Apoquel Chewable

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Apoquel Chewable
Apoquel 3.6 mg (sold per chewable)
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What is Apoquel Chewable?

Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours. Apoquel requires a prescription from your veterinarian, and is sold per chewable tablet.

Suitable For:

Dogs over 12 months in age and weighing more than 6.6 lbs.

Benefits:

  • Provides onset of relief within 4 hours
  • Effectively controls itch within 24 hours
  • Safe for short term and long term usage
  • Can be used along with many other common medications, including parasiticides, antibiotics, and vaccines
  • Uniquely targeted to stop the itch with minimal negative impact on immune function
  • Controls pruritus associated with allergic dermatitis and controls atopic dermatitis
  • Sold per tablet

How does Apoquel Chewable work?

Apoquel is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel or Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel and Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post approval. Apoquel and Apoquel Chewable have not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel and Apoquel Chewable have been used safely with many common medications including parasiticides, antibiotics and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel Chewable?

Apoquel Chewable is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel Chewable to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel Chewable be given?

The dose of Apoquel Chewables is 0.18 to 0.27 mg/lb of body weight. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is ½ of a 3.6 mg chewable twice daily. The dosage for dogs 10-14.9 lbs is ½ of a 5.4 mg chewable twice daily. The dosage for dogs 15-19.9 lbs is one 3.6 mg chewable twice daily. The dosage for dogs 20-29.9 lbs is one 5.4 mg chewable twice daily. The dosage for dogs 30-44.9 lbs is ½ of a 16 mg chewable twice daily. The dosage for dogs 45-59.9 lbs is two 5.4 mg chewables twice daily. The dosage for dogs 60-89.9 lbs is one 16 mg chewable twice daily. The dosage for dogs 90-129.9 lbs is 1½ 16 mg chewable twice daily. The dosage for dogs 130-175.9 lbs is two 16 mg chewables daily.

What are the potential side effects of Apoquel Chewable?

Apoquel Chewable may increase susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, anorexia, new cutaneous or subcutaneous lumps, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel Chewable?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel Chewable?

Contact your veterinarian immediately.

What should I avoid while giving Apoquel Chewable to my pet?

Apoquel Chewable should not be given to dogs younger than 12 months or those with serious infections. Apoquel Chewable is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel Chewable has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel Chewable should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel Chewable?

Talk to your veterinarian before giving any prescription or over the counter medications.

Apoquel Chewable Directions:

  • Administer to your dog orally twice daily for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.
Tip:

Apoquel Chewable may be administered with or without food

Apoquel Chewable Dosage:

Apoquel Chewable Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg chewable tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg chewable tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg chewable tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg chewable tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg chewable tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg chewable tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg chewable tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg chewable tablets twice daily for up to 14 days
Apoquel Chewable Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg chewable tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg chewable tablet once daily
15-19.9 lbs One 3.6 mg chewable tablet once daily
20-29.9 lbs One 5.4 mg chewable tablet once daily
30-44.9 lbs 1/2 of a 16 mg chewable tablet once daily
45-59.9 lbs Two 5.4 mg chewable tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg chewable tablets once daily
130-175.9 lbs Two 16 mg chewable tablets once daily
Apoquel Chewable Dosage for Cats:
Cats
Do not use!
Apoquel Chewable Dosage for Horses:
Horses
Do not use!

Apoquel Chewable Ingredients:

Apoquel 3.6 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate3.6 mg
Apoquel 5.4 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate5.4 mg
Apoquel 16 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate16 mg

What is Apoquel Chewable?

Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours. Apoquel requires a prescription from your veterinarian, and is sold per chewable tablet.

Suitable For:

Dogs over 12 months in age and weighing more than 6.6 lbs.

Benefits:

  • Provides onset of relief within 4 hours
  • Effectively controls itch within 24 hours
  • Safe for short term and long term usage
  • Can be used along with many other common medications, including parasiticides, antibiotics, and vaccines
  • Uniquely targeted to stop the itch with minimal negative impact on immune function
  • Controls pruritus associated with allergic dermatitis and controls atopic dermatitis
  • Sold per tablet

How does Apoquel Chewable work?

Apoquel is a selective janus kinase (JAK) inhibitor, which targets pruritogenic (itch creating) cytokines. It effectively controls itching due to food allergies, flea allergies, contact dermatitis, and atopic dermatitis. Apoquel works to control pruritus for fast-acting relief, and provides significant short-term and long-term reduction of itching and inflammation.

Cautions:

IMPORTANT SAFETY INFORMATION: Do not use Apoquel or Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel and Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post approval. Apoquel and Apoquel Chewable have not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel and Apoquel Chewable have been used safely with many common medications including parasiticides, antibiotics and vaccines.

Brand Name

Apoquel

Generic Name

oclacitinib (ah-clas-eh-tee-nib)

Manufacturer:

Zoetis

What is the most important thing I should know about Apoquel Chewable?

Apoquel Chewable is used to relieve itching and inflammation caused by a variety of diagnoses, including allergic dermatitis and atopic dermatitis.

What should I discuss with my veterinarian before giving Apoquel Chewable to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to the medication.

How should Apoquel Chewable be given?

