What is Simplicef?
Simplicef is a once-a-day antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. It may also be used for purposes other than those listed. Simplicef requires a prescription from your veterinarian, and is sold per tablet.
- FDA-approved for treating canine bacterial skin infections
- Simple once-a-day dosing
- Can be given with or without food
- Comes in a film-coated tablet for easy administration
How does Simplicef work?
Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.
Contact your veterinarian in the event of an allergic reaction (such as shortness of breath, hives, swelling, rash, fainting, vomiting, diarrhea, mucus or blood in the stool, unusual bleeding, or bruising). Do not give Simplicef at the same time as antacids such as Maalox or other stomach acid-reducers, like Tagamet.
Simplicef (Zoetis), Vantin (Pharmacia and Upjohn)
What is the most important thing I should know about Simplicef?
Simplicef is a prescription medication FDA-approved for use in dogs. Simplicef is available as 100 mg elliptical scored tablets and 200 mg tablets that can either be elliptical, unscored tablets marked 5229 or capsule-shaped, scored tablets marked 5229. The usual dose of Simplicef in dogs is 2.3-4.5 mg/lb, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Simplicef should be given with food to increase absorption by the body. Give all of the Simplicef that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.
What should I discuss with my veterinarian before giving Simplicef to my pet?
Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease. Tell your veterinarian if your pet is pregnant or lactating.
How should Simplicef be given?
Give this medication exactly as directed by your veterinarian. Simplicef should be given with food to increase absorption in the body. Keep plenty of water available for your pet to drink. Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet as this may decrease the absorption of Simplicef. Give all of the Simplicef even if your pet appears to be better. Symptoms may improve before the infection is completely treated. Store tablets at room temperature away from moisture or heat.
What are the potential side effects of Simplicef?
Stop giving Simplicef and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), severe nausea, vomiting or diarrhea, mucus or blood in the stool, and unusual bleeding or bruising. Other, less serious side effects such as mild nausea, diarrhea, or yeast infection may be more likely to occur. Continue to give Simplicef and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
What happens if I miss giving a dose of Simplicef?
Give the missed dose as soon as you remember. Do not give a double dose unless otherwise directed by your veterinarian.
What happens if I overdose my pet on Simplicef?
Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and abdominal cramps.
What should I avoid while giving Simplicef to my pet?
Do not give Simplicef at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.
What other drugs will affect Simplicef?
Before giving Simplicef, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), probenecid, a loop diuretic such as furosemide, or warfarin. You may need to have the dosage adjusted. Drugs other than those listed here may also interact with Simplicef. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
- Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body.
- Simplicef can be used to treat many different types of infections such as bronchitis and pneumonia as well as ear, skin, and urinary tract infections.
Simplicef should be given with food to increase absorption by the body.
Give this medication exactly as directed by your veterinarian. The usual dose of Simplicef in dogs is 2.3-4.5 mg/lb, given by mouth, once a day for 5 to 7 days or 2 to 3 days beyond the cessation of clinical signs, up to a maximum of 28 days.
Should be stored in a cool dry place.
Simplicef 100 mg tablets:
Simplicef 200 mg tablets:
Simplicef is rated
Rated 5 out of
Ordered meds one day 3 days later they were at my door. Very quick reasonably priced and great service . Very happy with company.
Date published: 2017-01-21
Rated 3 out of
Shadow boo 05
My pet was prescribed this on Tuesday Gave him a half pill for 2 days. He became very lathargic,feverish and now has some kind of muscle or joint pain. Whines when he moves. Stopped giving him the pill, hopefully he'll get back to his old self. Will never use again.
Date published: 2016-10-08
Rated 5 out of
My dog gets allergies in the summer months and this product really helps his skin. I love dealing with petmeds they are great
Date published: 2015-12-14
Rated 5 out of
This works great, all sores gone.
We had our little guy on the two week, or 20 day plan whenever the sores started. We read about someone giving their dog the Simplicef only on weekends and this kept it clean. We started Zorro on this plan and it has been 100% effective for him. When he was on the one a day 1/2 pill regiment he seemed to gain weight. Now he has lost a few pounds and is back to his "bossy" self with lots of energy.
Date published: 2014-02-03
Rated 5 out of
Very good product
My Ali suffers from bacteria around his chin and lips because he is a Boxer and they tend to slobber. His bumps are more like acne and when ruptured by scratching they bleed and become more irritating. Simplicef, after three days he is cured. Of course if I want to avoid future breakouts I give him a pill a day. This gives me peace of mind and a happy pet.
Date published: 2014-01-20
Rated 5 out of
My dog gets really dry skin, and when I say really, I mean REALLY BAD. It was getting to the point where I was giving him baths every day just so he would stop itchy. After a nice week wait to get an appointment, when the vet finally saw me, she gave my sheltie these pills. That was over a year ago. Now, when the whether is bad, which sets off the dryness/raw spots on my dog, I call in, and they give me a refill. It is the ONLY thing that I have found to work for my dog's dry skin.
Date published: 2013-08-02
Rated 5 out of
My Shih Tzu suffers from year round allergies. She is allergic to most foods and pollens (I am not exaggerating). She has been plagued with chronic Staph Infections since I adopted her 3.5 years ago. Her health issues have literally cost us a small fortune.
I couldn't get my pup into the vet this last time. So, she prescribed me Simplicef 100mg ($28/7pills) that I could pick up since she had just been treated 6 weeks prior with the usual meds, injectable Convenia and Steroids. To my amazement, she had NO obvious side effects and this is the first time that the infection has actually stayed away for any length of time. She usually would have the lingering allergy/staph odor and itchiness by now. But, so far so good. Fingers crossed that she (and I) will have some long lasting relief. It is great that other owners with similar issues are having such great success with this product as well. The other reviews assure me that long term relief is possible for my pup with this product.
Thanks to Pet Meds for offering this product with fair pricing.
Date published: 2013-06-09
Rated 5 out of
Great for treating skin allergies
Our cavalier king charles spaniel is susceptible to skin allergies - apparently common in this breed. A flare up usually results in large scabs. Ever since our vet suggested Simplicef as an alternative to the allergist route, we start it at the first sign of a flare up and the irritation clears up without going through the scab stage. And no apparent side effects. Love it!
Date published: 2013-01-01