ProZinc Insulin for Cats and Dogs

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ProZinc Insulin for Cats and Dogs
40 units/ml 10 ml Vial
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What is ProZinc Insulin?

ProZinc is insulin combined with zinc and protamine which helps to prolong the release of the insulin into your pet's body. ProZinc requires a prescription from your veterinarian. U-40 Syringes are sold separately. ProZinc Insulin requires refrigeration and must be kept at refrigerator temperatures at all times. To ensure proper temperature, it requires overnight shipping at an additional cost.

For:

Dogs and Cats

Benefits:

  • Helps control blood glucose and alleviate symptoms of diabetes.
  • It is the first and only FDA-approved insulin for cats made from recombinant DNA (DNA molecules created from the DNA of two unrelated organisms) that is identical to human insulin.
  • Now FDA-approved for use in dogs
  • The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with duration of effect for 10-14 hours.

How it Works:

Insulin helps regulate cellular metabolism by moving all-important glucose from the bloodstream into the cells. Cats and dogs with diabetes mellitus don’t produce enough of their own natural insulin, or their own insulin doesn’t work properly. This causes glucose to persistently build up in the bloodstream, leading to health problems. PROZINC® insulin becomes the essential replacement for diabetics to get their appropriate source of daily insulin.

Cautions:

Syringes are sold separately. We recommend using U-40 syringes. ProZinc is for use in dogs and cats only. Keep out of reach of children. Avoid contact with eyes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systematic allergic reaction in sensitized individuals. Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. Do not give your cat/dog its prescribed dose of PROZINC® insulin if it is experiencing an episode of low blood sugar (hypoglycemia). Common causes for low blood sugar include excessive doses of insulin, failure to eat, strenuous exercise, changes in the body’s need for insulin, diabetes-inducing disease or drug effects, is not eating or is vomiting, is sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC insulin, and do not give your cat/dog its prescribed dose of PROZINC insulin if you see clumps or visible white particles in the vial after gently rolling. SGLT2 inhibitors, are sodium-glucose cotransporter-2 inhibitors which are a class of drugs that work by preventing glucose reabsorption by SGLT2s in the kidneys and promote natural glucose excretion via the urine. SGLT2s are contraindicated to be used in cats that have previously or are currently being treated with an insulin, and not labeled for use in dogs. PROZINC is veterinary insulin approved by the FDA made with recombinant technology approved for dogs and cats for reduction of clinical signs. 1

Brand Name:

ProZinc

Generic Name:

protamine zinc recombinant human insulin

What is the most important information I should know about ProZinc:

Diabetes mellitus is a disease where the body produces insufficient insulin. The low insulin levels may result in high blood glucose that could produce the following changes in a pet; increased thirst, urination and appetite; weight loss; high levels of glucose in the urine. ProZinc is not a cure for diabetes mellitus, it can control the levels of glucose in the blood to help alleviate the clinical signs. Follow any diet or exercise plan developed by your Veterinarian. The safety and effectiveness of PROZINC® insulin in breeding, pregnant, and lactating cats and dogs has not been evaluated. The safety and effectiveness of PROZINC in puppies and kittens has not been evaluated. PROZINC insulin has a two-year shelf life from the date of manufacture. Use the 10 mL vial within 60 days of first puncture. Use the 20 mL vial within 80 days of first puncture. The vial of PROZINC® insulin should be stored in an upright position under refrigeration at 36-46°F (2-8°C). Do not freeze. Protect from light.

What is ProZinc:

PROZINC® is an injectable insulin for cats and dogs that is approved by the FDA and is indicated for the reduction of hyperglycemia (high blood glucose / high blood sugar) and the clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus. PROZINC® insulin is the only recombinant human insulin approved by the FDA for use in dogs and cats with diabetes. PROZINC insulin contains protamine and zinc in the formulation which helps promote optimal and consistent glycemic control. PROZINC® insulin is designed to be used with a U-40 syringe and using non U-40 syringes may result in incorrect dosing.

What should I discuss with my veterinarian before giving ProZinc:

Do not give ProZinc to pets sensitive to Protamine zinc recombinant human insulin or any other ingredients in the ProZinc product. Do not give ProZinc during episodes of hypoglycemia. Before using ProZinc, tell your veterinarian if your pet has any other medical conditions or allergies, or if your pet takes any other prescription or over the counter medications, including vitamins, minerals, and herbal supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your pet.

