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Adequan for Dogs

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2. We verify your prescription and ship your order!
$187.49 $134.99 
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100 mg/ml 2 x 5 ml Vials
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Product Info
How to Use
Customer Reviews
Product Info

What is Adequan Canine?

Adequan Canine (for dogs) is used to control symptoms associated with degenerative or traumatic arthritis. It is an injectable polysulfated glycosaminoglycan (PSGAG) and is the only FDA approved product of its type. Adequan has been clinically shown to help treat the disease while giving relief from pain. It modifies the disease cycle, stimulates cartilage repair processes and diminishes joint damage while reducing the pain caused by osteoarthritis. Adequan requires a prescription from your veterinarian. A syringe is needed, but not included in the package.




  • Helps control noninfectious degenerative or traumatic arthritis
  • Good for postsurgery treatment
  • Starts to work within hours and stays in the joint for about three days

How does Adequan Canine work?

Adequan inhibits enzymes that break down cartilage within your dog's joints. It reduces inflammation and increases the thickness of joint (synovial) fluid.


Not for use in humans. Do not give this medication to breeding, pregnant, or lactating pets. Use with caution in pets with kidney or liver disease, or bleeding disorders.

Brand Name:

Adequan (Manufactured by Luitpold)

Generic Name:

Polysulfated Glycosaminoglycan (PSGAG) Solution

What should I discuss with my veterinarian before giving Adequan Canine?

Tell your veterinarian if your dog has any known or suspected bleeding disorders. Tell your veterinarian if your dog has any liver or kidney disease. Tell your veterinarian if your dog is breeding, pregnant or lactating.

How should Adequan Canine be given?

Give this medication exactly as directed by your veterinarian. Adequan is given by intramuscular (IM, into the muscle) injection. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. If you have difficulty giving the medication, contact your veterinarian. Store Adequan at 68 - 77 F (20 - 25 C) excursions permitted to 59 - 86 (15 - 30 C). Keep this medication out of the reach of children and pets.

What are the possible side effects of Adequan Canine?

Few side effects are seen following Intramuscular injection. Stop giving Adequan and seek emergency veterinary medical attention if an allergic reaction (facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma) should occur. Bleeding from the nose, blood in the feces, or dark and tarry stools may indicate a decreased ability of blood to clot. Contact your veterinarian if you notice these symptoms. Other side effects may also occur. Talk to your veterinarian about any side effects that seem unusual or bothersome to your pet.

What happens if I miss giving a dose of Adequan Canine?

Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What should I avoid while giving Adequan Canine?

Do not give this medication to breeding, pregnant or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

What other drugs will affect Adequan Canine?

Consult your veterinarian before using any other prescription or over the counter medicines including vitamins and supplements.

How to Use
  • Adequan is a prescription medication used in dogs for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints and following surgical procedures involving a joint.

Do not give this medication to breeding, pregnant, or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

All weights
Inject 2 mg per lb of body weight given only by intramuscular (IM) injection twice a week for up to 4 weeks (a maximum of 8 injections)
Do not use!
Do not use!

Store Adequan at 68° - 77° F (20° - 25° C) excursions permitted to 59° - 86° (15° - 30° C). Keep this medication out of the reach of children and pets.

