5 out of 5 Customer Rating
Anipryl (Selegiline) is rated 4.6 out of 5 by 44.
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Anipryl (Selegiline)

Anipryl (Selegiline)

5 out of 5 Customer Rating
Anipryl (Selegiline) is rated 4.6 out of 5 by 44.
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Reviews

Rated 5 out of 5 by from saved my dog 9 year old lab was running around all night, barking, out of his mind seemingly. Vet recommened ritalyin wasn't much help, saw all the reviews that matched my dog and gave this a try. Seemed to make a difference as early as one week, much less severe episodes. One month in now and he still gets them but they are a 2 on a scale of 10 versus a 9 before. This is the real deal for dementia in dogs.
Date published: 2016-04-08
Rated 5 out of 5 by from Effective in short amount of time We are amazed how active our 14 year old Shellie mix is since being on anipryl. She is more alert and runs with our other dog. At the beginning of this year she used to sleep all the time. Now she is awake almost all day long. Her incontinence of urine has subsided. She does occasionally regurgitate her saliva but not sure the cause of this.
Date published: 2014-08-09
Rated 5 out of 5 by from We are thankful for Anipryl! Our 15 yr. old mixed breed dog began to get confused when we would let her outside to use the bathroom. She would wander around and not come in when we called her. She began to use the bathroom in the house - during the night, and sometimes during the day (she had never done this in her lifetime!). She also began to whine and whimper a lot throughout the day - for no apparent reason. Our vet diagnosed dementia and recommended Anipryl. We have been very happy with the improvement!! She rarely uses the bathroom in the house. Her whining is much reduced. She is much like her old self. We are soooo thankful that this medicine has worked for her.
Date published: 2014-05-21
Rated 2 out of 5 by from Anipryl for Cog. Dysfunction My 17 year old Jack Russell has been on Anipryl for dementia for 2 months now. Previously he was so disoriented he would walk into his food or water dish and get stuck there whining until someone rescued him. He would also get stuck in corners and bark for help - not remembering how to back up or get free. After about a week on Anipryl he stopped walking into his dishes and getting stuck in corners. He will still walk up against corners but after a while he'll turn his head and move along. I have not seen any change in his disposition. He is still pretty low energy and no interest in toys or people like he used to exhibit when he was younger. He also doesn't run around or wag his tail as some other reviewers have noted (unfortunately). However, we are keeping him on Anipryl as it keeps him from getting stuck and waking us up at night. He also seems to rest better at night (somewhat). So although it has not been a miracle drug for us we have seen some improvement - enough to keep our dog with us for a while longer. We were at the point prior to Anipryl that we were going to have to euthanize him as neither the dog nor the humans in our house could get any sleep at night. If you are having severe issues with dementia this is worth a try.
Date published: 2014-03-10
Rated 5 out of 5 by from my 18 yr old male cairn Had come to the point of just staring at the wall most of the time. The first 2 weeks on this great drug brought him back AND he was also walking and reacting like his old self. He's still with me! going on 19! dw
Date published: 2013-09-04
Rated 5 out of 5 by from Good for my best friend and me 15 yr old Cairn Terrier diagnosed with SDS after 6 months of little to no sleep at night for both of us; He was put on 15mg of anipryl a day and after 1 month he is back to normal and we both get a good nights sleep.
Date published: 2013-01-11
Rated 1 out of 5 by from nothing so far Buddy is a 50 lb Husky/Shepherd cross. He was a rescue dog so I am not sure how old he is but think he is 13. He has been on Anipryl for a month and has just started his second month so we shall see .... no change so far. I think anything to make your dog feel better is worth a try and obviously it does help some dogs. I will write more after he completes his 2nd month.
Date published: 2012-11-14
Rated 5 out of 5 by from Happy Home Anipryl is amazing. My 13 year old Golden Retriever constantly barked, day and night and just seemed overall agitated. After doing some research we determined his condition to be canine dementia. The poor boy was so confused and just stood at the open door and barked. He would not come into sleep at night but would sleep during the day. Today he is been on Anipryl for 7 days and it is working wonders. He is no longer barking and stays in the house at night and gets a restful night sleep (as we all do now). He is back to his normal personality and is smiling again! I highly recommend this product if you are dealing with an older dog who you know just isnt himself anymore. I also changed his food to canned for easier digestion and give him one 3mg Melotonin at night with is Anipryl.
