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Profender Cat Wormer

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1. We'll ask for your vet's info during checkout.
2. We verify your prescription and ship your order!
Starts $17.36 $12.50 
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Cat/Kitten 0.35 ml Small
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Product Info
How to Use
Customer Reviews
Product Info
What is Profender Cat Wormer?

Profender is the first-ever, topical dewormer used to treat and control intestinal parasites in cats, such as hookworms, tapeworms and roundworms. Not only is Profender easy to use, safe and effective, it also works in a single-dose capacity so there is no need for that pesky second dose! Profender requires a prescription from your veterinarian.


Cats (8 weeks of age or older)

  • Kills hookworms, tapeworms and roundworms
  • Fast-acting, powerful topical treatment
  • Onetime application
  • Safe and effective
How it Works:

Profender works by using the time-tested active ingredient praziquantel and a unique compound called emodepside to eradicate intestinal parasites. Once Profender encounters your cat's skin, it rapidly enters the bloodstream and travels to the intestines, controlling and eliminating unwanted parasites.


Not for use on kittens under 8 weeks old or those under 2.2 lbs. and safe use in breeding, pregnant, or lactating pets has not been determined. Use with caution in sick or debilitated cats. Keep out of reach of children, and to prevent accidental ingestion of the product, children should not come in contact with the application site for 24 hours while the product is being absorbed. Pregnant women or women who may become pregnant should avoid direct contact with, or wear disposable gloves when applying this product.

Brand Name:

Profender (Bayer)

Generic Name:

emodepside + praziquantel

What is the most important information I should know about Profender:

Profender is a prescription-required topical solution that is FDA-approved for the treatment and control of hookworm, roundworm, and tapeworm infections in cats 8 weeks of age and older and weighing at least 2.2 lbs. Profender is packaged in single unit dosing applicator tubes and is available as 0.35 ml tubes containing emodepside 7.5 mg and praziquantel 30 mg for use on cats 2.2-5.5 lbs, 0.70 ml tubes containing emodepside 15 mg and praziquantel 60.1 mg for use on cats 5.6-11 lbs, and 1.12 ml tubes containing emodepside 24 mg and praziquantel 96.1 mg for use on cats 11.1-17.6 lbs. For cats over 17.6 lbs, the appropriate combination of tubes should be used.

What is Profender:

Profender contains a combination of insecticides (emodepside and praziquantel) and is used for the treatment and control of hookworm, roundworm, and tapeworm infections in cats.

What should I discuss with my veterinarian before applying Profender:

Tell your veterinarian if your pet is breeding, pregnant or lactating since safe use of this product has not been determined in such pets. Do not use in animals allergic to Profender or to either of the individual ingredients emodepside or praziquantel (Droncit, Tape Worm Tabs).

How should this medication be used:

Profender is applied topically to the skin. It is not given by mouth. Do not apply to broken skin or if the hair coat is wet. Follow the manufacturer's directions for application. A single treatment is effective and a second treatment should not be necessary. If re-infection occurs, the product can be re-applied after 30 days. If you do not understand the directions, or if you have difficulty applying the medication, contact your pharmacist or veterinarian. Store Profender at or below 77° F.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of overdose may include increased salivation, tremors, or drowsiness.

What should I avoid when applying Profender:

Always follow the dosage instructions provided by your veterinarian. If you do not understand these instructions ask your veterinarian or pharmacist to explain them to you. Do not use in cats under 8 weeks of age or less than 2.2 lbs. Do not use on cats that are sick, debilitated, or underweight. Do not allow any animal to lick the application site for 24 hours. Separation of treated animals may be necessary. Children should not come in contact with the application site for 24 hours after application. Pregnant women, or women who may become pregnant, should avoid direct contact with, or wear disposable gloves when applying this product. In humans, Profender can cause skin or eye irritation and may be harmful if swallowed. Wash hands thoroughly with soap and water after handling. In case of accidental ingestion or if skin or eye irritation occurs, call a poison control center or physician for treatment advice.

What are the possible side effects of Profender:

Side effects that may occur include licking/excessive grooming, scratching at treatment site, salivation, lethargy, alopecia (loss of hair), agitation/nervousness, vomiting, diarrhea, eye irritation, respiratory irritation, and shaking/tremors. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What other drugs will affect Profender:

Talk to your veterinarian or pharmacist regarding any other medications, including vitamins and supplements, and other flea and tick products your pet is using.

Where can I get more information:

Your pharmacist has additional information about Profender for Cats written by health professionals that you may read.

How to Use
  • Profender is a prescription topical medication for the treatment and control of hookworm, roundworm, and tapeworm infections in cats and kittens.
  • Apply only once to your pet's skin and use the entire contents for one application.
  • Twist cap off the appropriate tube of Profender based on your cat's weight and part your pet's hair at the base of the neck until your cat's skin is visible (be sure your cat's skin is dry).
  • Place the tip of the tube on the exposed skin and squeeze entire contents directly onto your cat's skin. Lift tube away from the skin before releasing pressure on the tube.

Do not allow any animal to lick the application site for one hour after application, and make sure not to get the product in your cat's mouth or eyes. In houses with multiple pets, separation of treated animals may be necessary.

Cats/Kittens (8 weeks of age or older)
2.2-5.5 lbs
Apply contents of 1 tube once (Green box)
5.6-11 lbs
Apply contents of 1 tube once (Orange box)
11.1-17.6 lbs
Apply contents of 1 tube once (Purple box)
Over 17.6 lbs
Treat with the appropriate combination of tubes
Do not use!
Do not use!

Store at room temperature 15- 30C (59- 86F).

Profender for Kittens 2.2-5.5 lbs (Green box):
Active Ingredient (per single dose .35 mL tube)
30 mg
7.5 mg
Profender for Cats 5.6-11 lbs (Orange box):
Active Ingredient (per single dose .70 mL tube)
60.1 mg
15 mg
Profender for Cats 11.1-17.6 lbs (Purple box):
Active Ingredient (per single dose 1.12 mL tube)
96.1 mg
24 mg
Customer Reviews
Profender Cat Wormer is rated 3.8 out of 5 by 20.
Rated 5 out of 5 by from Easy to apply and effective Been buying this every year to treat my short hair cat's occasional tapeworm infestation. Easy to apply, no side effect other than some discolored hairs on the area of application. Very effective. Within 48 hours the tapeworm infestation is gone. It has worked consistently every time I have used it. I don't understand the bad reviews on this site.
Date published: 2016-02-14
Rated 5 out of 5 by from Great Product We got this product from our veterinarian, we didn't order it on this website, she recommended it. It is really easy to apply, especially to a cat that won't take medication orally. We gave it to our older cat who is seven and our six month old kitten. There were no bad reactions to the medication at all. Within a day our older cat, who had been lethargic and wasnt eating well, was playing with the kitten and eating like crazy. I think think this is a great product. Easy to use and very affective.
Date published: 2015-05-31
Rated 4 out of 5 by from Topical vs Oral I find this product being a topical application useful and helpful. The cat we applied this product to often would give us trouble applying the topical flea remedies, she hates anything applied on her fur. Light bathing is a pain. Obviously, most cat's don't like anything applied to their bodies. I noticed improvement right away after a few day's. I did notice however, bits of dried flakes of "not sure" on the back of her neck. Has anyone seen any of this on their cat's? I will definitely use this for our other cat's. So much easier to use!
Date published: 2014-12-08
Rated 5 out of 5 by from Worked For Me 24 hours after treatment, I saw dead roundworms in my cat's "end-product". No more worms seen since. No adverse reactions from my cat. Gave treatment to all inside cats (4 total) since they use same litter box. No adverse reactions from the other cats. Vet tech said one treatment per year should be given to cats. So, from now on I will do this once per year. Very satisfied with this treatment.
Date published: 2014-01-24
Rated 5 out of 5 by from THE BEST STUFF EVER!!! I used this on an outside cat that had the worst case of worms I'd ever seen. 2 days after application all the worms were gone!!! I'm recommending this to everyone!!!
Date published: 2013-12-18
Rated 1 out of 5 by from This product didn't work I recently adopted a rescue kitten that had a lot of problems to begin with. He was infested with fleas and we combed all of them off of him before we even took him inside our house. We found three more fleas on him the first two days that he had been inside the house. I have washed his beds and blankets regularly since then, just to be on the safe side. We treated him with Advantage II as soon as we got the fleas off of him and have seen absolutely no more signs of fleas since those last three (which was over a month ago). Well a little over a week ago we found the live and dried up tapeworm segments on his rear end. The vet prescribed Profender for the tapeworm and after a few days I was still finding the live and dried up segments. I called the vet again and they said it could take up to a week for it all to pass, depending on how long the tapeworm was. Well today it has been almost 10 days since he was treated and I'm still finding live segments today. I called the vet yet again and they blamed it on "the environment" in my house saying that he got re-infected from fleas. That is a load of bull because there have been no signs of fleas on him since we treated him over a month ago (he has even had the second treatment of Advantage II this month as well). Our other adult cat has never had fleas and doesn't have tapeworm either. Now the vet is prescribing another de-wormer that is an oral treatment. I would strongly suggest not even bothering with Profender because I strongly believe it didn't even work in the first place and that he didn't get re-infected. He is still infected with the one that Profender didn't get rid of!! I strongly suggest not using Profender after my experience! I know that my house doesn't have fleas because I have been in a house that has had them, and you find them all over the pets, all over the house, and on the people as well. This is not the case for me. As I said before I wash his bedding and our bedding regularly and I vacuum regularly. I think my adult cat would be showing signs of fleas or tapeworm too if my kitten was being re-infected!!
Date published: 2013-12-16
Rated 4 out of 5 by from Unexpected consequences We adopted two male cats - one 14 lbs and one 7 lbs. - and they tolerated the application pretty well. Got this from the vet as she did not have any Drontal at the time. The smell is not as overpowering as some topical flea treatments. The amount of liquid packaged for large cats is a lot so even though you apply it to a small area, the ensuing scratching spreads it into an area on the body that could be reached by the cat's tongue. The parasite positive cat already had loose bowels before the treatment but fair warning, this stuff gave both cats projectile pooping! I'm sure by the time the drug has run its course, things down South should normalize (crossing fingers). Until then, keep a disinfecting rag handy :) For the cost, I would rather chance pilling the cats with Drontal.
Date published: 2013-11-01
Rated 2 out of 5 by from Stress free?? They advertise this product as being a stress free way of de-worming your cat as opposed to the tablet variety. Stress free in whose opinion? I found the whole process to be very stressful. My cat absolutely hated the drops going on and ran around like crazy trying to get it off. There is the worry that your cat will ingest the stuff as contrary to popular veterinary belief, a cat can groom the back of it's neck. It must really irritate as well as she wouldn't stop grooming and scratching the area and was unhappy about us touching her there. The next day she was lethargic and quiet, so one wonders what the heck we are doing to our pet by forcing these poisons into them. Okay, the worms have to go, but unless you are absolutely certain that your cat has worms or if you have just picked her up from a shelter, routine de-worming is to be avoided. Does it work though? I don't know and it is very hard to ascertain.
Date published: 2013-10-11
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Do I need a prescription for this?

Asked by: Lisa17
Yes this does require a prescription from your veterinarian.
Answered by: Ben B
Date published: 2017-02-21

My cat is 15 pounds is that considered medium or large for the doses?

Asked by: Menutz
That is considered the large dose (purple box) for cats 11.1-17.6 lbs.
Answered by: Ben B
Date published: 2017-02-21

Can you take a large dose and divide it into small doses using a graduated syringe ?

Asked by: Magickat
It is not recommended to divide the doses.
Answered by: Ben B
Date published: 2017-02-21

Do you ship to Canada and what king of information do you need

Asked by: Mokey 66
Yes, we do ship to Canada as we are a global shipping company. Depending on what you are trying to get, you may need a prescription from a Vet. We will also need your shipping information, name, name of pet, weight of pet, etc. Hope this helps.
Answered by: Trey W
Date published: 2017-02-21

Can this product be used with advantage topical flea control?

Asked by: ang12
Hello, There are no documented drug interactions for Profender (brand name for emodepside and prazinquantel) and should be ok to take with advantage topical. If you apply them both on the same day I would not apply them to the same place on your pet and separate administering the two topicals by a couple hours. Thanks for asking, Pharmacy Intern
Answered by: Ben B
Date published: 2017-02-17


how long after applying profender do worms and/or eggs disappear? i gave my three cats profender and kept them in their room while i sprayed and vacuumed entire house for fleas and eggs. i don't want them to come back out while they are still infected and start the cycle again.
Asked by: Anonymous
Profender is NOT for fleas! It is only for specific intestinal parasites. 
Answered by: Littlemonstir
Date published: 2017-01-26

how many applications are in the Profender product?

Asked by: Lynn22
We carry Profender as a single dose unit so it is one application.
Answered by: Lisa M
Date published: 2017-02-24

How many tubes come in a box?

Asked by: April
The product is sold as 1 tube.
Answered by: Carolyn Petmed Pro
Date published: 2016-11-15
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