Zeniquin is a synthetic broad-spectrum antibacterial. It’s indicated for the treatment of infections associated with bacteria susceptible to marbofloxacin. Zeniquin requires a prescription from your veterinarian, and is sold by the tablet.
For: Cats (over 12 months of age) Dogs (small and medium breeds over 8 months of age, large breeds over 12 months of age and giant breeds over 18 months of age)
Benefits:
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Has an excellent safety profile
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Once-a-day dosing and easy-to-swallow film-coated tablets that help improve client compliance
How it works: Zeniquin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA replication.
Cautions: Tell your veterinarian if your pet has seizures or other central nervous system disorders, or if your pet is breeding, pregnant, or lactating. Do not give Zeniquin to pets that may be allergic to it or other fluoroquinolone antibiotics. Do not give Zeniquin within two hours of administering Carafate (sucralfate), antacids, or foods and vitamin/mineral products containing iron, aluminum, calcium, magnesium, or zinc.
More Information:
Brand Name Zeniquin (Pfizer Animal Health)
Generic Name marbofloxacin
What is the most important information I should know about Zeniquin: Zeniquin is a prescription medication FDA-approved for veterinary use in dogs and cats. Zeniquin is available as 25mg, 50mg, and 100mg film-coated scored tablets. Always follow the dosage instructions provided by your veterinarian. Do not give Zeniquin to any pet other than the pet for whom it was prescribed. Zeniquin is not for use in animals allergic to it or other fluoroquinolone antibiotic drugs. Zeniquin should not be used in cats younger than 12 months of age or dogs during their rapid growth phase which can vary from 8 to 18 months based on the breed. Zeniquin may affect the retina of cats.
What is Zeniquin: Zeniquin is a broad spectrum oral fluoroquinolone antibiotic used for the treatment of bacterial infections such as skin and soft-tissue infections and urinary tract infections due to susceptible organisms. This medication may also be used for purposes other than those listed in this guide.
What should I discuss with my veterinarian before giving Zeniquin to my pet: Tell your veterinarian if your pet has seizures or other central nervous system (CNS) disorders, or if your pet is breeding, pregnant, or lactating.
How should this medication be given: Give this medication exactly as directed by your veterinarian. Give all of the medication your veterinarian has prescribed. Symptoms may start to improve before the infection is completely treated. The usual dose of Zeniquin for dogs and cats is 1.25mg per pound given once a day, but the dosage may be increased to 2.5mg per pound. Treatment should continue for a maximum of 30 days; however, if there is no improvement after 5 days, your pet should be reevaluated. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Zeniquin at room temperature away from moisture and heat. Keep this medication away from children and pets.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.
What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of overdose may include loss of appetite, vomiting, dehydration, excessive salivation, tremors, reddened skin, or facial swelling.
What should I avoid while giving Zeniquin to my pet: Do not give Zeniquin to animals allergic to it or other fluoroquinolone antibiotics. Do not give Zeniquin within 2 hours of administering Carafate (sucralfate), or other antacids or foods and supplements containing iron, aluminum, calcium, magnesium, and zinc.
What are the possible side effects of Zeniquin: Stop giving the medication and seek emergency veterinary medical attention if your pet experiences an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue or face; or hives). Other less serious side effects may also occur. Continue to give the medication and talk to your veterinarian if your pet experiences loss of appetite, vomiting, diarrhea, dizziness, or drowsiness. Side effects other than those listed may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the pet.
What other drugs will affect Zeniquin: Drugs other than those listed may also interact with Zeniquin. Talk to your veterinarian or pharmacist before giving any other prescription or over-the-counter medications.
Where can I get more information: Your pharmacist has additional information about Zeniquin written for health professionals that you may read.
Directions:
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Zeniquin is a prescription broad-spectrum oral antibiotic used in dogs and cats for the treatment of bacterial infections such as skin and soft-tissue infections and urinary tract infections due to susceptible organisms.
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Give this medication exactly as directed by your veterinarian.
Tip: Zeniquin should not be used in cats younger than 12 months of age or dogs during their rapid growth phase which can vary from 8-18 months based on the breed (small and medium breeds up to 8 months of age, large breeds up to 12 months of age and giant breeds up to 18 months of age).
