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Product Info
How to Use
Customer Reviews
Product Info
What is Epizyme?

Epizyme is a mixture of pancreatic enzymes that is FDA-approved for use in cats and dogs to treat exocrine pancreatic insufficiency (also known as maldigestion syndrome). It is prescribed for pets whose pancreas has stopped producing digestive enzymes. Pancreatic enzymes are necessary for digestion, so animals who don't make enough of these enzymes get very sick and can lose a lot of weight because they cannot properly digest and absorb the fat, protein, and sugar in their food. Epizyme requires a prescription from your veterinarian.


Cats and Dogs

  • Effective treatment for exocrine pancreatic insufficiency (also known as maldigestion syndrome)
  • Begins working immediately after the first dose
  • Can reduce the symptoms and help your pet live a healthier life
  • Helps your pet regain weight lost due to exocrine pancreatic insufficiency
How it Works:

Epizyme replaces the pancreatic enzymes that the pancreas fails to produce when your pet suffers from exocrine pancreatic insufficiency. It is made up of three types of enzymes (lipase, protease, and amylase) that aid in digestion of fat, protein, and carbohydrates (sugar). It works because these natural enzymes, made from whole pig pancreas, mimic the pancreatic enzymes your pet is lacking. When the enzyme powder mixes with your pet's food, the enzymes begin to break down and work. Although exocrine pancreatic insufficiency is not yet curable, treating with pancreatic enzymes, such as Epizyme, can reduce the symptoms that occur with exocrine pancreatic insufficiency and can help your pet live a healthier life. Epizyme will begin working immediately to improve digestion after the first dose, but it will take a while before you'll see significant improvement in your pet's weight, stools, and coat. Once your pet needs Epizyme, he or she will likely have to continue taking Epizyme for the rest of his or her life.


Do not give Epizyme to any pets who are allergic or hypersensitive to pork products, as it is derived from whole pig (pork) pancreas. Although allergic reactions are rare, they are possible. See below for more information. Do not give Epizyme powder to your pet if he or she is taking any other medications without first talking with your veterinarian.

Brand Name:

Epizyme (Vet Brands International)

Generic Name:

Pancreatic Enzymes

What is the most important information I should know about Epizyme:

Epizyme is a prescription medication FDA approved for veterinary use in dogs and cats. Epizyme is available as a powder. Each 1 teaspoonful of powder (2.8 Gm) contains Lipase (71,400 USP Units), Protease (388,000 USP Units) and Amylase (460,000 USP Units). The usual dose of Epizyme powder in dogs is 3/4-1 teaspoonful mixed with each meal. After mixing, allow the mixture to stand for 15-20 minutes before feeding it to your pet. For cats, the usual dose of Epizyme powder is 1/4-3/4 teaspoonful of the powder mixed with each meal. After mixing, allow the mixture to stand for 15-20 minutes before feeding it to your pet.  

What is Epizyme:

Epizyme is a mixture of pancreatic enzymes that is FDA-approved for use in cats and dogs to treat exocrine pancreatic insufficiency (also known as maldigestion syndrome and Pancreatic Insufficiency Disorder (PID)). Epizyme is a generic equivalent to Pancrezyme. It has the same active ingredients in the same strengths.  

What should I discuss with my veterinarian before giving Epizyme to my pet:

Tell your veterinarian if your pet has an allergy to pork. Tell your veterinarian if your pet is being given antacids such as Maalox, H2 blockers such as cimetidine or proton pump inhibitors such as Prilosec. Tell your veterinarian if your pet is pregnant or lactating.  

How should this medication be given:

Give this medication exactly as directed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. You should avoid inhaling the powder as it might irritate the mouth. Epizyme should be given with food. Mix the powder with your pet's food and let stand for 15-20 minutes before feeding your pet. Store Epizyme powder at room temperature away from moisture and heat. Keep this medication away from children and pets.  

What happens if I miss giving a dose:

Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.  

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of Epizyme overdose may include diarrhea, excess fat in the feces, increased appetite, and weight loss.  

What should I avoid while giving Epizyme to my pet:

Epizyme should not be given to pets allergic to it, or to pets allergic to pork. You should avoid inhaling the powder as it might irritate the mouth.  

What are the possible side effects of Epizyme:

If any of the following serious side effects occur, stop giving Epizyme and seek emergency veterinary medical attention: an allergic reaction (difficulty breathing; swelling of the lips; tongue or face; hives). Continue giving Epizyme and talk to your veterinarian if your pet experiences diarrhea or loose stools. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.  

What other drugs will affect Epizyme:

Tell your veterinarian if your pet is being given antacids such as Maalox, H2 blockers such as cimetidine or proton pump inhibitors such as Prilosec. Drugs other than those listed may also interact with Epizyme. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.  

Where can I get more information:

Your pharmacist has additional information about Epizyme written for health professionals that you may read.

How to Use
  • Add a single dose of Epizyme to your pet's moistened food. If you use wet food, simply stir the powder into the wet food mixture. If you use dry food, wet the food with plenty of warm water first, then stir in the powder, making sure to thoroughly mix the food with the enzyme powder.
  • Let the food/enzyme mixture sit for 15 - 20 minutes before giving it to your pet, to give the enzymes adequate time to begin working and to decrease the chance of irritating your pet's mouth.

Avoid inhaling the powder as it might irritate your mouth, or cause lung irritation or asthma attacks. Avoid contact with your or your pet's skin, as it can cause burning and irritation. If contact occurs, wash the affected area immediately. Wash your hands after handling Epizyme.

