Simparica TRIO

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Simparica TRIO
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What is Simparica TRIO?

Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.

Suitable For:

Dogs and Puppies (8 weeks of age or older, weighing 2.8 lbs or more)

Benefits:

  • Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms
  • Tasty chewable that dogs love
  • Convenient, once-a-month dosing

How does Simparica TRIO work?

Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

Cautions:

IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Brand Name:

Simparica TRIO (Zoetis)

Generic Name:

Sarolaner, moxidectin, and pyrantel

What is the most important thing I should know about Simparica TRIO?

Simparica TRIO prevents heartworm disease caused by Dirofilaria immitis, kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick), and the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. It requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica TRIO to my pet?

Prior to administration of Simparica TRIO, your dog should be tested for existing heartworm infections. Let your veterinarian know if your dog is pregnant, lactating, or will be used for breeding. Tell your veterinarian if your pet has a hypersensitivity to any of the active ingredients.

How should Simparica TRIO be given?

Simparica TRIO is a flavored chewable tablet that is given by the mouth. It can be given with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dogs weighing 2.8-5.5 lbs should be given one 3 mg sarolaner, 0.06 mg moxidectin, and 12.5 mg pyrantel chewable tablet (Gold Box). Dogs weighing 5.6-11.0 lbs should be given one 6 mg sarolaner, 0.12 mg moxidectin, and 25 mg pyrantel chewable tablet (Purple Box). Dogs weighing 11.1-22.0 lbs should be given one 12 mg sarolaner, 0.24 mg moxidectin, and 50 mg pyrantel chewable tablet (Caramel Box). Dogs weighing 22.1-44.0 lbs should be given one 24 mg sarolaner, 0.48 mg moxidectin, and 100 mg pyrantel chewable tablet (Teal Box). Dogs weighing 44.1-88.0 should be given one 48 mg sarolaner, 0.96 mg moxidectin, and 200 mg pyrantel chewable tablet (Green Box). Dogs weighing 88.1-132.0 lbs should be given one 72 mg sarolaner, 1.44 mg moxidectin, and 300 mg pyrantel chewable tablet (Brown Box).

What are the potential side effects of Simparica TRIO?

Use with caution in dogs with a history of seizures. Simparica TRIO contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

What happens if I miss giving a dose of Simparica TRIO?

If a dose is missed, give Simparica TRIO immediately and resume monthly dosing.

What happens if I overdose my pet on Simparica TRIO?

If an overdose is suspected, contact your veterinarian immediately.

What should I avoid while giving Simparica TRIO to my pet?

Do not use Simparica TRIO in cats. Simparica TRIO should not be used in dogs less than 8 weeks of age, weighing less than 2.8 lbs. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica TRIO?

There are no known contraindications for the use of Simparica TRIO.

Storage:

Keep out of reach of children and pets. Store at or below room temperature.

Simparica TRIO Directions:

  • Give your dog one chewable monthly, with or without food.
  • Follow your veterinarian's instructions exactly as directed.
  • The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
Tip:

Make sure that your dog takes their entire dose.

Simparica TRIO Dosage:

Simparica TRIO Dosage for Dogs
Weight Dosage
2.8-5.5 lbs Administer one chewable tablet once a month (Gold Box)
5.6-11.0 lbs Administer one chewable tablet once a month (Purple Box)
11.1-22.0 lbs Administer one chewable tablet once a month (Caramel Box)
22.1-44.0 lbs Administer one chewable tablet once a month (Teal Box)
44.1-88.0 lbs Administer one chewable tablet once a month (Green Box)
88.1-132.0 lbs Administer one chewable tablet once a month (Brown Box)
132.1 lbs or more Administer the appropriate combination of chewable tablets once a month
Simparica TRIO Dosage for Cats
Cats
Do not use!
Simparica TRIO Dosage for Horses
Horses
Do not use!

Simparica TRIO Ingredients:

Simparica TRIO 2.8-5.5 lbs (Gold Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 3 mg
Moxidectin 0.06 mg
Pyrantel (as pamoate salt) 12.5 mg
Simparica TRIO 5.6-11.0 lbs (Purple Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 6 mg
Moxidectin 0.12 mg
Pyrantel (as pamoate salt) 25 mg
Simparica TRIO 11.1-22.0 lbs (Caramel Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 12 mg
Moxidectin 0.24 mg
Pyrantel (as pamoate salt) 50 mg
Simparica TRIO 22.1-44.0 lbs (Teal Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 24 mg
Moxidectin 0.48 mg
Pyrantel (as pamoate salt) 100 mg
Simparica TRIO 44.1-88.0 lbs (Green Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 48 mg
Moxidectin 0.96 mg
Pyrantel (as pamoate salt) 200 mg
Simparica TRIO 88.1-132.0 lbs (Brown Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 72 mg
Moxidectin 1.44 mg
Pyrantel (as pamoate salt) 300 mg

What is Simparica TRIO?

Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.

Suitable For:

Dogs and Puppies (8 weeks of age or older, weighing 2.8 lbs or more)

Benefits:

  • Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms
  • Tasty chewable that dogs love
  • Convenient, once-a-month dosing

How does Simparica TRIO work?

Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

Cautions:

IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Brand Name:

Simparica TRIO (Zoetis)

Generic Name:

Sarolaner, moxidectin, and pyrantel

What is the most important thing I should know about Simparica TRIO?