Adequan (for Dogs):
Active Ingredients
Polysulfated Glycosaminoglycan
100 mg
Benzyl alcohol (a preservative)
0.9% v/v
Other Ingredients: Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity.
Customer Reviews
Adequan for Dogs is rated 4.6 out of 5 by 99.
Rated 5 out of 5 by from She's a new dog My dog seemed to be in severe pain with walking, jumping, and playing. She does have arthritis due to her age; she's 10 years old. I want to make her as comfortable as possible. The vet suggested Adequan and since giving it to her she has improved by leaps and bounds. She doesn't seem sore when standing and has resumed playing. This is a miracle medication!!
Date published: 2016-10-25
Rated 5 out of 5 by from Magic c This has changed my dog's life. We moved our almost 11 year old lab across country and then 2 months later flew him to Hawaii for a permanent move. He has been sore, panting, miserable and mopey. We started this medicine after our vet wrote an RX for it and he's a new dog! He's even back to sneaking up onto our very high king sized bed! I couldn't be happier to have our old pup back.
Date published: 2016-10-24
Rated 5 out of 5 by from A miracle for my dog My Shepherd had FHO surgery due to serious hip dysplasia. We did PT with her, including underwater treadmill and anti-inflamatory drugs, which helped. But nothing has made a difference like the adequan shots. Every few days for 3 weeks now once every 3 weeks. It's made such a difference for her. She's even jumping up on people - it's an amazing problem to have with this dog!
Date published: 2016-09-18
Rated 5 out of 5 by from very effective for helping w hip dysplasia pain I've been using this for a year w my older boxer. This keeps he comfortable, active and playful. Just hate to have to inject it. Ugh
Date published: 2016-09-10
Rated 5 out of 5 by from My dog can walk again!!! I have a large Newfoundland/Labrador mix with hip problems and diabetes. He is 12 years old now. A few months ago he somewhat suddenly was unable to get up, walk around, or support his own weight in his back hips after simultaneously being diagnosed with diabetes. He would try, but I had to help him around, by using my arms like a sling. I honestly thought I was going to have to put him down. I didn't know what to do right away so it was 2 weeks before I found out about and received Adequan. I followed the instructions, giving him 2 shots a week for 4 weeks. Three and a half weeks after I started the injections he was still not walking. It wasn't until 2 days after the last loading dose that he was able to get up on his own and walk outside. So it took 30 days from the first injection before I saw him walk again. I could tell he was gaining strength as I helped him along in the weeks leading up to the end of the loading dose, so I know he was getting stronger and feeling better right away. I should also note that at the time his blood sugar was still quite high, about 3.5x what it should be. So, all thought he was also receiving insulin for about 6 weeks before he recovered, I feel the Adequan did more to treat his hips and help him regain strength but I'm an engineer, not a Dr. Now: 3 months later. I give my dog adequan every 2 weeks now to maintain his strenght and mobility. He is doing so much better its really unbelievable. I only wish I had known about adequan sooner and started it before his hips got as bad as they did. Still, I can't say enough how well this has worked for my dog. Be patient and work through the whole dose. I didn't observe any ill effects from using Adequan. I monitor his blood glucose closely and never witnessed a spike or abnormal readings after an Adequan injection.
Date published: 2016-06-07
Rated 5 out of 5 by from Great Pain Relief Really has helped my dog ...relieved his pain and he is able to walk without limping and wincing ...
Date published: 2016-04-27
Rated 4 out of 5 by from Improved movement My cat has been on this for 8 months. She is 16 years old with advanced arthritis in her elbows and knees. She moves better at the every 2 week maintenance dosing than our original 4 week plan. This is only part of her arthritis pain control plan but has shown the biggest impact. She is more active and social when she is on Adequan.
Date published: 2016-04-05
Rated 5 out of 5 by from Bought us some time. Our Shepherd is in terrible shape with arthritis and hip dysplasia. We were ready to put her down. Then we heard about Adequan. Our 12 yr old is still not in the best of shape but much better than what she was and also not in the pain she was in. I truly believe this drug has given us at least another year with our baby maybe even more.
Date published: 2016-03-16
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Asked by: NONE
Sorry we are currently out of stock on this medication. We do have other options available that can work for arthritis, pain, and inflammation such as Metacam and Carprofen. You could talk to your Vet about these other options that we have. If you are wanting this specific product, I would contact our customer service hotline, toll free 1-800-738-6337, and they can let you know more about stocking and when this product might become available again. Hope this helps.
Answered by: Trey W
Date published: 2017-03-07

I have a pit who weighs around 70 pds the vet want to do injections 2 x a week for 8 weeks. How long does this 2 pack last for?

Asked by: Danyel
Hello Danyel, This box contains a total of 10ml (100mg/ml). Based on your dogs weight, you will need 140mg (1.4ml) dose given twice a week. This box will give you 7 total doses (or 3.5 weeks worth). Hope this helps.
Answered by: Trey W
Date published: 2017-03-03

When will Adequan be back in stock?

Asked by: Linda
We do not have an ETA at this time. You may call our customer care department at a later date to verify if we have it in stock
Answered by: S Duesler PharmD MBA
Date published: 2017-03-03

Do you have a projected date as to when this product will be back in stock?

Asked by: Lizthewiz7
No, sorry not at this time. You may call our customer care department to verify if the product is in stock at a later date.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

Can you give Gloucosamine 600 mg to your dog while taking the Adequan?

Asked by: Carolyn
Over the counter joint supplements such as glucosamine may be administered concurrently with Adequan.
Answered by: Lisa M
Date published: 2016-11-10

Adequan injections for a Pug

My vet has asked us to think about starting our 25 lb pug on adequan injections for her degenerative hip disease. Our pug is 7 years old and will remain on Tramadol once daily. How many injections would I get from each vial of Adequan for my 25 lb pug
Asked by: Anonymous
Typical doses of adequan are 2 mg per lb of body weight given only by intramuscular (IM) injection twice a week for up to 4 weeks (a maximum of 8 injections), unless otherwise specified by your veterinarian. For a 25 lb pug, you would need to inject 50 mg twice a week. Each 5 mL vial will give you 10 injections. Adequan comes with two 5 mL vials, so for the full package you would get 20 injections (10 weeks worth).
Answered by: Christine
Date published: 2017-02-21

Adequan for Longer

My 11 yr old mixed breed Catahoula/Rott mix has arthritis in her spine and the vet has given her Adequan for 7 doses (every Tuesday and Saturday) 1.2ml but I haven't seen a lot of improvement. She's happier but still not moving around a lot and falling all over when she walks. Can I continue for longer or increase the dosage or frequency of doses?
Asked by: Anonymous
If you haven't seen improvement in your dog, you should let your veterinarian know. They may want to extend the duration or increase the dosage; however, I do not recommend you do this without speaking to your veterinarian first.
Answered by: Christine
Date published: 2016-10-21

Are Adequan injections beneficial if given subcutaneously?

I am told that Adequan injections given subcutaneously will give the same results as if given inter this true?
Asked by: Anonymous
Adequan should be injected intramuscularly, and NOT subcutaneously. It may not be absorbed properly or work effectively if it is given subcutaneously.
Answered by: Christine
Date published: 2017-01-27
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