Nutramax Denosyl Liver and Brain Health Supplement, With S-Adenosylmethionine (SAMe)

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About this product

What is Denosyl?

Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. Its main ingredient is S-Adenosylmethionine (SAMe). S-Adenosylmethionine, or SAMe, supports the liver by increasing levels of glutathione, a powerful antioxidant and the liver's main detoxifying agent.

For:

Cats and Dogs

Benefits:

  • Denosyl contains a stabilized form of SAMe, which supports healthy liver function
  • The SAMe in Denosyl has been shown to be bioavailable
  • May support cognitive function in dogs

How it Works:

Denosyl has been shown to increase the level of glutathione, an antioxidant that can fight deadly toxins in your pet's body. For optimal absorption, it should be taken on an empty stomach.

Cautions:

Denosyl tablets must be given to your pet whole. Store this product in a cool and dry place. Keep tablets in the original blister pack until they are used.

Brand Name:

Denosyl (Nutramax)

Active Ingredient(s):

S-Adenosylmethionine

What is this product used for:

Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.

Availability:

Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.

How this product should be used:

The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.

What are the side effects:

There are no reported side effects. However, Denosyl should be used with caution when given with medications such as amitriptyline, fluoxetine, clomipramine, tramadol, or Mitaban Dip.

What special precautions are there:

Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.

In the event of overdose:

Contact a veterinarian or veterinary emergency room.

How should I store this product:

Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.

See more

Denosyl Directions:

  • Tablets should be given on an empty stomach for optimal absorption.
  • They may be given at least two hours after a meal or one hour before a meal.
Tip:

The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian..

Denosyl Dosage

Denosyl for Small Dogs & Cats
WeightDosage
Up to 12 lbsGive 1 tablet daily
Over 12 lbsGive 1 tablet twice daily
Denosyl for Medium Dogs
WeightDosage
13-34 lbsGive 1 tablet daily
Denosyl for Large Dogs
WeightDosage
35-65 lbsGive 1 tablet daily
66-120 lbsGive 2 tablets daily
121 lbs and overGive 3 tablets daily
Denosyl Dosage for Horses:
Horses
Do not use!

Denosyl Ingredients:

Denosyl for Cats & Small Dogs
Active Ingredients (up to 12 lbs)Amount
S-Adenosylmethionine90 mg
Denosyl for Medium Dogs
Active Ingredients (13-34 lbs)Amount
S-Adenosylmethionine225 mg
Denosyl for Large Dogs
Active Ingredients (35 lbs and over)Amount
S-Adenosylmethionine425 mg
Product Details
plus minus

What is Denosyl?

Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. Its main ingredient is S-Adenosylmethionine (SAMe). S-Adenosylmethionine, or SAMe, supports the liver by increasing levels of glutathione, a powerful antioxidant and the liver's main detoxifying agent.

For:

Cats and Dogs

Benefits:

  • Denosyl contains a stabilized form of SAMe, which supports healthy liver function
  • The SAMe in Denosyl has been shown to be bioavailable
  • May support cognitive function in dogs

How it Works:

Denosyl has been shown to increase the level of glutathione, an antioxidant that can fight deadly toxins in your pet's body. For optimal absorption, it should be taken on an empty stomach.

Cautions:

Denosyl tablets must be given to your pet whole. Store this product in a cool and dry place. Keep tablets in the original blister pack until they are used.

Brand Name:

Denosyl (Nutramax)

Active Ingredient(s):

S-Adenosylmethionine

What is this product used for:

Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.

Availability:

Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.

How this product should be used:

The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.

What are the side effects:

There are no reported side effects. However, Denosyl should be used with caution when given with medications such as amitriptyline, fluoxetine, clomipramine, tramadol, or Mitaban Dip.

What special precautions are there:

Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.

In the event of overdose:

Contact a veterinarian or veterinary emergency room.

How should I store this product:

Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.

See more
How to use
plus minus

Denosyl Directions:

  • Tablets should be given on an empty stomach for optimal absorption.
  • They may be given at least two hours after a meal or one hour before a meal.
Tip:

The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian..

