Simparica

3.4 out of 5 Customer Rating
Simparica is rated 3.5 out of 5 by 59.
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prod11716 product detail number 1.0
Simparica

Simparica

3.4 out of 5 Customer Rating
Simparica is rated 3.5 out of 5 by 59.
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Starts $64.00 $44.80
Most orders ship the same day
Dog

Reviews

Rated 1 out of 5 by from This product doesn't work for us. We tried this, but our little Shih'zu couldn't tolerate it. She started having seizures so we had to discontinue use.
Date published: 2019-07-03
Rated 5 out of 5 by from Works great! Bought this product last month. VERY happy with results!, Works good, no fleas, ticks or scratching.
Date published: 2019-06-23
Rated 1 out of 5 by from More itching, more fleas. It doesn't work. I've NEVER had flea meds not work before, my dogs are itching constantly and still have many fleas after 2 months of treatment. Don't buy!!!
Date published: 2019-06-19
Rated 2 out of 5 by from Two flea infestations in 6 months with this produc I have been using this product monthy on my Border Collie and this is the second infestation. I have fleas all over my house. Only last week she started scratching and I didn't see any fleas on her after checking her multiple times. But then the fleas started biting me. My house is covered in fleas. It took me a bit to realize it was fleas since she was using this flea prevention. Will have to switch to another brand.
Date published: 2019-06-17
Rated 5 out of 5 by from Worked perfectly for my mixed dog I first bought this from my vet after my dog had a tick infestation that wouldn’t go away. I brought my dog home in December 2018 and by February 2019, she was full of ticks since I let her roam around the backyard. I foolishly tried to get them out by hand but my friend advised to get some sort of pill from the vet. After searching online, I found this website and realized it was cheaper to buy it here ($7 savings per pill compared to the vet). Happy to say that my dog has been tick free for 3 months and will continue using this as a preventative measure every other month. My dog has had no adverse effects and all the ticks have stayed gone.
Date published: 2019-05-25
Rated 1 out of 5 by from adverse reaction Take caution when administering Simparica. We gave my dog Simparica for the first time with her heartguard medication and she experienced the neurological symptoms in the case study on the insert. She experienced tremors and decrease consciousness. She had little perception awareness of her body and had a lot of difficulty walking or being able to get up. The sypmtoms went away after 2 days and pretty much back to normal after 3 days. It was very scary and want people to be aware of the potential side effects. I will not use the product again and have to throw away the remainder doses.
Date published: 2019-05-08
Rated 1 out of 5 by from Very disappointed! I was satisfied at first because it seemed to be effective, but within two weeks, the fleas were back. I had been using Bravecto, but thought I would try this since it was less expensive and my budget was tight. I wish I hadn't. It was just a waste of my money.
Date published: 2019-04-27
Rated 5 out of 5 by from Works great. Near Instant results It might be the breed, but my Shepard/Lab mix responds great to this medication. The first time my vet recommended this product, He warned me that the fleas would start to die in about 20 minutes....well, it was faster than that. No itching, no fleas, no ticks. Must be used with food, or she will vomit. I am 100% fan of this product. Using for 3 years now. She is 8+ years old, and we live in the country....woods, beans and corn everywhere. It works for us.
Date published: 2019-04-16
Rated 5 out of 5 by from Easier on her I decided to try Simparica this year in place of the Bravecto I used last year. Our standard poodle always had a hard week or two after administering the Bravecto, I felt terrible when I had to give it to her. With the Simparica she did outstanding by comparison. Simparica has had almost no visible negative effects on her digestion or behavior. We are so happy that we tried the switch.
Date published: 2019-03-31
Rated 5 out of 5 by from Its the only thing that works. I tried everything, from topical to collars. nothing worked until the vet recommended this and is all good with Chico.
Date published: 2019-03-23
Rated 1 out of 5 by from Did not work for my shih tzu. I was browsing this site and thought I would give my two cents. I received this from another place not Pet Meds, I should say. But I feel I echo a few more people who wrote about Simparica, wrote the same thing I will, yes for some reason, it made my dog itch more. And it did not work for her.
Date published: 2019-03-11
Rated 5 out of 5 by from Excellent I bought this from my vet last year and it was Awesome! It’s not going to work if your dog is infested with Fleas! You not only have to treat your dog you also have to get rid them out your HOME! Frontline is junk no longer works I hate the topical stuff anymore! So Treat you Dog And Your Home you won’t have An Issue !
Date published: 2019-01-22
Rated 5 out of 5 by from Worth a try I have 4 dogs and use this on all of them. They have not had a flea since I put them on it 2 years ago. I switched from Trifexis due to it giving one of my dogs seizures. It is worth the try to see if it helps your dog.
Date published: 2018-12-31
