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Proin


 
Q & A
 
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Proin is available in all states except Arkansas, Iowa, Louisiana, Illinois and Oregon where it is classified as a controlled substance.
 
                         
 
 
  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Proin?

Proin is an aid in the management of urinary incontinence in dogs. Proin requires a prescription from your veterinarian.
 
For: Dogs
 
Benefits:
Is a supplement for urinary incontinence in dogs
Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability
Proin
 
Alternate photos:
  Proin Chewable Flavor Tabs
  Proin Drops

How it works:
Proin contains the active ingredient phenylpropanolamine, an adrenergic agent that works by tightening the bladder sphincter muscle, which helps to control urine leakage.

Cautions:
Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately. We do not ship Proin to Arkansas, Iowa, Louisiana and Oregon where it is classified as a controlled substance.


More Information:
Brand Name
Proin (PRN Pharmacal)
Generic Name
Phenylpropanolamine

What is the most important information I should know about Proin: Proin is a prescription medication for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets and 25mg/ml drops in a 2 oz dropper bottle. Proin may cause restlessness, irritability, or loss of appetite.

What is Proin: Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Proin to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.

How should this medication be given: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets. 

What happens if I miss giving a dose: Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.

What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma.

What should I avoid while giving Proin to my pet: Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegilene or Preventic Collar.

What are the possible side effects of Proin: Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.

What other drugs will affect Proin: Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications. 

Where can I get more information: Your pharmacist has additional information about Proin written for health professionals that you may read.

Directions:
Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
Proin may cause restlessness, irritability, or loss of appetite.
Tell your veterinarian about any other medication you may be giving your pet.
Tip: Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.
Dosage:
Pet Weight Dosage
Dogs: All weights Tablets: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.
Drops: 0.4-0.8mg/pound every 12 hours.
Cats:
Horses:
Storage: Should be stored at room temperature away from moisture and heat. Keep this medication away from children and pets.
Proin Chewable Flavor Tabs 25 mg:
Active Ingredients Strength
Phenylpropanolamine 25 mg

Proin Chewable Flavor Tabs 50 mg:
Active Ingredients Strength
Phenylpropanolamine 50 mg

Proin Chewable Flavor Tabs 75 mg:
Active Ingredients Strength
Phenylpropanolamine 75 mg

