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Interceptor Plus

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2. We verify your prescription and ship your order!
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Product Info
How to Use
Customer Reviews
Product Info

What is Interceptor Plus?

Interceptor Plus is a monthly, broad spectrum parasiticide used to prevent heartworm disease, as well as treat and control common intestinal parasites including roundworms, hookworms, whipworms and tapeworms. Interceptor Plus offers long-lasting protection in the convenience of a tasty, easy-to-administer chewable. The chewable tablets are chicken flavored, which is an added benefit for dogs suffering from beef allergies. Most dogs love the taste, and you can rest assured that your best friend will be protected against heartworms for a full month. Interceptor Plus requires a prescription from your veterinarian. It is available as a 6-pack, which provides six months of heartworm protection or as a 12-pack which provides 12 months of protection.


Dogs and Puppies over 6 weeks of age and weighing more than 2 pounds


  • Each tablet provides a full month of protection against heartworms, roundworms, hookworms, whipworms and tapeworms
  • Tasty, chicken-flavored chewable is easy to administer
  • Chewables can be given directly to your dog or broken up and mixed with food
  • Available in four weight categories: 2-8 lbs, 8.1-25 lbs, 25.1-50 lbs, and 50.1-100 lbs
  • Package includes calendar reminder stickers to help make sure you never miss a dose

How does Interceptor Plus work?

Interceptor Plus contains the active ingredient milbemycin oxime to prevent heartworm disease caused by Dirofilaria immitis. It also contains praziquantel, which treats tapeworm infection. It also treats and controls roundworms, hookworms, whipworms.


For use in dogs and puppies over 6 weeks of age and weighing more than 2 pounds only. Do not use in cats or in humans. Keep this and all drugs out of the reach of children. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females.

Brand Name

Interceptor Plus

Generic Name

Milbemycin Oxime (mil-beh-my-sin ox-eem), praziquantel (pr'z-kwn'tl)



What is the most important thing I should know about Interceptor Plus?

Interceptor Plus is used for the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis) and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies over 6 weeks in age and weighing over 2 lbs.

How should Interceptor Plus be given?

Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure. Dogs weighing 2-8 lbs should be given one Interceptor Plus chewable tablet (Orange Box) monthly. Dogs weighing 8.1-25 lbs should be given one Interceptor Plus chewable tablet (Green Box) monthly. Dogs weighing 25.1-50 lbs should be given one Interceptor Plus chewable tablet (Yellow Box) monthly. Dogs weighing 50.1-100 lbs should be given one Interceptor Plus chewable tablet (Blue Box) monthly.

What are the potential side effects of Interceptor Plus?

The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation.

What happens if I miss giving a dose of Interceptor Plus?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Interceptor Plus?

Contact your veterinarian immediately.

What other drugs will affect Interceptor Plus?

Do not give Interceptor to your pet if your pet is already taking an alternate heartworm medication.

How to Use
  • Administer one Interceptor Plus chewable once every month.
  • Interceptor Plus may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
  • Interceptor Plus chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
  • Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Place the treatment reminder stickers (included) on your calendar for each of the months following the date of the initial treatment to help prevent missing a dose.

Dogs and Puppies:
Over 6 weeks of age weighing more than 2 lbs
2-8 lbs
One chewable tablet monthly (Orange)
8.1-25 lbs
One chewable tablet monthly (Green)
25.1-50 lbs
One chewable tablet monthly (Yellow)
50.1-100 lbs
One chewable tablet monthly (Blue)
Over 100 lbs
Use the appropriate combination of Interceptor Plus chewable tablets monthly
Do not use!
Do not use!

Store at controlled room temperature between 59°-77° F.

