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DES Compounded

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2. We verify your prescription and ship your order!
Starts $46.25 $31.50 

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DES 1mg/ml 15ml Liquid
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DES 1mg/ml 30ml Liquid
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DES 1mg/ml 60ml Liquid
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DES 1mg/ml 90ml Liquid
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DES 1mg 10 Capsules
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DES 1mg 30 Capsules
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DES 2mg 10 Capsules
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DES 2mg 30 Capsules
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DES 5mg 10 Capsules
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Starts $46.25 $31.50 
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Product Info

What is DES Compounded?

DES Compounded is used to treat urinary incontinence in spayed female dogs. It mimics the effects of the natural female hormone, estrogen. Compounding is beneficial in instances where a specific dosage is unavailable or in different forms to make it easier to dose your pet. DES Compounded requires a prescription from your veterinarian.




  • Treats urinary incontinence in spayed female dogs

How does DES Compounded work?

DES mimics the effects of estrogen, which works for urinary incontinence by improving the function of the nerves of the urinary sphincter.


Keep this and all drugs out of reach of children. Diethylstilbestrol is a prescription drug and should be used according to your veterinarian's directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person. Pregnant women should not come in contact with DES. DES should not be used in pregnant pets.

How to Use

DES Compounded Directions:

  • Give this medication to your pet exactly as your veterinarian prescribes.
  • If you miss giving your dog a dose of diethylstilbestrol, give the next dose as soon as you remember or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose to catch up.
  • DES is given by mouth and may be given with or without food.
  • When used to treat urinary incontinence, other drugs that complement the DES may be prescribed by your veterinarian.

Wash your hands after giving your pet this medication.

What is a compounded medication?

What is a Compounded Medication?

A compounded medication is the creation of a particular medication to fit the unique needs of a patient, including changing the form of the medication (e.g., from a solid pill to a liquid) for a variety reasons (e.g., to make it easier to take, to avoid a non-essential ingredient, to obtain the exact dose needed, adding favorite flavors).

If you are having difficulty giving your pet prescribed medication or need to find a discontinued medication, 1-800-PetMeds offers compounding services on select medications. We can prepare the following: (1) custom strength quantities of a medication (as capsules, liquid, chewable tablets, or transdermal (absorbed through the skin); (2) dosage forms to mask bitter or unpleasant taste (such as capsules or chewable tablets that can also be flavored); (3) dosage forms to make it easier to dose your pet such as a transdermal or liquid (that can also be flavored); and (4) discontinued products such as cisapride or DES.

Customer Reviews
DES Compounded is rated 5.0 out of 5 by 4.
Rated 5 out of 5 by from Works great Works great but my vet only charges $22 One 800 pet meds charges over $31
Date published: 2017-03-30
Rated 5 out of 5 by from Shelf Life-liquid 180 days I haven't used this yet. I spent this morning trying to find out what the shelf life is for the DES liquid. I called 1800petmeds, they researched it and called me back. DES LIQUID is good for 180 days from the time they compound it. You're welcome (;
Date published: 2017-03-27
Rated 5 out of 5 by from WHAT A GIFT! For a few weeks our 9 year old dog started wetting the bed. We started with basics like removing her water after 9pm but it didn't matter. Brought her to the vet, expecting some infection and going to pay hundreds. Luckily the vet perscribed DES. Gave it to her and after 2 days the wetting the bed STOPPED! Only down part is that it is a pill that your dog will need to be on for life. Well worth it though :)
Date published: 2014-05-04
Rated 5 out of 5 by from Super product for aging pet! After my 12 year old female mixed breed woke up in a puddle of urine, I thought for sure I would have to put her down. Luckily, I called the vet and she recommended DES about twice a week. It was a miracle! She has absolutely no incontinence whatsoever now, and I am so happy I'll have my girl around at least a little longer. I LOVE Petmeds! A geat company, with great customer service.
Date published: 2013-06-09
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My 14 yr old lab was taking proin but it wasn't working vet prescribed Des one /day for 5 days and 1x/week thereafter worked for first 10 days not now do I just need to give every other day is there any good combo of Meds 

Asked by: Me T
It is best that you consult your veterinarian regarding the DES and how it is no longer working appropriately. It is possible the dose may need to be adjusted or the veterinarian may want to try a different medication.
Answered by: Megan Student Pharmacist
Date published: 2017-06-27

I've been giving my dog the 1mg capsule. Does the 1mg/ml 90ml liquid come in 1mg doses? Can I use the liquid instead? Its' a lot cheaper for DES 1 mg/ml 90ml Liquid if its 90 doses vs the 30 1 mg capsules.

Asked by: AKDogger
Hello AKDogger, giving your dog 1mL of the DES 1mg/ml 90ml Liquid should be therapeutically equivalent to the 1mg capsule, just make sure you follow your veterinarian's instructions.
Answered by: Nemi Pharmacy Intern
Date published: 2017-06-01

My vet perscribed Incurin for my 4 year old 52 pound dog. Incurin is currently sold out and my dog does not tolerate Proin. Can I substitute DES? What would the dosage and frequently be? 

Asked by: RawliesMom
Your veterinarian would need to authorize the change to DES. Your veterinarian would determine the dosage and frequency for your dog.
Answered by: Christine
Date published: 2016-10-19

How can I get 0.5mg capsules diethylstilbestrol

My dog is prescribed this once a week
Asked by: Tojo
We do not make 0.5mg DES capsules; however, that dose can be obtained by using 0.5 ml of the DES 1mg/ml liquid.
Answered by: Lisa M
Date published: 2015-08-19

I used to get DES from you but now you don't sell it in NC. Why is that?

Asked by: rose
The compunding pharmacy that we use in not licensed in a few states, North Carolina is one of them. We cannot ship to the states that they are not licensed in.
Answered by: Kelly P
Date published: 2015-04-09

How Much DES is needed for my 7 yr old Husky for once a week?

My husky who turned 7 was put on Des my vet. put her on one pill a week. What mg does she need. The pill last 5-6 days and not the full 7 days?
Asked by: Kathleen
Call your vet and talk to him. He may just change the frequency for her.
Answered by: gabib
Date published: 2015-04-06

Regarding DES

I am wondering if upset stomach is a side effect of DES. I am trying to eliminate possibilities. I give her one dose about twice a week - it seems like she wants to eat grass the next day, often heaves spittle and sometimes won't eat the next meal. I can't seem to find any "common denominator beyond the DES although I can't find that it has possible side effects. She is an Aussie, about 60lb and about 8 years old (rescue dog). She gets one 1mg capsule three times a week
Asked by: Shorty
We have experienced the same with our Lab mix. She didn't want to ride in the car and would eat new bamboo shoots. Now she has DES -coated with peanut butter - with her evening meal and seems to do better with the nausea.
Answered by: Tippy K
Date published: 2014-06-17

Do you carry diethylstilbestrol 1MG in capsule? I am giving my dal this medicine in capsule every other day

Asked by: Indian Girl
Yes, PetMeds sells DES 1mg capsule (quantity 30). This medication does require a prescription from your vet.
Answered by: Janine Pharmacist
Date published: 2015-11-10
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