Proin Drops:
Active Ingredients Strength
Phenylpropanolamine 25 mg/mL
Proin 4.6 5 506 509
WORKS!!! thank goodness I have had my Samoyed for 10 1/2 years. She is diabetic, insuline dependent, blind and has recently become incontinent. My vet prescribed Proin at a VERY high price. :/ I was told to call PetMeds. What a great group of CARING people helping with our pets. The medicine TOTALLY works. Aphro doesn't love the taste so much but she takes them just fine. I am so happy that this is working so well..... THANK YOU 1800 Pet Meds! 05/24/2011
FANTASTIC - WORKED!! I did a little internet research, and decided to try this when our Border Collie (age 14) began to have incontinence when sleeping. When awake, she was OK, used the doggy door, no problem. About 3 days after starting her on the 25 mg. dose (once daily with her food), the incontinence STOPPED completely. I'm amazed and thankful!! No more bed washing, and carpet cleaning every day, and the odor is gone from the house - OUTSTANDING. And working with 1-800 is ALWAYS a pleasure. Their customer service is FANTASTIC and FAST. THANKS!! 05/12/2011
Great Solution My Ruby is a large Great Pyrenees/Airedale mix (94 lbs.). She is two years old and began "wetting her bed" after she was spayed. The Proin has totally eliminated that problem. We are very happy with this solution. 04/20/2011
Great Meds! My dog has been on Proin since he was 9 months old, he is now 4 years old. He was diagnosed with a loose sphincter muscle, which is why the urine would leak out. My two comments are....the sure fire way we have given him Proin for the past several years is whole in PUMPKIN PUREE on a fork! He will not take it on a spoon or with applesauce, yogurt, cheese, etc. This is great because it is healthy for him anyways. And my other comment is, there are times maybe once or twice a year when we have to bump his medicine up for a week or two because it seems to ware off for him. So, instead of doing a 1/2 tab in the morning and a whole tab at night- we will do a whole tab two times a day. This has seemed to work well for us. 04/13/2011
PROIN product review: PROIN product review: One of the most common problems seen in spayed or neutered pets, especially as they get older is the development of urine incontinence, where pets will sometimes leak urine involuntarily while laying, sleeping and even walking sometimes. In my 17 years of medical practice, our profession has looked into many drugs to help treat this frustrating yet common condition. While some of these alternative drugs have helped, they are sometimes very expensive, while in other cases side effects can occur. So most conventional veterinarians will usually reach first for one of two drugs to treat this frustrating problem. Either low dose estrogen/hormonal therapy, or more commonly a prescription drug like proin. The main ingredient(called phenylproponolamine) helps tighten the smooth muscle tone around the urethra thus helping to minimize this frustrating involuntary leaking of urine from the bladder. While it is commonly prescribed twice daily by many veterinarians, I have found it to be as equally effective when given once daily at a dose of 3/4 mg per per pound. I even saw a journal article touting this once day use at this dose over the more common twice daily use. Many clients will notice immediate relief, while others can take several days to a week or two. However I am often able to taper this drug down to every other day or even a once or twice weekly on rare cases, while others need it daily to control the urine leaking. It is very important, however for animal guardians to have a urinary tract infection ruled out first, before starting a drug like this, as well as rule out a genetic anatomic problem of the bladder or urinary tract, if the patient is a young puppy under one year of age, as well as masses/tumors in older animals. If a thorough workup fails to detect an underlying cause of the leaking then certainly ask your vet about possibly writing a prescription for this often effective medication. The only rare side effects I have seen are digestive upset and vomiting in some animals, as well as in some pets a more rapid heart rate, due to the main ingredient in this medicine called phenylproponolamine. In fact, in human medicine, this drug was taken off the market because of worries and risks of cardiovascular issues in human patients. I have not seen this to be a major factor in veterinary medicine, but if you have an older pet with either a heart murmur or heart ailment , or some other illness that might be associated with high blood pressure like kidney disease or Cushings disease, then it is probably best to have your vet monitor the blood pressure both before and if he/she decides to start this medication. And while it does come in a chewable tablet that most dogs will accept, I have found palatability to be a problem in some dogs in taking it, even with clever disguising in treats. My overall rating of this product is a 4, its efficacy a 4.5, and its ease of use/taste a 3. , 12/29/2008
2 3 4 5 ... 18 Next
147 Questions · 228 Answers

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4 years ago
by
whiskey
Queens, NY
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Answer: 
This is for life. We went on vacation and the dogsitter did not give her Proin for a week. She leaked again. We gave it twice a day until resolved, then once daily.
3 years, 11 months ago
by
Nanny
Huntsville, AL
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Answer: 
Yes. In most cases Proin is given for the life of the pet.
4 years ago
by
Gary, Dir. of Pharmacy Services
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It seems since starting proin, Maggie has had diarrhea. I don't want to trade one problem for another. No appetite changes, just diarrhea, everywhere!
4 years ago
by
Lolly
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Answer: 
Proin does not cause diarrhea on my doggie she goes when is time to go but she does not have diarrhea. maybe the food that she is eating causing the diarrhea. My poodle had diarrhea but a check what upset her stomach.
3 years, 11 months ago
by
bethayl@hotmail.com
Bronx New York
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Answer: 
I'm not familiar with diarrhea being a side effect of Proin. If the diarrhea only started when you began to give Proin I would recommend you bring this to your veterinarian's attention.
4 years ago
by
Gary, Dir. of Pharmacy Services
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is why we are trying this med proin. However, she has had movements of both 1 & @ for the past 5 nites in a row. Coincidence??
4 years ago
by
sandy
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Answer: 
It could be coincidence. However, I would suggest you tell your veterinarian about this.
4 years ago
by
Gary, Dir. of Pharmacy Services
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My vet has changed my dog's prescription from Proin 50 2x daily to Proin 75 once daily and I have several months supply of Proin 50 I don't want to waste.
4 years, 1 month ago
by
Nona
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Answer: 
Yes. If you give 1 and 1/2 tablets of the 50 mg Proin, that will equal a 75 mg dose
4 years, 1 month ago
by
Gary, Dir. of Pharmacy Services
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1 answer