Rated 1 out of 5 by from Simparica I bought this back in November and our Maggie is on her second month.I have tried Frontline and some other different flea and tick remedies and as far as fleas go I've seen none.She does itch some but no fleas.Ticks on the other hand we've removed 4 so in my opinion it's no good.Great price but no good.Unless it takes 6 months to work and that's still no good!
Date published: 2018-12-31
Rated 1 out of 5 by from Pulled out 4 ticks from my dog. Does not work! I switched from Frontline oils to Simparica since my vet recommended it. I have pulled 4 ticks attached to different parts of my dog. It does not work and I’m going back to Frontline Plus.
Date published: 2018-10-29
Rated 5 out of 5 by from Great Product I gave my dog this due to her having gotten infested with fleas. Within1 1/2 -2 hours later the dead fleas were just falling off of her. Simply it's an awesome product.
Date published: 2018-10-19
Rated 1 out of 5 by from Did not work for my dogs I bought this and gave it to my 2 dogs a few weeks ago and have seen no improvement. I used in conjunction with yard spray to kill the fleas.
Date published: 2018-10-01
Rated 5 out of 5 by from Works Great! I can no longer afford nexguard so i thought id give this product a try. it works just as well! we have not had one flea in our house since using it. it does take about a month to completely work but that is the same with any flea product. definitely worth the money!
Date published: 2018-09-18
Rated 4 out of 5 by from Great price, skeptical on quality This price can't be beat. But, I'm not entirely convinced that this keeps my pup flea free... he still seems to be unexiplicably itchy from time to time... it could be a multitude of things causing him to itch, however. Not 100% sold on the effectiveness, but I have yet to find any fleas on my doggo after using. Something must be causing him to scratch but we're unsure. For that reason, I'm giving it a 4/5 because I can't say with certainty that this product is doing what it needs to do. I could just be excessive critical
Date published: 2018-08-10
Rated 5 out of 5 by from Works Great Bought this for my Elliott three months ago. I got tired of using the topical preventive. My poor little dog would scratch himself to death every time I used it..I started giving him the Simparica and he hasn't had a flea or tick one....he likes the taste of these pills also.. no fuss giving them to him either...
Date published: 2018-08-05
Rated 1 out of 5 by from Does not work This flea and tick does not work. I have been giving this to my dog from my vet for the last 6 months and it seems that he is biting/itching more than he was when he was on NexGuard. Yes, it Simparica is cheaper than NexGuard, but it also seems it is cheaper in their preventative ingredients to protect my puppy from harm as well.
Date published: 2018-08-03
Rated 1 out of 5 by from Not working My dog is 3lbs and I really need a tick medication for her, when I found this I was so excited! But sadly when I bathe her I’m still finding ticks on her body. If there’s anything else that could work that anyone knows of, please let me know
Date published: 2018-07-10
Rated 5 out of 5 by from I bought this product on 6-24-28 my dog ate one pill and I have not seen a reduction in biting or scratching at fleas at all am still seeing ticks on my dog. So I am convinced this product is ineffective on my dog. This product might work for your dog so I cannot not recommend it for another dog but it isn't working for my dog. J.H.
Date published: 2018-07-07
Rated 1 out of 5 by from bringing bugs home I believe this product works by killing fleas and ticks AFTER they bite the dog, so my dog is picking up fleas and ticks on our walks and bringing them into the house. I am switching back to frontline.
Date published: 2018-06-18
Rated 5 out of 5 by from No two dogs are the same I had tried many different flea and tick medications on our three dogs. What worked great for most people did not work for my pups. Simparica has worked great for all three of our dogs. When there are more fleas in the area than normal my pups are still flea free. My pups have also not suffered any side effects from Simparica. If this medication does not work for your dogs try something else. Just like people, what works for some will not always work for all.
Date published: 2018-06-12
Rated 5 out of 5 by from Effective! No dog meds prevent fleas or ticks from getting on your dog. This however kills them before infecting your pup with disease or letting the insects breed. Thanks Simparica! You have kept my Shepard mutt from the ticks and fleas for 2 years and counting.
Date published: 2018-06-11
Rated 2 out of 5 by from Ineffective Seemed to work at first but after first two months my dog was still scratching himself.
Date published: 2018-06-03
Rated 2 out of 5 by from Simparica Review I gave Puffy a simperica dose exactly 3 weeks ago and saw a couple fleas on him this evening showing me that it is not effective for a whole month. He was previously treated with a pet action 6-month collar and I wanted to try something he could take internally. Strike!
Date published: 2018-05-19
Rated 5 out of 5 by from I tried a lot of things before Simparica, and none of it worked. This actually did, I've been using it for 6 months and I need to get some more for my dog. I love it, and so does she.
Date published: 2018-05-18
Rated 5 out of 5 by from works well I have used Simparica on my dog. The ticks die very quickly. Once the tick connects on to my dog, they die quickly and do not get a chance to engorge. Where I live, we have a lot of dog ticks in the spring and deer ticks in later summer and fall. This is the best flea and tick medicine I have used.
Date published: 2018-04-14
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Questions

