What are Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)?
Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets are a combination antibiotic used to treat respiratory, urinary tract, skin, or gastrointestinal infections, and other conditions. Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets Double Strength require a prescription from your veterinarian, and are sold per tablet.
Cats and Dogs
- Effective against a wide array of bacterial infections in dogs and cats
- Simple once-a-day dosing
How do Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) work?
Sulfamethoxazole is a sulfonamide antibiotic that limits the growth of bacteria. Sulfonamides inhibit synthesis of folic acid, important to bacterial DNA synthesis. Trimethoprim works by starving the bacteria of nucleotides necessary for DNA replication.
Do not use in pregnant or nursing animals. Leave plenty of water for your pet to drink. Report any unusual side effects to your veterinarian.
Bactrim, Bactrim DS (Roche), Septra, Septra DS (Monarch)
Sulfamethoxazole (SMZ) and Trimethoprim (TMP) (sulfa-meth-ox'-ah-zole with tri-meth'-o-prim)
What is the most important information I should know about Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) ?
Sulfamethoxadole and Trimethoprim is a prescription medication that is not FDA-approved for veterinary use; but it is commonly accepted practice for veterinarians to prescribe this medication for dogs and cats. Sulfamethoxazole and Trimethoprim Tablets are available as scored tablets. The usual initial dose for dogs and cats is 13mg/pound every 24 hours, which may be divided into two doses given 12 hours apart. Always follow the dosage instructions provided by your veterinarian. Do not give Sulfamethoxazole and Trimethoprim Tablets to any pet other than the pet for whom it was prescribed. Sulfamethoxazole and Trimethoprim Tablets are not for use in animals allergic to it or other sulfa drugs.
What should I discuss with my veterinarian before giving Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) to my pet?
Tell your veterinarian if your pet has liver or kidney disease, G6PD (glucose-6-phosphate dehydrogenase) deficiency, or if your pet is pregnant or lactating.
How should Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) be given?
Give this medication exactly as directed by your veterinarian. The dose and duration of therapy will depend on the type of infection and the response to the medication. Give all of the medication your veterinarian has prescribed. Symptoms may start to improve before the infection is completely treated. Give Sulfamethoxazole and Trimethoprim Tablets by mouth. The tablets may be given with food, and they can be crushed and put in food if needed. Allow plenty of water for your pet to drink. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Sulfamethoxazole and Trimethoprim Tablets at room temperature away from moisture and heat. Keep this medication away from children and pets.
What are the possible side effects of Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)?
Stop giving the medication and seek emergency veterinary medical attention if your pet experiences an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue or face, or hives), unusual bleeding or bruising, or yellow skin or eyes. Other less serious side effects may also occur. Continue to give the medication and talk to your veterinarian if your pet experiences fatigue, dizziness, nausea, vomiting, decreased appetite, diarrhea, weakness, or increased sensitivity to the sun. Side effects other than those listed may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
What happens if I miss giving a dose of Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)?
Give the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.
What happens if I overdose my pet on Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)?
Seek emergency veterinary medical treatment. Symptoms of overdose may include nausea, vomiting, decreased appetite, diarrhea, yellowing of the eyes, decreased urine production, bloody urine, and coma.
What should I avoid while giving Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) to my pet?
Do not give this medication to pets allergic to it or other sulfonamides (sulfa drugs). Avoid prolonged exposure to sunlight. This medication may increase sensitivity of the skin to sunlight.
What other drugs will affect Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)?
Before giving this medication to your pet, tell your veterinarian if your pet is being given warfarin, aspirin, glipizide, or phenytoin. Drugs other than those listed may also interact with sulfamethoxazole and trimethoprim. Talk to your veterinarian or pharmacist before giving prescription or over-the-counter medications.
- Sulfamethoxazole and Trimethoprim Tablets Double Strength are a broad-spectrum prescription antibiotic that is used in dogs and cats to treat respiratory infections such as bronchitis, urinary tract infections, skin infections, ear infections, gastrointestinal infections, and certain types of diarrhea.
- Sulfamethoxazole and Trimethoprim Tablets Double Strength are not FDA-approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to prescribe this medication for dogs and cats.
- Give this medication exactly as directed by your veterinarian.
The dose and duration of therapy will depend on the type of infection and the response to the Sulfamethoxazole and Trimethoprim Tablets Double Strength.
Give 13mg per pound of pet's body weight by mouth every 24 hours, which may be divided into two doses given 12 hours apart. You may crush the tablets and put them in food if needed. Allow plenty of water for your pet to drink.
Store at room temperature away from moisture and heat.
Sulfamethoxazole and Trimethoprim Tablets Double Strength:
Active Ingredients (per tablet)
Sulfamethoxazole and Trimethoprim Tablets Double Strength is rated
Rated 3 out of
We actually had this prescribed for our horse. It worked well only problem was she hated eating it. (she hates needles and its safer for everyone in pills).
