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Frontline Plus

Starts $53.82 $37.77 
Ships in one business day or less

Step 1. Select Pet's Weight:

Dog
Cat

Step 2. Select a Supply:

3 pack
$53.82
$47.21
$37.77
Price w/coupon SAVE20
6 pack
$99.30
$87.10
$69.68
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12 pack
$193.75
$169.96
$135.97
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Starts $53.82 $37.77 
Ships in one business day or less

Step 1. Select Pet's Weight:

Dog
Cat

Step 2. Select a Supply:

3 pack
$53.82
$47.21
$37.77
Price w/coupon SAVE20
6 pack
$99.30
$87.10
$69.68
Price w/coupon SAVE20
Free Shipping
Save $5 over 3 pk
12 pack
$193.75
$169.96
$135.97
Price w/coupon SAVE20
Free Shipping
Save $15 over 3 pk

Step 3. Select a Quantity:

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+
Please select all product options.

Step 3. Select a Quantity:

Please select all product options.
Product Info

What is Frontline Plus?

Frontline Plus is a monthly topical flea and tick preventative for dogs and cats. Frontline Plus kills 100% of adult fleas on your pet within 12 hours and 100% of all ticks and chewing lice within 48 hours. Frontline Plus contains an insect growth regulator, S-methoprene, which kills flea eggs and larvae. It's effective against all stages of the brown dog tick, the American dog tick, the lone star tick and the deer tick (the major carrier of Lyme disease). (3 Pack = 3 doses which lasts 3 months.)

For:

Cats/Kittens and Dogs/Puppies (8 weeks of age and older)

Benefits:

  • Kills all existing fleas on your pet within 12 hours
  • Each application provides a full month of protection
  • Also aids in the control of sarcoptic mange infections in dogs
  • Great for pets that swim since it's waterproof
  • Kills ticks and chewing lice

How does Frontline Plus work?

Frontline Plus contains fipronil, a broad-spectrum insecticide and slow-acting poison that disrupts the central nervous system of fleas and ticks and S-Methoprene, an insect growth regulator that kills flea eggs and larvae. The active ingredients are stored in the sebaceous glands and are wicked out of the hair follicles and continuously re-applied to the coat for long-lasting, waterproof protection.

Cautions:

Your pet may experience some temporary irritation at the site of application. If signs persist or become severe within a few days of application, consult your veterinarian immediately.

Brand Name:

Frontline Plus (Merial)

Generic Name:

Fipronil, S-methoprene

What is the most important thing I should know about Frontline Plus?

Frontline Plus provides convenient and effective flea and tick control in dogs and cats, puppies and kittens. It is effective against all stages of the brown dog tick, the American dog tick, lone star tick and deer ticks (the major carrier of Lyme disease). It also kills flea eggs and flea larvae. Frontline Plus rapidly eliminates infestations with chewing lice. Frontline Plus for Dogs and Puppies also aids in the control of sarcoptic mange infections.

How should Frontline Plus be applied?

Use Frontline Plus for Dogs (fipronil 9.8% and S-methoprene 8.8%) on dogs and puppies 8 weeks or older. Frontline Plus for Dogs is available as 0.67 ml applicators for use on dogs and puppies up to 22 lbs, 1.34 ml applicators for dogs 23-44 lbs, 2.68 ml applicators for dogs 45-88 lbs and 4.02 ml applicators for dogs 89-132 lbs. Wait 24 hours to fully dry before swimming or bathing. Do not reapply for 30 days. Use Frontline Plus for Cats (fipronil 9.8% and S-methoprene 11.8%), available as 0.5 ml applicators, on cats and kittens 8 weeks or older. Place the applicator tip through the animal's hair to the skin level between the shoulder blades. Apply the entire contents of the applicator in a single spot to the animal's skin. Use only one applicator per treatment.

What are the potential side effects of Frontline Plus?

Pets may experience some temporary irritation at the site of product application. If signs persist or become more severe within a few days of application, consult a veterinarian immediately.

What happens if I miss giving a dose of Frontline Plus?

Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Frontline Plus?

Contact your veterinarian immediately.