How often do I give my dogs 

Asked by: Ronnie
Simparica® (sarolaner) is given once every month, and requires a prescription from your veterinarian. Thank you.
Answered by: Joshua T
Date published: 2020-04-30

Is there a flea & tick med that kills mites too? My Bichon is loosing the hair on his tail, no signs of mites ticks etc. But vet and I know any reasoning but a possibility of mites.

Asked by: Rascals mom
Advantage Multi, which also prevents heartworms, is labeled to also kill Sarcoptes mange mites. Other flea and tick products, such as Simparica and NexGard, have been used OFF LABEL, by some vets to kill both Sarcoptes and Demodectic mange mites, but please consult your veterinarian before using these products to treat mites.
Answered by: SuzyCVT
Date published: 2020-04-25

How many pills are in a pack?

Asked by: debra
Simparica® (sarolaner) is available in a 3, 6, and 12 month supply. Thank you.
Answered by: Joshua T
Date published: 2020-04-20

Can I buy just one dose

Asked by: Marcy
No. It is available in a 3, 6, and 12 month supply. Thank you.
Answered by: Joshua T
Date published: 2020-04-14

Why did Simparica go up from $59.49 to $85.17 ???? This is so unfair to people who are not working and need to take care of their pets.

Asked by: Buns17
Please give us a call at 1-800-738-6337 so we can process a price match for you and honor the lower price.
Answered by: Cherley Petmeds Pro
Date published: 2020-04-07

Can I start this on my 4-month german shepard puppy?

Asked by: Jen1
No. Simparica® (sarolaner) is approved for dogs 6 months of age or older and weighing 2.8lbs or more. Simparica® (sarolaner) is a prescription – only medication. Consult your veterinarian to discuss if this medication is appropriate for your dog.
Answered by: Joshua T
Date published: 2020-04-06

my vet wrote me a prescription for this but normally i do the generic brand, will i need them to write me a new prescription?

Asked by: Bradley1km
Yes. In order for us to dispense Simparica, the prescription will have to say Simparica. This is because we do not offer a generic substitute for Simparica.
Answered by: Cherley Petmeds Pro
Date published: 2020-03-24

Dose this medication treat dog lice

Asked by: josfs
Simparica is not effective against dog lice.
Answered by: Cherley Petmeds Pro
Date published: 2020-04-11

Do you sell this in a single dose?

Asked by: Bella
I'm so sorry, We do not offer Simparica in single vials. We offer a package of 3, 6, or 12.
Answered by: Cherley Petmeds Pro
Date published: 2020-03-15

I just ordered on the phone to an automated rep and she never asked if I had a coupon  Can I add my Savemore coupon to the order?

Asked by: Dee dee
Please contact us for assistance: Toll Free Number (Call or Text) 1-800-PetMeds® (1-800-738-6337) Email Address customerservice@1800petmeds.com
Answered by: Lisa M
Date published: 2020-01-09

I’m assuming the 6 pack is a 6 month supply?

Asked by: Juan
That is correct. A 6 pack contains 6 single doses which is a 6 month supply for one pet.
Answered by: Cherley Petmeds Pro
Date published: 2020-01-09

My dog was 39 pounds when I got the medication and we’ve only had 1 dosage out of it and now she’s 45 pounds. What do I do? Buy another pack? Or can I get the right pack for her weight?