Date published: 2012-10-12
Rated 5 out of
SULFA/TRIM A Great Antibiotic!
My 7 yr old G. Shep has cancer and developed a respiratory infection that would not go away. Tried Amoxicillin no real effect, Cipro stopped the infection from spreading but would not get rid of it and FINALLY Sulfa/Trim is working!!! can be given once or twice a day depending on dogs tolerance. 100 lb dog taking 1300 mg per day.
Scooby did have vomiting on the 2nd day, Initial dose was given at night, he vomited food prior to 2nd dose. This is a powerful antibiotic and should be given with caution. For Scooby this drug is a life saver.
Date published: 2012-03-14
Rated 4 out of
It works, but use correct dosage
After surgery for an aural hematoma, the vet prescribed SMZ/TMP, 960 mg twice per day. After 6 days on it, our 87-lb female experienced extreme fatigue, vomitng, and complete loss of appetite. She can barely stand up with a lot of help from us. The PetMeds dosage page recommends 13 mg per pound of body weight every 24 hours, for a dosage of 1131 mg. We were giving her 1920 mg each day, or 70% too much! I've nothing against SMZ/TMP (by coincidence, my wife is taking it now), but the vet neglected to adjust the dosage to our dog's weight. Yesterday the vet had me stop givng the drug to our dog, and she appears to be improving. Buyer beware: compare the prescription from the vet to the recommended dosage.
Date published: 2011-11-30
Rated 5 out of
You guys w/ the 1 stars are a bunch of idiots
Ok first off, this drug is a highly effective antibiotic, and deserves at least 4 stars. Second, don't give an effective drug a bad review just because YOUR dog had an allergic reaction to it.(The vet prescribed it, not the drug companies, so go give your vet a bad review for bad judgment) The vast majority of dogs use this medication with success. Finally, drugs have side effects, EVERY SINGLE ONE. Know there are risks, and I'm sorry if your dog suffered or passed away, but coming on here telling everyone to "beware" of bactrim like it's the freaking anti-Christ is just plain ignorant. Guys, this is an effective antibiotic. It's the same deal with humans that are allergic to sulfa, but bactrim is still widely used. Why? because it's good!
Date published: 2011-05-03
Rated 1 out of
This drug was administered to my beautiful dog after he underwent knee surgery for a torn ACL. The photo attached was take the day we brought him home from his surgery. This drug evidently can cause severe reaction causing immune disease which can lead to death, 2 weeks after his surgery he was fighting for his life, a battle in which he lost.
Please be aware of the danger of using this drug and ask your vet for alternitive medication for your beloved pet. You have to be your pets advocate, do not just assume the vet knows best.
Date published: 2009-07-13
Rated 3 out of
Michael Dym, VMD Veterinarian
sulfamethoxazole/trimethoprim product review
Sulfamethoxazole/trimethoprim product review: This long term and still widely used antibiotic has been prescribed by veterinarians and MD/s for decades. It was one of the earlier and more effective antibiotics used to treat infections of the prostate, skin, urinary tract and airways. However with the development of newer and safer antibiotics, I have found that I have used this antibiotic much less in my veterinary practice, because of both safer and more effective newer alternatives. In certain breeds like Dobermans and Labrador retrievers(although these can occur rarely in any breed), we can see immune mediated reactions leading to joint problems, and bone marrow suppression, which can result in fevers, secondary super infections and joint pain. Use of this drug can also lower thyroid measurements in treated dogs, thus sometimes leading vets to mistakingly diagnose low thyroid levels or hypothyroidism, which is a disease that pets are treated for life. A major advantage of this antibiotic still in modern veterinary medicine is in treating neurologic or brain infections, where this drug often reaches higher therapeutic levels than many other drugs. In years past, this drug was also the first choice in treating cats affected with an infection called toxoplasmosis, however newer drugs like clindamycin are now more widely used for this purpose in feline medicine. A big major advantage of this drug is that it is still relatively inexpensive compared to many other antibiotics . However, given the potential reactions and newer and safer alternatives in many case situations , I give this prescription antibiotic an overall rating/efficacy of a 2.5 with a taste/ease of use of a 4.
Date published: 2009-05-05
Rated 1 out of
If your pet has any problems after starting this drug make sure your vet considers allergies to the drug. My dog's doctors kept on saying his symptoms where from his cancer and never considered he maybe allergic to the sulfa, now I wonder and I will never know the truth because we had him euthansized.
Date published: 2009-04-10
Rated 1 out of
This ABX is killing my dog
As I type this, my dog is in ICU and quarantine due to toxicity from this drug. It completely wiped out his immune system, and affected his liver. He is fighting for his life right now. He was not overdosed, the drug itself did this to him.
Date published: 2008-12-14