The dose of Apoquel Chewables is 0.18 to 0.27 mg/lb of body weight. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is ½ of a 3.6 mg chewable twice daily. The dosage for dogs 10-14.9 lbs is ½ of a 5.4 mg chewable twice daily. The dosage for dogs 15-19.9 lbs is one 3.6 mg chewable twice daily. The dosage for dogs 20-29.9 lbs is one 5.4 mg chewable twice daily. The dosage for dogs 30-44.9 lbs is ½ of a 16 mg chewable twice daily. The dosage for dogs 45-59.9 lbs is two 5.4 mg chewables twice daily. The dosage for dogs 60-89.9 lbs is one 16 mg chewable twice daily. The dosage for dogs 90-129.9 lbs is 1½ 16 mg chewable twice daily. The dosage for dogs 130-175.9 lbs is two 16 mg chewables daily.

What are the potential side effects of Apoquel Chewable?

Apoquel Chewable may increase susceptibility to infection, including demodicosis. It may also exacerbate neoplastic conditions. Adverse reactions reported in a masked field study included diarrhea, vomiting, anorexia, new cutaneous or subcutaneous lumps, and lethargy. In most cases, diarrhea, vomiting, anorexia, and lethargy spontaneously resolved with continued dosing.

What happens if I miss giving a dose of Apoquel Chewable?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

What happens if I overdose my pet on Apoquel Chewable?

Contact your veterinarian immediately.

What should I avoid while giving Apoquel Chewable to my pet?

Apoquel Chewable should not be given to dogs younger than 12 months or those with serious infections. Apoquel Chewable is not for use in breeding dogs, or pregnant or lactating bitches. The use of Apoquel Chewable has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents. Dogs receiving Apoquel Chewable should be monitored for the development of infections, including demodicosis and neoplasia.

What other drugs will affect Apoquel Chewable?

Talk to your veterinarian before giving any prescription or over the counter medications.

Apoquel Chewable Directions:

  • Administer to your dog orally twice daily for up to 14 days according to the weight chart below, then administer once daily for maintenance dose.
Tip:

Apoquel Chewable may be administered with or without food

Apoquel Chewable Dosage:

Apoquel Chewable Initial Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg chewable tablet twice daily for up to 14 days
10-14.9 lbs 1/2 of a 5.4 mg chewable tablet twice daily for up to 14 days
15-19.9 lbs One 3.6 mg chewable tablet twice daily for up to 14 days
20-29.9 lbs One 5.4 mg chewable tablet twice daily for up to 14 days
30-44.9 lbs 1/2 of a 16 mg chewable tablet twice daily for up to 14 days
45-59.9 lbs Two 5.4 mg chewable tablets twice daily for up to 14 days
60-89.9 lbs One 16 mg table twice daily for up to 14 days
90-129.9 lbs 1 1/2 16 mg chewable tablets twice daily for up to 14 days
130-175.9 lbs Two 16 mg chewable tablets twice daily for up to 14 days
Apoquel Chewable Maintenance Dosage for Dogs: (over 12 months of age)
Weight Amount
6.6-9.9 lbs 1/2 of a 3.6 mg chewable tablet once daily
10-14.9 lbs 1/2 of a 5.4 mg chewable tablet once daily
15-19.9 lbs One 3.6 mg chewable tablet once daily
20-29.9 lbs One 5.4 mg chewable tablet once daily
30-44.9 lbs 1/2 of a 16 mg chewable tablet once daily
45-59.9 lbs Two 5.4 mg chewable tablets once daily
60-89.9 lbs One 16 mg table once daily
90-129.9 lbs 1 1/216 mg chewable tablets once daily
130-175.9 lbs Two 16 mg chewable tablets once daily
Apoquel Chewable Dosage for Cats:
Cats
Do not use!
Apoquel Chewable Dosage for Horses:
Horses
Do not use!

Apoquel Chewable Ingredients:

Apoquel 3.6 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate3.6 mg
Apoquel 5.4 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate5.4 mg
Apoquel 16 mg chewable tablet
Active IngredientAmount
Oclacitinib maleate16 mg
LEARN MORE ABOUT

The Welcome Taste of Fast-Acting Allergic Itch Relief

Apoquel Chewable is the first and only chewable treatment for the relief of allergic itch in dogs. With a treat-like formulation, it may simplify dosing and help eliminate the stress from giving pills.


Relief You Can Count On

Apoquel Chewable
effectively controls allergic dog
itch within 24 hours.1

Tasty pork liver-flavored chewables designed to be as delicious as a treat. A recent study found that over 90% of dogs ate Apoquel Chewable voluntarily.2

Safe to use for long-term maintenance or short-term therapy3,4 in dogs 12 months of age and older.

Why Does Apoquel Lead The Pack?

Apoquel Chewable stops allergic itch right at the source.5

  • Antihistamines offer little or no benefit in treating flare-ups in a majority of dogs with allergic itch.6
  • Steroids may offer relief but may not be a good option if your dog requires long-term treatment
  • Home remedies, such as, topicals, may provide some temporary relief but don’t treat the underlying cause of allergic itch.
Indications
Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

REFERENCES
1. Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022.
2. Visser M, Walsh K, King V, Sture G, Caneva L. Acceptance of oclacitinib maleate(Apoquel) chewable tablets in client-owned dogs with allergic and atopic dermatitis. BMC veterinary research. 2022;18(1):103. doi:10.1186/s12917-022-03210-x
3. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.
4. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.
5. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101.
6. Olivry T, DeBoer DJ, Favrot C, et al. for the International Committee on Allergic Diseases of Animals. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Vet Res. 2015;11:210. doi: 10.1186/s12917-015-0514-6.

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