Asked by: Dchavis
Please call us at 1-800-738-6337 so we can assist you in getting the correct medication for your pet.
Answered by: Lisa M
Date published: 2019-10-30

What color is.it

Asked by: Bail
The tablet is a light brown color (see image provided above).
Answered by: SuzyCVT
Date published: 2019-10-23

How do I get prescription to you 

Asked by: Ronda
Provide your veterinarian's information when you place your order and Pet Meds will contact him/her for approval. The only other option is to mail them the written prescription.
Answered by: SuzyCVT
Date published: 2019-10-18

Do I need a prescription for this?

Asked by: Tina
Yes, Simparica requires a veterinarian's prescription.
Answered by: SusyCVT
Date published: 2019-10-08

Are these oral chews?

Asked by: Vick
Simparica is a liver-flavored chewable tablet.
Answered by: SuzyCVT
Date published: 2019-09-06

What is the shelf life for the tablets?

Asked by: Mcshu
The product expiration date depends on the weight range and package size. Please call us at 1-800-738-6337 for more information.
Answered by: Lisa M
Date published: 2019-08-24

What do I do if I overdose my 3 pound Yorkie with simparica. Are there any remedies anything I can do? She 8 3/4 are they pill I cut in 4 pieces of a 44 to 88 pound

Asked by: Ramona
Monitor your pet closely for untoward effects and contact your veterinarian immediately if you believe an overdose of Simparica may have been administered.
Answered by: Lisa M
Date published: 2019-07-31

I've heard many claims of (catfleas) in Florida building a tolerance/resistance towards other medications,causing less effectiveness; I'm sure it's not an over night development but is it a concern?

Asked by: Bos surrogate father
Tolerance is always a concern; however, it has not been commonly associated with Simparica administration. Consult your veterinarian for more information.
Answered by: Lisa M
Date published: 2019-12-24

I've heard many claims of (catfleas) in Florida building a tolerance/resistance towards other medications,causing less effectiveness; I'm sure it's not an over night development but is it a concern?

Asked by: Bos surrogate father
Tolerance is always a concern; however, it has not been commonly associated with Simparica administration. Consult your veterinarian for more information.
Answered by: Lisa M
Date published: 2019-07-28

is a 3-pack: 3 total in one package or 3 packages?

Asked by: Holly
A 3-pack contains 3 tablets in the one package.
Answered by: SuzyCVT
Date published: 2019-07-03

Do i need vet prescription for this flea pills?

Asked by: Jae star
Yes, Simparica requires a prescription from your veterinarian.
Answered by: Lisa M
Date published: 2019-05-11

How long does it take to start killing fleas

Asked by: Lucy60
Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations.
Answered by: Lisa M
Date published: 2019-05-10

Does simparica repell mosquitoes? Or do I need to use a herbal spray on my 1 yr old lab mix.hes mainly an outside dog.

Asked by: Gregory H
No, Simparica does not repel mosquitoes.
Answered by: Lisa M
Date published: 2019-04-29

My dog has been on Simparica for almost 7 months now and today he had 2 ticks on him that we had to pull off.  How does the medicine work? Should he have never been bitten or does it kill the tick after it bites?

Asked by: mvadino
Dead ticks can still be seen on animals following treatment because of the way they burrow into your dog’s skin to attach while they feed. The dead ticks can be easily removed as opposed to live ticks which take some force to dislodge from the skin of the animals.
Answered by: Cherley Petmeds Pro
Date published: 2019-05-20

Is this safe to use with Triflexis?

Asked by: Trish
Yes. It is safe to use the Simparica in conjunction with Trifexis for tick coverage.
Answered by: Cherley Petmeds Pro
Date published: 2019-04-11

Does Simparica kill flea eggs? Also, has anyone experienced their pets having seizures after receiving this medication? I have an older Chihuahua and cat who are 13, and last year after giving them their monthly dose, the suffered seizures the next day.

Asked by: OverprotectivePetMom
No. Simparica kills fleas and prevents flea infestations for the full month. Simparica also kills newly emerged fleas before they can lay eggs.
Answered by: Cherley Petmeds Pro
Date published: 2019-08-19

Dose simpatico need to be chewed if so why?

