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Trifexis

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Starts $138.74 $99.89 
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Trifexis?

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. This tasty, beef-flavored tablet (containing pork liver and hydrolyzed soy) is easy to give your dog to protect against multiple parasites with one medication. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more. Trifexis requires a prescription from your veterinarian.

For:

Dogs (8+ weeks of age, weighing 5+ lbs)

Benefits:

  • Begins killing biting fleas within 30 minutes
  • Kills fleas before they can lay eggs
  • Prevents heartworm disease
  • Treats and controls roundworms, hookworms, and whipworms
  • Artificial beef flavor made from pork liver and hydrolyzed soy
  • Easy-to-administer chewable tablet

How does Trifexis work?

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important thing I should know about Trifexis?

Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a Pink box for dogs 5 to 10 lbs (140 mg/2.3 mg), Orange box for dogs 10.1 to 20 lbs (270 mg/4.5 mg), Green box for dogs 20.1 to 40 lbs (560 mg/9.3 mg), Blue box for dogs 40.1 to 60 lbs (810 mg/13.5 mg), and Brown box for dogs 60.1 to 120 lbs (1620 mg/27 mg). For dogs over 120 lbs, give the appropriate combination of tablets.

What should I discuss with my veterinarian before giving Trifexis to my pet?

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should Trifexis be given?

Give Trifexis chewable tablets once a month with food. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose your pet with another full dose. Consult your veterinarian for pregnant or lactating dogs.

What are the potential side effects of Trifexis?

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to your pet.

What happens if I miss giving a dose of Trifexis?

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose my pet on Trifexis?

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis to my pet?

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What other drugs will affect Trifexis?

Talk to your veterinarian before giving any prescription or over the counter medications.

How to Use

Trifexis Directions:

  • Please view the chart below for the correct dosage of Trifexis for your dog.
Tip:

Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.

Trifexis Dosage for Dogs (8+ weeks of age, weighing 5+ lbs)

Dogs (8+ weeks of age, weighing 5+ lbs)
WeightDosage
5-10 lbsGive one tablet (Pink box)
10.1-20 lbsGive one tablet (Orange box)
20.1-40 lbsGive one tablet (Green box)
40.1-60 lbsGive one tablet (Blue box)
60.1-120 lbsGive one tablet (Brown box)
Over 120 lbsAdminister the appropriate combination of tablets
Trifexis Dosage for Cats:
Cats
Do not use!
Trifexis Dosage for Horses:
Horses
Do not use!
Storage:

Store Trifexis at room temperature (68°-77° F).

Ingredients

Trifexis Ingredients:

Trifexis Pink box (5-10 lbs):
Active Ingredients per tabletAmount
Spinosad140 mg
Milbemycin oxime2.3 mg
Trifexis Orange box (10.1-20 lbs):
Active Ingredients per tabletAmount
Spinosad270 mg
Milbemycin oxime4.5 mg
Trifexis Green box (20.1-40 lbs):
Active Ingredients per tabletAmount
Spinosad560 mg
Milbemycin oxime9.3 mg
Trifexis Blue box(40.1-60 lbs):
Active Ingredients per tabletAmount
Spinosad810 mg
Milbemycin oxime13.5 mg
Trifexis Brown box(60.1-120 lbs):
Active Ingredients per tabletAmount
Spinosad1620 mg
Milbemycin oxime27 mg
Customer Reviews
Trifexis is rated 4.0 out of 5 by 651.
Rated 5 out of 5 by from Worth Every Penny Trifexis works great for Kizzie. A little pricey but worth every penny!!!
Date published: 2018-01-09
Rated 4 out of 5 by from Works great on fleas, cost is a bit high I got this because fleas were causing an allergy for my dog and it works the best. It is not very affordable, though.
Date published: 2018-01-08
Rated 5 out of 5 by from Best Heartworm & Flea Protection Best Heartworm & Flea Protection for my baby. Booger has been on Trifexis for years he almost 10 years old. We go to dog park and never had flees. I feel good knowing he is protected from heartworms.
Date published: 2018-01-08
Rated 4 out of 5 by from Good experience I have had my 70 lb Doberman on trifexis since we got him and he has done very well. No weird reactions, I always have him take the pill on a full stomach of food. 1-800-PetMeds has wonderful customer service and they helped me with my order through the end.
Date published: 2018-01-08
Rated 5 out of 5 by from My dogs have been on Trifexis for several years. It's the greatest dtuff. My vet quit selling it, so this was my first time with Pet meds. They were great and prompt. I will use Pet Meds for my other dogs!
Date published: 2018-01-08
Rated 4 out of 5 by from Too expensive It works great and she gobbles it up like candy. I wish it didn't cost so much - regular people have a tough time affording it. It would be nice if it helped with ticks and tapeworms.
Date published: 2018-01-02
Rated 5 out of 5 by from Trifexis 1-800 pet meds makes it so easy to acquire the proper meds for my blue heeler!
Date published: 2017-12-31
Rated 5 out of 5 by from Trifexis and 1800PetMeds Are Great! Have been using Trifexis for 2 years now since Madison was a puppy and it works as advertised. But 1800PetMeds has the most amazing customer service of any company I have come across! They overnighted these meds so my pup would not miss a scheduled dose. Would highly recommend this company!
Date published: 2017-12-31
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Q&A

