Skip to Main Content ›
FREE Shipping on orders over $49
15% OFFCoupon Code:
SAVE15
100% Satisfaction Guaranteed
 15% OFF w/code
SAVE15
FREE Shipping $49+
100% Satisfaction Guaranteed
My Account
Errors:

Zymox Otic Enzymatic Solution with Hydrocortisone

Starts $32.34 $21.99 
Ships in one business day or less
1
Select an Option:
1.25 oz
$32.34
$25.87
$21.99
Price w/coupon SAVE15
You save $10
4 oz
$76.46
$61.17
$51.99
Price w/coupon SAVE15
Free Shipping
You save $24
Starts $32.34 $21.99 
Ships in one business day or less
Please select all product options.
2
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info

What is Zymox Otic Enzymatic Solution with Hydrocortisone?

Zymox Otic Enzymatic Solution with Hydrocortisone is an enzymatic treatment for otitis externa (outer ear infection) in cats and dogs. It treats the ear externally for acute and chronic inflammation caused by bacterial, fungal, and yeast infections. This effective enzymatic system supports the natural defense mechanism of your pet's body to kill harmful bacteria, fungi, and yeast. Some factors that may contribute to possible ear infections include: excessive hair, a suppressed immune system, and excessive skin folds in the ear. The addition of hydrocortisone provides added relief from inflammation as well as relief from itching. Zymox Otic Enzymatic Solution with Hydrocortisone is a once-a-day treatment that requires no pre-cleaning and is non-invasive for easy use. It may be used to treat both acute and chronic ear infections and is safe for extended use on persistent cases of otitis externa.

NOTE: Zymox Otic Enzymatic Solution Hydrocortisone Free is also available for dogs and cats who cannot tolerate hydrocortisone.

For:

Cats and Dogs

Benefits:

  • Effectively treats acute and chronic outer ear infections caused by bacterial, fungal, and yeast infections
  • Naturally works with your pet's body to react with present pus and debris to kill microbes
  • Contains hydrocortisone to reduce itching
  • No reported side effects
  • Non-invasive, once-a-day application

How does Zymox Otic Enzymatic Solution with Hydrocortisone work?

Zymox Otic Enzymatic Solution with Hydrocortisone has what the manufacturer calls the Zymox LP3 Enzyme System. Each enzyme has its own unique properties that, when combined, becomes a powerful antimicrobial formula. Glucose Oxidase is an enzyme that works with Lactoperoxidase to form antimicrobial ions. Lactoferrin is an iron-binding protein that inhibits microorganism growth by depriving them of iron. Lactoperoxidase is a milk derived enzyme that is combined in a system along with glucose oxidase to form the hypothiocyanate or hypoiodite ion to oxidize the metabolic pathways of microorganisms. Lysozyme is an enzyme that effectively kills harmful bacteria by disrupting the formation of the cell wall. The anti-inflammatory action of hydrocortisone reduces itching and inflammation. Zymox Otic Enzymatic Solution with Hydrocortisone may not work if used with other topical ear medications or cleansers.

Cautions:

DO NOT clean your pet's ears before or during use. Doing so will disrupt the enzyme system. Do not use this product when using any other topical ear medications or cleaners. This product is for pet use only. Do not use on punctured ear drums. Do not use on pregnant or lactating females. Do not allow water in or near your pet's ears during use. Reapply if water gets in the ears. If the condition persists or worsens, discontinue use and consult your veterinarian.

Brand Name:

Zymox Otic Enzymatic Solution with Hydrocortisone (PKB Animal Health)

Active Ingredient(s):

Hydrocortisone (1%).

Other Ingredients:

Benzyl Alcohol, Dextrose, Glucose Oxidase, Glycerin, Hydroxy Propyl Cellulose, Lactoferrin, Lactoperoxidase, Lysozyme, Potassium Iodide, Propylene Glycol, Purified Water.

What is the most important thing I should know about Zymox Otic Enzymatic Solution with Hydrocortisone?

