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Compare Bio Spot Defense Flea & Tick Control For Dogs to K9 Advantix II to Sentinel
Call Us: 1-800-738-6337
K9 Advantix II
K9 Advantix II
Starts $60.61 $43.64
Starts $53.74 $38.69
Kills Fleas
Repels Fleas
Kills Flea eggs and Larvae Prevents Development
Kills Ticks
Repels Ticks
Kills and/or Repels Mosquitoes
Prevents Heartworm
Other Parasites Information Repels and prevents blood-feeding by biting flies and kills chewing lice. Controls adult hookworms and removes and controls adult roundworms & whipworms
(shampooing once a week can reduce effectiveness)
Not Applicable
Safe for pregnant or nursing Pets Consult your veterinarian Consult your veterinarian
How long does it take to work 1-2 Days Kills Fleas 12 hours Begins to work Immediately, However, pre-existing flea populations may continue to develop and emerge.
Taste Applied to Skin Applied to Skin Beef Flavor
Active Ingredient(s) Permethrin/Pyriproxyfen (Nylar) Imidacloprid/ Permethrin/Pyriproxyfen Milbemycin Oxime/Lufenuron
Rx Prescription Required(Details)
Dosage Monthly Monthly Monthly
Video coming soon
Video coming soon
Video coming soon
Veterinarian Review
(Michael Dym, VMD)
This topical product that has been around for years is really a potluck type product in my opinion and experience. Many of my clients, who could not afford the other commonly veterinary recommended topical flea/tick pesticides, have found this product a quite helpful much more economic and effective product than the more expensive competitors. . However I have had equal number of clients, who have used this product, been quite disappointed with the results, and their infestations seemed to have gotten worse after starting with this product. I personally don't recommend this product,for my biggest concern that overrides any economic savings that clients have, are the sometimes serious side effects I have seen with certain sensitive pets in my practice and experience. This has ranged from local irritation and greasiness in the coat, to an almost burn like eruption at place of application, to more serious systemic effects like excess drooling, ear itching/irritation and in rare cases neurological side effects including suspected seizures shortly after application. Although these side effects are not common, I feel their severity over rides my ability to recommend this product, I would stick with the more widely veterinary recommended products like Frontline, Advantage or Advantix. I therefore give this product an overall rating of a 2. Its efficacy is a 2 and its ease of use is a 4. I love the broad acting antiparasitic effects of this product, which covers protection against a wider variety of pests to our pets than the competition. I feel it works the quickest in terms of flea/tick killing, and I love the fact that it repels fleas and ticks as well. Given that we are uncovering new and emerging tick born diseases, I prefer a product that repels in addition to quickly killing ticks, as well, and thus prevents tick attachment and transmission of disease. We are also now recognizing that mosquitoes can transmit diseases like West Nile virus to dogs, and so the added protective benefit of Advantix on mosquitoes and flies makes it quite attractive, especially for those clients whose pets spend a lot of time outside in the yard in the warmer months, when flies are most active. With this product I see much less fly strike and maggot infestation of outside dogs because of this added benefit. By repelling mosquitoes, we also get less transmission of potential heartworms to dogs. I have found that some smaller breeds of dogs are sometimes sensitive to the permethrin ingredient in this product, occasionally becoming excessively sensitive after application. I also find that although the product is labelled as water proof, on those pets, who are frequently bathed or swimming for long periods, that the product may need to be applied more frequently than once monthly. Some clients also find it somewhat more inconvenient in larger breeds having to apply the product in several spots, rather than in a single spot like its competitor. Sentinel is a wonderful combination of the heartworm prevention pill interceptor and the flea control product program both in this one pill.  Many clients enjoy the convenience of having such broad acting internal and external parasites in one pill, without having to worry about giving two separate medicines.  Lufenuron, which is the main flea control ingredient, stops the flea life cycle in its track at the egg and larval stage, thus being like a birth control pill for fleas who get on our pets. Given that the main problem of fleas is how rapidly they reproduce, this pill literally stops escalating growth of flea populations, before they can become established in our homes, where most of the flea life cycle occurs.  The main disadvantage to this product is that it does not kill or repel adult fleas, so in situations with already established heavy infestations, it is best combined with a great topical product like advantage or front line or with the oral adulticide flea pill Capstar for maximal effect.  The only other rare disadvantage I see is the slight increase in reactions when two products  are  combined into one like this, but fortunately this is not common in clinical practice. With milbemycin for prevention of heartworms and controlling and treating most common intestinal worms, I overall highly recommend this versatile product.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.

The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.

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