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Advantage II

Starts $59.84 $41.99 
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Advantage II?

Advantage II is a monthly flea preventative for dogs and cats that offers comprehensive flea protection by killing adult fleas, larvae, and eggs. Plus, it kills fleas through contact, which means fleas don't have to bite your pet to die. Advantage II also treats, prevents, and controls lice on dogs. Advantage II does not kill ticks, so we recommend using the Preventic Tick Collar along with Advantage II (dogs only). Advantage II for small cats 5-9 lbs can also be used for ferrets weighing 1 lb or over and 10 weeks of age or older.

For:

Dogs (7+ weeks of age, weighing 3+ lbs), Cats (8+ weeks of age, weighing 2+ lbs), Ferrets (10+ weeks of age, weighing 1+ lbs)

Benefits:

  • Convenient, once-a-month application
  • Kills through contact - fleas don't have to bite to die
  • Kills fleas within 12 hours of application on cats and dogs
  • Kills fleas within 24 hours of application on ferrets
  • Kills all flea life stages including flea eggs and larvae to prevent infestation
  • Treats, prevents, and controls lice infestations (dogs only)
  • Safe and easy to apply
  • Waterproof - remains effective even if pet gets wet (use of a soap-free shampoo is recommended)

How does Advantage II work?

The first active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Within 12 hours of application on cats and dogs, 98-100 percent of fleas are dead. Advantage II Small Cat kills the existing fleas on ferrets within 24 hours. The second active ingredient, pyriproxyfen, is an insect growth regulator. Once a female flea lays her eggs, pyriproxyfen works to prevent the eggs from hatching, ending the flea life cycle. Also, the active ingredient in Advantage II kills through contact, which means that fleas don't have to bite your pet to die. Reinfesting fleas are killed with protection against further flea infestation lasting for up to 4 weeks. Pre-existing pupae in the environment may continue to emerge for 6 weeks or longer depending upon the climactic conditions.

Cautions:

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become severe, consult a veterinarian immediately. Do not get this product in your pet's eyes or mouth.

Brand Name:

Advantage II (Bayer)

What is the most important thing I should know about Advantage II?

The active ingredients in Advantage II are Imidacloprid (9.1%) and Pyriproxyfen (0.46%). Advantage II Kitten, Advantage II Small Cat and Advantage II Large Cat are once a month topical flea prevention and treatment for cats and kittens over 8 weeks or older. Advantage II Small Cat may also be used for ferrets weighing 1 lb or over and 10 weeks of age or older. Advantage II Small Dog, Advantage II Medium Dog, Advantage II Large Dog, and Advantage II Extra Large Dog are once a month topical flea prevention and treatment for dogs and puppies 4 lbs or more and 7 weeks or older. Advantage II kills all flea life stages. Advantage II kills fleas within 12 hours of application. Advantage II for Dogs also treats, prevents, and controls lice infestations. Advantage II is waterproof and fragrance free. Advantage II for cats or ferrets and Advantage II for dogs are non-prescription (OTC) products.

What should I discuss with my veterinarian before giving Advantage II to my pet?

Consult a veterinarian before using on medicated pets, if the pet is being given this product along with other pesticides, and debilitated, aged, pregnant or nursing pets.

How should Advantage II be applied?

Advantage II Kitten is available in 0.23 ml applicators for kittens 2-5 lbs (turquoise). Advantage II Small Cat is available in 0.4 ml applicators for cats 5-9 lbs or ferrets weighing 1 lb or over and 10 weeks of age or older (orange). Advantage II Large Cat is available in 0.8 ml applicators for cats 9 lbs & up (purple). Advantage II Small Dog is available in 0.4 ml applicators for dogs 3-10 lbs (green). Advantage II Medium Dog is available in 1.0 ml applicators for dogs 11-20 lbs (teal). Advantage II Large Dog is available in 2.5 ml applicators for dogs 21-55 lbs (red). Advantage II Extra Large Dog is available in 4.0 ml applicators for dogs over 55 lbs (blue). To apply, place the applicator tip through your pet's hair to the skin level. On cats and ferrets, apply to skin on neck at the base of the skull. For dogs up to 20 lbs, apply to skin on back between the shoulder blades. For dogs 21 lbs or over apply the contents of one tube to 3 or 4 spots along the skin on back from the shoulder to the tail. Do not get this product in the pet's eyes or mouth.