Date published: 2012-05-16
Rated 5 out of 5 by from New Leash On Life! 15mg dosage Symptoms were moderate to advanced prior to starting Anipryl. Anipryl was highly effective for my previously owned 12 year old Basset Hound--This medication greatly improved most symptoms quickly and bought us close to 2 yrs additional time with him. 30mg dosage for my 11 1/2 yr old male Beagle/Basset Hound Mix Symptoms treated shortly after onset Immediate positive difference--less agitation, less confusion, less depressed, less anxiety, more animated, improved sleep/wake cycle, improved response to his name being called, and being petted, less purposeless behaviors, more playful
Date published: 2011-12-24
Rated 5 out of 5 by from Finally, a good night's sleep. My dog is 12 yrs old and for the past two years, has been needing to get up and go outside 2-3 times a night. The uninterrupted sleep was taking a toll on both of us....but at least the dog could sleep during the day! I stumbled across Anipryl after researching dog's that were unable to sleep through the night....I wish I'd done it 2 years ago LOL. It has taken about 1.5 months to work, but now my dog is sleeping 6 consecutive hours at night, which is so much better than 3 hours. Consider getting a higher dose and cutting the pill in half to save money - of course, consult with your vet. Definitely recommend.
Date published: 2011-12-21
Rated 5 out of 5 by from It Gave us Bonus Time Our 15 year old Yellow Lab responded very well to a daily morning 30mg dose @ a 70lb body weight. It did take nearly a month to kick in, but when it did, the change was exceptional. It truly did return him to us. It was an unforgettable Fall season where a 15 year old puppy ran on the beach at full joy...bonus time.
Date published: 2011-12-09
Rated 4 out of 5 by from Our 14 year old Golden Retriever began taking Anapril over a year ago. Within a month of beginning the medication we saw a positive change: decreased wandering and more restful sleep. We've never had such an old golden! It's a pleasure to see him age more gracefully than expected.
Date published: 2011-08-16
Rated 5 out of 5 by from Definitely has made a positive difference!
Date published: 2011-07-10
Rated 5 out of 5 by from It Made a Difference Lucy has been on Anypril for a year now. We think that the drug has been a major factor in eliminating her "sundowner syndrome" and nighttime panic. We had her on a tranquilizer, too, and have been able to discontinue that. We have also added an evening pain med (Tramadol) which may be helping.
Date published: 2011-05-28
Rated 5 out of 5 by from Reversed cushings symptoms Millie was only 8 when diagnosed with Cushings. Her symptoms included panting, susceptibility to infection, being hot and nocturnal wandering. One night when she got up, it was clear she did not recognize me. After 30 days on Anapryl, she was back -- fully aware of us and engaged with her pack. She's almost 14 now and still doing well. The panting really never stopped though. Don't really care about taste since she never likes the supposedly chewable meds. Pill Pockets are great!
Date published: 2011-04-21
Rated 5 out of 5 by from Newly, my 13 year old Westie, has been on Anipryl since January 2011. He has stopped his midnight pacing and panting and no longer experiences the early evening panic attacks ("sundowners?") that included barking, pawing and extreme trembling. This morning he was back outside, running like a mad man, barking at birds and bugs and having a great time!
Date published: 2011-04-12
Rated 5 out of 5 by from Anipryl Our very old dog, Heidi, began taking Anipryl at the end of January 2011. I began to notice improvement in her behavior during late February (after about a month on the medication). She still digs the carpeting in the corners of the house, but now she is resting more and not pacing the house 24/7. Also, I notice that she is more stable on her feet and not shaking as much. We are happy with the results!
Date published: 2011-03-01
Rated 4 out of 5 by from SIBERIAN HUSKY My 15 year old husky is back!!!!! Thanks Anipryl
Date published: 2010-11-01
Rated 4 out of 5 by from Older Chessie Sam is almost 13. Since starting anipryl he certainly seems to be more "with it" than previously. Can't say I see physical improvement - his hind quarters are still shaky, but he's mentally better.
Date published: 2010-10-11
Rated 4 out of 5 by from anipyl After just a few days, Lucky showed improvement. He is acting like his old playful self and he turned 13 this year !
Date published: 2010-09-10
Rated 4 out of 5 by from Lily is doing much better After just a few weeks on Anipryl, Lily showed a marked improvement. Now she has been on it for a few months and she is still barking a lot but none of the "sundowning" symptoms of trying to get out of the gate and spending hours outside looking like she is lost. Big thing is no more pottly accidents. She is actually more affectionate but still pants a bit at night. I think if it were not for this medication, we would have had to put her to sleep already.
