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Diphenhydramine (Generic Benadryl)

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Product Info

What is Diphenhydramine (Generic Benadryl)?

Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions.

For:

Cats and Dogs

Benefits:

  • Effectively relieves allergy symptoms and itching caused by insect bites
  • Can be used as a sedative to treat motion sickness or travel anxiety
  • Relieves coughing

How does Diphenhydramine (Generic Benadryl) work?

Diphenhydramine comes in 25 mg minitabs or 50 mg capsules, and is a generic version of Benadryl. As an antihistamine, it counteracts the effect of histamine, which causes symptoms like itching and sneezing.

Cautions:

This medication should not be used in pregnant or nursing animals. Do not use the diphenhydramine available in combination with sinus or cold medicines in your pet.

Brand Name:

Benadryl (Warner Lambert), Histacalm (Virbac)

Generic Name:

Diphenhydramine (dye-fen-hy'-dra-meen)

Manufacturer:

Various

What is the most important thing I should know about Diphenhydramine (Generic Benadryl)?

Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect bites or stings and other causes of itching. It is also used for its sedative and antiemetic effects in the treatment of motion sickness and travel anxiety. It is also used for its antitussive effect. Diphenhydramine is a non-prescription (OTC) product available as 25 mg minitabs and 50 mg capsules.

What should I discuss with my veterinarian before giving Diphenhydramine (Generic Benadryl) to my pet?

Tell your veterinarian if your pet is allergic to diphenhydramine or other antihistamines. Also tell your veterinarian if your pet is pregnant or lactating, or has history of glaucoma, prostate disease, urinary obstruction, or high blood pressure. Always tell your veterinarian and pharmacist what other medications your pet is taking.

How should Diphenhydramine (Generic Benadryl) be given?

Oral diphenhydramine is not FDA-approved for use in veterinary medicine; however, it is a commonly accepted practice to use this medication in dogs and cats. The usual dose in dogs and cats is 0.5-2 mg/lb every 8-12 hours. The slow release capsule should not be mixed or dissolved in food.

What are the potential side effects of Diphenhydramine (Generic Benadryl)?

Side effects of diphenhydramine include drowsiness, dry mouth and urinary retention. Rarely, vomiting and diarrhea can occur.

What happens if I miss giving a dose of Diphenhydramine (Generic Benadryl)?

Give the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

What happens if I overdose my pet on Diphenhydramine (Generic Benadryl)?

Contact your veterinarian or veterinary emergency room. Symptoms of overdose can include seizures, extreme drowsiness, coma, respiratory depression, and death.

What should I avoid while giving Diphenhydramine (Generic Benadryl) to my pet?

Do not give other sinus or cold medicines containing diphenhydramine to your pet while giving Diphenhydramine (Generic Benadryl).

What other drugs will affect Diphenhydramine (Generic Benadryl)?

Use with caution when given with other CNS (central nervous system)-depressant drugs such as tranquilizers or barbiturates.

How to Use

Diphenhydramine (Generic Benadryl) Directions:

  • Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety and other conditions.
  • It is available over-the-counter (OTC) as 25 mg tablets and 50 mg capsules.
  • Diphenhydramine should not be used in dogs or cats that are pregnant or nursing.
Tip:

The slow release capsule should NOT be mixed or dissolved in food. Do not use sinus or cold medications containing diphenhydramine in your pet.

Dosage:
Dogs/Cats:
Weight
Dosage
All weights
Give 0.5-2 mg/lb of pet's body weight every 8-12 hours
Horses:
Do not use!
Storage:

Store this medication at room temperature, away from excess heat, light and moisture. Keep this medication in the container it came in, tightly closed. Store this medication at room temperature, away from excess heat, light, and moisture. Do not store in the bathroom. Throw away any medication that is outdated or no longer needed. Keep medication away from children and pets.

Ingredients

Diphenhydramine (Generic Benadryl) Ingredients:

Diphenhydramine HCl 25 mg minitabs:
Active Ingredients (per minitab)
Amount
Diphenhydramine Hydrochloride
25 mg

Other Ingredients (per capsule): Corn starch, D&C red #27, Dicalcium Phosphate, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polyvinyl Alcohol, Silicon Dioxide, Stearic Acid, Talc, Titanium Dioxide.

Diphenhydramine HCl 50 mg capsules:
Active Ingredients (per capsule)
Amount
Diphenhydramine Hydrochloride
50 mg

Other Ingredients (per capsule): Colloidal Silicon Dioxide, Croscarmellose Sodium, D&C Red #28, FD&C Blue #1, FD&C Red #3, FD&C Red #40, Gelatin, Lactose, Magnesium Stearate. May also contain Polysorbate 80 and iron oxide.

Customer Reviews
Diphenhydramine (Generic Benadryl) is rated 4.1 out of 5 by 58.
Rated 5 out of 5 by from VERY GOOD PRODUCT!!!! I have a nine year old cat who suffers from allergies. Pop-Pop is his name and he is a feral cat. We tried many different meds but nothing worked. So, I looked up 1800petmeds and was helped by a very knowledgable representative and Wow, he is a lot better thanks to Diphenhydramine. Thank you kindly, Georgene
Date published: 2017-10-25
Rated 4 out of 5 by from Works for my cocker spaniel We have been using Benadryl for a few years now. We buy it at The Dollar Tree for 1 buck. You don't have to spend a lot to get the same results.
Date published: 2017-10-17
Rated 5 out of 5 by from Working At my first review I said it wasn’t helping with My dogs itching but now that’s Shes been on it a while I’m very happy to say it does help!
Date published: 2017-10-01
Rated 1 out of 5 by from Not only sneezing, but now drooling! The product help Annabelle with a seasonal allergy/cold, but getting it down, forget it! Why can these be gel caps that can be syringed and shot in the back of her mouth. Because of her size I can't giver her the entire pill, so has to be crumbled in laxitone which never helps! The taste is apparently so bad she salivates and spits out whats left for 20 minutes!! What a mess and then she won't eat for a day b/c the taste is still in her mouth!
Date published: 2016-08-24
Rated 4 out of 5 by from It does the job. This product does seem to help relieve the allergy problems my dog was having and it does calm him down and makes him a little sleepy. I don't like the capsules though, I have to open them and put the powder in a spoon with a little water to give them to him, he is wise to all the other tricks. All in all, I would purchased this product again.
Date published: 2015-06-10
Rated 3 out of 5 by from This medication is not helpful in my dog's itching, so I have found big relief in Piriton and Zyrtec.
Date published: 2015-03-04
Rated 5 out of 5 by from For cats, place it far back in throat Giving Benadryl to my dogs has always been easy---just hide it in a spoon of peanut butter, and it's gone down the hatch, easy peasy. But cats don't believe in gulping down a glob of peanut butter, and Benadryl apparently tastes pretty horrendous to a cat. After some trial and error, I have deduced that it is taste-induced nausea which leads to vomiting (and of course the foaming). So I experienced the same thing as many of the other cat owners here when giving Benadryl---the result is lots of foaming and vomiting. I switched to Zyrtec, since it doesn't seem to taste as bad to a cat, but after Zyrtec failed to help with her symptoms, and by this time having had lots of practice pilling my cat, I decided to give Benadryl another try. I have found that I CAN dose my cat with Benadryl without making her sick. The trick is to place the pill far back in the throat. With the cat's head back and the mouth open, drop the pill in---aiming for the back of the throat---while trying to avoid the tongue altogether. If it lands on the tongue (even the back part) rather than in the throat, quickly push the pill back with a finger. Getting it as far back as possible without ever hitting the tongue keeps the cat from being able to eject the pill back up into the mouth, and thus never tastes the pill. Now that I am preventing her from tasting the Benadryl, there has been no more vomiting, no more foaming, and best of all, no more chewiing off her fur and sneezing fits (at least so far).
Date published: 2015-01-04
Rated 5 out of 5 by from very effective Buster takes one 50mg pill before bed. His sleep cycle had been disturbed but he now sleeps his regular hours and is more active when he wakes up. If I notice his breathing during the day indicates some congestion when the wind is blowing dust and pollen around, one pill relieves it within 30 minutes. His vet has examined him and agrees he has occasional allergies and diphenhydramine is the perfect solution.
Date published: 2014-12-23
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Q&A

Can the 25mg pills be cut or would that affect the release of it once ingested?

Asked by: DianaR
Thank you for your question. The pills can be cut however they are not scored. The pills should be dosed according to dosing instructions.
Answered by: Crystal PetMed Pro
Date published: 2017-11-28

Is apoquel 16 mg the same as benadryl What's the difference?

Asked by: Rebecca
Thank you for your question. The Apoquel is a prescription medication and requires a veternarians approval. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. The Diphenhydramine (Generic Benadryl) is an over the counter non-prescirption medication used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions.
Answered by: Crystal PetMed Pro
Date published: 2017-10-17

Can I give my 8 week old German Shepherd puppy benedryl? He has dry skin from being given a bath.

Asked by: Sully 55
Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions. As you mentioned your puppy has dry skin we would recommend instead using Super Pure Omega 3 and our Oatmeal & Aloe Vera Shampoo.
Answered by: Crystal PetMed Pro
Date published: 2017-10-07

I have a 40lb. Muscular Boston terrier and an overweight 75 lb. Labrador mix and the vet had prescribed Apoquel 16 mg. - 1 tab/day to the Lab and 1/2 tab /day for the Boston Terrier. Would the Diphenhydramine be an equivalent ? If so, what strength and do

Asked by: Neil
The equivalence would be a question for your veterinarian based on the severity of your pets' needs; however, since you already have the Apoquel, would suggest to continue that use for ease rather than switching medications.
Answered by: leanniejo
Date published: 2017-08-14

My weighs 110lbs what dose do you recommend 

Asked by: Chas
As per the manufacturer, give 0.5 - 2mg per lb. of pets body weight every 8 -12 hours.
Answered by: Megan Student Pharmacist
Date published: 2017-11-25

Does this come in liquid form?

Asked by: Tootsie
Diphenhydramine only comes in 25mg minitabs or 50mg capsules.
Answered by: Cherley Petmeds Pro
Date published: 2017-12-07

For my boxer that weighs 59.9 lbs what dose would you recommend? 

Asked by: Tilesetter83
Hello, thank you for your question. For this product you give 0.5 - 2mg per lb of pets body weight every 8 -12 hours. For your pet it would be 29.95 - 119.8 mg every 8-12 hours. Hope this helps!
Answered by: Roseanna Pharmacy Intern
Date published: 2017-11-25

Is it good for nasal Sign us

Asked by: Geear
Diphenhydramine is an antihistamine used to relieve allergy symptoms, insect stings, motion sickness, travel anxiety, and other conditions. As an antihistamine, it counteracts the effect of histamine, which causes symptoms like itching and sneezing.
Answered by: Amy Petmed Pro
Date published: 2017-02-20
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