What should I avoid while giving Frontline Plus to my pet?

Keep away from heat and open flame. This product is harmful to humans if swallowed. Call a physician or poison control center for advice. Have patient sip water do not induce vomiting unless advised to and patient is conscious. This product can cause eye injury. Flush eyes with plenty of water. Call a physician if irritation persists. Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling.

How to Use

Frontline Plus Directions:

  • Remove the Frontline Plus applicator from the child-resistant package. You can use scissors to snip the foil, or pull the tab to remove the applicator.
  • Snap open the tip of the Frontline applicator - away from your body and face.
  • Part your pet's hair between the shoulder blades until you can see the skin, and place the tip of the applicator on the skin.
Tip:

Wait until application site is fully dry (usually 24 hours) before bathing your pet or letting your pet go swimming.

Frontline Plus Dosage for Dogs/Puppies: (8 weeks of age or older)

Dogs/Puppies: (8 weeks of age or older)
WeightDosage
Up to 22 lbsApply contents of 1 applicator once a month (0.67 ml)
23-44 lbsApply contents of 1 applicator once a month (1.34 ml)
45-88 lbsApply contents of 1 applicator once a month (2.68 ml)
89-132 lbsApply contents of 1 applicator once a month (4.02 ml)
All weightsApply contents of 1 applicator once a month (0.5 ml)
Frontline Plus Dosage for Horses:
Horses
Do not use!
Storage:

Should be stored at room temperature.

Ingredients

Frontline Plus Ingredients:

Frontline Plus for Dogs & Puppies 8 weeks or older and up to 22 lbs
Active ingredients (per 0.67 ml applicator)Amount
Fipronil9.8%
(S)-methoprene8.8%
Frontline Plus for Dogs 23-44 lbs:
Active ingredients (per 1.34 ml applicator)Amount
Fipronil9.8%
(S)-methoprene8.8%
Frontline Plus for Dogs 45-88 lbs
Active ingredients (per 2.68 ml applicator)Amount
Fipronil9.8%
(S)-methoprene8.8%
Frontline Plus for Dogs 89-132 lbs
Active ingredients (per 4.02 ml applicator)Amount
Fipronil9.8%
(S)-methoprene8.8%
Frontline Plus for Cats & Kittens 8 weeks or older:
Active ingredients (per 0.50 ml applicator)Amount
Fipronil9.8%
(S)-methoprene11.8%
Customer Reviews
Frontline Plus is rated 3.4 out of 5 by 4040.
Rated 5 out of 5 by from Frontline Plus Both our Lab and our Golden have had regular applications of Frontline Plus for years. Flea infestations have never been an issue! Nor have any allergic responses to the product.
Date published: 2017-12-27
Rated 4 out of 5 by from Great prices! I had gone shopping for front line for dogs and cats. By far 180 pet meds had the best price. The order came alot faster then I expected. I am very happy and will order again.
Date published: 2017-12-06
Rated 5 out of 5 by from GREAT STUFF My poor cat has been covered in ticks, I have had to pull them off every night! I had a few that I couldn't remove. I used Frontline and within hours, they were gone and he has not had one since!! Love frontline.. it will be my go to from now on!
Date published: 2017-11-17
Rated 5 out of 5 by from Frontline We have had a particularly bad year and Fall with ticks and the Frontline has worked to keep them off the cats and therefore off of us when the animal comes inside.
Date published: 2017-11-13
Rated 1 out of 5 by from Stopped Working Frontline used to work for our dogs but this summer it stopped working. Our dogs have fleas so I do not recommend this product for flea provention.
Date published: 2017-11-08
Rated 5 out of 5 by from Works great.. We have been using frontline for 15 plus yrs on big dogs . GD, Mastiff , Great Pyrenees, Labs. Works great no fleas . I think the problem with the people who says it doesn't work is they don't get the product directly on the skin . You just can't put it on the hair.
Date published: 2017-11-08
Rated 1 out of 5 by from What the heck!? I've used Frontline on my 4lb Chihuahuas for over 10 years with great results. Be for that, I used Frontline on my (late) Yorkshire Terrier, again perfect. My dogs are very spoiled and well groomed inside dogs. They only go out to potty and come back in. Since I'm not a big fan of medicines, I only used this when I saw a flea, and discontinued it in the winter. This fall (2017) I spotted a couple fleas so I purchased Frontline and behold! It didn't work! Thinking I had a bad batch, I ordered again. Fail. Since then I've read online this seems to be a problem lately, with a strain of super fleas resistant to the chemical. Not knowing what to try next, I took my dogs to the vet who again mentioned the resistant fleas. She prescribed a pill for $20 each called Comfortis. Still, no luck. Back to the vet on Monday.
Date published: 2017-11-04
Rated 5 out of 5 by from Been Using Frontline for Years I can’t understand why there are customers for whom Frontline doesn’t work, but of course I believe them. All I can report is that I have been using Frontline Plus on my German Shepherds for many, many years, and it has always been highly effective. I live in Connecticut, deer tick central, so this is very important for the health of both human and animal family members! In fact I haven’t even set eyes on a flea in a couple of decades and am not sure I’d know one now if I saw one!
Date published: 2017-11-03
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Q&A