Date published: 2010-08-09
Rated 5 out of 5 by from Great product!!! Mikki was dignosed with cognitive dysfunction a couple of years ago. She seemed confused, scared, and nervous. She wouldn't do her normal daily activities as she used to. Sometimes she wouldn't move off the couch for 10-12 hours. The vet diagnosed her with cognitive dysfunction and put her on Anipyrl and it has helped significately. She is much more active and goes outside often. She seems much happier and more like her old self again. Wouldn't want to be without Anipyrl!!
Date published: 2010-08-08
Rated 5 out of 5 by from Because it works. My dog has been diagnosed with cushings and dimentia. This med has improved his quality of life greatly. He still has problems but he is now happy, likes to eat, playful at times and able to settle down for the night - and a wonderful snuggler. Although he wears "diapers" he does well.
Date published: 2010-06-25
Rated 5 out of 5 by from Much Better Quality Of Life My 18 year old dog was diagnosed with CDS last year after pacing and wandering aimlessly, getting confused, getting lost inside and outside, no longer recognizing family, losing house training habits and just retreating to his bed most of the time. After several months on this drug, he has regained much of his personality back and has rejoined the family. He now has a much better quality of life. He is old and still has some problems, but this drug has been a life-saver for us. (I wrap the pills in a "pill pocket" and he eats it right up).
Date published: 2010-06-04
Rated 4 out of 5 by from Helps my older dog I have noticed a difference in my dog since she started taking it. She's a 14 y.o. springer and she paced constantly, was borderline panic-y. Anipryl really calmed her down and helps her sleep, relax and she is less tense in new situations. Its not a cure, but it sure alleviates her symptoms and makes her more comfortable.
Date published: 2010-05-11
Rated 4 out of 5 by from HAS HELPED JOY ISMUCH YOUNGER THAN THE OTHER DOGS, SHE IS ONLY 7 YRS, OLD WITH THIS TERRIBLE PROBLEM....ANIPRYL HAS HELPED A LOT, BUT WE STILL HAVE PROBLEMS OCCASIONALLY OF HER NOT KNOWING WHERE SHE IS, LOOKING OUT OF SPACE. GOING INTO CORNERS ALL THE SYMPTOMS THAT HAV E BEEN MENTIONED....SO FAR ONLY 1 HOME ACCIDENT. SHE DOESN'T PLAY WITH HER TOYS ANYMORE. BUT ANIPRYL HAS REALLY HELPED.
Date published: 2010-04-27
Rated 5 out of 5 by from Sleeping through the night This medication was prescribed in order to help her 12 years old rhodesian ridgeback sleep all night. She definately confused and would walk around the house, ask to go out and was also showing lots of anxiety. Althoug this drug is not meant for that it has help her. Yes, we can now say our three kids are sleeping and so is our old citizen girl!!!! Thanks to our vet for researching and finding Anypril. You need pill pockets for that one!!!
Date published: 2010-04-03
Rated 5 out of 5 by from Anipryl gave us Phoenix back... My fiesty 15 year old Jack Russell terrier began to show signs of confusion, lethargy and her tail, which never stood still, was always down. A few months on amipryl and she is wagging her tail again, less frequently having accidents in the house, much more responsive and she has a lot more energy. Although the medicine is not cheap, it has given us back a dog we have loved, treasured and has been a huge part of our family and community for a very long time. She has given so much to this world so it is great to see that we, in turn, can give back to her!
Date published: 2010-03-27
Rated 5 out of 5 by from Danny is 18 now. Danny is now 18 and seemed to be slipping a bit. He had accidents and was on Silegeline until it was discontinued. He did very well on it. Now he is on Anapryl and seems to be doing well. He has always liked to eat and still loves it. He is not "out of it" but he occasionally has accidents in the house. I don't think it has anything to do with mental confusion. He does ask to go out, etc. I think he just can't hold it. Anapryl is much more expensive than Silegeline but if it helps Danny it is worth it.
Date published: 2010-03-18
Rated 5 out of 5 by from Anipryl has made a difference Our 14-year-old, Serena, is deaf and blind, and she wasn't getting along as well as other blind dogs we have had. We had to go get her at meal time and treat time and she seemed to have no "connection." After a month, she comes to the kitchen at meal time (we have other dogs) and always shows up when the cookies are being handed out. Her house training was starting to slip before, just a little, but now she goes to the door when she has to go out. We highly recommend at least trying this drug for canine dementia.
Date published: 2010-03-01
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Questions