Proin and Benadryl

My dog is allergic to Proin. It causes her to break out in hives, swell at the mouth and tongue, and she has trouble breathing. My vet suggested that I give her a benadryl tablet with every Proin. This does work, she has been on it for about a year with no problems. Is there any long term side effects from taking Benadryl BID everyday?
4 years, 1 month ago
by
Jen0109
Indiana
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Answer: 
Giving your pet Benadryl twice a day every day should not cause any harm. HOWEVER, the reaction your pet is having to Proin is very troubling. Even with giving Benadryl to control symptoms, the symptoms you describe would cause me to advise someone to stop giving the medication. There are other options for urinary incontinence including estriol and DES. You may want to consider those options.
4 years, 1 month ago
by
Gary, Dir. of Pharmacy Services
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I just picked up a new bottle of Proin from my vet and noticed that the pills no long have that strong smell like they use to. Also since I starting giving them to her incontinence is back. Could I have a bad batch?
4 years, 1 month ago
by
mary
chicago
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Answer: 
I am not aware of any change in the Proin tablet. You should contact your veterinarian and discuss this with him/her.
4 years, 1 month ago
by
Gary, Dir. of Pharmacy Services
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1 answer

Proin and UTI's

Hi,
Do you know if using Proin on a daily basis for my German Shepherd could cause UTI's?
4 years, 2 months ago
by
Dense
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Answer: 
I am not aware of this medication being the cause of a UTI.
4 years, 2 months ago
by
Gary, Dir. of Pharmacy Services
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My boxer's appetitie has changed now after being on Proin since March. She is taking 37 mg a day. We tried to take her off the daily dosage but the leaking would immediately come back. Proin is working great for her incontinence. This loss of appetitie has just come on within the last 2 weeks.
4 years, 3 months ago
by
Tina
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Answer: 
My dogs eat less now too. I think it is the heat. Hormones make us all more proned to heat thus eat less. I feed my dogs now in the am when they are cooler and give them a little at night if they want it.
Hormones change taste buds, too, so maybe add some yummy wet food or scraps.
4 years, 2 months ago
by
winter's mom
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Answer: 
I know of no drug interaction between Proin and Thyrozine (levothyroxine).
4 years, 3 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 3 months ago
by
Colbiegirl
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Answer: 
It can be, but you need to be aware that the side effect potential of Proin may increase.
4 years, 3 months ago
by
Gary, Dir. of Pharmacy Services
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2 answers