Are we supposed to use flea & tick year round?

Asked by: Sadie
I recommend using flea and tick control year round as while it may be freezing outside, inside your house is still warm enough for fleas and ticks to survive and bite your pet(s).
Answered by: Anonymous
Date published: 2018-01-09

My delivery of Frontline Plus was left outside in freezing temperatures for over 24 hours. Is it still safe and effective to use?

Asked by: lmason
Thank you for your question. We would not recommend using the product , if the product was purchased from us please give us a call at 1-800-738-6337 and we would be more than happy to send you out a replacement at no additional cost.
Answered by: Crystal PetMed Pro
Date published: 2018-01-09

I Have a collie. I have heard that collies can not have some of the flea / tick preventions because they have a genetic reaction to it. Is this safe for him?

Asked by: Jellybean
Thank you for your question. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. The most serious adverse drug reactions involve several antiparasitic agents (ivermectin, milbemycin and related drugs), the antidiarrheal agent loperamide (Imodium), and several anticancer drugs (vincristine, doxorubicin, others). These drug sensitivities result from a mutation in the multidrug resistance gene (MDR1 gene). It is recommended to have your furry friend tested to see if your pet has the MDR1 gene.
Answered by: Crystal PetMed Pro
Date published: 2017-12-27

why don't I see Frontline Gold or has it been removed

Asked by: Jean
Thank you for your question. We are very sorry but the product you are looking for is not a product we currently carry. Your interest in this product has been forwarded to our purchasing department as a possible item for us to sell in the future. Please check back periodically because we are always adding new products to our inventory.
Answered by: Crystal PetMed Pro
Date published: 2017-12-03

Is this frontline the same as you get from a vet ?

Asked by: Tammy
Thank you for your question. Yes, the Frontline Plus we sell is the same as sold at the vets office.
Answered by: Crystal PetMed Pro
Date published: 2017-11-26

Can I use this with the front line spray?

Asked by: Dessy797
Thank you for your question. The Frontline Plus topical and the spray should not be used together.
Answered by: Crystal PetMed Pro
Date published: 2017-11-13

Have a dog that will eventually be over the 132 pounds. Do you have another packet for larger dogs 

Asked by: Karen
The largest size we have available is for dogs up to 132 lbs. If your pet is over 132 lbs, you can purchase one of the smaller doses that adds up to your furry baby's weight and apply both tubes on your furry baby. For example, if your furry baby is 150 lbs, you will purchase the 89-132 lbs dose and also a package for small dogs up to 22 lbs.
Answered by: Cherley Petmeds Pro
Date published: 2017-11-07

So we put this on or dogs 3 days ago (basset hound and a jack Ruslle) and we are still noticing fleas, more so on the Jack Ruslle. What should we do? 

Asked by: Emilychr
Please contact our customer service department at 1-800-738-6337 so we can further assist you.
Answered by: Cherley Petmeds Pro
Date published: 2017-11-13
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