How should this medication be given:

Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. ProZinc should be given according to your veterinarian's instructions. ProZinc is given using a U-40 syringe only. Use of a syringe other than a U-40 syringe will result in incorrect dosing. ProZinc should not be shaken. Just prior to use, the vial should be mixed by rolling the vial between the palms of your hands. Do not reuse a syringe. Dispose of all syringes in an appropriate puncture-resistant disposal container. Dosage regimens of ProZinc will vary among patients. The recommended starting dose for cats is 0.1 to 0.3 units per lb of body weight every 12 hours. The recommended starting dose for dogs is 0.2 to 0.5 units per lb of body weight once daily. This dose should be adjusted based on changes in blood glucose levels and resolution of clinical signs. Further adjustments may be necessary with changes in the pet's diet, body weight or other medications, or if the pet develops an infection, inflammation, neoplasia or an additional endocrine or other medical disorder. Store ProZinc in an upright position, in the refrigerator, between 36°-46° F. Do not freeze. Protect from light. Keep this medication out of the reach of children and pets.

What happens if I miss giving a dose:

Contact and follow your veterinarian's directions if you miss giving a dose of ProZinc. If you cannot contact your veterinarian and your pet is eating and acting normally, give your pet the usual dose at the next regularly scheduled time. To prevent missed doses, be sure to always have enough ProZinc on hand.

What happens if I overdose the pet:

Contact your veterinarian immediately and, if your veterinarian is not available, seek other veterinary advice at once.

What should I avoid while giving ProZinc:

ProZinc should be given to dogs and cats only. ProZinc should not be administered to humans. Call a physician immediately if you accidentally inject yourself with ProZinc. Do not give a dose of ProZinc to a pet experiencing an episode of low blood glucose (hypoglycemia). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, accidental doubling of insulin dose, strenuous exercise, correction of obesity or diabetes-inducing disease, drug effects. Do not give a dose of PROZINC if the pet has not eaten or is vomiting. Consult your veterinarian prior to using PROZINC® insulin in order to establish the dosing needs of your pet. As per the product insert, it is recommended to initiate PROZINC insulin for dogs with a one-daily starting dose of 0.2-0.5 IU insulin/pound of body weight (0.5- 1.0 IU/kg). The recommended starting dose for naïve diabetic dogs is the lower end of the dose range. For cats, it is recommended that PROZINC insulin be given twice per day with a recommended starting dose of 0.1 – 0.3 IU insulin/pound of body weight (0.2 – 0.7 IU/kg). Consult your vet prior to using PROZINC insulin to establish the dosing needs of your pet. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

What are the possible side effects of ProZinc:

PROZINC® (protamine zinc recombinant human insulin) has been rigorously tested for safety in cats and dogs and has been approved by the FDA to be safe and effective for diabetes control (when used as prescribed). As with the use of all dog and cat insulin products, careful patient monitoring for low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia), is essential to prevent possible associated complications. The most common insulin-related side effect is hypoglycemia. Signs of low blood sugar can occur suddenly and may include weakness, staggering gait, muscle twitching, coma, depression, lethargy, sluggishness, behavioral changes, seizures, convulsions, and death.

What other drugs will affect ProZinc:

PROZINC® insulin can be given with other medications, but the dose may need to be adjusted due to the medication resulting in either increased or decreased insulin requirements. Tell your veterinarian about all medications you have given your pet in the past, and any medications that you are planning to give with PROZINC insulin. This should include medications that you can get for your pet without a prescription. Your veterinarian may want to ensure that all of your pet’s medications can be given together.

Where can I get more information:

Refer to your veterinarian for general questions. For any specific product questions, please refer to the prescribing information or call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251. Your pharmacist has additional information about ProZinc written for health professionals that you can read. PROZINC® insulin is available in 20 mL and 10 mL multidose vials. Each mL of PROZINC insulin product contains 40 IU (international units) of protamine zinc recombinant human insulin.