All weights
The usual dose for dogs is ¾ - 1 teaspoon of the powder with each meal, and for cats is ¼ to ¾ teaspoon of the powder with each meal, but always follow your veterinarian's instructions. Make sure you thoroughly mix the powder with moistened food (either wet food or food moistened with plenty of warm water). After mixing, allow the food and enzyme mixture to stand for 15 - 20 minutes before giving it to your pet.
Do not use!

Store this product at room temperature in a tight, light resistant container in a dry, cool place. Keep product in a child-proof container, and keep out of reach of children.

Ingredients (per teaspoon)
71,400 USP units
388,000 USP units
460,000 USP units
Other Ingredients: Esterases, peptidases, nucleases, and elastase.
Customer Reviews
Epizyme is rated 4.5 out of 5 by 11.
Rated 5 out of 5 by from Saved my dogs liife My Aussie mix Dakota has been taking Epizyme for 6 years now and it saved her life. After many visits to serveral vets I finally found a vet that was able to diagnose her properly and prescribe Epizyme. Although this medication is expensive I can always count on 1800petmeds for a good price and great customer service.
Date published: 2017-10-02
Rated 5 out of 5 by from This company is the best! We have been using Epizyme for 7 years. If it weren't for this medication our Cavalier King Charles would have died years ago. She is a nice healthy 11 pounds and she is 11 years old. so lucky this works.
Date published: 2017-09-09
Rated 5 out of 5 by from epizyme My Papillon has Exocrine Pancreatic Insufficiency (EPI). Pancreazyme was prescribed by my vet, however it was unavailable everywhere and your site recommended the epizyme. It is working well for him at this time and I would buy it again.
Date published: 2017-06-13
Rated 2 out of 5 by from Not as good? My dog as used Pancrenzyme for a couple of years. We switched are are about 75% into a new bottle. My dog has lost weight over the past several weeks despite doubling the dose. I will continue to use it otherwise my dog would starve to death...but would prefer to buy Pancrenzyme if it were available. Don't forget to keep lid closed spring - fall as both brands will get hard and lumpy.
Date published: 2016-06-18
Rated 5 out of 5 by from This is truly a life saver My German Shepherd, Bubba, had chronic diarrhea and was looking a bit thinner. Long story short, took him to his vet and learned that he had EPI and was literally starving to death. He had already lost 20#. He was prescribed Epizyme and almost immediately started to gain weight back. This stuff works and has saved Bubbas life.
Date published: 2016-05-08
Rated 5 out of 5 by from Saved my sweet Bella Mae's life!!! My sweet Bella Mae was literally starving to death. We brought her to 3 different vets and they took blood work, fecal samples, etc...yet could not figure out why she couldn't gain weight no matter how much food we fed her. Once she got down to around 28 lbs I took upon myself to google "my dog is not absorbing nutrients" and it brought me to a page that told me there was a possibility that she no longer produced the enzyme that made that possible, which led me to a few options. I picked Epizyme powder and it CHANGED HER LIFE!!! She gained 20 lbs in just 2 months and now up to 56lbs, full of energy and vibrant as can be! THANKFUL!
Date published: 2016-05-02
Rated 5 out of 5 by from Works Well! We had to switch to Epizyme from pancreazyme and it seems to work just as well, if not, better!
Date published: 2016-02-16
Rated 4 out of 5 by from Product works, but... I've been giving this product to my miniature schnauzer. It is helping with bowel problems, however this product gives her a very unpleasant sour smell. I even make a point of washing her face after each meal and it doesn't help. It also seems to make her belch.
Date published: 2014-05-29
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Can you mix the enzyme with food, let it sit for 20 minutes, then store it in the refrigerator for use a few days later?  Also, is it possible to compound the enzyme into a yummy liquid or tablet form?

Asked by: Chris
Thank you for your question. Store Epizyme powder at room temperature away from moisture and heat otherwise it will alter the drug. To my knowledge, Epizyme only comes in powder form. May want to double-check with your veterinarian if there are other options.
Answered by: leanniejo
Date published: 2017-08-09

My dog takers Pepcid and Regaln twice a day for mega-esophagus, what is the interaction with this medication and when should these meds be given in relation to meals using Epizyme?

Asked by: Cathy
Pepcid, Reglan, and Epizyme are all digestive type medications. They all can be given together without significant interaction, however it is important to let your Vet know they are on the Pepcid before starting Epizyme. Epizyme should be mixed with the pet's food 15-20 minutes before feeding. Pepcid and Reglan can also be given before the dog eats. Hope this helps.
Answered by: Trey W
Date published: 2017-02-21

makes my dog have an oder

Does anyone elses dog that is on this powder smell? Our dog has been on this product for a few days now and we have seen significant improvement. He is a 5 year old Lhasa Apso and loves to play.
Asked by: sergs mom
I have a cat on this medication, and he also has an odor. I read recently that this is alleviated if you make sure to wait at least 15 minutes before letting your pet eat. I wasn't adhering to that as well as I should, so am now using a timer to be sure the full time passes before letting my cat eat. We'll see if it helps.
Answered by: caboodle
Date published: 2015-08-25

Where can i get beef pancreatic powder

my cat requires pancreatic powder but will not eat her food with the current powder on it. I have done everything to disguise the smell and taste. My vet suggested i try to locate beef powder instead of the pork powder.
Asked by: rita
All of the pancreatic enzymes we carry are derived from pork.
Answered by: Pharmacist
Date published: 2014-04-24

Is this the generic to Pancrezyme? Is it as effective?

Asked by: Noremac
Yes. I was told it is the generic for Pancrzyme. It is effective when you use the correct amount and let the food sit 18/20 minutes before serving it to your pet.
Answered by: Chaz
Date published: 2013-10-22
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