What is Clomipramine Hydrochloride Tablets - Generic to Clomicalm?
Clomipramine Hydrochloride Tablets belong to the dibenzazepine class of tricyclic antidepressants. Clomipramine hydrochloride reduces the clinical signs of separation anxiety. Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) may be alleviated by the use of Clomipramine Hydrochloride Tablets in conjunction with behavior modification. The tablets are beef flavored to make administration easy. Scored for accurate dosing. For use in dogs older than 6 months of age. It can be used as part of a comprehensive behavior management program.
Dogs (6 months of age of age or older)
- Reduces signs of separation anxiety
- Use as part of a comprehensive behavior management program
- Can alleviate inappropriate barking or destructive behavior, as well as inappropriate elimination
- Tasty beef flavor tablets are easy to give
How does Clomipramine Hydrochloride Tablets work?
Clomipramine Hydrochloride Tablets reduce the clinical signs of separation anxiety by affecting serotonergic and noradrenergic neuronal transmission in the central nervous system. While clomipramine hydrochloride can cause lethargy in dogs its mode of action is not as a sedative. Clomipramine hydrochloride’s capacity to inhibit re-uptake of serotonin in the central nervous system is believed to be the primary mechanism of action.
Clomipramine Hydrochloride Tablets are not recommended for other behavior problems, such as aggression. Studies to establish the safety and efficacy of clomipramine hydrochloride tablets in dogs less than 6 months of age have not been conducted.
clomipramine hydrochloride tablet
What is the most important thing I should know about Clomipramine Hydrochloride Tablets?
Clomipramine Hydrochloride Tablets reduce the clinical signs of separation anxiety by affecting serotonergic and noradrenergic neuronal transmission in the central nervous system. Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) may be alleviated by the use of Clomipramine Hydrochloride Tablets in conjunction with behavior modification.
What should I discuss with my veterinarian before giving Clomipramine Hydrochloride Tablets to my pet?
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Tell your veterinarian if your pet has liver or kidney disease, asthma, thyroid disease, diabetes, stomach or intestinal problems, high blood pressure or heart disease, difficulty urinating, seizures, or glaucoma. Tell your veterinarian if your pet is pregnant or lactating.
How should Clomipramine Hydrochloride Tablets be given?
Clomipramine Hydrochloride Tablets should be given once or twice daily with a small amount of food.
What are the potential side effects of Clomipramine Hydrochloride Tablets?
The following adverse reactions have been reported associated with administration of clomipramine hydrochloride tablets: lethargy/depression, vomiting, diarrhea, elevation in liver enzymes, convulsion(s), increased heart rate, decreased heart rate, increased thirst and confusion. Liver disease has occurred, especially in the presence of pre-existing conditions or with concurrent administration of drugs metabolized by the liver.
To reduce the incidence of vomiting that may be experienced by some dogs, Clomipramine Hydrochloride Tablets may be given with a small amount of food.
What happens if I miss giving a dose of Clomipramine Hydrochloride Tablets?
If a dose is missed, the next dose should be administered (without doubling) at the next scheduled dosing time.
What happens if I overdose my pet on Clomipramine Hydrochloride Tablets?
In case of overdose, contact your veterinarian immediately.
What should I avoid while giving Clomipramine Hydrochloride Tablets to my pet?
The use of Clomipramine Hydrochloride Tablets should not replace appropriate behavioral and environmental management but should be used to facilitate a comprehensive behavior management program. Clomipramine Hydrochloride Tablets are contraindicated in dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants. Clomipramine Hydrochloride Tablets should not be used in male breeding dogs. Testicular hypoplasia was seen in dogs treated for 1 year at 12.5 times the maximum daily dose.
What other drugs will affect Clomipramine Hydrochloride Tablets?
Clomipramine Hydrochloride Tablets should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor [e.g. selegiline hydrochloride (L-deprenyl),amitraz]. Clomipramine Hydrochloride Tablets are contraindicated for use in dogs with a history of seizures or concomitantly with drugs which lower the seizure threshold.
Clomipramine Hydrochloride Tablets Directions:
- Administer as a daily dose or divide into twice daily doses to minimize side effects. To reduce the incidence of vomiting that may be experienced by some dogs, Clomipramine Hydrochloride Tablets may be given with a small amount of food.
- The recommended daily dose of Clomipramine Hydrochloride Tablets is 2 to 4 mg/kg/day (0.9 – 1.8 mg/lb/day) (see dosing table below).
Clomipramine Hydrochloride Tablets help to reduce anxiety, thus allowing your dog to more effectively benefit from behavior training. The specific methods of behavioral modification used in clinical trials involved desensitization and counterconditioning techniques. Since the manifestation of separation anxiety can vary according to the individual dog, it is advised that a specific behavior modification plan be developed based on a professional assessment of each individual case.
Clomipramine Hydrochloride Tablets Dosage:
|2.75 — 5.5 lbs||5 mg|
|5.6 — 10.9 lbs||10 mg|
|11 — 22 lbs||20 mg|
|22.1 — 44 lbs||40 mg|
|44.1 — 88 lbs||80 mg|
|88.1 — 176 lbs||160 mg|
|Cats||Do not use!|
|Horses||Do not use!|
Keep out of reach of children and other pets. Store in a dry place at controlled room temperature, between 59° and 86° F (15-30° C). Store unused tablets in the original closed container.
Clomipramine Hydrochloride Tablets Ingredients: