Prascend is used for the control of clinical signs associated with Equine Cushing's Disease (Pituitary Pars Intermedia Dysfunction) in horses. Prascend safely and effectively treats pain and discomfort due to Cushing's Disease. It is available as scored tablets for easy administration. Prascend requires a prescription from your veterinarian.
Prascend contains the active ingredient, pergolide mesylate, which is a potent dopamine receptor agonist. It inhibits the release of prolactin, a hormone released by the pituitary gland. In horses with Equine Cushing's Disease, pergolide is believed to exert its therapeutic effect by stimulating dopamine receptors.
Treatment with Prascend may cause inappetance (lack of appetite). The use of Prascend in breeding, pregnant, or lactating horses hasn't been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Prascend (Boehringer Ingelheim)
Prascend requires a prescription from your veterinarian. It is for the control of Equine Cushing's Disease, also known as Pituitary Pars Intermedia Dysfunction (PPID) in horses. Prascend is available as 1 mg, half-scored tablets. The recommended starting dose is 0.9 mcg/lb (2 mcg/kg) once daily. Dosage may be adjusted to effect, not to exceed 1.8 mcg/lb (4 mcg/kg). Depending on the specific symptom, improvement can start within 30 days of initial treatment.
Tell your veterinarian if your pet is pregnant, lactating, or breeding. Consult with your veterinarian if your pet has previously shown a hypersensitivity to pergolide mesylate or other ergot derivatives. Tell your veterinarian if your pet is currently taking any other medications.
Prascend should be given by the mouth. Follow your veterinarian's instructions exactly as directed. The recommended starting dose is 0.9 mcg/lb (2 mcg/kg) once daily. Dosage may be adjusted to effect, not to exceed 1.8 mcg/lb (4 mcg/kg). The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment. Extra care is recommended when splitting tablets to minimize exposure. Pregnant or lactating women should wear gloves when administering Prascend. Tablets can be hidden in an apple or treat. The tablet may also be administered orally by dissolving in a small amount of water with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately.
The most common side effect of Prascend reported is decreased appetite.
Give the missed dose as soon as you remember. If it is close to the next dose, skip the missed dose and resume a regular dosing schedule. Do not double dose.
If an overdose is suspected, contact your veterinarian immediately.
Avoid crushing the tablets due to the potential for increased human exposure. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when tablets are split or crushed. Extra care is recommended when splitting tablets to minimize exposure.
Prascend is approximately 90% bound to plasma proteins. Use caution if administering Prascend with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with Prascend (a dopamine agonist) since these agents may diminish the effectiveness of Prascend.
Tablets can be hidden in an apple or treat. The tablet may be also be administered orally by dissolving in a small amount of water with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately.
|300-749 lbs||Starting dose of 0.5 tablet daily, not to exceed 1 tablet daily or as directed by your veterinarian|
|750-1,249 lbs||Starting dose of 1 tablet daily, not to exceed 2 tablets daily or as directed by your veterinarian|
|1,250-1,749 lbs||Starting dose of 1.5 tablets daily, not to exceed 3 tablets daily or as directed by your veterinarian|
|1,750-2,249 lbs||Starting dose of 2 tablets daily, not to exceed 4 tablets daily or as directed by your veterinarian|
|Cats||Do not use!|
|Dogs||Do not use!|
Store at or below room temperature. Keep out of the reach of children and pets.
|Active Ingredient (per tablet)||Amount|
|Pergolide (as pergolide mesylate)||1 mg|