My dog test positive after taking trifexis for 8 mts, and has been on meds for over a month now. She will now begin taking shots. I am afraid that she can't tolerate the shots. She is 2 yrs old. What should I do?

Asked by: Snowy
Your veterinarian would be the best judge as to how well your dog will tolerate the heartworm treatment injections. Your dog's age (which is still young) and overall condition is a factor as well as any other underlying medical conditoins which can be determines with bloodwork and possible radiographs. If your dog is showing any physical symptoms of heartworms will also have an affect on how well your dog does. I recommend you talk to your vet about your concerns.
Answered by: Anonymous
Date published: 2018-01-09

what does trifectas have to do with seizures

Asked by: jerrie arkansas
Thank you for your question. There is a caution per the manufactuer of Trifexis that the product be used with caution in dogs with pre-existing epilepsy or history of seizures. Seizures are not listed as a possible side effect however of using the medication. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to your pet.
Answered by: Crystal PetMed Pro
Date published: 2018-01-09

Do i need a prescription for trifexis?

Asked by: Linda
Thank you for your question. Trifexis does require a veterinarians prescription.
Answered by: Crystal PetMed Pro
Date published: 2018-01-03

I have two huskys. Female is 41 pounds, male is 63 pounds. Can I buy the 40-60 dose and give to both dogs?

Asked by: Katie
No! Your male dog will not be covered and could still contract fleas, heartworms, and GI parasites.
Answered by: Erika89
Date published: 2017-12-31

Does this product work for ticks?

Asked by: GraciesMom
No, Trifexis prevents heartworms, kills fleas and deworms for hookworms, roundworms and whipworms. It does not kill or repel ticks. The manufacturer keeps telling us they are working on a product that will also kill ticks, but to date, none is available.
Answered by: SuzyCVT
Date published: 2017-12-22

My dog has taken trifexis for approximately six months but he still has fleas on him. My vet told me that trifexis is not for fleas. But it states on the package that it is for fleas heart worms hookworms another intestinal worms. I am really confused.

Asked by: Hantayo79
Thank you for your question. Trifexis does work to kill fleas and prevent flea infestations.
Answered by: Adriane
Date published: 2017-12-15

My dog wont take his pill unless I put it in pudding. So, he takes it but swallows it whole, he doesn't chew it. Will it still be effective?

Asked by: Debbie
Thank you for your questions. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. It is advised that the product be given with food.
Answered by: Crystal PetMed Pro
Date published: 2017-12-11

If I’m buying treflix do I need to use nexgard?

Asked by: Gonzo4077
Thank you for your question. Both medication provide different protection. Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. NexGard Chewables keep your pet protected from adult fleas by killing them before they have a chance to lay eggs, which reduces the possibility of a flea infestation. Plus, they kill 3 types of ticks (the American dog tick, the black-legged (Deer) tick and the Lone Star tick), which decreases the risk of your pet developing a deadly tick-borne disease.
Answered by: Crystal PetMed Pro
Date published: 2017-12-12
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