My Account

Zymox Otic Enzymatic Solution Hydrocortisone Free

Starts $24.99 $16.99 
Ships in one business day or less
Select an Option:
1.25 oz
Price w/coupon PETS15
You save $7
4 oz
Price w/coupon PETS15
You save $15
Starts $24.99 $16.99 
Ships in one business day or less
Please select all product options.
Select a Quantity:
Please select all product options.
Product Info
How to Use
Customer Reviews
Product Info
What is Zymox Otic Enzymatic Solution Hydrocortisone Free?

Zymox Otic Enzymatic Solution Hydrocortisone Free for dogs and cats treats the external ear for acute and chronic inflammation caused by bacterial, viral, and yeast infections. Some factors that may contribute to possible ear infections include: excessive hair, a suppressed immune system, and excessive skin folds in the ear. Zymox Otic Enzymatic Solution with Hydrocortisone is available for dogs and cats who need relief from itching, inflammation, redness, and swelling. Note: Zymox Otic Enzymatic Solution may not work if used with other topical ear medications or cleansers.


Cats and Dogs

  • Treats both acute and chronic ear infections
  • Prevents viral infections
  • Great alternative to more expensive prescription medications
  • No reported side effects
How it works:

Zymox Otic Enzymatic Solution has what the manufacturer calls a Three-Point Enzyme System. Each enzyme - lactoperoxidase, lysozyme, and lactoferrin - has its own unique properties that, when combined, becomes a powerful antimicrobial formula.

The antibacterial property of the lactoperoxidase is based upon inhibiting vital bacterial metabolic enzymes. Lysozyme kills bacteria by disrupting the formation of a glycosidic bond between the two components of peptidoglycan, a constituent of the bacterial cell wall. Lastly, lactoferrin - an iron-binding protein - is bacteriostatic against a wide range of microorganisms, which means it inhibits the growth of the bacteria.


Do not use this product when using any other topical ear medications or cleansers, since the enzyme activity of Zymox Otic Enzymatic Solution Hydrocortisone Free may not work.

Brand Name:

Zymox Otic Enzymatic Solution (Pet King Brands)

Active Ingredient(s)

Lactoperoxidase system plus Lysozyme, Lactoferrin

What is this product used for:

Zymox Otic (without hydrocortisone) is used in cats and dogs for the treatment of acute and chronic otitis externa due to bacterial, viral and yeast infections.


Zymox Otic is a non-prescription (OTC) product available in 1.25 oz and 4 oz containers.

How this product should be used:

Apply liberally to fill the ear canal. Gently massage, working the medication into the infected area. Permit the pet to shake their head to remove excess medication. For acute infections treat once a day for 7 days. For chronic infections, treat once a day for 14 days.

In the event of overdose:

Not applicable.

What are the side effects:

There are no reported side effects.

What special precautions are there:

Do not use this product when using any other topical ear medications or cleaners. This product is for animal use only.

How should I store this product:

Store the unopened product in a cool, dry place. After opening, store in the refrigerator and use within 90 days.

How to Use
  • Zymox Otic Enzymatic Solution is used for the treatment of ear infections in dogs and cats.
  • Do not use this product when using any other topical ear medications or cleansers.
  • For animal use only.

Gently massage, working medication into infected area. Allow your pet to shake head to remove excess medication.

All weights
Apply liberally to fill ear canal. Gently massage and work into infected area. Wipe to remove excess. For acute infections, treat once a day for 7 days. For chronic infections, treat once a day for 14 days.
Do not use!

Store at room temperature.

Zymox Otic Enzymatic Solution Hydrocortisone Free:

Active Ingredients: Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.