Proin and other drugs

My dog started taking Proin about 2 weeks ago and was doing great on it. She recently had surgery and was given an antiobiotic and pain medication and the Proin stopped working. I got rid of the pain medication but she is still leaking like crazy. Would the antiobiotic cause this? Thanks for the help.
4 years, 4 months ago
by
rguedel
Massillon, Ohio
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Answer: 
I had the same proble, but Cheyenne is a big dog so the vet changed it to twice a day and it works great now for over 3 years. I hope you have good luck too. May she got a little infection from her surgery which effected those mucles temporarily.
4 years, 2 months ago
by
Cheyenne
Arizona
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Answer: 
I am not familiar with any antibiotic that would interfere with Proin. It could be the trauma of the surgery that's causing the bladder leakage.
4 years, 4 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 4 months ago
by
Anonymous
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Answer: 
Sorry. We do not.
4 years, 4 months ago
by
Gary, Dir. of Pharmacy Services
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we want to do right by our female Mastiff, named Vor. What can you tell us that can reassure us we are making the best choice in medications for urinary incontinence?
antbx and a costly vulvoplasty did not seem to help , She is only 2 yrs old , and 115 lbs, & it seems she needs more meds than the family combined. Help us as we want the BEST for her. thank you
4 years, 5 months ago
by
jb
Battle Ground, wa
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Answer: 
We've been giving our 11 year old (50 lbs) black lab mix Proin for 10 years. It's a wonder drug. But it took us year and 3 vets to get a diagnosis and prescription. We get the Proin 75mg and give her 1/4 of a tablet morning and evening.
4 years, 3 months ago
by
Molliedog
Texas
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Answer: 
Our dog is a 15 year old Chow who required Proin 25mg for bladder incontinence after a botched surgery. I don't know what dose would be appropriate for your dog regarding the age and weight, but Proin is completely effective for our dog. We only have to give her 1/2 tablet morning and night.
4 years, 4 months ago
by
Codster
Belleview, FL
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Answer: 
I can only advise that Proin is widely used by veterinarians in the treatment of urinary incontinence.
4 years, 4 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
jb
Battle Ground, wa
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Answer: 
Once a day doesn't work for our dog, 50lbs black lab mix.
4 years, 3 months ago
by
Molliedog
Texas
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Answer: 
Proin is intended for twice a day dosing because the effects of each dose only last about 12 hours. Proin will not have, to my knowledge any effect on struvites.
4 years, 4 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
cocoa
malden
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Answer: 
That depends on the strength you need and how many tablets you want. Please visit our website or call customer care at 1-800-738-6337 for prices.
4 years, 4 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
JB
Battle Ground, Wa
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Answer: 
Yes it is.
4 years, 5 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
JB
Battle Ground, Wa
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Answer: 
The usual dose for a 115 lb dog is 50-100mg every 12 hours.
4 years, 5 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
Wille
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Answer: 
Besides the chewable tablet, Proin (phenylpropanolamine) is also available as a 25mg/ml liquid in a 2 oz dropper bottle.
4 years, 5 months ago
by
Gary, Dir. of Pharmacy Services
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1 answer

Is this normal?

Hi,
My 11 year old GSD has been incontinent for a couple years now but has always been on DES. However, last week she had 3 accidents and the vet determined that the DES is no longer working. The vet prescribed Proin today (1 1/2 50 mg tablets at dinner) and she just took her first dosage a couple of hours ago. She's been panting non-stop since then. Is this normal? She also has arthritis (on Rimadyl), hypothyroidism (on Soloxine) and currently an infection (on Clavamox). I'm afraid this Proin interacted negatively with the other medications in a way that wasn't anticipated. Is the panting normal? What are signs to look for?
4 years, 5 months ago
by
cbyoung
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Answer: 
It is possible that the panting is caused by Proin. It's also possible that the combination of Proin and Soloxine could increase the chance of panting occurring. I would suggest speaking to your veterinarian to let him know of your pet's panting.
4 years, 5 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
Lore
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Answer: 
One of the side effects of Proin is loss of appetite.
4 years, 5 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 5 months ago
by
debbie
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Answer: 
Yes, My 11yr old Dobe has had 3 bladder infections and has takin Cephflexin at the same time with great results and no side effects
4 years, 5 months ago
by
Dobe Mom
Iron River, WI
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Answer: 
Yes, My Doberman has had bladder infections and my vet had her on Cephflexin at the same time. Try cranberry juice too. It will help til you get her on antibbiotics
4 years, 5 months ago
by
Dobe Mom
Iron River WI
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4 years, 6 months ago
by
Karen
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Answer: 
Yes, they can be cut in half. My Dobe is on 25mg 3 times a week now(every other day) She started out 10years ago on 2 50mg a day and I have reduced it enough until she had accidents again. It takes time and patience. I have had her completely off them for a few months til the bed was wet in the morning. Then put her back on them at a lower dosage
4 years, 5 months ago
by
Dobe Mom
Iron River WI
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Answer: 
My vet said we could. Our dog started on the 50mg then decreased to 25mg after a week. Our vet told us to just cut the pill in half.
4 years, 6 months ago
by
Char
Haslet,Tx
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4 years, 6 months ago
by
3000
georgia
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Answer: 
Get your dog to the vet for heartworm treatment. The blood in urine could be prstrate problems
4 years, 5 months ago
by
Dobe Mom
Iron River, WI
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Answer: 
Can't answer that. You need to have your veterinarian examine your pet.
4 years, 6 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 6 months ago
by
Deborah
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Answer: 
No. We do not.
4 years, 6 months ago
by
Gary, Dir. of Pharmacy Services
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I have a 4 year old beagle/coonhound mix and she can not stand the garlic smell and taste of the medicine. I had to go to crushing the pill up and mixing with applesauce and treats so she would take it. I tried peanut butter, cheese, bread, hot dogs and summer sausage. Everytime she would eat around the pill and then spit it out. If this comes in a different flavor I think that would help.
4 years, 6 months ago
by
Lady Phoebe
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Answer: 
I have found "Liverwurst" wrapped around any pill so it is shapped into a ball with the pill in the middle as the most effective way to pill a dog. They love it and it isn't as messy or expensive as other food.
4 years, 6 months ago
by
Diane
Rapid City
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Answer: 
Unfortunately, Proin only comes in the one flavor.
4 years, 6 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 6 months ago
by
Anonymous
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Answer: 
Ask your vet
4 years, 5 months ago
by
Dobe Mom
Iron River, WI
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Answer: 
The two medications can be given together. However, the pet should be monitored for symptoms such as increased heart rate. It most likely will jot occur, but there is always the possibility
4 years, 6 months ago
by
Gary, Dir. of Pharmacy Services
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4 years, 6 months ago
by
Anonymous
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Answer: 
In the 50 mg strength, yes.
4 years, 6 months ago
by
Gary, Dir. of Pharmacy Services
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My vet says to give my 14 lb. toy fox terrier 25 mg 2 times a day. This is double the dose stated on the bottle. So I was afraid to give her that much so I cut the 25 in half and give her half in the morning and half at night, but she still leaks a little. Is it O.K. to give her double the dose stated on the bottle? Also, the vet really didn't figure the dose, the receptionist did, so that scares me.
4 years, 7 months ago
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Anonymous
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Find a better vet!
4 years, 5 months ago
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Dobe Mom
Iron River, WI
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Answer: 
My best answer is to contact the veterinarian and ask him/her about the strength. Do not let the receptionist answer the question, speak to the veterinarian only. Then follow his/her directions.
4 years, 6 months ago
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Gary, Dir. of Pharmacy Services
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incontienence she had before. Very little if any.
4 years, 7 months ago
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KC in Fort Lauderdale
fort lauderdale
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I would not just start your pet on Proin. I would check with your veterinarian and follow his/her directions.
4 years, 6 months ago
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Gary, Dir. of Pharmacy Services
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Answer: 
I took my dog off it too but the accidents did come back slowly. Once I put her back on because she was uncomfortable, the accidents went away again.
4 years, 7 months ago
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Jennifer
New Jersey
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4 years, 8 months ago
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Chi
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my dog weighs much more than your dog but I only give her one pill a day & it works...no accidents
4 years, 7 months ago
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Jennifer
New Jersey
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Answer: 
My dog is 45 lbs and was prescribed 50mg Proin 2x a day. She had major personality changes, I've cut it down to 25 mg 1x a day. in the evening. Be careful, this medicine is an amphetamine.
4 years, 8 months ago
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Astro
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Sarah has never had a seizure. She convulsed for about a minute violently, legs stiff eyes wide open drooling, a little incontinence. Is the dosage maybe to high. She is taking 50 mb am. & pm.
4 years, 8 months ago
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Sarah's mom
Gilbert
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What you need to do is contact your veterinarian.
4 years, 6 months ago
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Gary, Dir. of Pharmacy Services
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Answer: 
you should call your vet. my dog takes proin but she also takes phenobarbital for seizures which is a whole different problem she has had for a long time. we had her on phenobarb way before she started proin but it never caused her to have a seizure.
4 years, 8 months ago
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rose
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
 
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