The generic drug of Anipryl is selegiline and is cheaper. Why should I buy Anipryl.

Asked by: MattyG
You may chose to purchase brand if your doctor indicates the brand is medically necessary for your pet, or the strength you need for your pet's dose is only available in the brand.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

I'm going to be starting my lab mix on Anipryl. She is currently in Prozac. I will discontinue the Prozac, but is there a recommended waiting period between the 2 drugs?

Asked by: Rae J
Yes, you may want to wait a week before starting the Anipryl, as Prozac can stay in your system for about a week after discontinuation. However, Prozac should not be stopped immediately, and should instead be tapered off under your veterinarians supervision. Your vet would have more information on how to taper off of Prozac and how long you should wait before starting Anipryl.
Answered by: Christine
Date published: 2016-10-14

Drug Interactions

I have a 14 yr old dog that has CCD. I read that Anipryl may be able to help with her symptoms (extremely restless, pacing & panting, confusion, going to the bathroom in the house, very clingy, weight loss, etc.). My dog was put on anti-anxiety & anti-depressants together to try and help with these symptoms. They do not seem to help much, except for making her sleepy. I also understand that you cannot combine Anipryl with certain other medications. So my question is this...my dog is currently on fluoxetine, alprazolam & trazodone, which of these meds could possibly be eliminated if she were to begin taking Anipryl? I believe that the Anipryl would help with almost all of her symptoms, so I am thinking that potentially she may be able to come off all of the ones she is currently on. I'm very concerned about drug interactions. The product description specifically states that you cannot take Prozac (fluoxetine) with Anipryl. However, what about the other two meds she is on - alprazolam & trazodone - can or should those even be taken with Anipryl? As for the dosage of Anipryl, my dog is 39 lbs., what would the proper dosage be just so I have an idea on getting prices? I plan to speak with my vet about this medication. I wanted to gain a little more knowledge of what could be expected beforehand though. Please advise. Thank you.
Asked by: Val
Fluoxetine and Trazodone should not be administered concurrently with Selegiline. No drug interaction exists between Alprazolam and Selegiline. The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. Your veterinarian will determine the appropriate dose if Selegiline is indicated for your pet's condition.
Answered by: Lisa M
Date published: 2016-04-16

This is very frustrating...my dog weighs 7 lbs and has been diagnosed with CCD. His dose is .5ml per our vet. Is there a smaller tablet?