Denosyl Dosage

Denosyl for Small Dogs & Cats
WeightDosage
Up to 12 lbsGive 1 tablet daily
Over 12 lbsGive 1 tablet twice daily
Denosyl for Medium Dogs
WeightDosage
13-34 lbsGive 1 tablet daily
Denosyl for Large Dogs
WeightDosage
35-65 lbsGive 1 tablet daily
66-120 lbsGive 2 tablets daily
121 lbs and overGive 3 tablets daily
Denosyl Dosage for Horses:
Horses
Do not use!
Ingredients
plus minus

Denosyl Ingredients:

Denosyl for Cats & Small Dogs
Active Ingredients (up to 12 lbs)Amount
S-Adenosylmethionine90 mg
Denosyl for Medium Dogs
Active Ingredients (13-34 lbs)Amount
S-Adenosylmethionine225 mg
Denosyl for Large Dogs
Active Ingredients (35 lbs and over)Amount
S-Adenosylmethionine425 mg
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Racheln36
4 years ago
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Breed Terrier Mix
Well ...
All products don't work for all. In fact, the fatty tumor got bigger; so discontinued use after 6 weeks.
Thumbs up Would not recommend this product
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Zoey
5 years ago
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Breed Beagle
This product works well for my senior beagle girl with improving her liver function and overall well being. I do have to say we miss the chewable form of Denosyl. These caplets are large, and I need a pill pocket or a glob or cream cheese to get it down her. The chewables were perfect!
Thumbs up Would recommend this product
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Cherry
11 years ago
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Breed Beagle
Genetic Liver Dysfunction
My adopted beagle had seizure the second day after we brought her home. She was one year old then. We thought it was due to the new environment. Clinic vet prescribe her with only some relaxant medication and vitamins. She continues to have seizure once every few weeks. Till a serious episode in the middle of the night one day made us to bring her to the animal hospital. A thorough check by the vet and after few follow-up check diagnosed her with genetic liver dysfunction and also genetic epilepsy. Her liver reading was far exceeding the normal range. Denosyl had helped to keep her liver at normal range with her seizure medication that is not good for her liver . She is put on long term Denosyl, a pill a day before her l/d diet. She is healthy and active after 2 years now. All of us are happy with this cutie pie at home!
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skitslover
12 years ago
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Breed Chartreux
Best Medicine in the World
My 13yr old cat had blood work drawn for her dental and her ALT enzyme was 1965, normal level should be from 10-100. The vet recommended Denosyl and Prednosone for 30 days and to retest her levels. I got the results back today and her ALT is 44-which is astonishing. I was given the prognosis of having to put her down if the pill didn't work, and now we're instructed to give it to her 2x a week for maint. This pill is a miracle!! Lifesaver
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Erin
13 years ago
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Breed Bichon Frise
Miracle worker
Maddie is my 12 year old bichon. She is my heart. I'm not sure about the technical terminology but one of her liver enzymes has been escalating for years and was way way above normal. It's supposed to be under 100 and her count was over 800. Shortly after giving her this pill that number was cut in half and it continues to go down, I am thrilled. Since the pill has to be given whole, it's kind of hard to give it to her. She hates it... But it is so worth it. I need my girl with me a long time, so she's taking it. It's very effective.
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Terry
15 years ago
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Breed Terrier
Denosyl liver med's
We use to be able to get this medicine in a small round orange pill. Was able to push down our dogs throat easily. Now they have changed this to a larger thicker oval shaped pill. Our little dog has trouble swallowing it. It says on the bottle not to be split or crumbled. It is too easy for a little dog to choke on it. It is also very difficult when says has to be on a empty stomach a hour before meals. We end up giving in the evening after meals. Getting this medicine from the Vet costs $32.50, the only good thing is PetMeds is only $17.99. But our Vet can at least get the small thin ones where Petmeds only has the long thick ones.
Thumbs up Would not recommend this product
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caroly
15 years ago
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Breed mutt
life saver
This drug literally saved my dog's life and has enabled her to continue to live 2 years past being diagnosed with liver failure. She was very sick and it took about 7 days on the denosyl before she improved. Don't give up if you are struggling with watching your dog suffer. It just might be the miracle you are praying for.
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brava4
15 years ago
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Breed domestic
My Kitties Liver enzymes are back to normal!!
My old girl, Lilly, gets this every day... it works so well for her and I am so happy her liver is better. she is happy too!!
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