What is Zycortal Suspension?
Zycortal Suspension is an injectable medication for use as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison's disease). This medication replaces the mineralocorticoid hormones only. Zycortal Suspension is an alternative to Percorten-V and requires a prescription from your veterinarian.
You will need a syringe to use Zycortal Suspension, but it is not included in the package. Please see 3cc (3 ml) Luer-Slip syringe with a 3/4-inch 22 G needle or 3 cc/mL 22g x 3/4 Needle.
- Treats Addison's disease (hypoadrenocorticism) in dogs
- Subcutaneous injectable medication
How does Zycortal Suspension work?
Zycortal Suspension works by replacing the mineralocorticoids, which are deficient in dogs with hypoadrenocorticism. Dogs with combined glucocorticoid and mineralocorticoid deficiency need to most likely be treated with other medication that your veterinarian will prescribe.
For use in dogs only. Not for human use. Keep this and all medications out of the reach of children. Consult a physician in case of accidental human exposure. Do not use Zycortal Suspension in pregnant or lactating dogs. Do not use Zycortal Suspension in dogs that have previously had a hypersensitivity reaction to desoxycorticosterone pivalate.
Zycortal Suspension (Dechra)
Desoxycorticosterone pivalate injectable suspension
What is the most important thing I should know about Zycortal Suspension?
Zycortal Suspension is a subcutaneous injectable medication used to treat Addison's disease in dogs as replacement therapy for mineralocorticoid deficiency. It is available by veterinary prescription only.
What should I discuss with my veterinarian before giving Zycortal Suspension to my pet?
Tell your veterinarian if your dog is pregnant or lactating. Also, inform your veterinarian if your pet has congestive heart disease, edema (swelling), severe renal disease or primary hepatic failure.
How should Zycortal Suspension be given?
Shake the vial vigorously prior to use. Use only according to your veterinarian's instructions. The usual recommended initial dosage is 2.2 mg/kg (1 mg/lb) of your dog's body weight, administered by subcutaneous injection. An interim monitoring veterinary visit is usually required for re-evaluation and to measure the serum sodium/potassium (Na+/K+) ratio approximately 10 days after the first dose. The second dose is usually given approximately 25 days after the first dose, after which your pet will likely be re-evaluated by your veterinarian to measure the serum sodium/potassium (Na+/K+) ratio and recommendations for subsequent doses and long-term management will be made.
What are the potential side effects of Zycortal Suspension?
Possible side effects of Zycortal Suspension include polyuria (excessive urination), polydipsia (excessive thirst), increased blood volume, edema, and cardiac enlargement. Excessive weight gain may indicate fluid retention secondary to sodium retention.
What happens if I miss giving a dose of Zycortal Suspension?
Give the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and give the next regularly scheduled dose. Do not give a double dose unless otherwise directed by your veterinarian.
What happens if I overdose my pet on Zycortal Suspension?
Signs of Zycortal Suspension overdose include increased thirst, excessive urination, changes in heart rate or rhythm or edema. Enlargement of the heart is possible in cases of long-term overdosage. If you suspect that your pet has received an overdose of Zycortal Suspension, consult your veterinarian or emergency veterinary clinic immediately.
What should I avoid while giving Zycortal Suspension to my pet?
Do not use Zycortal Suspension on pets who may be pregnant or lactating. Zycortal Suspension should be injected subcutaneously (under the skin); do not inject intravenously (in the vein). Do not use in dogs with congestive heart failure, kidney disease, or edema. Do not use in dogs who are allergic or hypersensitive to Zycortal Suspension or any of its ingredients.
What other drugs will affect Zycortal Suspension?
Consult your veterinarian if your pet is currently taking any other medications, including vitamins and supplements. Interactions may occur with insulin, diuretics, digitalis, amphotericin B or potassium-depleting diuretics such as Furosemide (Lasix, Salix).
Zycortal Suspension Directions:
- Use according to your veterinarian's instructions.
- Zycortal Suspension should be injected subcutaneously; do not inject intravenously (in the vein).
Use within 120 days of first puncture of the vial and puncture a maximum of 4 times.
Zycortal Suspension Dosage:
|All weights||Use as prescribed by your veterinarian.|
|Cats||Do not use!|
|Horses||Do not use!|
Store at controlled room temperature 77°F (25°C) with excursions between 59-86°F (15-30°C) permitted. Do not freeze.
Zycortal Suspension Ingredients:
|Active Ingredients (per ml)||Amount|
|Desoxycorticosterone pivalate||25 mg|
|Sodium carboxymethylcellulose||3 mg|
|Polysorbate 60||1 mg|
|Sodium chloride||8 mg|
|Other Ingredients: Water for injection (to 100%).|