Simparica TRIO prevents heartworm disease caused by Dirofilaria immitis, kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick), and the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. It requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica TRIO to my pet?

Prior to administration of Simparica TRIO, your dog should be tested for existing heartworm infections. Let your veterinarian know if your dog is pregnant, lactating, or will be used for breeding. Tell your veterinarian if your pet has a hypersensitivity to any of the active ingredients.

How should Simparica TRIO be given?

Simparica TRIO is a flavored chewable tablet that is given by the mouth. It can be given with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dogs weighing 2.8-5.5 lbs should be given one 3 mg sarolaner, 0.06 mg moxidectin, and 12.5 mg pyrantel chewable tablet (Gold Box). Dogs weighing 5.6-11.0 lbs should be given one 6 mg sarolaner, 0.12 mg moxidectin, and 25 mg pyrantel chewable tablet (Purple Box). Dogs weighing 11.1-22.0 lbs should be given one 12 mg sarolaner, 0.24 mg moxidectin, and 50 mg pyrantel chewable tablet (Caramel Box). Dogs weighing 22.1-44.0 lbs should be given one 24 mg sarolaner, 0.48 mg moxidectin, and 100 mg pyrantel chewable tablet (Teal Box). Dogs weighing 44.1-88.0 should be given one 48 mg sarolaner, 0.96 mg moxidectin, and 200 mg pyrantel chewable tablet (Green Box). Dogs weighing 88.1-132.0 lbs should be given one 72 mg sarolaner, 1.44 mg moxidectin, and 300 mg pyrantel chewable tablet (Brown Box).

What are the potential side effects of Simparica TRIO?

Use with caution in dogs with a history of seizures. Simparica TRIO contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

What happens if I miss giving a dose of Simparica TRIO?

If a dose is missed, give Simparica TRIO immediately and resume monthly dosing.

What happens if I overdose my pet on Simparica TRIO?

If an overdose is suspected, contact your veterinarian immediately.

What should I avoid while giving Simparica TRIO to my pet?

Do not use Simparica TRIO in cats. Simparica TRIO should not be used in dogs less than 8 weeks of age, weighing less than 2.8 lbs. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica TRIO?

There are no known contraindications for the use of Simparica TRIO.

Storage:

Keep out of reach of children and pets. Store at or below room temperature.

Simparica TRIO Directions:

  • Give your dog one chewable monthly, with or without food.
  • Follow your veterinarian's instructions exactly as directed.
  • The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
Tip:

Make sure that your dog takes their entire dose.

Simparica TRIO Dosage:

Simparica TRIO Dosage for Dogs
Weight Dosage
2.8-5.5 lbs Administer one chewable tablet once a month (Gold Box)
5.6-11.0 lbs Administer one chewable tablet once a month (Purple Box)
11.1-22.0 lbs Administer one chewable tablet once a month (Caramel Box)
22.1-44.0 lbs Administer one chewable tablet once a month (Teal Box)
44.1-88.0 lbs Administer one chewable tablet once a month (Green Box)
88.1-132.0 lbs Administer one chewable tablet once a month (Brown Box)
132.1 lbs or more Administer the appropriate combination of chewable tablets once a month
Simparica TRIO Dosage for Cats
Cats
Do not use!
Simparica TRIO Dosage for Horses
Horses
Do not use!

Simparica TRIO Ingredients:

Simparica TRIO 2.8-5.5 lbs (Gold Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 3 mg
Moxidectin 0.06 mg
Pyrantel (as pamoate salt) 12.5 mg
Simparica TRIO 5.6-11.0 lbs (Purple Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 6 mg
Moxidectin 0.12 mg
Pyrantel (as pamoate salt) 25 mg
Simparica TRIO 11.1-22.0 lbs (Caramel Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 12 mg
Moxidectin 0.24 mg
Pyrantel (as pamoate salt) 50 mg
Simparica TRIO 22.1-44.0 lbs (Teal Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 24 mg
Moxidectin 0.48 mg
Pyrantel (as pamoate salt) 100 mg
Simparica TRIO 44.1-88.0 lbs (Green Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 48 mg
Moxidectin 0.96 mg
Pyrantel (as pamoate salt) 200 mg
Simparica TRIO 88.1-132.0 lbs (Brown Box)
Active Ingredients (per chewable tablet) Amount
Sarolaner 72 mg
Moxidectin 1.44 mg
Pyrantel (as pamoate salt) 300 mg
LEARN MORE ABOUT

One Chew,
Triple Protection

Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms.

How Simparica Trio Simplifies Protection

With three proven ingredients designed for defense, a single monthly
chewable does the job of two or three preventatives.

Prevents Heartworm Disease*
Kills 5 Types of Ticks**
Kills Fleas
Treats Intestinal Parasites
Prevents Lyme Infections***
Loved by Dogs

Savory and easy to chew – a study found 9 out of 10
dogs ate Simparica Trio voluntarily.1

Simparica Trio comes with a 100% satisfaction guarantee on prevention.
Safe for puppies as young as 8 weeks old, weighing at least 2.8 lbs.
Which Product is Right for My Dog?

Available for six body weights.

* As a direct result of killing deer ticks.
** Gulf Coast tick, American dog tick, deer tick, lone star tick and brown dog tick.
*** For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina); (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.

REFERENCES
1. Study A161C-US-15-634. Data on file. Zoetis Inc.

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