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Adequan

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What is Adequan?

Adequan Canine (for dogs) and Adequan Equine (for horses) is used to control symptoms associated with degenerative or traumatic arthritis. Adequan requires a prescription from your veterinarian.

You will need a syringe to use Adequan, but it is not included in the package. Please see 3cc (3ml) luer lock syringe with 3/4" 25 g Needle.

For: Dogs and Horses

Benefits:
•	Helps control non-infectious degenerative or traumatic arthritis
•	Good for post-surgery treatment
•	Starts to work within hours and stays in the joint for about three days

How it works:
Adequan inhibits enzymes that break down cartilage within your dogs or horses joints. It reduces inflammation and increases the thickness of joint (synovial) fluid.

Cautions:
Do not give this medication to breeding, pregnant, or lactating animals. Use with caution in animals with kidney or liver disease, or bleeding disorders.

More Information:

Brand Name
Adequan (Manufactured by Luitpold)

Generic Name
Polysulfated Glycosaminoglycan (PSGAG) Solution

What is the most important information I should know about Adequan:
Adequan is a prescription medication used in dogs and horses to control signs associated with degenerative or traumatic arthritis. Adequan Canine 100mg/ml is available by prescription in a box containing 2 x 5 ml vials. The usual dose in dogs is 2mg per lb given by intramuscular injection only, twice a week for up to 4 weeks. Adequan Equine 500mg/5ml is available by prescription in a box containing 7 x 5ml ampoules. The usual dose in horses is 500mg given by intramuscular injection every 4 days for 28 days. Do not mix this medication with other drugs or chemicals.

What is Adequan:
Adequan belongs to a unique class of drugs called Disease-Modifying Osteoarthritis Drugs (DMOAD). It is an injectable polysulfated glycosaminoglycan (PSGAG) and is the only FDA approved product of its type. Adequan has been clinically shown to help treat the disease while giving relief from pain. It modifies the disease cycle, stimulates cartilage repair processes and diminishes joint damage while reducing the pain caused by osteoarthritis.

What should I discuss with my veterinarian before giving Adequan:
Tell your veterinarian if your dog or horse has any known or suspected bleeding disorders. Tell your veterinarian if your dog or horse has any liver or kidney disease. Tell your veterinarian if your dog or horse is breeding, pregnant or lactating.

How should this medication be given:
Give this medication exactly as directed by your veterinarian. Adequan is given by intramuscular (IM, into the muscle) injection. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. If you have difficulty giving the medication, contact your veterinarian. Store Adequan at room temperature (64º-77º F). Keep this medication out of the reach of children and pets.

What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What happens if I give an overdose:
Overdose is extremely rare. Symptoms that may indicate toxicity include joint pain, swelling and lameness.

What should I avoid while giving Adequan:
Do not give this medication to breeding, pregnant or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

What are the possible side effects of Adequan:
Few side effects are seen following Intramuscular injection. Stop giving Adequan and seek emergency veterinary medical attention if an allergic reaction (facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma) should occur. Bleeding from the nose, blood in the feces, or dark and tarry stools may indicate a decreased ability of blood to clot. Contact your veterinarian if you notice these symptoms. Other side effects may also occur. Talk to your veterinarian about any side effects that seem unusual or bothersome to the animal.

What other drugs will affect Adequan:
Consult your veterinarian before using any other prescription or over the counter medicines including vitamins and supplements.

Where can I get more information:
Your pharmacist has additional information about Adequan Canine and Adequan Equine written for health professionals that you may read.

Directions:

•	Adequan Canine is a prescription medication used in dogs for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints and following surgical procedures involving a joint.
•	Adequan Equine is a prescription medication used in horses to control signs associated with degenerative or traumatic arthritis.