ProZinc Insulin Directions:

PROZINC® insulin should be given with or right after a meal and at about the same time each day. Before administration, mix PROZINC insulin by gently rolling the vial. Once mixed, PROZINC insulin has a white, cloudy appearance. After mixing, use a U-40 syringe to draw up the dose of insulin prescribed by your veterinarian. Administer the injection under the skin along the back of the neck or on the side of the dog or cat. Do not give your cat/dog its vet-prescribed dose of PROZINC insulin if it:

  • Is experiencing an episode of low blood sugar (hypoglycemia). Common causes for low blood sugar include excessive doses of insulin, failure to eat, strenuous exercise, changes in the body’s need for insulin, diabetes-inducing disease or drug effects.
  • Is not eating or is vomiting.
  • Is sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC® (protamine zinc recombinant human insulin).
  • Do not give your cat/dog its prescribed dose of PROZINC insulin if you see clumps or visible white particles in the vial after gently rolling

Tip:

Speak to your veterinarian about your pet's exercise and diet, as these can help maintain healthy glucose levels.

ProZinc Insulin Dosage:

Cats:
WeightDosage
All weightsBefore using ProZinc you should have your vet the proper way to inject insulin. Your cat's injection should be given at feeding time or just afterward. Give the injections at the same time every day, approximately 12 hours apart to help your cat maintain the most stable blood glucose levels. The initial recommended dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2-0.7 IU/kg) every 12 hours.
Dogs:
WeightDosage
All weights Before using ProZinc you should have your vet the proper way to inject insulin. Your dog's injection should be given at feeding time or just afterward. Give the injections at the same time every day, to help your dog maintain the most stable blood glucose levels. The initial recommended dose is 0.2 - 0.5 IU insulin/pound of body weight (0.5-1.0 IU/kg) daily.
ProZinc Insulin Dosage for Horses:
Horses
Do not use!

ProZinc Insulin Ingredients:

ProZinc Insulin
Active Ingredients per mLAmount
Recombinant Human Insulin40 IU (International Units)
Protamine Sulfate.466 mg
Zinc Oxide0.088 mg
Glycerin16.00 mg
Dibasic Sodium Phosphate Heptahydrate3.78 mg
Phenol (added as a preservative)2.50 mg
Hydrochloric Acid1.63 mg
Water for injection (maximum)1005 mg
Other: pH is adjusted with hydrochloric acid and/or sodium hydroxide.

What is ProZinc Insulin?

ProZinc is insulin combined with zinc and protamine which helps to prolong the release of the insulin into your pet's body. ProZinc requires a prescription from your veterinarian. U-40 Syringes are sold separately. ProZinc Insulin requires refrigeration and must be kept at refrigerator temperatures at all times. To ensure proper temperature, it requires overnight shipping at an additional cost.

For:

Dogs and Cats

Benefits:

  • Helps control blood glucose and alleviate symptoms of diabetes.
  • It is the first and only FDA-approved insulin for cats made from recombinant DNA (DNA molecules created from the DNA of two unrelated organisms) that is identical to human insulin.
  • Now FDA-approved for use in dogs
  • The ingredients in ProZinc (protamine zinc insulin) are classified as long-acting with duration of effect for 10-14 hours.

How it Works:

Insulin helps regulate cellular metabolism by moving all-important glucose from the bloodstream into the cells. Cats and dogs with diabetes mellitus don’t produce enough of their own natural insulin, or their own insulin doesn’t work properly. This causes glucose to persistently build up in the bloodstream, leading to health problems. PROZINC® insulin becomes the essential replacement for diabetics to get their appropriate source of daily insulin.

Cautions:

Syringes are sold separately. We recommend using U-40 syringes. ProZinc is for use in dogs and cats only. Keep out of reach of children. Avoid contact with eyes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systematic allergic reaction in sensitized individuals. Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. Do not give your cat/dog its prescribed dose of PROZINC® insulin if it is experiencing an episode of low blood sugar (hypoglycemia). Common causes for low blood sugar include excessive doses of insulin, failure to eat, strenuous exercise, changes in the body’s need for insulin, diabetes-inducing disease or drug effects, is not eating or is vomiting, is sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC insulin, and do not give your cat/dog its prescribed dose of PROZINC insulin if you see clumps or visible white particles in the vial after gently rolling. SGLT2 inhibitors, are sodium-glucose cotransporter-2 inhibitors which are a class of drugs that work by preventing glucose reabsorption by SGLT2s in the kidneys and promote natural glucose excretion via the urine. SGLT2s are contraindicated to be used in cats that have previously or are currently being treated with an insulin, and not labeled for use in dogs. PROZINC is veterinary insulin approved by the FDA made with recombinant technology approved for dogs and cats for reduction of clinical signs. 1

