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Product Info
How to Use
Customer Reviews
Product Info

What is Prednisolone?

Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. It reduces swelling and inflammation which can reduce pain or decrease the possible joint damage that is caused by chronic inflammation. Prednisolone requires a prescription from your veterinarian, and is sold per tablet.

Note: Prednisolone Compound is also available.


Cats and Dogs


  • Treats a wide range of inflammatory and auto-immune conditions
  • Remedies swelling and itchy skin caused by allergies
  • Reduces redness, itching, and allergic reactions affecting the eyes

How does Prednisolone work?

Prednisolone is a corticosteroid, which suppresses the inflammatory response to a variety of agents. Prednisolone can also be used as an immunosuppressive drug for organ transplants and in cases of adrenal insufficiency (Addison's disease).


Without first talking to your veterinarian, don't give your pet any over-the-counter or other prescription medications while giving Prednisolone. There are possible side effects, including insomnia, nausea, vomiting, upset stomach, and fatigue. Tell your veterinarian if your pet has kidney or liver disease, heart disease, stomach ulcers, hypothyroidism, diabetes mellitus, or any other medical conditions.

Brand Name:

PrednisTab (Vet-A-Mix)

Generic Name:


What is the most important information I should know about Prednisolone?

Prednisolone is a prescription medication that is used in dogs and cats. Prednisolone is available as 5mg scored tablets. The usual dose is determined based on the condition being treated and the pet's response to treatment. Prednisolone should not be stopped suddenly. There should be a gradual reduction in dosage before stopping. Prednisolone should be taken with food to lessen stomach upset.

What should I discuss with my veterinarian before giving Prednisolone to my pet?

Do not give Prednisolone to your pet if the pet has a serious bacterial, viral, or fungal infection. Prednisolone weakens a pet's immune response and its ability to fight infections. Tell your veterinarian if your pet has kidney or liver disease, heart disease, stomach ulcers, hypothyroidism, diabetes mellitus, or any other medical conditions. Also tell your veterinarian if your pet is pregnant or lactating.

How should Prednisolone be given?

Give this medication exactly as directed by your veterinarian. Do not give more or less than is prescribed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Keep plenty of water available for your pet. Prednisolone should be given with food. Store Prednisolone at room temperature away from moisture and heat. Keep this medication away from children and pets.

What are the possible side effects of Prednisolone?

If any of the following serious side effects occur, stop giving Prednisolone and seek emergency veterinary medical attention: an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure, or sudden weight gain. Other less serious side effects may occur. Continue giving Prednisolone and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control, or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of Prednisolone include thinning of the skin, cataracts, glaucoma, or behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What happens if I miss giving a dose of Prednisolone?

If you give one dose daily, give the missed dose as soon as remembered. However, if you don't remember until the next day, skip the missed dose and give only the regular daily dose. If you give more than one dose daily, either give the missed dose as soon as remembered, or give two doses the next dose time. If you give one dose every other day, give the missed dose as soon as remembered, then go back to the regular every other day schedule.

What happens if I overdose my pet on Prednisolone?

Seek emergency veterinary medical treatment. A single large dose of Prednisolone is unlikely to cause symptoms or death. An overdose is more likely to occur due to large doses being taken over a period of time. Symptoms of overdose include weight gain, panting, increased thirst, hunger and urination, vomiting, diarrhea, and Cushing's syndrome.

What other drugs will affect Prednisolone?

Do not give any other over-the-counter or prescription medications, including herbal products, during treatment with Prednisolone without first talking to your veterinarian. Many other medications can interact with Prednisolone resulting in side effects or altered effectiveness.

How to Use
  • Prednisolone is a prescription corticosteroid that is used in dogs and cats to treat various conditions such as Addison's disease, inflammation from arthritis, allergies and certain autoimmune diseases.
  • Prednisolone reduces swelling and decreases a pet's ability to fight infections.
  • Give Prednisolone with food to lessen stomach upset.

Prednisolone should not be stopped suddenly. There should be a gradual reduction in dosage before stopping.

All weights
The usual dose is determined based on the condition being treated and the pets response to treatment. Prednisolone should be given with food. Allow plenty of water for your pet to drink.
Do not use!

Store this product at room temperature, away from moisture and heat.