Customer Reviews
Zymox Otic Enzymatic Solution Hydrocortisone Free is rated 4.6667 out of 5 by 84.
Rated 5 out of 5 by from Life saving My dog has had very bad ear infections we have changed her foods paid tons of money for medicines that's didn't seem to help and actually made her cry. We were at the point one Benadryl on days her ears were bad wasn't helpin anymore. She was scratch her ears until they gushed blood and shaking her head got blood all over the house. Bought this medicine and on the 3day you could tell the difference. She's a happy dog again and back to wagging her tail.
Date published: 2016-05-05
Rated 5 out of 5 by from Works awesome!! We took in a senior bulldog with chronic ear problems. She had swelling causing hearing difficulties prior to using the meds. The swelling has reduced drastically and she is hearing again!!!
Date published: 2016-03-20
Rated 4 out of 5 by from Helpful As soon as I received this med, I used it on my dog who is 15 years old and has always had ear problems (yellow lab). The very next day he was more active than he has been in a very long time. I am grateful I found this product. Thank you.
Date published: 2015-06-29
Rated 5 out of 5 by from Would highly recommend My dog has had chronic ear issues for a long time. I used this product for 14 days and the change is amazing. Ears look pink and healthy. He willingly lets me perform the treatments. I have to put a Gentle Leader on him first. I will continue a little longer as I can still see some infection deeper.
Date published: 2015-05-08
Rated 5 out of 5 by from Amazing Bear is a big, strong, serious dog. In 7 years, I've never heard him cry - till I saw him desperately rubbing his inflamed ears. It was heartbreaking. His ears have been a recurring problem for years. This products is the ONLY thing that has ever worked. It took a few days to get things under control but now Bear's ears are much better. He hates anything dripping down into his ears so my own method is to slip an old sock over my hand, soak the end of the sock with Zymox, apply it to his ears, and immediately wash the sock.
Date published: 2015-04-08
Rated 5 out of 5 by from Relief! I admit being skeptical about the purported benefits of this product. Boy was I wrong. Zeus actually WANTS his ear treatment each evening. He hears better, the scratching and rubbing has stopped. He feels better, too! Knowing this is available, I will keep some handy. Am also surprised at the amount that comes in this small bottle. Thank you for helping my Big Guy!
Date published: 2014-08-07
Rated 5 out of 5 by from Excellent!!! Our dog shakes her head due to "allergies". I add the drops & change her diet to raw diet (meat & whole foods only) w/in 3 days she is cleared up thanks to the meds! and diet...
Date published: 2014-06-29
Rated 5 out of 5 by from Ears cured! I purchased this product not really thinking it would help with my dogs ears, but at this point I figured it couldn't hurt.I have been to more than one vet with bills after bills, with no results to helping his ears which were infected , itchy and very smelly.After a week of using this product the results have been amazing.Im not one to write reviews but this time I had to!
Date published: 2014-05-26
  • 2017-01-22T06:06CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_1, tr_83
  • loc_en_US, sid_prod338153, PRD, sort_mostRecent
  • clientName_1800petmeds

My pet is on several eye drops that she takes 3 times a day. Does they zymox interfere or affect these mess she takes Diclofenac, neopolydex (Abv),latanoprost, dorzolamide. For her eye pressure.  

Asked by: Lily may
Zymox is an EAR drop and should be placed in the ear only. It should not interfere with any of the eye drops your pet is taking for her eye pressure.
Answered by: Christine
Date published: 2016-10-21

Can i use the product if my cat has no ear drum?

Asked by: carrie
Hi there, This medication is not dropped in the ear it is simply massaged in the ear however it would be a question to ask your vet since he would know your Furry Baby the best.
Answered by: James PetMeds Pro
Date published: 2015-03-27

Does this ear product have any scent?

I can only find the active ingredients not the total list of ingredients. Is this product scented and can someone list all the ingredients for and inactive ingredients please. Thank you. :)
Asked by: DRex
This does not have a scent. Active Ingredients: Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase. It does not list any inactive ingredients. As with many pet products, Many companies have Proprietary inert ingredients which any product could have. It is a way manufacturers do not reveal their ingredients so other companies do not copy there product. The EPA/ FDA are aware of the ingredients but the company is not required to disclose it to the public. You may contact them directly
Answered by: James PetMeds Pro
Date published: 2014-11-21

Can Cat or Dog ingest medication?

Asked by: cricket
Thank you for your question. No, this should not be ingested.
Answered by: Maureen PetMeds Pro
Date published: 2014-10-27

Can this cause eye irritation if it gets in the eye?

Asked by: Mandy
Answered by: Lilli Pharmacist
Date published: 2013-11-18

Ear infections and allergies

Seems like our golden retriever has had too many ear infections these last 3 years. We understand it is from allergies. He scratches less now that we found a food that is working finally. But he just came down with another ear infection so I had some extra Otibiotic from the vet last time. Our vet suggested we give him one adult size 50 mg Benadryl non drowsy to help him with his scratching but I don't want to do this. I am confussed, do I order the ZymoxOtic Enzymatic Solution Hydrocortison Free product or the Zymox Otic topical ear maintenance? Which one clears up an ear infection and which one is weekly maintenance? How long do I wait to use the correct Zymox after I stop the Otibiotic?
Asked by: Sandra
We are very sorry to hear about your furry baby's ear infections. Both Zymox Enzymatic Solution with hydrocortisone and the hydrocortisone free Zymox will clear your furry baby's ear infection. The only difference in the two is that one includes hydrocortisone which helps with the itching and the other one is hydrocortisone free. Both forms comes in two sizes, 1.25 oz and 4.0 oz. For acute infections, treat once a day for 7 days. For chronic infections, treat once a day for 14 days. You should consult with your veterinarian to see how long you should wait to start your furry baby on the Zymox after stopping the Otibiotic....
Answered by: Cherley Petmeds Pro
Date published: 2013-03-23

how many drops should i put in each of my dog's ear?

Asked by: harley
I "filled" the ear canals, rubbed it around so it got everywhere within the ear, and wiped away the excess.
Answered by: Josie's Person
Date published: 2013-02-05

I have Zymox ear drops already but it expired 07/2012 can I still use it or should I purchase another.

Asked by: Linda
I would say to give it a try. If is doesn't work, buy a new bottle.
Answered by: Josie's Person
Date published: 2013-02-05
  • 2017-01-22T06:08CST
  • bvseo_cps, prod_bvqa, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_31
  • loc_en_US, sid_prod338153, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Share Website Feedback