Asked by: Nicole
1800Petmeds carries 15mg and 30 mg dose tablets. Please check with your veterinarian what mg your pet requires as we cannot determine by the mLs what your pet requires.
Answered by: Cheryl-Pharmacist
Date published: 2015-04-13

ANIPRYL

Why are you completely out of this medication is all doses?
Asked by: Percy
Our supply issues would correlate with how much medication is being manufactured. If the product is unavailable, it's most likely due to it being on back order with the manufacturer.
Answered by: Lilli Pharmacist
Date published: 2013-10-22

cutting anipryl

started my dog on 5mg anipryl for cushings can i buy 10mg and split them ? and will they work as good.
Asked by: spencer
Spencer, it would be best to contact your vet to see if the 10mg tabs are an option for your furry friend.
Answered by: Jason Pet Med Pro
Date published: 2016-08-15

Can I get a package of 30 mg Anipryl and cut the tablet in half since his recommended dosage is 15 mg?

can the vet prescribe a 30mg packet and I split it in half to get the recommended 15mg dosage? please let me know. thanks smita
Asked by: smitty
Great question. Yes. You can take the 30mg tablet and cut it in half if the recommended dose is 15mg. I would recommend using a pill splitter to do this.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2016-08-15

How long do the side effects of Anipryl last? My dog is on her second day and has diarrhea and is vomiting. Does she need to adjust to the medication?

Do the side affects eventually subside or do I need to stop giving them to her? Her vet is unfortunately not familiar with this medication. So I have to do all the ground work. I would appreciate any input Thank you
Asked by: Nite
You're saying your veterinarian prescribed a medication for your pet that she is not familiar with? Diarrhea and vomiting are common side effects for this medication. It's possible that the symptoms will go away as the pet gets used to the medication. However, if these symptoms continue more than 4 or 5 days, your veterinarian may want to consider either adjusting the dose or possibly using a different medication. In the meantime you should watch what you feed your pet and keep plenty of water available for her to drink.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2013-10-22

Is there a generic for Anipryl?

Or coupons from the drug manufacturer to help pay for this very costly medication? My Lab takes 2, 30mg tabs every morning for Cushings.
Asked by: Kim
Unfortunately there is no generic available for this product.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2014-01-23

Is Anipryl compatible with Metacam and Vetmedin?

I'd love to try Anipryl for my senile dog but I need to make sure it is ok with her other meds. Thanks
Asked by: Eve
To my knowledge, there's no reason why your pet cannot be given Anipryl while also being given Metacam and Vetmedin.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2013-10-22

Can this tablet be split?

Asked by: budbee
Yes, but you will probably need to use a pill splitter.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2013-10-22

May I return a new, unopened package of Anipril?

Bonnie was recently deceased. May I return an unused package?
Asked by: Bonnie
You should dispose of any unused medication by mixing it in with coffee grounds and throwing it out in your garbage.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2018-06-16

What antibiotics are safe with Anipryl

My 17 year old Dachshund is currently on 10mg of Anipryl 1xper day. He has severe dental decay and takes antibiotics to curb the infections. We are stationed in Italy and my local veterinarian is unfamiliar with Anipryl and asked if I could provide her with a list of acceptable antibiotics. Thank you.
Asked by: Vicky B
Your veterinarian may know Anipryl under the generic name selegilene. Selegilene is classified as an MAO inhibitor and must be used with caution or not used at all with certain other medications. However, to my knowledge, any antibiotic is safe to give with selegilene
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2013-10-22

Concerned about side effects?