Active Ingredient (per tablet)
5 mg
Customer Reviews
Prednisolone is rated 4.8 out of 5 by 5.
Rated 5 out of 5 by from Very Satisfied PetMeds contacted my Vet and handled everything.
Date published: 2016-10-13
Rated 5 out of 5 by from Excellent Service & Fast Shipping! Once the prescription was signed, the medication was shipped immediately. Very smooth and convenient, and I absolutely love the ability to chat live if I have any questions! They have always been so nice! Unfortunately, she wouldn't take the Prednisolone even when concealed in Pill Pockets and treats; it must be too bitter. The alternative is to revert back to Prednisone.
Date published: 2016-04-02
Rated 5 out of 5 by from better than Prednisone My cat is on this medication for asthma. It does seem to work better than Prednisone- he seems to need to take less.
Date published: 2013-05-06
Rated 4 out of 5 by from thank you petmeds My cat has a serious lung problem. I couldn't find prenisolone locally the pharmacy said it was discontinued. I tried everywhere even the vet didn't have it. prednisone was not as effective and it started to have a negative effect on kitty. The vet said we had to have prednisolone because it has a better effect in cats. So thank you pet meds you helped my kitty get the proper meds when no one else could. .
Date published: 2009-05-09
Rated 5 out of 5 by from Helped cats dry skin I have two cats in my home and my American Longhair has had skin problems ever since she was a kitten. I just started buying these for her after the vet prescribed them for her skin and I must say, her skin is doing a lot better. Only downside from the med, is that my cat seemed to develop "cat acne" around her bottom lip but it's a small price to pay for the rest of her skin to be doing so good.
Date published: 2009-02-16
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Pill identification do I have prednisone or prednisolone I need the latter and wonder if they gave me wrong pills.

Asked by: Dave of Florida
Prednisolone made by Lloyd is an oblong white tablet. I have seen many generic versions of Prednisone tablets of various strengths and they have all been round tablets. Hope this helps.
Answered by: SuzyCVT
Date published: 2017-03-17

Can you crush the pill and put in my cats food

Asked by: Dnice
Hello, You should not crush this pill as it would interfere with the absorption and mechanism of this medication. Thanks for asking, Pharmacy Intern
Answered by: Ben B
Date published: 2017-02-17

My small breed dog is itching so badly that the wounds (which are on her back side and on her upper tail) are completely red and have welts on them. I tried using salves with no success.  Will the prednisolone help her? I feel helpless.  

Asked by: Sky037
Prednisone may help reduce inflammation, however it is best to have your pet examined by a veterinarian to reach a diagnosis. Your pet may have an infection that may need to be treated in conjunction with the use of other medications. Your vet will determine which medication regime will be best suited for your pet's condition.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

My dog has arthritis he has had some anti inflammatory medicine from the vets it worked for a bit. If I give him steroids is 5mg enough for his size he weights 38kg

Asked by: Jill299a
Your veterinarian will determine the appropriate dose if steroid therapy is indicated for your pet's condition.
Answered by: Lisa M
Date published: 2016-11-16

2.5 mg per tablet needed

Can you supply 2.5mg strength rather than 5mg?
Asked by: Anonymous
No, unfortunately we only have the 5 mg tablets available. You can always cut the 5 mg tablets in half to achieve a dose of 2.5 mg.
Answered by: Christine
Date published: 2016-10-21

How long does prednisolone take to work? My cat been on 5mg for three days and  now half for two days but no improvement for asthma.

Asked by: Mel 111
Your cat should have seen some improvement by now. I recommend contacting your veterinarian to let them know the prednisolone has not resulted in any improvements in your cats asthma. They may want to increase the dose or try something else.
Answered by: Christine
Date published: 2017-03-06

I have a 50 lb English Bull Dog. The prescription bottle got wet and I can't read the instructions on how to disburse them to her. They are 5 mg. I have 20 pills left on this prescription. Can you help?

Asked by: Ga Bull Dog
Contact your veterinarian for the correct use. This medication has many different doses depending on the problem your pet may have.
Answered by: paulpharmacistintern
Date published: 2016-08-04

can this med be crushed?

I'm having a hard time getting my cat to take this med. she keeps pushing it out with her tongue.
Asked by: Anonymous
I had 2 cats that needed medicine in tablet form. What works best and fast: Straddle your cat, gently pull the head back which opens up the throat area. Gently push the tablet down the throat, then rub the front of the throat downwards so the pill will not eject.
Answered by: Anonymous
Date published: 2017-03-12
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