Brand Name:

ProZinc

Generic Name:

protamine zinc recombinant human insulin

What is the most important information I should know about ProZinc:

Diabetes mellitus is a disease where the body produces insufficient insulin. The low insulin levels may result in high blood glucose that could produce the following changes in a pet; increased thirst, urination and appetite; weight loss; high levels of glucose in the urine. ProZinc is not a cure for diabetes mellitus, it can control the levels of glucose in the blood to help alleviate the clinical signs. Follow any diet or exercise plan developed by your Veterinarian. The safety and effectiveness of PROZINC® insulin in breeding, pregnant, and lactating cats and dogs has not been evaluated. The safety and effectiveness of PROZINC in puppies and kittens has not been evaluated. PROZINC insulin has a two-year shelf life from the date of manufacture. Use the 10 mL vial within 60 days of first puncture. Use the 20 mL vial within 80 days of first puncture. The vial of PROZINC® insulin should be stored in an upright position under refrigeration at 36-46°F (2-8°C). Do not freeze. Protect from light.

What is ProZinc:

PROZINC® is an injectable insulin for cats and dogs that is approved by the FDA and is indicated for the reduction of hyperglycemia (high blood glucose / high blood sugar) and the clinical signs associated with hyperglycemia in cats and dogs with diabetes mellitus. PROZINC® insulin is the only recombinant human insulin approved by the FDA for use in dogs and cats with diabetes. PROZINC insulin contains protamine and zinc in the formulation which helps promote optimal and consistent glycemic control. PROZINC® insulin is designed to be used with a U-40 syringe and using non U-40 syringes may result in incorrect dosing.

What should I discuss with my veterinarian before giving ProZinc:

Do not give ProZinc to pets sensitive to Protamine zinc recombinant human insulin or any other ingredients in the ProZinc product. Do not give ProZinc during episodes of hypoglycemia. Before using ProZinc, tell your veterinarian if your pet has any other medical conditions or allergies, or if your pet takes any other prescription or over the counter medications, including vitamins, minerals, and herbal supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your pet.

How should this medication be given:

Do not switch from one type insulin to another unless under the directions of a veterinarian. Changing from one insulin to another may require an adjustment in the dose. ProZinc should be given according to your veterinarian's instructions. ProZinc is given using a U-40 syringe only. Use of a syringe other than a U-40 syringe will result in incorrect dosing. ProZinc should not be shaken. Just prior to use, the vial should be mixed by rolling the vial between the palms of your hands. Do not reuse a syringe. Dispose of all syringes in an appropriate puncture-resistant disposal container. Dosage regimens of ProZinc will vary among patients. The recommended starting dose for cats is 0.1 to 0.3 units per lb of body weight every 12 hours. The recommended starting dose for dogs is 0.2 to 0.5 units per lb of body weight once daily. This dose should be adjusted based on changes in blood glucose levels and resolution of clinical signs. Further adjustments may be necessary with changes in the pet's diet, body weight or other medications, or if the pet develops an infection, inflammation, neoplasia or an additional endocrine or other medical disorder. Store ProZinc in an upright position, in the refrigerator, between 36°-46° F. Do not freeze. Protect from light. Keep this medication out of the reach of children and pets.

What happens if I miss giving a dose:

Contact and follow your veterinarian's directions if you miss giving a dose of ProZinc. If you cannot contact your veterinarian and your pet is eating and acting normally, give your pet the usual dose at the next regularly scheduled time. To prevent missed doses, be sure to always have enough ProZinc on hand.

What happens if I overdose the pet:

Contact your veterinarian immediately and, if your veterinarian is not available, seek other veterinary advice at once.