Tip: Do not give this medication to breeding, pregnant, or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

Dosage:

Pet	Weight	Dosage
Dogs:	All weights	Inject 2mg per lb given only by intramuscular (IM) injection twice a week for up to 4 weeks (a maximum of 8 injections)
Cats:
Horses:	All weights	The usual dose is 500mg by intramuscular (IM) injection every 4 days for 28 days

Storage: Store at room temperature (64º-77º F).

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Adequan Canine (for Dogs):

Active Ingredients	Amount
Polysulfated Glycosaminoglycan	100 mg
benzyl alcohol (a preservative)	0.9% v/v
water
Other Ingredients: Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity

Adequan Equine (for Horses):

Active Ingredients	Amount
Polysulfated Glycosaminoglycan	500 mg
water
Other Ingredients: Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity

Adequan 4.7 5 58 58

Adequan For Dogs Adequan product review: One of the first products of its kind in veterinary medicine, now in use over many years and thousands of dogs and happy dog guardians , my clinical experience with this pioneering injectable FDA approved joint supplement has also been very positive. By injecting this product intramuscularly, one avoids some of the problems with absorption that is occasionally seen with other natural joint supplements given orally. The polysulfated glycosaminglycan solution quickly goes to the joints that need it, modifying the disease process of degenerative joint disease, by inhibiting enzymes that break down the supportive cartilage of the joints, while at the same time increasing the thickness of the lubricating joint fluid, just as shock absorbers do for ones automobile. The results are a decrease in inflammation and joint pain. I have even used this product in cats on occasion with terrific results, which is so important, given the paucity of effective and safe drugs for cats available on the market for arthritis. Results can be seen within hours to days. I usually will follow the manufacturer's recommendations giving it twice weekly for first 4 weeks. Some pets will have long term relief, while others will need periodic injections anywhere from every 2-4 weeks. I will often combine use of this product with omega 3 fatty acids, as well as antioxidants like proanthozone, also available from 1800petmeds, and find that with this multipronged supplement approach, that I often can avoid the need for stronger prescription drugs which may have occasional side effects. The only side effects I have occasionally seen in animals is very rare bleeding tendencies. This is best avoided by having blood work done first by your veterinarian to make sure there are no pre existing problems of the liver or kidneys that may predispose to this. The only other negative I can see is the need to get your vet to write a prescription for it, and the need for some clients to get over the fear of learning how to give these injections to their pets at home. Once I have shown clients the first time, they often find it quite easy and money saving to do right at home themselves. I give this product an overall efficacy rating of a 5, with an ease of use a 3. . 04/20/2009

Adequan works wonders My BIG girl ( 128 Lbs ) was diagnosed with degenerative arthritis in her hips causing her pain, & inability to go upstairs or get into a vehicle by herself. One of her Vets suggested { adequan } which I am giving to her subcutaneously ( injected under her skin, not into muscle - which is a lot easier than Intra-muscular) . The change has been dramatic for her. She is doing so much better, goes up stairs easily, & loves to go for romps in the woods. She seems to be living pain free, granted she has meds like tramadol to thank for that too, but she was on those before the Adequan , and was clearly not doing this well. Helpful hint : she took her vets advice to heart, and lost those extra few pounds as well. Gotta love those low-cal treats ! Thank-you for helping my Angel. 05/14/2013

help for hip dysplasia Prescribed for my chow/aus shep mix because of severe hip dysplasia in very young dog. After a year of monthly injections, his hips have improved so much! He used to be prone to dislocating one or the other, but that has not happened since he started this med, and his leg muscles have more fully developed since exercise is more comfortable. Love this med! 04/21/2013

question? OK... (my dogs weight) = 40mg twice weekly for 4 weeks .... are the 2 vials going to atleast last the 4 weeks?? before I have to purchase more.. I don't know how many ml's will be in 1 injec.. so I can't figure out how long the 2 vials will last ... any DVM reading??? who can give me some insight please 02/23/2013

Not great for my dog My four year old Berner just had her fourth shot, with the last two shots I noticed a worsening of her limp, then with the 4th one a definate worsening. I have cancelled the remaining 'load' shots. Not sure what happened but I won't try this again. I had high hopes, Vet said that 'when it works it works great'. Just wanted people to realize is may not be the miracle some are making it out to be. 01/24/2013

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92 Questions · 116 Answers

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1 answer

Liver and renal toxicity?