Asked by: 1_SYDtheSQUID
Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole. Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose. Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Answered by: Cherley Petmeds Pro
Date published: 2019-04-09

Does this have heart guard in it

Asked by: Debby
No. Simparica controls fleas and ticks only. You need another product for heartworm prevention.
Answered by: SuzyCVT
Date published: 2019-03-26

My dog’s weight fluctuates around the 11lb mark. Sometimes he weighs a bit more and sometimes a bit less. Which dosage should I go with?

Asked by: Jmp9212
Thank you for your question. Most DVM's recommend higher dosage, consult with your DVM.
Answered by: Crystal RPTechnician
Date published: 2019-02-27
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What is Simparica?

Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (deer tick/black-legged tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly and requires a prescription from your veterinarian.

For:

Dogs (6+ months of age, weighing 2.8+ lbs)

Benefits:

  • Each tablet provides a full month of protection against fleas and ticks
  • Tasty, liver-flavored chewable tablet is easy to administer
  • Chewable tablets can be given directly to your dog or broken up and mixed with food
  • Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs

How does Simparica work?

Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Simparica is administered once a month directly by mouth or can be crumbled and mixed with food. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

Cautions:

Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age weighing less than 2.8 lbs. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

Brand Name

Simparica (Zoetis)

Generic Name

Sarolaner (sar-oh-lan-ur)

What is the most important thing I should know about Simparica?

Simparica is used for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (deer tick/black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] in dogs over 6 months of age weighing 2.8 lbs and over. Simparica is available as a liver-flavored, chewable tablet. Simparica requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica to my pet?

Tell your veterinarian if your pet is breeding, pregnant, or lactating.

How Simparica should be given?

Simparica should be administered orally, once every month, at the minimum dosage of 0.91 mg/lb (2 mg/kg) sarolaner. Dogs weighing 2.8 to 5.5 lbs should be given one 5 mg Simparica chewable tablet monthly. Dogs weighing 5.6 to 11.0 lbs should be given one 10 mg Simparica chewable tablet monthly. Dogs weighing 11.1 to 22.0 lbs should be given one 20 mg Simparica chewable tablet monthly. Dogs weighing 22.1 to 44.0 lbs should be given one 40 mg Simparica chewable tablet monthly. Dogs weighing 44.1 to 88.0 lbs should be given one 80 mg Simparica chewable tablet monthly. Dogs weighing 88.1 to 132.0 lbs should be given one 120 mg Simparica chewable tablet monthly. Dogs weighing more than 132.0 lbs should be given appropriate combination of Simparica tablets monthly. Care should be taken that your dog consumes the complete dose, and treated pets should be observed for a few minutes to ensure that part of the dose is not lost or refused.

For flea treatment and prevention: Treatment may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

For tick treatment and control: Treatment with Simparica can begin at any time of the year.

What are the potential side effects of Simparica?

The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.

What happens if I miss giving a dose of Simparica?

If a dose is missed, administer Simparica and resume a monthly dosing schedule.

What happens if I overdose my pet on Simparica?

Contact your veterinarian immediately.

What should I avoid while giving Simparica to my pet?

Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica?

There are no known contraindications for the use of Simparica.

Simparica Directions:

  • Administer one Simparica chewable once every month.
  • Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
  • Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
  • Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tip:

Always make sure ample water is available for your dog.

Simparica Dosage for Dogs:

Dogs/Puppies: (6+ months of age, weighing 2.8+ lbs)
WeightDosage
2.8-5.5 lbs One 5 mg chewable tablet monthly
5.6-11.0 lbsOne 10 mg chewable tablet monthly
11.1-22.0 lbsOne 20 mg chewable tablet monthly
22.1-44.0 lbsOne 40 mg chewable tablet monthly
44.1-88.0 lbs One 80 mg chewable tablet monthly
88.1-132.0 lbsOne 120 mg chewable tablet monthly
Over 132.1 lbsAdminister the appropriate combination of Simparica chewable tablets monthly
Simparica Dosage for Cats:
Cats
Do not use!
Simparica Dosage for Horses:
Horses
Do not use!
Storage:

Store at or below 86F (30C) with excursions permitted up to 104F (40C).

Simparica Ingredients:

Simparica for Dogs 2.8-5.5 lbs:
Active Ingredient (per tablet)Amount
Sarolaner5 mg
Simparica for Dogs 5.6-11 lbs:
Active Ingredient (per tablet)Amount
Sarolaner10 mg
Simparica for Dogs 11.1-22.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner20 mg
Simparica for Dogs 22.1-44.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner40 mg
Simparica for Dogs 44.1-88.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner80 mg
Simparica for Dogs 88.1-132.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner120 mg

What is Simparica?

Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (deer tick/black-legged tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly and requires a prescription from your veterinarian.

For:

Dogs (6+ months of age, weighing 2.8+ lbs)

Benefits:

  • Each tablet provides a full month of protection against fleas and ticks
  • Tasty, liver-flavored chewable tablet is easy to administer
  • Chewable tablets can be given directly to your dog or broken up and mixed with food
  • Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs

How does Simparica work?

Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Simparica is administered once a month directly by mouth or can be crumbled and mixed with food. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

Cautions:

Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age weighing less than 2.8 lbs. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

Brand Name

Simparica (Zoetis)

Generic Name

Sarolaner (sar-oh-lan-ur)

What is the most important thing I should know about Simparica?

Simparica is used for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (deer tick/black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] in dogs over 6 months of age weighing 2.8 lbs and over. Simparica is available as a liver-flavored, chewable tablet. Simparica requires a prescription from your veterinarian.

What should I discuss with my veterinarian before giving Simparica to my pet?

Tell your veterinarian if your pet is breeding, pregnant, or lactating.

How Simparica should be given?

Simparica should be administered orally, once every month, at the minimum dosage of 0.91 mg/lb (2 mg/kg) sarolaner. Dogs weighing 2.8 to 5.5 lbs should be given one 5 mg Simparica chewable tablet monthly. Dogs weighing 5.6 to 11.0 lbs should be given one 10 mg Simparica chewable tablet monthly. Dogs weighing 11.1 to 22.0 lbs should be given one 20 mg Simparica chewable tablet monthly. Dogs weighing 22.1 to 44.0 lbs should be given one 40 mg Simparica chewable tablet monthly. Dogs weighing 44.1 to 88.0 lbs should be given one 80 mg Simparica chewable tablet monthly. Dogs weighing 88.1 to 132.0 lbs should be given one 120 mg Simparica chewable tablet monthly. Dogs weighing more than 132.0 lbs should be given appropriate combination of Simparica tablets monthly. Care should be taken that your dog consumes the complete dose, and treated pets should be observed for a few minutes to ensure that part of the dose is not lost or refused.

For flea treatment and prevention: Treatment may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

For tick treatment and control: Treatment with Simparica can begin at any time of the year.

What are the potential side effects of Simparica?

The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.

What happens if I miss giving a dose of Simparica?

If a dose is missed, administer Simparica and resume a monthly dosing schedule.

What happens if I overdose my pet on Simparica?

Contact your veterinarian immediately.

What should I avoid while giving Simparica to my pet?

Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

What other drugs will affect Simparica?

There are no known contraindications for the use of Simparica.

Simparica Directions:

  • Administer one Simparica chewable once every month.
  • Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
  • Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
  • Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tip:

Always make sure ample water is available for your dog.

Simparica Dosage for Dogs:

Dogs/Puppies: (6+ months of age, weighing 2.8+ lbs)
WeightDosage
2.8-5.5 lbs One 5 mg chewable tablet monthly
5.6-11.0 lbsOne 10 mg chewable tablet monthly
11.1-22.0 lbsOne 20 mg chewable tablet monthly
22.1-44.0 lbsOne 40 mg chewable tablet monthly
44.1-88.0 lbs One 80 mg chewable tablet monthly
88.1-132.0 lbsOne 120 mg chewable tablet monthly
Over 132.1 lbsAdminister the appropriate combination of Simparica chewable tablets monthly
Simparica Dosage for Cats:
Cats
Do not use!
Simparica Dosage for Horses:
Horses
Do not use!
Storage:

Store at or below 86F (30C) with excursions permitted up to 104F (40C).

Simparica Ingredients:

Simparica for Dogs 2.8-5.5 lbs:
Active Ingredient (per tablet)Amount
Sarolaner5 mg
Simparica for Dogs 5.6-11 lbs:
Active Ingredient (per tablet)Amount
Sarolaner10 mg
Simparica for Dogs 11.1-22.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner20 mg
Simparica for Dogs 22.1-44.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner40 mg
Simparica for Dogs 44.1-88.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner80 mg
Simparica for Dogs 88.1-132.0 lbs:
Active Ingredient (per tablet)Amount
Sarolaner120 mg