What should I avoid while giving ProZinc:

ProZinc should be given to dogs and cats only. ProZinc should not be administered to humans. Call a physician immediately if you accidentally inject yourself with ProZinc. Do not give a dose of ProZinc to a pet experiencing an episode of low blood glucose (hypoglycemia). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, accidental doubling of insulin dose, strenuous exercise, correction of obesity or diabetes-inducing disease, drug effects. Do not give a dose of PROZINC if the pet has not eaten or is vomiting. Consult your veterinarian prior to using PROZINC® insulin in order to establish the dosing needs of your pet. As per the product insert, it is recommended to initiate PROZINC insulin for dogs with a one-daily starting dose of 0.2-0.5 IU insulin/pound of body weight (0.5- 1.0 IU/kg). The recommended starting dose for naïve diabetic dogs is the lower end of the dose range. For cats, it is recommended that PROZINC insulin be given twice per day with a recommended starting dose of 0.1 – 0.3 IU insulin/pound of body weight (0.2 – 0.7 IU/kg). Consult your vet prior to using PROZINC insulin to establish the dosing needs of your pet. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

What are the possible side effects of ProZinc:

PROZINC® (protamine zinc recombinant human insulin) has been rigorously tested for safety in cats and dogs and has been approved by the FDA to be safe and effective for diabetes control (when used as prescribed). As with the use of all dog and cat insulin products, careful patient monitoring for low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia), is essential to prevent possible associated complications. The most common insulin-related side effect is hypoglycemia. Signs of low blood sugar can occur suddenly and may include weakness, staggering gait, muscle twitching, coma, depression, lethargy, sluggishness, behavioral changes, seizures, convulsions, and death.

What other drugs will affect ProZinc:

PROZINC® insulin can be given with other medications, but the dose may need to be adjusted due to the medication resulting in either increased or decreased insulin requirements. Tell your veterinarian about all medications you have given your pet in the past, and any medications that you are planning to give with PROZINC insulin. This should include medications that you can get for your pet without a prescription. Your veterinarian may want to ensure that all of your pet’s medications can be given together.

Where can I get more information:

Refer to your veterinarian for general questions. For any specific product questions, please refer to the prescribing information or call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251. Your pharmacist has additional information about ProZinc written for health professionals that you can read. PROZINC® insulin is available in 20 mL and 10 mL multidose vials. Each mL of PROZINC insulin product contains 40 IU (international units) of protamine zinc recombinant human insulin.

ProZinc Insulin Directions:

PROZINC® insulin should be given with or right after a meal and at about the same time each day. Before administration, mix PROZINC insulin by gently rolling the vial. Once mixed, PROZINC insulin has a white, cloudy appearance. After mixing, use a U-40 syringe to draw up the dose of insulin prescribed by your veterinarian. Administer the injection under the skin along the back of the neck or on the side of the dog or cat. Do not give your cat/dog its vet-prescribed dose of PROZINC insulin if it:

  • Is experiencing an episode of low blood sugar (hypoglycemia). Common causes for low blood sugar include excessive doses of insulin, failure to eat, strenuous exercise, changes in the body’s need for insulin, diabetes-inducing disease or drug effects.
  • Is not eating or is vomiting.
  • Is sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC® (protamine zinc recombinant human insulin).
  • Do not give your cat/dog its prescribed dose of PROZINC insulin if you see clumps or visible white particles in the vial after gently rolling

Tip:

Speak to your veterinarian about your pet's exercise and diet, as these can help maintain healthy glucose levels.

ProZinc Insulin Dosage:

Cats:
WeightDosage
All weightsBefore using ProZinc you should have your vet the proper way to inject insulin. Your cat's injection should be given at feeding time or just afterward. Give the injections at the same time every day, approximately 12 hours apart to help your cat maintain the most stable blood glucose levels. The initial recommended dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2-0.7 IU/kg) every 12 hours.
Dogs:
WeightDosage
All weights Before using ProZinc you should have your vet the proper way to inject insulin. Your dog's injection should be given at feeding time or just afterward. Give the injections at the same time every day, to help your dog maintain the most stable blood glucose levels. The initial recommended dose is 0.2 - 0.5 IU insulin/pound of body weight (0.5-1.0 IU/kg) daily.
ProZinc Insulin Dosage for Horses:
Horses
Do not use!

ProZinc Insulin Ingredients:

ProZinc Insulin
Active Ingredients per mLAmount
Recombinant Human Insulin40 IU (International Units)
Protamine Sulfate.466 mg
Zinc Oxide0.088 mg
Glycerin16.00 mg
Dibasic Sodium Phosphate Heptahydrate3.78 mg
Phenol (added as a preservative)2.50 mg
Hydrochloric Acid1.63 mg
Water for injection (maximum)1005 mg
Other: pH is adjusted with hydrochloric acid and/or sodium hydroxide.

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