Skip to Main Content ›
FREE Shipping on orders over $49
20% OFFCoupon Code:
Expires in:
days hrs min secs
 20% OFF w/code
Expires in:
days hrs min secs
My Account


Rx Info
1. We'll ask for your vet's info during checkout.
2. We verify your prescription and ship your order!
Starts $112.21 $76.40 
Ships in one business day or less
Select an Option:
10 mg Capsules 30 ct
Price w/coupon SAVE20
Free Shipping
You save $35
30 mg Capsules 30 ct
Price w/coupon SAVE20
Free Shipping
You save $38
60 mg Capsules 30 ct
Price w/coupon SAVE20
Free Shipping
You save $44
120 mg Capsules 30 ct
Price w/coupon SAVE20
Free Shipping
You save $77
Starts $112.21 $76.40 
Ships in one business day or less
Please select all product options.
Select a Quantity:
Please select all product options.
Product Info
How to Use
Customer Reviews
Product Info

What is Vetoryl?

Vetoryl is used to treat dogs with hyperadrenocorticism (Cushing's Disease). Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependent Cushing's Disease and Cushing's Disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl. Vetoryl requires a prescription from your veterinarian.


Dogs & Puppies (weighing 3.8+ lbs)


  • Treats Cushing's Disease in dogs and puppies weighing over 3.8 lbs
  • Improvement may be seen within several weeks
  • Available in 10 mg, 30 mg, 60 mg or 120 mg capsules (based on weight)

How does Vetoryl work?

Vetoryl controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress.


Do not give this medication to dogs with kidney or liver disease. Vetoryl Capsules should not be given to dogs taking certain medications or dogs that are pregnant. Speak with your veterinarian about all medications your dog is taking, including over-the-counter medicines.

Brand Name:


Generic Name:


What is the most important thing I should know about Vetoryl?

Vetoryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's Disease. Vetoryl is indicated for use in pituitary-dependent hyperadrenocorticism. Vetoryl also has a Minor Use designation for treatment of Cushing's Disease caused by adrenal tumors. Vetoryl is available as 10 mg capsules, 30 mg capsules, 60 mg capsules and 120 mg capsules. The usual initial starting dose to treat Cushing's Disease in dogs is 1.0 to 3.0 mg/lb given once a day based on body weight and capsule size. For dogs weighing 3.8-10 lbs, give one 10 mg capsule once a day. For dogs weighing 10-22 lbs, give one 30 mg capsule once a day. For dogs weighing 22-44 lbs, give one 60 mg capsule. For dogs weighing 44-88 lbs, give one 120 mg capsule. For dogs weighing 88-132 lbs, give one 120 mg capsule and one 60 mg capsule, totaling 180 mg. For dogs weighing over 132 lbs, give the appropriate combination of capsules. Vetoryl should be given with food. After approximately 10 to 14 days, your pet will need to be re-examined and dosage adjustments may be required. Pets may require further re-examination at 30 days, 90 days, and every 3 months thereafter.

What should I discuss with my veterinarian before giving Vetoryl to my pet?

Tell your veterinarian if your pet has kidney or liver disease. Tell your veterinarian about any other medical problems or allergies your dog has now or has had in the past. Tell your veterinarian about any medications your dog is taking including over the counter products and nutritional supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your dog.

How should Vetoryl be given?

Give this medication exactly as directed by your veterinarian. Give this medication with food. Do not open capsules and do not attempt to split or divide capsules. Wash your hands after use. Do not handle the capsules if you are pregnant or trying to become pregnant. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you.

What are the potential side effects of Vetoryl?

If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What happens if I miss giving a dose of Vetoryl?

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose my pet on Vetoryl?

Seek emergency veterinary medical treatment. Symptoms of Vetoryl overdose may include lethargy, weakness, vomiting, or collapse.

What should I avoid while giving Vetoryl to my pet?

Do not give Vetoryl to dogs with kidney or liver disease. Do not give to pregnant or nursing dogs or dogs intended for breeding. Do not touch Vetoryl capsules if you are pregnant or trying to become pregnant.

What other drugs will affect Vetoryl?

Before giving Vetoryl, tell your veterinarian if your pet is also taking ACE inhibitors such as enalapril, potassium sparing diuretics such as spironolactone, ketoconazole, or potassium supplements. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines or nutritional supplements.


How to Use

Vetoryl Directions:

  • Vetoryl is used to treat dogs with hyperadrenocorticism, also known as Cushing's Disease.
  • Vetoryl capsules should be given with food.

Do not open capsules and do not attempt to split or divide capsule.

Vetoryl Dosage for Dogs/Puppies (weighing 3.8+ lbs):

Dogs/Puppies (weighing 3.8+ lbs):
3.8-10 lbsOne 10 mg capsule daily
10-22 lbsOne 30 mg capsule daily
22-44 lbsOne 60 mg capsule daily
44-88 lbsOne 120 mg capsule daily
88-132 lbsOne 120 mg capsule plus one 60 mg capsule daily (180 mg total)
Over 132 lbsAdminister the appropriate amount of capsules based on your dog's weight. Speak with your veterinarian to help you determine the correct dosage for your dog.
Vetoryl Dosage for Cats/Kittens:
Do not use!
Vetoryl Dosage for Horses:
Do not use!

Store Vetoryl at controlled room temperature (77°F) with excursions to 86° F allowed. Keep this medication away from children and other pets.


