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Ivermectin-Pyrantel - Generic to Heartgard Plus

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2. We verify your prescription and ship your order!
Starts $36.24 $25.92 
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26-50 lbs
51-100 lbs
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Product Info
How to Use
Customer Reviews
Product Info

What is Ivermectin-Pyrantel - Generic to Heartgard Plus?

Tri-Heart Plus Ivermectin/Pyrantel for dogs is a heartworm preventative that also controls roundworms and hookworms. Ivermectin/Pyrantel is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Ivermectin/Pyrantel is considered to be the #1 generic heartworm preventative recommended by veterinarians.


Dogs (6+ weeks of age, no weight requirement)


  • Tasty flavored chewable tablets
  • Easy to administer
  • Small, easy-to-chew tablet for smaller or finicky dogs
  • Given once a month

How does Ivermectin/Pyrantel work?

Ivermectin/Pyrantel is an anthelmintic (dewormer). The ingredient pyrantel pamoate is used to treat and control roundworms and hookworms in dogs.

Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.


Can cause sensitivities in herding dog breeds. The safe use of this drug has not been evaluated in pregnant or lactating bitches. Store Ivermectin/Pyrantel at room temperature. Do not remove the tablet from its wrapper until ready to give to your pet. Keep this medication away from children and pets.

Brand Name:

Tri-Heart Plus (Merck)

Generic Name:


What is the most important thing I should know about Ivermectin/Pyrantel?

Ivermectin/Pyrantel is a prescription medication available as flavored chewable tablets. The usual dose of Ivermectin/Pyrantel in dogs up to 25 lbs is 68 mcg/57 mg (Blue box), for dogs 26-50 lbs is 136 mcg/114 mg (Green box) and for dogs 51-100 lbs is 272 mcg/227 mg (Brown box). Dogs over 100 lbs are given a combination of tablets.

What should I discuss with my veterinarian before giving Ivermectin/Pyrantel to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Ivermectin/Pyrantel be given?

Give Ivermectin/Pyrantel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Ivermectin/Pyrantel for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result.

What are the potential side effects of Ivermectin/Pyrantel?

Side effects of Ivermectin/Pyrantel are rare at the recommended heartworm prevention dose, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.

What happens if I miss giving a dose of Ivermectin/Pyrantel?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Ivermectin/Pyrantel?

If you suspect that your pet has received an overdose of Ivermectin/Pyrantel, consult your veterinarian or emergency veterinary clinic immediately.

What should I avoid while giving Ivermectin/Pyrantel to my pet?

Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents. To prevent reinfection, daily cleanup of stools is recommended.

What other drugs will affect Ivermectin/Pyrantel?

Do not give Ivermectin/Pyrantel if your pet is already being given another heartworm medication.

How to Use

Ivermectin/Pyrantel Directions:

  • Give Ivermectin/Pyrantel Flavored Chewables once a month on the same day of each month year-round.
  • Ivermectin/Pyrantel Flavored Chewables can be given by hand, mixed intact with a small amount of food, or placed in the back of your dog's mouth for forced swallowing.
  • Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.

Do not remove the chewable from its wrapper until ready to give to your pet.

Dogs/Puppies: (6+ weeks of age)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
26-50 lbs
Give 1 chewable every month (Green Box)
51-100 lbs
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Do not use!
Do not use!

Should be stored at room temperature.


Ivermectin/Pyrantel Ingredients:

Ivermectin/Pyrantel - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet)
68 mcg
57 mg
Ivermectin/Pyrantel - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet)
136 mcg
114 mg
Ivermectin/Pyrantel - Brown Box (Dogs 51-100 lbs):
Active Ingredients (per chewable tablet)
272 mcg
227 mg
Customer Reviews
Ivermectin-Pyrantel - Generic to Heartgard Plus is rated 4.4 out of 5 by 1004.
Rated 4 out of 5 by from Great Product My dog Jake, a large white lab, has been taking Tri-Heart Plus for the last two years and he has been super healthy each time he goes to the vet. The only bad thing about this pill is that its large and it smells so if I don't dip it in liquid dog food or broth and wrap it in bread then he's not taking it. He refuses once he finds it. Just the pill alone in bread or a piece of ham isn't good enough because he will smell it. But overall I Def will continue to purchase this product!
Date published: 2017-03-13
Rated 5 out of 5 by from Affordable! My baby takes his with a small piece of cheese!
Date published: 2017-03-13
Rated 4 out of 5 by from Using it only a month, pill isn't appealing looking, but my pitbull didn't care he hobbled it up like he does everything else! Works great price is cheap for the same result.
Date published: 2017-03-07
Rated 5 out of 5 by from Amazing Bought it for my 56 pound pitbull and she's doing so much better!!! No more coughing and no more throwing up because of the heartworm eggs.
Date published: 2017-03-05
Rated 5 out of 5 by from GREAT MEDS Max has been on this heart worm meds...for years..... Generic for Heart Guard at a affordable price...He's thriving and very healthy with this product....10 years old and very happy and energetic. It is a large pill so we cut it into and then he takes it...would recommend this product..
Date published: 2017-02-27
Rated 5 out of 5 by from Works well at an affordable price I've been using this Tri-Heart on both of my Airedales for years,both are close to 50lbs. Last time I was at the Vet in Jan 2017 they did a heart worm test because according to them these worms are getting resistant to some meds. They did the test and she passed without any problems.
Date published: 2017-02-25
Rated 5 out of 5 by from Great tasting. I've been giving this to my dog for months now and glad not to have to wrap it up in lunch meat to get her to eat it. She gobbles it up as soon as I place it in front of her.
Date published: 2017-02-24
Rated 5 out of 5 by from Easy to give I have been using this product for about a year now. My dog hikes with my all the time and I had pulled a few ticks off her in the past, since using this product I have not had any issues with ticks! My mom is a vet and she recommends this product to her clients. Wonderful costumer service as well.
Date published: 2017-02-22
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Why is this item advertised at $25.92 but I'm being charged $30+?

Asked by: Sylvie
Most likely you either did not enter the promo code for the discount or did not account for shipping and handling charges for your order.
Answered by: SuzyCVT
Date published: 2017-03-05

Will giving my dog which is a cross Australian shepherd/lab Heartgard plus have her break out with red welts on her nose and sneeze alot?

Asked by: Rya1
This should not cause break outs and sneezing. That sounds like an allergic reaction. This product is cautioned in herding breeds. Consult with your veterinarian to make sure this product is right for your dog.
Answered by: Ben B
Date published: 2017-03-12

Is the tri heart (generic heart guard ) a beef flavor or chicken?

Asked by: Skap
This is artificially flavored beef.
Answered by: Ben B
Date published: 2017-02-21

My dog is about 7 months old and about 50 lbs and she just ate 5 tri-heart plus pills what are the risks? We are very concerned

Asked by: Gusbug
That is a lot, as it is well above the recommended dose for your dog. You should contact your vet right away about the situation as a lot of this medication can cause tremors, loss of body weight, and even death.
Answered by: Trey W
Date published: 2017-02-21

Do I need my vet's prescription for this product?  And is it the same as heartguard?

Asked by: Terry
Hello, This is the generic for Heartgard plus and thus contains the same active ingredients that bring about its therapeutic effects. This medication does require a prescription. Thanks for asking, Pharmacy Intern
Answered by: Ben B
Date published: 2017-02-17

My 10-months old Welsh Corgi's weight ranges from 24.5 to 25.3 lbs, depending on what day I weigh her. Should I buy the 1-25 lbs or 26-50 lbs package? Thanks.

Asked by: Binh
Because your Corgi is only 10 months old, she is not at her full adult weight so she will likely go over 25 pounds and you should use the 26-50 pound dose.
Answered by: SuzyCVT
Date published: 2017-02-03

Australian shepherds 

Asked by: Pjlcnp
You are probably concerned about giving Ivermectin to a potentially Ivermectin-sensitive breed. Your dog may or may not be carrying the gene that causes the sensitivity so you can either use another product that does not have Ivermectin as an ingredient, such as Interceptor, Trifexis or Revolution, or you can give a single dose (try purchasing it from your veterinarian), perhaps even using a lesser than prescribed dose, to see if your dog has the sensitivity.
Answered by: SuzyCVT
Date published: 2017-01-26

My puppy is 10 months old & weighs 48.7 lbs. I need to order more tri-heart plus, but the smallest dose is 6 months. I'm afraid she'll weigh too much before the medication runs out. Is it possible to order less than 6 or can I give her the next dose up? 

Asked by: DeRae
Tri-Heart Plus is very safe. Since your pup will likely weigh over 50 pounds soon, I recommend you purchase the 50-100 pound size and if one or 2 doses are given before she weighs 50 pounds, that is okay.
Answered by: SuzyCVT
Date published: 2017-01-26
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