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Simplicef

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Starts $2.78 $1.90 per tablet
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100 mg Tablet
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200 mg Tablet
$5.81
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Starts $2.78 $1.90 per tablet
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Product Info

What is Simplicef?

Simplicef is a once-a-day antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. It may also be used for purposes other than those listed. Simplicef requires a prescription from your veterinarian, and is sold per tablet.

For:

Dogs

Benefits:

  • FDA-approved for treating canine bacterial skin infections
  • Simple once-a-day dosing
  • Can be given with or without food
  • Comes in a film-coated tablet for easy administration

How does Simplicef work?

Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.

Cautions:

Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, mucus or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.

Brand Name:

Simplicef (Zoetis), Vantin (Pharmacia and Upjohn)

Generic Name:

Cefpodoxime proxetil

What is the most important thing I should know about Simplicef?

Simplicef is a prescription medication FDA-approved for use in dogs. Simplicef is available as 100 mg elliptical scored tablets and 200 mg tablets that can either be elliptical, unscored tablets marked 5229 or capsule-shaped, scored tablets marked 5229. The usual dose of Simplicef in dogs is 2.3-4.5 mg/lb, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Simplicef should be given with food to increase absorption by the body. Give all of the Simplicef that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.

What should I discuss with my veterinarian before giving Simplicef to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease. Tell your veterinarian if your pet is pregnant or lactating.

How should Simplicef be given?

Give this medication exactly as directed by your veterinarian. Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated. Store tablets at room temperature away from moisture or heat. 

What are the potential side effects of Simplicef?

Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur.  Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What happens if I miss giving a dose of Simplicef?

Give the missed dose as soon as you remember. Do not give a double dose unless otherwise directed by your veterinarian.

What happens if I overdose my pet on Simplicef?

Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal cramps.

What should I avoid while giving Simplicef to my pet?

Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.

What other drugs will affect Simplicef?

Before giving Simplicef, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

How to Use

Simplicef Directions:

  • Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body.
  • Simplicef can be used to treat many different types of infections such as bronchitis and pneumonia as well as ear, skin, and urinary tract infections.
Tip:

Simplicef should be given with food to increase absorption by the body.

Dosage:
Dogs:
Weight
Dosage
All weights
Give this medication exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5 mg/lb, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
Cats
Do not use!
Horses:
Do not use!
Storage:

Should be stored in a cool dry place.

Ingredients

Simplicef Ingredients:

Simplicef 100 mg tablets:
Ingredient
Amount
Cefpodoxime proxetil
100 mg
Simplicef 200 mg tablets:
Ingredient
Amount
Cefpodoxime proxetil
200 mg
Customer Reviews
Simplicef is rated 4.5 out of 5 by 31.
Rated 1 out of 5 by from Simplicef Adverse Side Effects My Pomeranian was given Simplicef for 14 Days. Tonight he has been screaming out and whimpering in pain really stiff. Difficulty transitioning from laying position, holding front legs and hind legs like cramping, craning his neck, comforting and consoling him rubbing near neck area. I questioned why he was given a different antibiotic for his chronic condition. I am very upset. At this moment he is having another episode of pain 3rd time in the past 3 hours 30 minutes!! I think this medicine shouldn't be given to certain dogs due to adverse side effects. He is having pain and suffering uncertainty of how long this is going to last!! Now this will become another Vetrinarian visit for him with high cost. I usually take my pets to Emergency Animal Clinic After Hours but, since just recently took both dogs to Vet given pharmaceuticals.
Date published: 2017-05-18
Rated 5 out of 5 by from Ordered meds one day 3 days later they were at my door. Very quick reasonably priced and great service . Very happy with company.
Date published: 2017-01-21
Rated 3 out of 5 by from bad product My pet was prescribed this on Tuesday Gave him a half pill for 2 days. He became very lathargic,feverish and now has some kind of muscle or joint pain. Whines when he moves. Stopped giving him the pill, hopefully he'll get back to his old self. Will never use again.
Date published: 2016-10-08
Rated 5 out of 5 by from Great service My dog gets allergies in the summer months and this product really helps his skin. I love dealing with petmeds they are great
Date published: 2015-12-14
Rated 5 out of 5 by from This works great, all sores gone. We had our little guy on the two week, or 20 day plan whenever the sores started. We read about someone giving their dog the Simplicef only on weekends and this kept it clean. We started Zorro on this plan and it has been 100% effective for him. When he was on the one a day 1/2 pill regiment he seemed to gain weight. Now he has lost a few pounds and is back to his "bossy" self with lots of energy.
Date published: 2014-02-03
Rated 5 out of 5 by from Very good product My Ali suffers from bacteria around his chin and lips because he is a Boxer and they tend to slobber. His bumps are more like acne and when ruptured by scratching they bleed and become more irritating. Simplicef, after three days he is cured. Of course if I want to avoid future breakouts I give him a pill a day. This gives me peace of mind and a happy pet.
Date published: 2014-01-20
Rated 5 out of 5 by from Excellent! My dog gets really dry skin, and when I say really, I mean REALLY BAD. It was getting to the point where I was giving him baths every day just so he would stop itchy. After a nice week wait to get an appointment, when the vet finally saw me, she gave my sheltie these pills. That was over a year ago. Now, when the whether is bad, which sets off the dryness/raw spots on my dog, I call in, and they give me a refill. It is the ONLY thing that I have found to work for my dog's dry skin.
Date published: 2013-08-02
Rated 5 out of 5 by from Happy Dog My Shih Tzu suffers from year round allergies. She is allergic to most foods and pollens (I am not exaggerating). She has been plagued with chronic Staph Infections since I adopted her 3.5 years ago. Her health issues have literally cost us a small fortune. I couldn't get my pup into the vet this last time. So, she prescribed me Simplicef 100mg ($28/7pills) that I could pick up since she had just been treated 6 weeks prior with the usual meds, injectable Convenia and Steroids. To my amazement, she had NO obvious side effects and this is the first time that the infection has actually stayed away for any length of time. She usually would have the lingering allergy/staph odor and itchiness by now. But, so far so good. Fingers crossed that she (and I) will have some long lasting relief. It is great that other owners with similar issues are having such great success with this product as well. The other reviews assure me that long term relief is possible for my pup with this product. Thanks to Pet Meds for offering this product with fair pricing.
Date published: 2013-06-09
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Q&A

