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Simparica

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Simparica?

Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly and requires a prescription from your veterinarian.

For:

Dogs (over 6 months of age weighing 2.8+ lbs)

Benefits:
  • Each tablet provides a full month of protection against fleas and ticks
  • Tasty, liver-flavored chewable tablet is easy to administer
  • Chewable tablets can be given directly to your dog or broken up and mixed with food
  • Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs
How it works:

Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Simparica is administered once a month directly by mouth or can be crumbled and mixed with food. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

Cautions:

Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age weighing less than 2.8 lbs. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

Brand Name

Simparica

Generic Name

Sarolaner (sar-oh-lan-ur)

Manufacturer:

Zoetis

What is this medication used for:

Simparica is used for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] in dogs over 6 months of age weighing 2.8 lbs and over.

Availability:

Simparica is available as a liver-flavored, chewable tablet. Simparica requires a prescription from your veterinarian.

How this medicine should be used:

Simparica should be administered orally, once every month, at the minimum dosage of 0.91 mg/lb (2 mg/kg) sarolaner. Dogs weighing 2.8 to 5.5 lbs should be given one 5 mg Simparica chewable tablet monthly. Dogs weighing 5.6 to 11.0 lbs should be given one 10 mg Simparica chewable tablet monthly. Dogs weighing 11.1 to 22.0 lbs should be given one 20 mg Simparica chewable tablet monthly. Dogs weighing 22.1 to 44.0 lbs should be given one 40 mg Simparica chewable tablet monthly. Dogs weighing 44.1 to 88.0 lbs should be given one 80 mg Simparica chewable tablet monthly. Dogs weighing 88.1 to 132.0 lbs should be given one 120 mg Simparica chewable tablet monthly. Dogs weighing more than 132.0 lbs should be given appropriate combination of Simparica tablets monthly. Care should be taken that your dog consumes the complete dose, and treated pets should be observed for a few minutes to ensure that part of the dose is not lost or refused. If a dose is missed, administer Simparica and resume a monthly dosing schedule.

For flea treatment and prevention: Treatment may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.

For tick treatment and control: Treatment with Simparica can begin at any time of the year.

What are the side effects:

The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.

What special precautions are there:

The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.

In the event of an overdose:

Contact your veterinarian immediately.

How should I store this medication:

Store at or below 86°F (30°C) with excursions permitted up to 104°F (40°C).

How to Use
Directions:
  • Administer one Simparica chewable once every month.
  • Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
  • Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
  • Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tip:

Always make sure ample water is available for your dog.

Dosage:
Dogs:
Over 6 months of age weighing 2.8 lbs or more
Weight:
Amount:
2.8 to 5.5 lbs
One 5 mg chewable tablet monthly
5.6 to 11.0 lbs
One 10 mg chewable tablet monthly
11.1 to 22.0 lbs
One 20 mg chewable tablet monthly
22.1 to 44.0 lbs
One 40 mg chewable tablet monthly
44.1 to 88.0 lbs
One 80 mg chewable tablet monthly
88.1 to 132.0 lbs
One 120 mg chewable tablet monthly
Over 132.1 lbs
Administer the appropriate combination of Simparica chewable tablets monthly
Cats:
Do not use!
Horses:
Do not use!
Storage:

Store at or below 86°F (30°C) with excursions permitted up to 104°F (40°C).