Zymox Otic Enzymatic Solution with Hydrocortisone is used in cats and dogs for the treatment of acute and chronic otitis externa due to bacterial, fungal, and yeast infections accompanied with itching and inflammation. This broad-spectrum solution has been tested to be effective against microbes such as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, Streptococcus intermedius, Corynebacterium diphtheriae, Proteus mirabilis, Malassezia pachydermatis, and MRSA.

How should Zymox Otic Enzymatic Solution with Hydrocortisone be applied?

Shake well before use. Apply liberally to un-cleaned ear, filling the ear canal. Gently massage and work into affected area. Wipe to remove excess. Apply once a day for 7 days. For chronic infections, treat once a day for 14 days. Zymox Otic Enzymatic Solution with Hydrocortisone is safe for extended use on persistent cases.

What are the potential side effects of Zymox Otic Enzymatic Solution with Hydrocortisone?

There are no reported side effects.

How to Use
Directions:
  • Zymox Otic Enzymatic Solution with Hydrocortisone is used in cases of otitis externa where there is inflammation or itching.
  • Shake well before use.
  • DO NOT clean ear before or during use. Doing so will disrupt the enzyme system.
  • Do not use on punctured ear drums.
  • Do not use on pregnant or lactating females.
  • Do not use in conjunction with other topical ear products or ear cleaners.
  • Do not allow water in or near ear during use.
  • For pet use only.
Tip:

Zymox Otic Enzymatic Solution with Hydrocortisone is safe for extended use on persistent cases.

Dosage:
Dogs/Cats:
Weight
Dosage
All weights
Shake well before use. Apply liberally to un-cleaned ear, filling the ear canal. Gently massage and work into affected area. Wipe to remove excess. Apply once a day for 7 days. For chronic infections, treat once a day for 14 days.
Horses:
Do not use!
Storage:

Store at room temperature.

Ingredients
Zymox Otic Enzymatic Solution with Hydrocortisone:
Active Ingredients
Amount
Hydrocortisone
(1.0%)

Other Ingredients: Benzyl Alcohol, Dextrose, Glucose Oxidase, Glycerin, Hydroxy Propyl Cellulose, Lactoferrin, Lactoperoxidase, Lysozyme, Potassium Iodide, Propylene Glycol, Purified Water.

Customer Reviews
Zymox Otic Enzymatic Solution with Hydrocortisone is rated 4.9 out of 5 by 1082.
Rated 4 out of 5 by from So far so good My Golden and my lab have chronic ear infections. We’ve been using the product for a couple days and it seems like the scratching and shaking their heads has subsided for the most part. So far I am happy with the product and glad it saved me a trip to the vet.
Date published: 2017-12-08
Rated 5 out of 5 by from Kitty's ears I also noticed the difference in the box, as not everyone Carry's the 1% hydrocortisone. I have just 1 kitty that has the tar buildup and They aren't sure if it was at 1 time ear mites! But it works and he can't handle the ear mite meds anyway his ears swell and get bright red and he cried for at least 2 hours! I just need to catch him to do it more often!
Date published: 2017-12-02
Rated 5 out of 5 by from Higher hydrocorticone Around Thanksgiving week I ordered a bottle of zymox ear solution w/ hydrocortisone. While I was waiting for the delivery my husband bought what we thought was the same thing @ petco. I used it on our Cocker Spaneil for two days before the petmeds order came. I noticed the boxes we're different so I searched the boxes to see why. The box from Petco only had 0.5% hydrocortisone in it. But the Petmeds box has 1.0% hydrocortisone. I can still use them both our dogs ears always get bad infection. It's much easier to get this from the store or to order it online & have it delivered.
Date published: 2017-11-29
Rated 5 out of 5 by from Ilifesaver! My poor dog had a pretty bad ear infection and this medication has completely taken care of it! I was worried about having to go to the vet but it really worked and she’s is doing so much better! Thank you so much! Great product, great price, and it came in 3 days when it said 5-7 days! It’s a must have when ear infections happens
Date published: 2017-11-26
Rated 5 out of 5 by from Helped my furbabies I'm so glad :) Works great! No more itching or ear pain. Follow directions exactly. Ears are very clean too. I used this on all 3 of my dogs. This will be my go to product for now on thank you!
Date published: 2017-11-21
Rated 5 out of 5 by from Yorkie Approved! I bought this a few days ago because I ran out of what I had and was told that I couldn't get it without an expensive Vet Exam for my little Yorkie named Benji. Thanks to 1800PETMEDS Benji is no longer scratching his Ears. This seems to work for my Yorkie as he has a history of Yeast Infection in his ears. I apply this daily into his ears and it only takes a few minutes and he quits scratching at his ears. I've tried other expensive products but this seems to work the best. Thumbs up to 1800PETMEDS and Zymox. Benji agrees to. He is much Happier now! I know where I will be buying my Pet Products in the Future. Thanks from Benji and I.
Date published: 2017-11-20
Rated 5 out of 5 by from Great product Immediate results. After only a couple of days worth of use I can tell that my dog is more comfortable, and his ear is much clearer.
Date published: 2017-11-20
Rated 5 out of 5 by from miracle medicine This is miracle medicine for Libby; I have been using it for many years.
Date published: 2017-11-19
  • y_2017, m_12, d_12, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_8, tr_1074
  • loc_en_US, sid_prod10622, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds
Q&A