Does this medicine have an  expiration date ?

Asked by: Shar
Yes, the expiration dates for the product we currently have in stock are 4/2019 for Simplicef 100 mg tablets and 7/2019 for the 200 mg tablets.
Answered by: Lisa M
Date published: 2017-11-13

Can I give this to my cat ? 

Asked by: Debbie
Thank you for your question. This medication is by prescription only and is for use in dogs unless otherwise specified by a veterinarian.
Answered by: Crystal PetMed Pro
Date published: 2017-08-28

Your website on 2 of my browsers after, clearing cookies, cache etc.still isn't showing Customer Reviews 9 to 31. The arrow is greyed out not allowing to read the remaining customer reviews. My Second Request to fix the issue in order to show the Vet

Asked by: beautybodacious
Thank you for your question. The product only has 31 reviews total, the reviews are only two pages long. The first page is 1-8 reviews second page is 8-31 reviews individually.
Answered by: Crystal PetMed Pro
Date published: 2017-05-26

Simplicef Reviews only shows up to 9 Reviews when 30 reviews are listed. I would like to read all the reviews and show to the Vetrinarian. Can you correct the problem? 

Asked by: beautybodacious
There is a tab on the bottom that can be clicked to bring up the rest of the reviews. If that doesn't work for you maybe clearing the browser history or using a different browser will help. If you are still not able to see them please call us to trouble shoot this with you.
Answered by: 1800Petmeds Pharmacist
Date published: 2017-05-19

Do you price match ...

Asked by: Theodora
Hello, see a lower price somewhere? We'll match it! We offer great savings to our customers with Free Standard Shipping on orders over $49*. However, if you find a lower price including shipping on the identical product from a Vet-VIPPS® accredited online pet pharmacy, we will honor that price at the time of order as long as the product is FDA/EPA approved for sale in the United States. The price being matched must be a product dispensed by an accredited licensed-pharmacy or veterinarian residing in the United States. The price considered will be the total price (including shipping charges, handling fees, and other charges that may apply). Price-match products are not eligible for additional special offers. Please contact us at 1-800-PetMeds® (1-800-738-6337) or email at: customerservice@1800petmeds.com
Answered by: Roseanna Pharmacy Intern
Date published: 2017-04-17

Can simplicef be taken with yogurt? It has recently upset my dog's stomach and I thought yogurt would help?

Asked by: Anthe
Hello, Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. I do not recommend giving it with yogurt because not all dogs can tolerate yogurt. Many brands of yogurt also contain sugar and sweeteners, which can be harmful to the dog. Please contact your vet if you notice that your dog is not getting better.
Answered by: Roseanna Pharmacy Intern
Date published: 2017-04-14

Can this medication cause drowsiness in dogs? My dog seems to get really sleepy an hour at rr taking it. 

Asked by: Heather08
Drowsiness is not a common side effect associated with Simplicef but it is possible. Consult your veterinarian if it is excessive.
Answered by: Lisa M
Date published: 2016-11-24

What are the long term affects? I have a very itchy lab that weighs 110lbs. When he's on it he is fine but a few day after he is off he is iching again. His joints also seem to be much better while he is on it. He seems like a puppy but he's 7.

Asked by: Sdcd
Simplicef is an antibiotic that may be used to treat skin infections, that my have caused your pet to be itchy. Common side effects include diarrhea, vomiting or blood in stool.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17
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