Ingredients
Simparica for Dogs 2.8-5.5 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
5 mg
Simparica for Dogs 5.6-11 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
10 mg
Simparica for Dogs 11.1 to 22.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
20 mg
Simparica for Dogs 22.1 to 44.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
40 mg
Simparica for Dogs 44.1 to 88.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
80 mg
Simparica for Dogs 88.1 to 132.0 lbs:
Active Ingredient (per tablet)
Amount
Sarolaner
120 mg
Customer Reviews
Simparica is rated 4.3 out of 5 by 6.
Rated 5 out of 5 by from Works great We've given our 12 lb dog this medicine since December of last year and have not seen 1 flea. This is a flavored tablet, not chewy, but my dog likes the flavor and takes it well. One could hide it in a treat if needed.
Date published: 2017-02-22
Rated 5 out of 5 by from highly recommend We had a particularly bad flea infestation. My husband eats all organic food and is against pesticide or insecticides of any kind so he wouldn't allow me to use flea preventative treatment on our animals (2 dachshunds and a cat). We tried all sorts of holistic treatments without success. I finally convinced him to try Revolution; which worked well. However, my vet recommended Simperica for my dogs as a chewable is much more convenient then a spot on treatment and just as effective. I agree completely. Now, I just wish they had Simperica for cats. However, Revolution is a very effective treatment for cats and much less messy then other spot-ons. So, I highly recommend Simperica for dogs and Revolution for cats.
Date published: 2016-12-03
Rated 5 out of 5 by from Easy to give-works great! In the past I found ticks on my Lab and tried Bravecto! Unfortunately Gracie wouldn't eat the larger pill very well and I have pulled some ticks of her early this summer. I also usually had to break it up and do whatever possible to "trick" her into eating it. I asked my vet for an alternative and switched to Simparica and she eats it up great- you have to give monthly so I just put it in my phone - I have yet to see any ticks so it seems to work great! No side effects- recommend!
Date published: 2016-09-30
Rated 5 out of 5 by from Best Product Available. Fast and Relentless. I bought this product in April to eradicate a flea infestation but my dogs frequently have ticks also. It knocked out the fleas in just a few hours and I've yet to see a tick. One of my fur babies is very allergic to the flea bites. Simparica killed them so quickly that Max stopped scratching and his hair grew back quickly. It worked better than the other oral products I've used in the past and it cost less! I would always see fleas or those ticks with the white dot at the end of the month. I always forget to give it. I'm always a few days late, so an extra bonus feature of the product is that it has some cushioning so my pups are still protected against nasty fleas and ticks when I forget a few days! It's super tasty too and one of my pups is particular. I wish they sold it without the medicine so I could give them as treats. I love this stuff and my pups love it more.
Date published: 2016-09-24
Rated 1 out of 5 by from Terrible I'm a veterinarian tech I was given this product by a Simparica representative. I live in Texas where fleas are abundant and I gave my dog this preventative a couple weeks ago for the first time and he has a flea allergy so if he does get them he becomes very itchy. Well low and behold he has fleas. I watched him eat the entire tablet so I know he took the medication with no vomiting afterwards so he got it! And now he has fleas. Some bad flea preventatives like Frontline will stop working over time bc fleas build up immunity but Simparica just straight does not work!!!! Do not waste your time and money on this product please! Use Bravecto or Nexgard if you don't want your dog to have fleas.
Date published: 2016-08-20
Rated 5 out of 5 by from Works great! We live in a place with lots of high grass and fleas and ticks are a problem. I had been using pet armour drops. It worked well but you would still see an occasional flea. We tried these from the vew and they are awesome! Haven't even seen 1 flea and it didn't have any side effects.
Date published: 2016-07-11
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Q&A

when will you get this product in?

Asked by: mmr6
We should already have this product in our warehouse.
Answered by: Ben B
Date published: 2017-02-21

Is this product safe to give in conjunction with Sentinel? I am trying to reach maximum protection and prevention for my dogs and we live in a rather wooded area. Is Sentinel and Simparica the best combo for woods/deer/etc.?

Asked by: hannah1990
I would disagree with Christine in that these 2 products work differently. Sentinel is a heartworm prevention, intestinal parasite dewormer and controls fleas by sterilization. It does not kill fleas. Simparica will actually kill fleas as well as ticks. For years, the manufacturer of Sentinel has stated that the use of products to kill fleas in conjunction with their product is perfectly safe and even recommended with heavy flea infestations on allergic dogs.
Answered by: SuzyCVT
Date published: 2017-01-27

I bought this from a vet and it been a month since my dogs been on it they have what it looks like a rash on the nose mouth and chin they never had that before is that one of the side effects to the pill or what could it be

Asked by: Alley
The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious, proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures. Rash is not a reported side effect of the medication. If it does not go away or becomes worse contact your veterinarian.
Answered by: Christine
Date published: 2016-10-18

Is this product safe to use if giving the dog ivermectin for heartworm treatment?

Asked by: Linda
Yes, it is safe to give Simparica for flea and tick prevention with Ivermectin for heartworm protection.
Answered by: Christine
Date published: 2017-01-12

Does it prevent heartworm?

Asked by: Tito
No Simparica does not prevent against heartworm.
Answered by: paulpharmacistintern
Date published: 2017-01-27

Saludos.  ¿Se puede dividir una tableta de 22-44 lb, entre dos perros de 20 libras? Lo pregunto porque tengo 6 perros y estoy pensando comprar las pastillas para dividirlas entre dos, ya que así me sale más económico.

Asked by: Wanda
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