Interceptor Plus for Dogs 2-8 lbs (Orange):
Active Ingredient (per tablet)
Milbemycin Oxime
2.3 mg
22.8 mg
Interceptor Plus for Dogs 8.1-25 lbs (Green):
Active Ingredient (per tablet)
Milbemycin Oxime
5.75 mg
57 mg
Interceptor Plus for Dogs 25.1-50 lbs (Yellow):
Active Ingredient (per tablet)
Milbemycin Oxime
11.5 mg
114 mg
Interceptor Plus for Dogs 50.1-100 lbs (Blue):
Active Ingredient (per tablet)
Milbemycin Oxime
23 mg
228 mg
Customer Reviews
Interceptor Plus is rated 4.0 out of 5 by 8.
Rated 5 out of 5 by from So far so good I have a Standard Poodle girl. She is now 18 mo. at 45 lbs. Have been using Interceptor Plus since she was a pup. I also use BraVetco every 10-12 wks.
Date published: 2017-03-18
Rated 5 out of 5 by from Oliver loves it! My vet put my GSD/husky puppy mix on this. He's only had two months worth so far, but he takes them no problem. Takes it just as if it were a treat. I can't speak to the efficacy of it, but my dog is in great health.
Date published: 2017-03-07
Rated 5 out of 5 by from Creepy Crawly Killer! I wanted a product with high efficacy for killing most if not all the nasty creepy crawlies my dog could have and pass on to me, her grateful owner, minus or with a low possibility for side effects. Thankfully, all is well after having used this product. We are both very happy.
Date published: 2017-01-30
Rated 5 out of 5 by from Great product My one year old labradoodle was on a heartworm medication that looked like a horse pill. I rescued a 10 year old black lab mix a few months ago and the vet in the town where I adopted her, had her on this. I ended up switching the labradoodle to this because it is so much easier to give. My dogs do really well on it. So grateful to not have to give the horse pills anymore. My dogs take these with no problem. I rescued a dog a few years ago then found out she had heartworms. I wouldn't want that for any dog. So glad I can treat these dogs easily.
Date published: 2016-10-09
Rated 5 out of 5 by from Works for me! I switched to this product when one of my dogs was having a reaction to Trifexis. I now give Interceptor Plus once a month and Bravecto every three months. Interceptor has the same heartworm medication as Trifexis but also controls tapeworms. Between the two products I never have to worry about fleas, heartworm or any other intestinal parasites. Other than one or two loose stools, my two 17 lb dogs have not had any adverse reactions to these meds.
Date published: 2016-10-03
Rated 1 out of 5 by from PROCEED WITH CAUTION Young 2 year old very healthy Labrador developed severe tremors within hours of taking this drug.....I would NOT recommend....
Date published: 2016-10-02
Rated 1 out of 5 by from Makes dog too agressive. Our husky takes these and immediately starts freaking out more than usual. The day we started doing this medication, she would bite the leash in public, which she never does. It says there's a chance of neurological side effects in dogs, not sure if other brands are safer.
Date published: 2016-09-28
Rated 5 out of 5 by from Never seen a flea on my outside dogs! I have two labs that stay outside. With this pill I have had only 1 tick in 6 months and have never seen a flea on my girls! Very much worth it!
Date published: 2016-07-02
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Where is Interceptor Plus manufactured and where is it shipped from?

Asked by: Ralph
It may be made by Novartis but it is not shipped from them. Novartis only distributes to Veterinary clinics.
Answered by: megs289
Date published: 2017-01-26

I bought 6 tabs of Tri-Heart Plus from 1800petmeds for my 7 lb 3 month old chihweenie puppy. Never opened the box. Her vet just started her on Interceptor Plus. Do these two preventables do the exact same thing?

Asked by: ChihweenieMom
Both products will prevent heartworms and deworm for hookworms and roundworms, but the Interceptor Plus will also deworm for whipworms and tapeworms.
Answered by: SuzyCVT
Date published: 2017-01-19

How are you able to sell Interctptor Plus online when my vet says a prescription is required? Thank you. 

Asked by: Mike
A veterinarian's prescription is required to purchase Interceptor Plus from 1800PetMeds.
Answered by: Lisa M
Date published: 2016-12-12

I have a 64 pound yellow lab, and he has heartworms he's two years old, will this get rid of the heartworms he has now?

Asked by: Opie
No, heartworm preventatives do not treat/kill adult heartworms. They instead kill infective larval stages before they can reach adulthood. You need to talk to your vet about treatment for the adult heartworms your dog has. The preventatives will pervent your dog from getting any additional heartworms and in several years, the adult worms will die off, but until then, your dog may suffer from the affects of having adult worms and be a source of infection to other dogs that are not on heartworm prevention.
Answered by: SuzyCVT
Date published: 2016-11-18

I bought the interceptor plus 6 chewables. My dog has tapeworms. Do i have to finish all 6, once a month, to get rid of them or can i split it up with my other dog and do 3 and 3

Asked by: zabbiee
This product kills tapeworms only once a month when it is given. Considering the life cycle of tapeworms, if your dog were to swallow a flea containing the tapeworm larva the next day, the tapeworm may grow to adulthood and you will see the segments in the stool before the next dose of Interceptor Plus is due, thus requiring an additional deworming. Controlling the fleas is your best option to control tapeworms.
Answered by: SuzyCVT
Date published: 2016-12-29

My dog is about 9lbs, which one should I buy? 2lb to 8lb or 8lb-25lbs? Vet suggested me to buy 2-8lbs, they said 25 is too much to him.  I'm very confusing... what if 2-8 lbs is not enough to protect from heat worm?

Asked by: Sherry
I recommend you use the 8-25 lb range to ensure your dog is protected. The manufacturer has done testing to make sure the product is safe for use in dogs at the indicated weight ranges. The products is very safe even at much higher doses.
Answered by: SuzyCVT
Date published: 2016-11-01

is this a soft chewable or is it hard?

Asked by: grymsmom
It is soft, similar to the consistency of a Tootsie Roll.
Answered by: Mrsmmben
Date published: 2016-09-18

I gave my dog the correct dosage a week and a half ago because he had tapeworms. They went away after the pill was given, but have returned again. Will the pill eventually kill them or does he have to suffer another 3 weeks before I redose?

Asked by: shadowmom
Tapes should be retreated ten days after the first treatment because the initial dosage usually misses the eggs. However, once the infestation is down, the monthly prevention wil do its job to prevent this from happening again
Answered by: Lab Mommy
Date published: 2016-09-06
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