My Yorkie has a bulge filled with liquid I purchased the medicine but bulge does not go away I have only been applying it for 4 days

Asked by: Cari
Consult your veterinarian for a proper diagnosis. A prescription medication may be necessary for your pet's condition.
Answered by: Lisa M
Date published: 2017-10-27

Can this medication be used for either yeast or bacterial infection

Asked by: Renee
Yes. This product treats the ear externally for acute and chronic inflammation caused by bacterial, fungal, and yeast infections. This effective enzymatic system supports the natural defense mechanism of your pet's body to kill harmful bacteria, fungi, and yeast.
Answered by: Cherley Petmeds Pro
Date published: 2017-09-20

Can this be used to calm the itching of ear mites until I get the other medication? I'm short on extra money.

Asked by: roxiemom02
Thank you for your question. The Zymox treats the ear externally for acute and chronic inflammation caused by bacterial, fungal, and yeast infections. It does not treat ear mites, we do have Eradimite which kills ear mites and ear ticks https://www.1800petmeds.com/Eradimite+Ear+Mite+Treatment-prod3311.html?Ntt=earadmte.
Answered by: Crystal PetMed Pro
Date published: 2017-09-20

Is this ok if they possibly could have ruptured eardrum? 

Asked by: Tunya
Zymox Otic treats the ear externally for acute and chronic inflammation caused by bacterial, fungal, and yeast infections. We advise to please check with your veterinarian to confirm if this medication would benefit your pet.
Answered by: Amy Petmed Pro
Date published: 2017-06-15

Hi, I have a cocker spaniel who has seizures. And recently he got a infection on his left ear and we don't have money to take him to the vet, I was wandering if this will work or does it need something else to fix the infection?

Asked by: Samurai
I have a cocker too and this stuff is a miracle cure. When I start to see yellow to white discharge with that nasty smell I use this stuff for a few days in a row and it's gone. Also, when the inside ear flap gets crusty and scaly, I will apply zymox to a cloth and run it into flap for a few days and the difference is amazing. I have recommended this to many people and can't say enough how well and fast it works. Lifetime user here for sure!!!
Answered by: Leftbob
Date published: 2017-11-04

Can this be used when combined with Amoxicillin?

Asked by: Gomez
Do not use this product when using any other topical ear medications or cleaners. Also, always check with your veterinarian before giving this or any other over the counter medication to your pet if he/she is taking prescribed medications.
Answered by: Amy Petmed Pro
Date published: 2017-09-20

Does this this medicine  require a prescription?

Asked by: Hoss
No
Answered by: Lilli Pharmacist
Date published: 2017-07-29

Dosage for 8 pound dog?

Asked by: Baby
Apply liberally to fill ear canal. Gently massage and work into infected area. Wipe to remove excess. For acute infections, treat once a day for 7 days. For chronic infections, treat once a day for 14 days.
Answered by: Lisa M
Date published: 2016-12-01
  • y_2017, m_12, d_12, h_19CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_149
  • loc_en_US, sid_prod10622, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_1800petmeds
Get 10% OFF Now Offer
Close
Live Chat Share Website Feedback