Vetoryl Ingredients:

Vetoryl 10 mg capsules:
Active IngredientsAmount
Trilostane10 mg
Vetoryl 30 mg capsules:
Active IngredientsAmount
Trilostane30 mg
Vetoryl 60 mg capsules:
Active IngredientsAmount
Trilostane60 mg
Vetoryl 120 mg capsules:
Active IngredientsAmount
Trilostane120 mg
Customer Reviews
Vetoryl is rated 4.3 out of 5 by 20.
Rated 4 out of 5 by from My Age 9 Carin Terrior Josee Josee was diagnosed with cushings a year ago. The vet did exstensive testing monthly to find right dosage. Josee gets 15ml. AM and 15ml PM. She has been on meds 1 yr. Her belly is not big anymore and drinking is less. Ive seen good improvement. I can't find 5ml. On line. Also price too high on internet. I had noticed her limping the last month so she is taking gabapentin due to joint plain as a result of Cushing. Yes this medicine is helping.
Date published: 2018-01-03
Rated 2 out of 5 by from It works My 14 year old mini dachshund was diagnosed with Cushings 10 weeks ago, taking 10 mgs daily. I've noticed some weight gain. No other side effects. Price is outrageous, cheaper at the vets office. Prayers that it works for her.
Date published: 2017-04-09
Rated 5 out of 5 by from Worked Great! My doxie Sandi was diagnosed with cushings at age 10. She was on the meds for 5 years until she passed this year at age 15. Once a dog is diagnosed with cushings, they are expected to live an average of 3 more years before the tumor can no longer be managed. My Sandi lived for 5 years. Vetoryl was amazing for her. Within weeks of starting it, she showed huge improvements. She lived a full and happy life with no side effects from the medication. It helped give us many great years together. It was also much cheaper than the original meds my vet wanted to prescribe.
Date published: 2016-04-16
Rated 5 out of 5 by from Incredible I bought Vetoryl because the vet advise my family it would help our dog (lapsa apso), she was diagnosed with cushing disease and she lost all her hair and energy. After just 5 months she has improved incredibly and her hair is growing back FAST!
Date published: 2016-03-27
Rated 5 out of 5 by from Meds have helped! Since my dog has been on the vetoryl capsules, she seems to her old self. That have made a difference in her quality of life.
Date published: 2016-03-12
Rated 5 out of 5 by from The product has helped my dog greatly. The product is excellent. The price on this website is outrageous. I can get it for much less at my vet's office.
Date published: 2014-03-08
Rated 5 out of 5 by from Wonderful for Cushings Syndrome Our girl, Molly, an Australian Cattle Dog, was drinking water and eating all the time. She would even eat rocks as she was thinking she was thirsty and hungry all the time. She got so fat and we were cleaning up "accidents" all the time. I found what I thought was her problem on the internet and advised our Vet of what I thought it was. We did all the "tests" and nothing was conclusive. But convinced Vet to put her on a Cushings Medication. She choose Vetoryl 120 mg. It took a couple of weeks before we noticed a difference. It has been 5 months and Molly is back to herself! Her eyes were bulging as she has the Pituitary Cushings, her stomach was huge and she had no energy, her fur was falling out and she had no muscle tone. She is now acting like a pup again and she is 11 years old. Amazing stuff! Thank you God!
Date published: 2013-07-20
Rated 1 out of 5 by from Careful of Diagnosis and Dose Vet determined our German Shorthair had Cushings. Prescribed 60mg dose for 60# dog. Caused her to pace uncontrollably and lose balance. Backed off to 30mg dose with similar results in about 5 days of drug. Have backed her off of Vetoryl completely - she was much healthier and happier without this prescription. Not clear why it didn't work for our dog.
Date published: 2013-02-06
  • y_2018, m_1, d_11, h_10
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_19
  • loc_en_US, sid_prod11110, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds

Vetoryl will be the first medication that our Vet is trying for our dogs cushings disease. She is prescribing 5mg to start.  He has lost weight & is currently 16 lbs

Asked by: Maureen
The dose of Vetoryl is dependent on many factors. Consult your veterinarian regarding your specific concern.
Answered by: Lisa M
Date published: 2017-10-16

I need this medicine in 120mg

Asked by: camilanc
We do offer the medication in 120mg. You would first need to place an order. We would then contact your veterinarian for the prescription before dispensing the medication.
Answered by: Crystal PetMed Pro
Date published: 2017-08-08

I need this medicine in 5mg capsules 

Asked by: Sandy
Unfortunately we do not have the medication available in 5mg.
Answered by: Crystal PetMed Pro
Date published: 2017-08-27

Your discounted prices are more than what I am charged by my vet. Why?

Asked by: Elaine
Please contact our sales department with questions on pricing.
Answered by: S Duesler PharmD MBA
Date published: 2017-04-19

My dog and I sleep during the day and stay awake during the night. Our day and night waking and sleeping are reversed. She also eats at night not mornings. Is it ok to give her the medication in the morning instead of night?

Asked by: Igor
Please contact your veterinarian regarding dosing instructions.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

My vet proscribed vetoryl, fortekor, and vetmedin. Can this drugs be mixed together? 

Asked by: Gibby1992
There are no contraindications to administering Vetoryl, Fortekor and Vetmedin concurrently.
Answered by: Lisa M
Date published: 2016-11-10

What's the expiration date?

Trying to calculate how many packs I can buy each time, since I'm sending it overseas for a friend's dog.
Asked by: Anna
The expiration date varies based on when the product was manufactured.
Answered by: Christine
Date published: 2016-10-22

I meant to ask if it is ok to give her the medication at night instead of mornings. We are awake at nights and sleep in mornings.

Asked by: Igor
Vetoryl helps to treat Cushing's disease by decreasing cortisol levels. Cortisol levels are highest in the morning, which is why it is beneficial to give Vetoryl in the morning. It is also important to give it with food, as this increases absorption.
Answered by: Christine
Date published: 2017-10-27
  • y_2018, m_1, d_11, h_10CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_33
  • loc_en_US, sid_prod11110, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds
Get 10% OFF Now Offer
Live Chat Share Website Feedback