I just got Anipryl today for my "Scoobee's" CDS and have read and re-read the package insert at least 5 times. Also I called my vet regarding the vitamins and flea medication I currently use. I hesitated for a moment to start this medication, as I always try to weigh the benefits against the possible adverse reactions. I feel better reading the positive reviews from the other reviewers and will start the meds tomorrow morning. Thank you all for your reviews regarding this drug. If anyone has noticed side effects I would really appreciate a "heads up" as to what may be forthcoming. The package insert makes the side effects seem ominus and my vet won't tell me what to expect because I don't think he knows. He didn't know about the flea medication interaction when I called him, so I figure I have to be the voice for my dog and make the right decision the first time. Any feedback would be very much appreciated.
Asked by: Christina in California
It's great that you are an informed consumer and "the voice" for your dog. I don't think there's any medication that does not have the potential for some side effect and Anipryl is no exception. Listing these side effects doesn't mean your pet will develop any but you should be aware of them. I would suggest that before you begin any new prescription or OTC product that you check with your veterinarian or one of our pharmacists since there are medications that can interact with Anipryl.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2013-10-22

Mr dog has Cushings, and has been on anipril for about a year what will if we discontinue the meds.

Asked by: Steve
If the medication is discontinued, the disease will get worse, Untreated Cushing's disease is fatal.
Answered by: Gary, Dir. of Pharmacy Services
Date published: 2018-06-16
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What is Anipryl (Selegiline)?

Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian.

For:

Dogs

Benefits:

  • First and only FDA-approved drug used to control clinical signs associated with Canine Cognitive Dysfunction Syndrome
  • First and only product approved to control uncomplicated PDH (pituitary-dependent hyperadrenocorticism) Cushing's disease

How it Works:

Anipryl increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal gland's production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.

Cautions:

Because Anipryl belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation; swelling of the lips, tongue or face), stop giving Anipryl and seek emergency veterinary medical attention.

Brand Name:

Anipryl (Zoetis), Eldepryl (Somerset)

Generic Name:

selegiline

What is the most important information I should know about Anipryl (Selegiline):

Anipryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Anipryl is also used to treat canine cognitive dysfunction. The usual initial starting dose to treat Cushing's disease in dogs is 0.45 mg/pound given once a day in the morning. If no results within 2 months may increase to 0.9 mg/pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45 mg/pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

What is Anipryl (Selegiline):

Anipryl, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how Anipryl works. However, it is believed that Anipryl prevents the breakdown of dopamine. Anipryl may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Anipryl (Selegiline) to my pet:

Anipryl should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anipryl at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of Anipryl overdose include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, weakness, sweating and seizures.

What should I avoid while giving Anipryl (Selegiline) to my pet:

Anipryl may cause dizziness or drowsiness. Do not give higher doses than those prescribed.

What are the possible side effects of Anipryl (Selegiline):

If any of the following serious side effects occur, stop giving Anipryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving Anipryl and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Anipryl (Selegiline):

Before giving Anipryl tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.

Where can I get more information:

Your pharmacist has additional information about Anipryl written for health professionals that you may read.

Anipryl (Selegiline) Directions:

  • Anipryl is a prescription medication used in dogs for the treatment of Cushing's disease caused by a pituitary tumor.
  • Anipryl is also used in dogs to treat canine cognitive dysfunction.
Tip:

Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

Anipryl (Selegiline) Dosage:

Anipryl (Selegiline) Dosage for Dogs (when used for cognitive dysfunction)
Weight Dosage
All weights The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. It may take up to one month or more to see improvement
Anipryl (Selegiline) Dosage for Dogs (when used for Cushing's disease)
Weight Dosage
All weights The usual starting dose to treat Cushing's disease is 0.45mg per pound of pet's body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pet's body weight. If still no response after one month of the increased dose, reevaluate the pet
Anipryl (Selegiline) Dosage for Cats
Cats
Do not use!
Anipryl (Selegiline) Dosage for Horses
Horses
Do not use!

Storage:

Should be stored at room temperature, away from moisture and heat.

