What is Ivermectin-Pyrantel - Generic to Heartgard Plus?
Tri-Heart Plus Ivermectin/Pyrantel for dogs is a heartworm preventative that also controls roundworms and hookworms. Ivermectin/Pyrantel is a generic equivalent to Heartgard Plus, and requires a prescription from your veterinarian. It has the same active ingredients and is the same strength. Ivermectin/Pyrantel is considered to be the #1 generic heartworm preventative recommended by veterinarians.
Dogs (6+ weeks of age, no weight requirement)
Tasty flavored chewable tablets
Easy to administer
Small, easy-to-chew tablet for smaller or finicky dogs
Given once a month
Note: Unlike Heartgard Plus which is a soft chew, this product is a hard tablet. If your pet will not eat the flavored tablet like a treat, you can mix it intact with a small amount of food or place it in the back of your dog's mouth (far enough back in order to leave no other option but for the tablet to get swallowed). Only attempt this if you're comfortable with the procedure. Some dogs may get upset with this forceful handling which can possibly cause the tablet to come back up and be expelled.
How does Ivermectin/Pyrantel work?
Ivermectin/Pyrantel is an anthelmintic (dewormer). The ingredient pyrantel pamoate is used to treat and control roundworms and hookworms in dogs.
Studies have indicated that certain dogs of the herding breeds are more sensitive to the effects of ivermectin administered at elevated dose levels due to the MDR1 gene. Dog breeds that may be affected include Australian Shepherd, Australian Shepherd Mini, Border Collie, Collie and English Shepherd.
Can cause sensitivities in herding dog breeds. The safe use of this drug has not been evaluated in pregnant or lactating bitches. Store Ivermectin/Pyrantel at room temperature. Do not remove the tablet from its wrapper until ready to give to your pet. Keep this medication away from children and pets.
Tri-Heart Plus (Merck)
What is the most important thing I should know about Ivermectin/Pyrantel?
Ivermectin/Pyrantel is a prescription medication available as flavored chewable tablets. The usual dose of Ivermectin/Pyrantel in dogs up to 25 lbs is 68 mcg/57 mg (Blue box), for dogs 26-50 lbs is 136 mcg/114 mg (Green box) and for dogs 51-100 lbs is 272 mcg/227 mg (Brown box). Dogs over 100 lbs are given a combination of tablets.
What should I discuss with my veterinarian before giving Ivermectin/Pyrantel to my pet?
Tell your veterinarian if your pet has ever had an allergic reaction to the medication.
How should Ivermectin/Pyrantel be given?
Give Ivermectin/Pyrantel exactly as directed by your veterinarian. If you do not understand the directions ask your pharmacist or veterinarian to explain them to you. Use with caution, Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Ivermectin/Pyrantel for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result.
What are the potential side effects of Ivermectin/Pyrantel?
Side effects of Ivermectin/Pyrantel are rare at the recommended heartworm prevention dose, but may include lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight, or death.
What happens if I miss giving a dose of Ivermectin/Pyrantel?
Give the missed dose as soon as you remember. Do not give a double dose of the medication.
What happens if I overdose my pet on Ivermectin/Pyrantel?
If you suspect that your pet has received an overdose of Ivermectin/Pyrantel, consult your veterinarian or emergency veterinary clinic immediately.
What should I avoid while giving Ivermectin/Pyrantel to my pet?
Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents. To prevent reinfection, daily cleanup of stools is recommended.
What other drugs will affect Ivermectin/Pyrantel?
Do not give Ivermectin/Pyrantel if your pet is already being given another heartworm medication.
How to Use
Give Ivermectin/Pyrantel Flavored Chewables once a month on the same day of each month year-round.
Ivermectin/Pyrantel Flavored Chewables can be given by hand, mixed intact with a small amount of food, or placed in the back of your dog's mouth for forced swallowing.
Watch your dog closely following dosing to be sure the entire dose has been swallowed. If it is not completely swallowed, give one more full recommended dose as soon as possible.
Do not remove the chewable from its wrapper until ready to give to your pet.
Ivermectin-Pyrantel - Generic to Heartgard Plus Dosage for Dogs/Puppies: (6+ weeks of age)
Dogs/Puppies: (6+ weeks of age)
Up to 25 lbs
Give 1 chewable every month (Blue Box)
Give 1 chewable every month (Green Box)
Give 1 chewable every month (Brown Box)
Over 100 lbs
Give combination of chewables based on weight
Ivermectin-Pyrantel - Generic to Heartgard Plus Dosage for Cats:
Do not use!
Ivermectin-Pyrantel - Generic to Heartgard Plus Dosage for Horses:
Do not use!
Should be stored at room temperature.
Ivermectin/Pyrantel - Blue Box (Dogs up to 25 lbs):
Active Ingredients (per chewable tablet)
Ivermectin/Pyrantel - Green Box (Dogs 26-50 lbs):
Active Ingredients (per chewable tablet)
Ivermectin/Pyrantel - Brown Box (Dogs 51-100 lbs):