Dosage:
Pet
Weight
Dosage
Dogs: (Over 8-18 months of age depending on breed) Cats: (Over 12 months of age)
All weights
The usual dose 1.25mg per pound of pet’s body weight given once a day, but the dosage may be increased to 2.5mg per pound of pet’s body weight. For treatment of skin and soft tissue infections, give for 2-3 days after symptoms are gone, for a maximum of 30 days. For treatment of urinary tract infections, give for at least 10 days. However, if there is no improvement after 5 days the pet should be reevaluated.
Horses:
Storage: Store Zeniquin at room temperature away from moisture and heat.
Rocky's prognosis for a nasal tumor after surgery was 3 months and that was almost 5 years ago. Zeniquin has worked really well for her. We started with a round of one week on, 3 weeks off but she now gets every day. It is expensive but has bought us years together. She is comfortable and she lives a pretty good life. We definitely have had quality time together as she is much more social and more like her old self when she doesn't feel poorly.
Casey developed a mycobacterial infection which is rare and most vets do not know how to treat. We started out on doxycyclene, which worked until we took him off thinking it was cured. When the infection returned he had become resistant to it. The vet offered very little hope of recovery. My husband is an RN and he researched for a solution and came up with this med. We presented the facts to the vet and she gave us the prescription. Casey has been on it for over a year and looks like he will be on it for life. Expensive - yes, but he is in remission and living a normal life.
Our bloodhound, Ginger, has had chronic ear infections- especially as she ages. She had a round of another antibiotic and then a culture showed the (human) med she was on was not going to touch what she had. The ear was absolutely disgusting by the time the Zeniquin arrived. After only 6 days it was almost completely clear- she is like a puppy again ( a 120 lb, 10 year old puppy).
Be careful and watch your animal when giving Zenequin. Veterinarians will not admit it but I strongly believe Zenequin caused the demise of my cat. She was on this drug for 16 days for a urinary tract infection and in the end had uncontrollable seizures that couldn't be stopped by any procedure the vet tried. This was even after the medicine was stopped for two days. I didn't put the Zenequin together with the seizures till I took her off the medicine and started researching side effects. Seizures and tremors and staggering are the like are definitely side effects of Zenequin. Vets will tell you that Zenequin is safe but i have strong doubts. Please be very very careful when dealing with Zenequin and watch the cat behavior very carefully. Don't lose your beloved pet like i did.
He has taken 2 months and greatly improved but not completely better. Is is safe to give him another month? He seems to be tolerating it well but has not had any bloodwork or anything. He is 9 and I worry about side effects.
Our vet suggested giving her Pepsid AC about 3hrs prior to giving her the Zenequin. Does this sound about right since I know that this medication may not be absorbed properly???
Unfortunately, vomiting is a common side effect of Zeniquin. As long as you give Pepcid AC 3 hours before giving Zeniquin, there will be no problem. There is only a potential issue when it is given within 2 hours of the Zeniquin dose.
About 6-9 hours after I give him his pill he acts like he feels real bad and kind of shivers when you hold him. Also, right after I give it to him he acts like his stomach hurts. Later in the evening and over night and especially by the next morning he is like his old self. Then it starts over again when I give him the pill. He has had 5 pills and today I did not give him one. What is your opinion? Do you think it is alright to have stopped the meds to see if he is acting right all the time, or should I finish them eventhough he seems to feel bad?
Antibiotics such as Zeniquin are meant to be given until used up. You've already stopped giving the medication. I would have recommended continuing the medicine but also calling the veterinarian to discuss your pet's side effects, I would still recommend you speak to your veterinarian, at least to let him/her know you've stopped giving the antibiotic.
There is data to suggest that giving Zeniquin to a diabetic dog may affect the action of insulin. Therefore, the pet's insulin dose may need to be adjusted by your veterinarian.
My cat has had blood in her urine (only seen by vet at exam time) for a long time. Never treated b/c Dr. didn't know what it was. Always cultured, always neg. This time she showed up with an infection and is on Zeniquin. I am thinking she might have a cyst causing the bleeding that then was susceptible to the infection. What do you think? How would she be tested for a cyst? Thanks.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.
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