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Adequan for Dogs

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Product Info
How to Use
Customer Reviews
Product Info
What is Adequan?

Adequan Canine (for dogs) is used to control symptoms associated with degenerative or traumatic arthritis. Adequan requires a prescription from your veterinarian. A syringe is needed, but not included in the package. Please see 3cc (3ml) luer lock syringe with 3/4" 25 g Needle.



  • Helps control noninfectious degenerative or traumatic arthritis
  • Good for postsurgery treatment
  • Starts to work within hours and stays in the joint for about three days
How it Works:

Adequan inhibits enzymes that break down cartilage within your dog's joints. It reduces inflammation and increases the thickness of joint (synovial) fluid.


Not for use in humans. Do not give this medication to breeding, pregnant, or lactating pets. Use with caution in pets with kidney or liver disease, or bleeding disorders.

Brand Name:

Adequan (Manufactured by Luitpold)

Generic Name:

Polysulfated Glycosaminoglycan (PSGAG) Solution

What is Adequan:

Adequan belongs to a unique class of drugs called Disease-Modifying Osteoarthritis Drugs (DMOAD). It is an injectable polysulfated glycosaminoglycan (PSGAG) and is the only FDA approved product of its type. Adequan has been clinically shown to help treat the disease while giving relief from pain. It modifies the disease cycle, stimulates cartilage repair processes and diminishes joint damage while reducing the pain caused by osteoarthritis.

What should I discuss with my veterinarian before giving Adequan:

Tell your veterinarian if your dog has any known or suspected bleeding disorders. Tell your veterinarian if your dog has any liver or kidney disease. Tell your veterinarian if your dog is breeding, pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Adequan is given by intramuscular (IM, into the muscle) injection. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. If you have difficulty giving the medication, contact your veterinarian. Store Adequan at 68° - 77° F (20° - 25° C) excursions permitted to 59° - 86° (15° - 30° C). Keep this medication out of the reach of children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What should I avoid while giving Adequan:

Do not give this medication to breeding, pregnant or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

What are the possible side effects of Adequan:

Few side effects are seen following Intramuscular injection. Stop giving Adequan and seek emergency veterinary medical attention if an allergic reaction (facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma) should occur. Bleeding from the nose, blood in the feces, or dark and tarry stools may indicate a decreased ability of blood to clot. Contact your veterinarian if you notice these symptoms. Other side effects may also occur. Talk to your veterinarian about any side effects that seem unusual or bothersome to your pet.

What other drugs will affect Adequan:

Consult your veterinarian before using any other prescription or over the counter medicines including vitamins and supplements.

Where can I get more information:

Your pharmacist has additional information about Adequan Canine written for health professionals that you may read.

How to Use
  • Adequan is a prescription medication used in dogs for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints and following surgical procedures involving a joint.

Do not give this medication to breeding, pregnant, or lactating animals. Use with caution in animals with kidney or liver disease, or blood clotting or coagulation disorders.

All weights
Inject 2 mg per lb of body weight given only by intramuscular (IM) injection twice a week for up to 4 weeks (a maximum of 8 injections)
Do not use!
Do not use!

Store Adequan at 68° - 77° F (20° - 25° C) excursions permitted to 59° - 86° (15° - 30° C). Keep this medication out of the reach of children and pets.

Adequan (for Dogs):
Active Ingredients
Polysulfated Glycosaminoglycan
100 mg
Benzyl alcohol (a preservative)
0.9% v/v
Other Ingredients: Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity.
Customer Reviews
Adequan for Dogs is rated 4.628865979381444 out of 5 by 97.
Rated 5 out of 5 by from A miracle for my dog My Shepherd had FHO surgery due to serious hip dysplasia. We did PT with her, including underwater treadmill and anti-inflamatory drugs, which helped. But nothing has made a difference like the adequan shots. Every few days for 3 weeks now once every 3 weeks. It's made such a difference for her. She's even jumping up on people - it's an amazing problem to have with this dog!
Date published: 2016-09-18
Rated 5 out of 5 by from very effective for helping w hip dysplasia pain I've been using this for a year w my older boxer. This keeps he comfortable, active and playful. Just hate to have to inject it. Ugh
Date published: 2016-09-10
Rated 5 out of 5 by from My dog can walk again!!! I have a large Newfoundland/Labrador mix with hip problems and diabetes. He is 12 years old now. A few months ago he somewhat suddenly was unable to get up, walk around, or support his own weight in his back hips after simultaneously being diagnosed with diabetes. He would try, but I had to help him around, by using my arms like a sling. I honestly thought I was going to have to put him down. I didn't know what to do right away so it was 2 weeks before I found out about and received Adequan. I followed the instructions, giving him 2 shots a week for 4 weeks. Three and a half weeks after I started the injections he was still not walking. It wasn't until 2 days after the last loading dose that he was able to get up on his own and walk outside. So it took 30 days from the first injection before I saw him walk again. I could tell he was gaining strength as I helped him along in the weeks leading up to the end of the loading dose, so I know he was getting stronger and feeling better right away. I should also note that at the time his blood sugar was still quite high, about 3.5x what it should be. So, all thought he was also receiving insulin for about 6 weeks before he recovered, I feel the Adequan did more to treat his hips and help him regain strength but I'm an engineer, not a Dr. Now: 3 months later. I give my dog adequan every 2 weeks now to maintain his strenght and mobility. He is doing so much better its really unbelievable. I only wish I had known about adequan sooner and started it before his hips got as bad as they did. Still, I can't say enough how well this has worked for my dog. Be patient and work through the whole dose. I didn't observe any ill effects from using Adequan. I monitor his blood glucose closely and never witnessed a spike or abnormal readings after an Adequan injection.
Date published: 2016-06-07
Rated 5 out of 5 by from Great Pain Relief Really has helped my dog ...relieved his pain and he is able to walk without limping and wincing ...
Date published: 2016-04-27
Rated 4 out of 5 by from Improved movement My cat has been on this for 8 months. She is 16 years old with advanced arthritis in her elbows and knees. She moves better at the every 2 week maintenance dosing than our original 4 week plan. This is only part of her arthritis pain control plan but has shown the biggest impact. She is more active and social when she is on Adequan.
Date published: 2016-04-05
Rated 5 out of 5 by from Bought us some time. Our Shepherd is in terrible shape with arthritis and hip dysplasia. We were ready to put her down. Then we heard about Adequan. Our 12 yr old is still not in the best of shape but much better than what she was and also not in the pain she was in. I truly believe this drug has given us at least another year with our baby maybe even more.
Date published: 2016-03-16
Rated 4 out of 5 by from I believe it has helped... My german shepherd was tearing her ACL's on both knees when our vet suggested we try this drug. Yes its expensive when you first try it because you have to get 4 weeks at first but now its only once a month. Our german shepherd is going to be 11 yrs old in April and we have noticed a difference but we know that when its icy out we take her out on a leash even though we have a fenced in yard because we don't want her to hurt herself. She is our baby and you take care of your baby. We have had her since she was 6 weeks old she has birth defects in which this adequan maybe helping her because she has one paw that is 2 inches shorter gives the joints a little more wear and tear.
Date published: 2016-03-06
Rated 5 out of 5 by from Magic! I've been giving my 10 year old 80lb Rottweiler, Brandy Adequan shots once a month for about a year now. This is the only product that makes her like a puppy again. She suffers from hip dysplasia and arthritis, but after the Adequan, she trots along with ease.
Date published: 2016-01-29
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What dosage of canine adequate for 65lb dog?

