Adequan for Dogs vs. Galliprant Comparison

Adequan for Dogs

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Galliprant

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Reduces Pain and Inflammation associated with Arthritis?

Reduces Fever?

Reduces Joint Stiffness?

Controls Symptoms of Osteoarthritis

Additional Benefits

Can also be used for post surgery pets

Targets canine osteoarthritis pain and inflammation while reducing the impact on GI, kidney, and liver homeostasis.

What Makes it Different?

It is given by given by intramuscular injection, instead of orally

Galliprant (grapiprant tablets) is a first-in-class non-COX-inhibiting prostaglandin receptor antagonist. It specifically blocks the EP4 receptor, the primary mediator of canine osteoarthritis pain and inflammation. Galliprant (grapiprant tablets) does not inhibit the production of many housekeeping prostanoids that maintain homeostatic functions.

Recommended For?

Dogs & Horses

Dogs (9 months of age or older, weighing 8 lbs or more)

Product Type

Injection

Tablet

Usage

RX Required

How Long does it Take to Work?

Within Hours of Dose

Video

Ingredients

Polysulfated Glycosaminoglycan, Benzyl alcohol and Water

Grapiprant

Does it have long-term side effects?

No known

In a 9-month toxicity study, vomiting and soft-formed or mucus stool were observed in all groups, including controls, with higher incidence in grapiprant-treated dogs. Decreases in serum albumin and total protein were seen with increasing doses of grapiprant. Hypoalbuminemia and hypoproteinemia were reversible when treatement was discontinued. Three treated dogs and one control dog had elevated alkaline phosphatase values.

Cautions

Do not give this medication to breeding, pregnant, or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

Galliprant (grapiprant tablets) is for use in dogs 9 months of age or older, weighing 8 lbs or more only. Do not use in cats. Galliprant (grapiprant tablets) are not for use in humans. Keep this and all medications out of reach of children and pets. Consult a physician in case of accidental ingestion by humans. Store Galliprant (grapiprant tablets) out of reach of dogs and other pets in a secured location in order to prevent accidental ingestion or overdose.

What are Customers saying Pros

This product is amazing. Our 10 month old Boxer was diaghosed with Hip Displasia. He had a difficult time getting up and walking after a long day. It was sad to see him in the state he was, especially since he was SO young. Our vet recommended Adequan injections and taught us to do them at home. It only took one day for his entire demeanor to change. Words cannot describe the difference. This medication has enabled him to live an active lifestyle :) he's running, jumping endlessly now - we got our puppy back.

I cannot say enough how great this med is. My lab’s pain was so bad that I thought she had experienced a stroke…..she couldn’t walk without help, and her face and eyes showed confusion and pain. After one pill, she began to feel better and in less than 24 hours she was back to her normal self. I was afraid I was going to lose her, but this med has brought her back to me. It is a miracle worker.

What are Customers saying Cons

"...twice a week for 4 weeks and saw absolutely no improvement with either of them. The vet wasn't pushing Adequan either and now I'm wondering if they knew it didn't work very well,¿

From a helping stand point it's perfect; he’s so much better…from a money standpoint, saddening this is so expensive.

Vet Recommendations

Adequan product review: One of the first products of its kind in veterinary medicine, now in use over many years and thousands of dogs and happy dog guardians, my clinical experience with this pioneering injectable FDA approved joint supplement has also been very positive. By injecting this product intramuscularly, one avoids some of the problems with absorption that is occasionally seen with other natural joint supplements given orally. The polysulfated glycosaminglycan solution quickly goes to the joints that need it, modifying the disease process of degenerative joint disease, by inhibiting enzymes that break down the supportive cartilage of the joints, while at the same time increasing the thickness of the lubricating joint fluid, just as shock absorbers do for ones automobile. The results are a decrease in inflammation and joint pain. I have even used this product in cats on occasion with terrific results, which is so important, given the paucity of effective and safe drugs for cats available on the market for arthritis. Results can be seen within hours to days. I usually will follow the manufacturer's recommendations giving it twice weekly for first 4 weeks. Some pets will have long term relief, while others will need periodic injections anywhere from every 2-4 weeks. I will often combine use of this product with omega 3 fatty acids, as well as antioxidants like proanthozone, also available from 1-800-PetMeds, and find that with this multipronged supplement approach, that I often can avoid the need for stronger prescription drugs which may have occasional side effects. The only side effects I have occasionally seen in animals is very rare bleeding tendencies. This is best avoided by having blood work done first by your veterinarian to make sure there are no pre-existing problems of the liver or kidneys that may predispose to this. The only other negative I can see is the need to get your vet to write a prescription for it, and the need for some clients to get over the fear of learning how to give these injections to their pets at home. Once I have shown clients the first time, they often find it quite easy and money-saving to do it right at home themselves. I give this product an overall efficacy rating of a 5, with an ease of use a 3.

There has been an exciting development in the area of pain management in the past year. The recognition, understanding, and use of pain management medications in veterinary medicine has grown dramatically, especially for osteoarthritis in dogs. Over the past 20 years, improved nonsteroidal anti-inflammatory medications such as Rimadyl, Metacam, Deramaxx, and Previcox, have indeed been great helps in managing pain and inflammation in arthritic patients, however, there remain risks in occasional, sensitive animals of serious side effects, whether it be on the digestive tract, kidneys or liver. With the arrival of the new drug Galliprant, conventional veterinarians now have a unique and innovative product that targets the clinical signs(i.e pain, inflammation) of arthritis by specifically blocking a particular receptor, while sparing other similar receptors to continue, do help with balance and health. Therefore there are much fewer risks of especially kidney and liver dysfunction. While GI side effects can occasionally occur, they are much rarer and milder than with many nonsteroidal anti-inflammatory medications and can be minimized by giving with food. The medication starts working within the day, but more typical is gradual improvement over the first month of therapy. While veterinarians are still gaining clinical experience in this newly approved drug, the main side effect rarely encountered is short lived vomiting, which typically resolves on its own. Even rarer are loose, mucoid stools. An outstanding benefit of this novel product is that it can be used in animals as young as one year of age. It also comes in a very palatable pork liver flavor formulation. I give this medication an overall rating of a 4.5.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.