Anipryl (Selegiline) Ingredients:

Anipryl (Selegiline) 5 mg
Active Ingredient Amount
Selegiline Hydrochloride 5 mg
Anipryl (Selegiline) 10 mg
Active Ingredient Amount
Selegiline Hydrochloride 10 mg
Anipryl (Selegiline) 15 mg
Active Ingredient Amount
Selegiline Hydrochloride 15 mg
Anipryl (Selegiline) 30 mg
Active Ingredient Amount
Selegiline Hydrochloride 30 mg

What is Anipryl (Selegiline)?

Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian.

For:

Dogs

Benefits:

  • First and only FDA-approved drug used to control clinical signs associated with Canine Cognitive Dysfunction Syndrome
  • First and only product approved to control uncomplicated PDH (pituitary-dependent hyperadrenocorticism) Cushing's disease

How it Works:

Anipryl increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal gland's production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.

Cautions:

Because Anipryl belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation; swelling of the lips, tongue or face), stop giving Anipryl and seek emergency veterinary medical attention.

Brand Name:

Anipryl (Zoetis), Eldepryl (Somerset)

Generic Name:

selegiline

What is the most important information I should know about Anipryl (Selegiline):

Anipryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Anipryl is also used to treat canine cognitive dysfunction. The usual initial starting dose to treat Cushing's disease in dogs is 0.45 mg/pound given once a day in the morning. If no results within 2 months may increase to 0.9 mg/pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45 mg/pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

What is Anipryl (Selegiline):

Anipryl, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how Anipryl works. However, it is believed that Anipryl prevents the breakdown of dopamine. Anipryl may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Anipryl (Selegiline) to my pet:

Anipryl should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anipryl at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of Anipryl overdose include excitement, irritability, nervousness, insomnia, dizziness, severe headache, hallucinations, weakness, sweating and seizures.

What should I avoid while giving Anipryl (Selegiline) to my pet:

Anipryl may cause dizziness or drowsiness. Do not give higher doses than those prescribed.

What are the possible side effects of Anipryl (Selegiline):

If any of the following serious side effects occur, stop giving Anipryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving Anipryl and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Anipryl (Selegiline):

Before giving Anipryl tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.

Where can I get more information:

Your pharmacist has additional information about Anipryl written for health professionals that you may read.

Anipryl (Selegiline) Directions:

  • Anipryl is a prescription medication used in dogs for the treatment of Cushing's disease caused by a pituitary tumor.
  • Anipryl is also used in dogs to treat canine cognitive dysfunction.
Tip:

Do not give more of this medication than is prescribed without consulting your veterinarian. Anipryl may cause drowsiness or dizziness.

Anipryl (Selegiline) Dosage:

Anipryl (Selegiline) Dosage for Dogs (when used for cognitive dysfunction)
Weight Dosage
All weights The dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of body weight. It may take up to one month or more to see improvement
Anipryl (Selegiline) Dosage for Dogs (when used for Cushing's disease)
Weight Dosage
All weights The usual starting dose to treat Cushing's disease is 0.45mg per pound of pet's body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pet's body weight. If still no response after one month of the increased dose, reevaluate the pet
Anipryl (Selegiline) Dosage for Cats
Cats
Do not use!
Anipryl (Selegiline) Dosage for Horses
Horses
Do not use!

Storage:

Should be stored at room temperature, away from moisture and heat.

Anipryl (Selegiline) Ingredients:

Anipryl (Selegiline) 5 mg
Active Ingredient Amount
Selegiline Hydrochloride 5 mg
Anipryl (Selegiline) 10 mg
Active Ingredient Amount
Selegiline Hydrochloride 10 mg
Anipryl (Selegiline) 15 mg
Active Ingredient Amount
Selegiline Hydrochloride 15 mg
Anipryl (Selegiline) 30 mg
Active Ingredient Amount
Selegiline Hydrochloride 30 mg

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