Asked by: Liberty001
An estimated dose would be 130mg twice weekly. Contact your veterinarian about a more specific dosing regimen.
Answered by: paulpharmacistintern
Date published: 2016-08-17

How often can I give my dog 1.5 cc Adequan

Asked by: PaulShaktman
It's normally dosed twice a week, however if you want to do that more frequently, contact your veterinarian about this before doing so.
Answered by: paulpharmacistintern
Date published: 2016-07-28

How often can Cosequan injections be repeated for dogs

I gave Cosequan injection to my dog about a year ago but he is now progressively getting worse with DJD and probable hip dysplasia. How often can the doses be repeated after the 4 weei regiman. Thank you
Asked by: Robinvrn
Ask your vet--if they know your dog well, they may recommend increasing the frequency. 
Answered by: SFDogmom
Date published: 2016-05-12

Adequan and Novox

Small dog has been taking 25 mg carprofen (Novox) once a day. Today, the vet wants to start .25mg Adequan twice a week for four weeks and then once every two to four weeks after that. Is it safe to give the carprofen daily while give twice weekly shots of Adequan?
Asked by: Anttee
There is no known drug interaction between these 2 medications. Talk to your veterinarian if using both are appropriate for your pet.
Answered by: Cheryl-Pharmacist
Date published: 2015-04-10

veternarian perscription

what if im a Canadian and want to buy adequan and some heartworm meds.? do you accept a Canadian vets info I provide ,do you call or notify him? what if he wont ok it for some reason. im sure the vet here would not give the script if they are getting $49.00 for 1 shot,of 1cc of adequan.i would like to buy it for sure when I can get 100 cc bottle for $149.00 before dec.14. do you have other way of me getting this in this case??
Asked by: dancer
We can accept international prescriptons for this medication as long as we are provided with a valid prescription from a licensed veterinarian.
Answered by: Stephanie Duesler, Pharm. D, MBA
Date published: 2015-01-14

Can I use Adequan with Rimadyl and Dasuquin w/ msm?

Asked by: Kanch
My 90 pound Rottweiler is receiving Adequan injections and has also been prescribed Rimadyl and Dasuquin to be taken daily. Eventually I will use the Rimadyl PRN as needed, but continue the Dasuquin on a daily basis.
Answered by: mikihaas
Date published: 2014-12-08

So confused.

I use adequan on my horse and it is a miracle worker. With the canine (my dog is 90lbs.) to start is it once a week for 6 weeks, than 1 injection a month?
Asked by: Laura
I have a young 90 pound Rottweiler who recently had bilateral elbow surgery related to arthritis. The Rehab Vet is administering Adequan IM twice a week for one month and then my Rottweiler will be receiving the medication SQ once a week for life.
Answered by: mikihaas
Date published: 2014-12-08

The directions say to inject into the muscle, my vet has me pull up her neck scruff and inject it in, is it as effective this way?

Asked by: Destiny
My young Rottweiler recently had bilateral elbow surgery and is in rehab. The rehab Vet is administering the medication IM into her thigh muscle twice a week for one month and then she will be receiving the medication once a week SQ for life. The scruff of the neck in which you are referencing is SQ. The Vet noted that the IM injection causes discomfort, but is necessary when initiating the medication and stated SQ administration causes minor discomfort if any.
Answered by: mikihaas
Date published: 2014-12-08
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