What are the potential side effects of Advantage II?

Individual sensitivities, while rare, may occur after using any pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately.

What happens if I miss giving a dose of Advantage II?

If a dose is missed, apply the usual dose of Advantage II and resume a monthly dosing schedule.

What happens if I overdose my pet on Advantage II?

Contact your veterinarian or veterinary emergency room.

What should I avoid while giving Advantage II to my pet?

Advantage II is for external use on dogs and puppies 3 lbs or more and 7 weeks or older, cats and kittens 2 lbs or more and 8 weeks or older, or ferrets weighing 1 lb or over and 10 weeks of age or older. This product causes eye irritation in humans and is harmful if swallowed. Avoid contact with skin. Call poison control center if swallowed. If on skin, wash with plenty of soap and water. If in eyes, flush with plenty of water.

What other drugs will affect Advantage II?

Consult your veterinarian prior to giving this product along with other pesticides.

How to Use

Advantage II Directions:

  • Only use Advantage II on dogs/puppies over 3 lbs and over 7 weeks of age, cats/kittens over 2 lbs and over 8 weeks of age, and ferrets 1 lb or over and 10 weeks of age or older.
  • Apply Advantage II once a month every month.
  • For dogs up to 20 lbs, part the pet's hair between the shoulder blades until you can see the skin. Place the tip of the applicator on the skin and release all of the tube's contents on a single spot directly on the skin.
  • For dogs 21 lbs and over, apply entire contents of the tube evenly in 3 or 4 spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the applicator on the skin and release a portion of the Advantage II solution directly on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
  • For kittens, cats and ferrets, place the applicator tip through the cat's hair to the skin on the neck at the base of the skull and release all of the tube's contents on a single spot directly on the skin.
  • Use only one applicator per treatment.
Tip:

Under normal conditions Advantage II is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not re-treat cats or dogs more often than once every 7 days. For ferrets, do not retreat more often than every 14 days. After flea control is obtained, return to a monthly treatment.

Advantage II Dosage for Dogs/Puppies: (7+ weeks of age, weighing 3+ lbs)

Dogs/Puppies: (7+ weeks of age, weighing 3+ lbs)
WeightDosage
3-10 lbsApply contents of 1 applicator once a month (Green Box)
11-20 lbsApply contents of 1 applicator once a month (Teal Box)
21-55 lbsApply contents of 1 applicator once a month (Red Box)
Over 55 lbsApply contents of 1 applicator once a month (Blue Box)
2-5 lbsApply contents of 1 applicator once a month (Turquoise Box)
5-9 lbsApply contents of 1 applicator once a month (Orange Box)
9 lbs & upApply contents of 1 applicator once a month (Purple Box)
Ferrets 1+ lbsApply contents of 1 applicator once a month (Orange Box)
Advantage II Dosage for Horses:
Horses
Do not use!
Storage:

Store this product in a cool dry place. Do not store in the refrigerator. Do not reuse empty container. Do not contaminate water, food or feed by storage or disposal. To dispose of empty container place in trash or offer for recycling if available. If container is partly filled call local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. Keep out of reach of children and pets.

Ingredients

Advantage II Ingredients:

Advantage II for Kittens 2-5 lbs (Kitten - Turquoise Box) (0.23 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Cats 5- 9 lbs or Ferrets 1 lb or over and 10 weeks of age or older (Small Cat - Orange Box) (0.4 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Cats Over 9 lbs (Large Cat - Purple Box) (0.8 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Dogs 3-10 lbs (Small Dog - Green Box) (0.4 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Dogs 11-20 lbs (Medium Dog - Teal Box) (1.0 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Dogs 21-55 lbs (Large Dog - Red Box) (2.5 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Advantage II for Dogs 55 lbs and Over (Extra Large Dog - Blue Box) (4.0 ml):
Active Ingredients% By Weight
Imidacloprid9.10%
Pyriproxyfen0.46%
Other Ingredients (not specified)90.44%
Customer Reviews
Advantage II is rated 4.3 out of 5 by 2946.
Rated 5 out of 5 by from Advantage II made my dog calmer and happier I dunno where my girl got exposed to fleas, but I noticed she'd been chewing on her tail hair. So I ordered some Advantage II. After she dashed around the yard for a few minutes, she came in a much calmer doggie--and no more waking up to her gnawing on herself. Thank you Advantage!!
Date published: 2017-12-13
Rated 5 out of 5 by from Happy kitty Excellent product my cats are happy now they can sleep without the fleas biting them
Date published: 2017-12-09
Rated 5 out of 5 by from My cats are doing better I had been giving my cats another flea medication and they were not doing well. My older can started losing hair in spots, and my maine coon was itching all over. That's why I decided to try advantage II. They are both doing well now and the hair is growing back. Thank you for making a working product.
Date published: 2017-12-06
Rated 5 out of 5 by from My fur baby BeeBee is so happy!!! His fleas are go My vet recommended Advantage II but could not find it locally. So I was glad that your company carried it. I used it on my cat and the two outside cats that like to be with my cat whenever he goes out on the patio. Thank you so much! I will be reordering this soon.
Date published: 2017-12-02
Rated 5 out of 5 by from Works Great! My vet recommend this product because it works quickly and IT DOES! Thanks 1800petmeds for the bone in the shipping box, my dog loved!
Date published: 2017-11-25
Rated 5 out of 5 by from works great This works fast, and after only a month, I see a big difference.
Date published: 2017-11-24
Rated 4 out of 5 by from Worked fast I purchased Advantage11 for my dog and 4 cats and it worked so fast and gave them instant relief. I never had a flea problem before and hoping I won't again with continued use. My dog is happy again and back to himself.
Date published: 2017-11-22
Rated 5 out of 5 by from Cured my Cat's Miliary Dermatitis from Flees! This product was basically the only thing that cured my cats miliary dermatitis from flea bites! Wow! I was desperate and tried everything. After 2 to 3 days my cat is clearly, clearly comfortable, and happy now. The numerous scabs around her neck and on top of her head are gone! Pay the extra money for this. Don't buy cheap products and waste your money.
Date published: 2017-11-22
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Q&A

Will this prevent roundworm in cats?  If not are here any nonprescription topical treatments that do?

Asked by: Kristin
The only topical dewormer for cats is Profender and it does require a veterinarian's prescription.
Answered by: Anonymous
Date published: 2018-01-09

Keep typing in feline flea treatment and Get dog. How do I find cat?

Asked by: Felix2017
For Advantage II, the cat sizes are listed on the same page as the dog sizes, just below them.
Answered by: Anonymous
Date published: 2018-01-09

Does this work on bed bugs?

Asked by: miranda
Thank you for your question. Advantage II is not used to protect against bed bugs. We do have Advantage Household Spot & Crevice Spray which kills fleas, ticks, certain spiders, bed bugs and many other bugs in your home.
Answered by: Crystal PetMed Pro
Date published: 2018-01-03

what to do if fleas came back in 1 week? how soon I can reapply or use something different?

Asked by: julie
Thank you for your question. The soonest you can redose your pet with the same product is 3 weeks. If you wish to use a different product you would wait at least 4 weeks.
Answered by: Crystal PetMed Pro
Date published: 2017-12-18

Does this control mites in cats?

Asked by: Jaime437
Thank you for your question. The Advantage II does not control mites in cats.
Answered by: Crystal PetMed Pro
Date published: 2017-12-13

I Applied advantage 2 to my dog(70lbs) 10 days ago, I gave him a bath with your be flea free shampoo the otherday. Is it necessary to re-apply a new dose of advantage 2 to my dog..thanks, Pete D.

Asked by: pete d
Thank you for your question. The Advantage II should only be applied monthly.
Answered by: Crystal PetMed Pro
Date published: 2017-12-13

Will it be safe to use this product, on my cat, along with Revolution, to kill & prevent worms as well?

Asked by: Lia5kids
Thank you for your question. You should not use Advantage II with Revolution for cats. You will only need Revolution for cats, as it both treats and prevents heartworms, fleas, ear mites, hookworms, and roundworms.
Answered by: Adriane
Date published: 2017-11-28

I have a total of 8 cats. can I buy this flea and tick medication in bulk liquid?

Asked by: Kiddcan
Thank you for your question. We offer the medication in a 12 pack if you wish to order a large quantity , as we are not a wholesaler please keep in mind we do not sell in bulk. You may give s a call at 1-800-738-6337 for more details.
Answered by: Crystal PetMed Pro
Date published: 2017-11-26
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