My vet took my 13-year old Lab off Rimadyl a few weeks ago because of abnormal kidney and liver function lab values. She had been on it PRN for a couple years and daily for the last year. I came across all this positive info about Adequan and am wondering if it is as renal- and/or hepatotoxic as NSAIDs...? She is really suffering (taking tramadole but it isn't working that great for her) and I would love to be one of the success stories here...

2 weeks, 2 days ago

Lulu's mom

San Francisco

Answers

Answer:

Please consult with your veterinarian. Adequan should be used with caution in animals with kidney and liver issues.

2 weeks, 1 day ago

Lilli Pharmacist

Pompano Beach, FL

1 answer

My Irish Wolfhound needs 324 mg's of Adequan per dose. What is the equivalent in cc's?

4 weeks ago

Anonymous

Answers

Top 250 Contributor

Answer:

Adequan is 100mg/cc so 324mg would be equivalent to 3.24cc

3 weeks ago

Laura H.

1 answer

Adequan with other meds

My dog is on 1/4 tablet Deramaxx, 2 x 20 mg of famodotine, and 2 x 100 mg of tramadol. Any issues giving him Adequan?

3 months ago

Couper the lab!

Florida

Answers

Top 10 Contributor

Answer:

There is no interaction between Adequan, Deramaxx, Tramadol and Famotidine.

2 months, 4 weeks ago

Lisa M

1 answer

Will Adequan work on a strained,inflamed, or hurt cervical disc?

My 90lb. yellow lab has been diagnosed with a strained(or inflamed, or hurt in someway) cervical disc in his neck. He is in very bad pain and has been on co-sequin ds 2 X's a day for at least a year.
Just for right now until I can do a miliogram test to be positive what is wrong in his neck, he is taking 1 rimadyl 100mg in the a.m., for 15 days and tramadol 100 Mg's 3 X's a day for 5 days, then 100mg's 2 X's a day for 5 days, then 100mg's 1 x a day for 5 days, then just 1-50mg tablet for either just 5 days and stop the tramadol or give 1-50 mg tramadol a day everyday with the cosequin ds or until milogram testing can be done.

My main question is will adequan with the cosequin DS work better than the rimadyl and tramadol?or can I give a tramadol as needed if on cosequin ds and adequan?

Also I heard rimadyl and adequan shouldn't be mixed?Is that true?

I also seen that a dog chiropractor might be of big help?Or possibly acupuncture?Will either of these help and which is better?

4 months, 3 weeks ago

Anonymous

Answers

Answer:

Please consult with your veterinarian.

4 months, 2 weeks ago

Lilli Pharmacist

Pompano Beach, FL

1 answer

multiple doses per vial

I read this Q&A on this list:

it comes 2-ml bottles. so i have a 75 lb dog and it says to give 2 mg. per pound. so how many injections will the 2- 5ml bottles provide.
6 months ago
by
dawn

Answers
Staff Answer
Answer:
The usual dose for a 75 pound dog is 150 mg which is 1.5 ml per dose. The 2 vials of adequan would last for approximately 6
doses, depending on the dose that your
veterinarian prescribes.

But elsewhere it was stated that once the vial is entered it won't be usuable for long since it's not preserved? My dog is on a maintenance dose of once a month. She also weights 75 pounds. Can I get 3 does from one vial at that dosage?

4 months, 3 weeks ago

Steve

Answers

Answer:

The Adequan Canine 100mg/ml 5ml vial contains a preservative and is designed for multiple uses. It is the Adequan Equine that does not contain a preservative and is a single use vial.

4 months, 3 weeks ago

Lilli Pharmacist

Pompano Beach, FL

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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
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