule.

What happens if I overdose my pet on Simparica?

Contact your veterinarian immediately.

What should I avoid while giving Simparica to my pet?

Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica?

There are no known contraindications for the use of Simparica.

How to Use

Simparica Directions:

  • Administer one Simparica chewable once every month.
  • Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
  • Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
  • Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tip:

Always make sure ample water is available for your dog.

Dosage:
Dogs:
6+ months of age, weighing 2.8+ lbs
Weight:
Amount:
2.8-5.5 lbs
One 5 mg chewable tablet monthly
5.6-11.0 lbs
One 10 mg chewable tablet monthly
11.1-22.0 lbs
One 20 mg chewable tablet monthly
22.1-44.0 lbs
One 40 mg chewable tablet monthly
44.1-88.0 lbs
One 80 mg chewable tablet monthly
88.1-132.0 lbs
One 120 mg chewable tablet monthly
Over 132.1 lbs
Administer the appropriate combination of Simparica chewable tablets monthly
Cats:
Do not use!
Horses:
Do not use!
Storage:

Store at or below 86°F (30°C) with excursions permitted up to 104°F (40°C).

Ingredients

Simparica Ingredients:

Simparica for Dogs 2.8-5.5 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
5 mg
Simparica for Dogs 5.6-11 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
10 mg
Simparica for Dogs 11.1-22.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
20 mg
Simparica for Dogs 22.1-44.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
40 mg
Simparica for Dogs 44.1-88.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
80 mg
Simparica for Dogs 88.1-132.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
120 mg
Customer Reviews
Simparica is rated 3.6 out of 5 by 19.
Rated 3 out of 5 by from Less harsh than other brands but..... I went with this brand b cause it had the best reviews, Little to no side effects as compared to others, and cheaper! Sounded too good to be true. It wasn’t really. I’m pleased overall. We are at the 48 hour mark after dosing and no vomiting or bloody diarrhea like the others seem to cause BUT we do have some mild diarrhea and a touch of lethargy today. Nothing alarming though. Not sure exactly how long it’s suppose to take to be completely effective, we definitely have a decrease in scratching but still some scratching none the less. I’m trying to remain hopeful that after the 72 hour mark we should be flea free....fingers crossed. The shipping however was outstanding! Ordered on Thursday with the standard free shipping which was the slowest option and received it on Saturday! Very surprised!
Date published: 2017-11-19
Rated 5 out of 5 by from Best flea medication by far!!!! I have been a big fan of Revolution until the vet switched us to this new flea medication. The fleas are gone!!! I have also found that one of my pups USE to chew/bite himself so badly that he would rip out his hair, get sores and scabs, and form bundles of hair between his teeth from ripping out his hair-This problem has been rectified after using Simparica!!! I am extremely satisfied and highly recommend this product!!
Date published: 2017-11-13
Rated 5 out of 5 by from Awesome!! A little expensive but this is the only pill that works for my dog's flea allergy. I crush it into some wet food. Great product!
Date published: 2017-10-29
Rated 5 out of 5 by from Saved by Simparica I used Advantage but my 1 year old Boston kept scratching. Told Vet and she recommended Simparica. Great news.. .no more fleas, no more scratches. Did find a dead tick. Vet said as soon as the tick bites they die instantly.No side effects. No scratching.
Date published: 2017-10-06
Rated 1 out of 5 by from Be careful This medication has quite a few side effects. All clearly listed on the package. My dog had all of them and ended up in the hospital for 18 hours. If your dog is sensitive to medications this might not be the right one.
Date published: 2017-09-18
Rated 5 out of 5 by from Awesome! My little Pennelope had been covered in fleas. I usually give her advantage, but it wasn't working anymore, so my vet gave my pup this chewable. Works GREAT! No fleas at all!
Date published: 2017-09-02
Rated 5 out of 5 by from Relief at last Our poor Bassett hound has suffered from fleas for his entire life ( 1 year) We literally tried everything and it didn't work at all or it only partially worked. Either way, it always made him sick. We were very reluctant to give him an oral med with his history, but this summer he suffered so badly we felt we had no choice. I gave him the chew and he loved it. Then I watched him like a hawk. All I saw was dead fleas in a few hours! He never got sick at all! I'm so glad we tried this! It is the best solution for our dog.
Date published: 2017-08-30
Rated 1 out of 5 by from Does not work We switched out dogs to Simparica and a few weeks later the are flea in the house! This product does not work plain and simple.
Date published: 2017-08-23
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Q&A

My dog is 12 pounds can I cut the pill in half 

Asked by: Sherry
Simparica 5.6-11 lbs is the appropriate size for your pet. The tablet may be cut in half; however, it is not recommended. Consult your veterinarian for more information.
Answered by: Lisa M
Date published: 2017-10-11

The Banfield vet assistant gave my dog this tablet. She is a 7 lb 9 week old corgi. It's been about 3 hours and she seems ok, but I'm horribly worried after reading some horror stories about this chewable.. should I be overly concerned because of her age?

Asked by: MichelleSK
Simparica is usually well tolerated. Consult your veterinarian with your concern regarding your pet's age and the use of this drug.
Answered by: Lisa M
Date published: 2017-09-14

Can I bath my dog while she is taking simpatico?

Asked by: Debbie
Since  it's good for 35 days, do you administer every 35 days?  
Answered by: Daisy
Date published: 2017-09-06

What will happen if I've gave my dog 2 pills in one month?

Asked by: Joel
Thank you for your question. There is a possibility that you may overdose them. It's not necessary to administer two.
Answered by: leanniejo
Date published: 2017-11-19

Will Simparica kill demodex that causes mange?

Asked by: Sherrie T
Thank you for your question. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)].
Answered by: leanniejo
Date published: 2017-08-21

I gave my dog who is 198 lbs, simprico sun.night.mon had a little dihreeha. Tues. Had no food or water. Wed some food a water.thurs. would not leave me at all and tonight some water and food.and wasn't tottaly up my butt,just wond. Is it still side e

Asked by: Triciascal
Thank you for your question. The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.
Answered by: leanniejo
Date published: 2017-08-08

Can I give Simparica with Interceptor Plus? 

Asked by: Msmith1
Thank you for your question. Yes, you can give Simparica with Interceptor Plus. Unless otherwise advised by your veterinarian.
Answered by: Crystal PetMed Pro
Date published: 2017-07-25

I gave my dog a dose in early June and early July. He's been really itchy and I just found a flea on him...?? I have the proper dosage from my vet btw. 

Asked by: Nancy
Thank you for your question. If the product was purchased with our company we do have a 100% satisfaction guarantee please contact us at 1-800-738-6337 and we will be happy to help.
Answered by: Crystal PetMed Pro
Date published: 2017-07-12
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