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Frontline Plus - Sentinel
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Frontline Plus
Sentinel
Kills Fleas checkmark X mark
Repels Fleas X mark X mark
Kills Flea eggs and Larvae checkmark Prevents Development
Kills Ticks checkmark X mark
Repels Ticks X mark X mark
Kills and/or Repels Mosquitoes checkmark X mark
Prevents Heartworm X mark checkmark
Other Parasites Information Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation Controls adult hookworms and removes and controls adult roundworms & whipworms
Waterproof (shampooing once a week can reduce effectiveness) checkmark N/A
Safe for pregnant or nursing Pets checkmark checkmark
How long does it take to work Kills Fleas within 12 hours and Ticks within 48 hours Begins to work Immediately, However, pre-existing flea populations may continue to develop and emerge.
Taste Applied to Skin Beef Flavor
Active Ingredient(s) Fipronil/(S)-Methoprene Milbemycin Oxime/Lufenuron
RX Required X mark checkmark
Dosage
Usage Frontline Plus Usage Sentinel Usage
Video /images/products/video/petmeds-flea-preventative-frontline-plus.flv /images/products/video/petmeds-heartworm-disease-sentinel.flv
Vet Review I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first. Sentinel is a wonderful combination of the heartworm prevention pill interceptor and the flea control product program both in this one pill.  Many clients enjoy the convenience of having such broad acting internal and external parasites in one pill, without having to worry about giving two separate medicines.  Lufenuron, which is the main flea control ingredient, stops the flea life cycle in its track at the egg and larval stage, thus being like a birth control pill for fleas who get on our pets. Given that the main problem of fleas is how rapidly they reproduce, this pill literally stops escalating growth of flea populations, before they can become established in our homes, where most of the flea life cycle occurs.  The main disadvantage to this product is that it does not kill or repel adult fleas, so in situations with already established heavy infestations, it is best combined with a great topical product like advantage or front line or with the oral adulticide flea pill Capstar for maximal effect.  The only other rare disadvantage I see is the slight increase in reactions when two products  are  combined into one like this, but fortunately this is not common in clinical practice. With milbemycin for prevention of heartworms and controlling and treating most common intestinal worms, I overall highly recommend this versatile product.
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.

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