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Product Info
How to Use
Customer Reviews
Product Info
What is Vetoryl?

Vetoryl Capsules are used to treat dogs with hyperadrenocorticism (Cushing's Disease). Vetoryl requires a prescription from your veterinarian.



  • Improvement may be seen within several weeks
  • Available in 10 mg, 30 mg, 60 mg or 120 mg capsules (based on weight)
How it Works:

Vetoryl contains a drug that controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress.


Do not give this medication to dogs with kidney or liver disease. Vetoryl capsules should not be given to dogs taking certain medications or dogs that are pregnant. Speak with your veterinarian about all medications your dog is taking, including over-the-counter medicines.

Brand Name:


Generic Name:


What is the most important information I should know about Vetoryl:

Vetoryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's Disease. Vetoryl is indicated for use in pituitary-dependent hyperadrenocorticism. Vetoryl also has a Minor Use designation for treatment of Cushing's Disease caused by adrenal tumors. Vetoryl is available as 10mg capsules, 30 mg capsules, 60 mg capsules and 120 mg capsules. The usual initial starting dose to treat Cushing's Disease in dogs is 1.0 to 3.0 mg/pound given once a day based on body weight and capsule size. For dogs at least 3.8 up to 10 lbs give one 10 mg capsules once a day. For dogs at least 10 lbs up to 22 lbs give one 30 mg capsules once a day. For dogs at least 22 lbs up to 44 lbs give one 60 mg capsule. For dogs at least 44 lbs up to 88 lbs give one 120 mg capsule. For dogs at least 88 lbs up to 132 lbs give one 120 mg capsule and one 60 mg capsule, totaling 180 mg. For dogs over 132 lbs give the appropriate combination of capsules. Vetoryl should be given with food. After approximately 10 to 14 days the pet will need to be re-examined and dosage adjustments may be required. Pets may require further re-examination at 30 days, 90 days, and every 3 months thereafter.

What is Vetoryl:

Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependent Cushing's Disease and Cushing's Disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl.

What should I discuss with my veterinarian before giving Vetoryl to my pet:

Tell your veterinarian if your pet has kidney or liver disease. Tell your veterinarian about any other medical problems or allergies your dog has now or has had in the past. Tell your veterinarian about any medications your dog is taking including over the counter products and nutritional supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your dog.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Give this medication with food. Do not open capsules and do not attempt to split or divide capsules. Wash your hands after use. Do not handle the capsules if you are pregnant or trying to become pregnant. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Vetoryl at controlled room temperature (77°F) with excursions to 86° F allowed. Keep this medication away from children and other pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of Vetoryl overdose may include lethargy, weakness, vomiting, or collapse.

What should I avoid while giving Vetoryl to my pet:

Do not give Vetoryl to dogs with kidney or liver disease. Do not give to pregnant or nursing dogs or dogs intended for breeding. Do not touch Vetoryl capsules if you are pregnant or trying to become pregnant.

What are the possible side effects of Vetoryl:

If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Vetoryl:

Before giving Vetoryl tell your veterinarian if your pet is also taking ACE inhibitors such as enalapril, potassium sparing diuretics such as spironolactone, ketoconazole, or potassium supplements. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines or nutritional supplements.

Where can I get more information:

Your pharmacist has additional information about Vetoryl written for health professionals that you may read.

How to Use
  • Vetoryl is used to treat dogs with hyperadrenocorticism, also known as Cushing's Disease.
  • Vetoryl capsules should be given with food.

Do not open capsules and do not attempt to split or divide capsule.

3.8 to 10 lbs
1 capsule of 10 mg daily
10 to 22 lbs
1 capsule of 30 mg daily
22 to 44 lbs
1 capsule of 60 mg daily
44 to 88 lbs
1 capsule of 120 mg daily
88 to 132 lbs
1 capsule of 120 mg plus 1 60 mg capsule daily (180 mg total)
Over 132 lbs
Administer the appropriate amount of capsules based on dog's weight. Speak with your veterinarian to help you determine the correct dosage for your dog.
Do not use!
Do not use!

Should be stored at room temperature. Keep out of reach of children.

Vetoryl Capsules (10 mg)
Active Ingredients
10 mg
Vetoryl Capsules (30 mg)
Active Ingredients
30 mg
Vetoryl Capsules (60 mg)
Active Ingredients
60 mg
Vetoryl Capsules (120 mg)
Active Ingredients
120 mg
Customer Reviews
Vetoryl is rated 4.388888888888889 out of 5 by 18.
Rated 5 out of 5 by from Worked Great! My doxie Sandi was diagnosed with cushings at age 10. She was on the meds for 5 years until she passed this year at age 15. Once a dog is diagnosed with cushings, they are expected to live an average of 3 more years before the tumor can no longer be managed. My Sandi lived for 5 years. Vetoryl was amazing for her. Within weeks of starting it, she showed huge improvements. She lived a full and happy life with no side effects from the medication. It helped give us many great years together. It was also much cheaper than the original meds my vet wanted to prescribe.
Date published: 2016-04-16
Rated 5 out of 5 by from Incredible I bought Vetoryl because the vet advise my family it would help our dog (lapsa apso), she was diagnosed with cushing disease and she lost all her hair and energy. After just 5 months she has improved incredibly and her hair is growing back FAST!
Date published: 2016-03-27
Rated 5 out of 5 by from Meds have helped! Since my dog has been on the vetoryl capsules, she seems to her old self. That have made a difference in her quality of life.
Date published: 2016-03-12
Rated 5 out of 5 by from The product has helped my dog greatly. The product is excellent. The price on this website is outrageous. I can get it for much less at my vet's office.
Date published: 2014-03-08
Rated 5 out of 5 by from Wonderful for Cushings Syndrome Our girl, Molly, an Australian Cattle Dog, was drinking water and eating all the time. She would even eat rocks as she was thinking she was thirsty and hungry all the time. She got so fat and we were cleaning up "accidents" all the time. I found what I thought was her problem on the internet and advised our Vet of what I thought it was. We did all the "tests" and nothing was conclusive. But convinced Vet to put her on a Cushings Medication. She choose Vetoryl 120 mg. It took a couple of weeks before we noticed a difference. It has been 5 months and Molly is back to herself! Her eyes were bulging as she has the Pituitary Cushings, her stomach was huge and she had no energy, her fur was falling out and she had no muscle tone. She is now acting like a pup again and she is 11 years old. Amazing stuff! Thank you God!
Date published: 2013-07-20
Rated 1 out of 5 by from Careful of Diagnosis and Dose Vet determined our German Shorthair had Cushings. Prescribed 60mg dose for 60# dog. Caused her to pace uncontrollably and lose balance. Backed off to 30mg dose with similar results in about 5 days of drug. Have backed her off of Vetoryl completely - she was much healthier and happier without this prescription. Not clear why it didn't work for our dog.
Date published: 2013-02-06
Rated 5 out of 5 by from vetoryl Wow, We too have a 14 year old cocker spaniel and she had uncontrollable shakes and panting. drinking water non stop and urinating wife diagnosed using internet. Vet prescribed Vetoryl capsules and it saved her life, shes old but is back to normal, if we miss a day on the pill she gets symptoms right back so we give it to her every other day and shes just fine. Thanks, Tony
Date published: 2012-02-03
Rated 5 out of 5 by from Life changer I have a 7 year old Cocker mix that has developed Cushings. She used to pant uncontrollably, have very dry brittle hair, and was always thirsty and hungry. She was very needy because she seemed to need constant pampering and reassurance. After starting this product, she has become a new dog. She sleeps through the night without having to go out continually, and she doesn't pant all the time. She now has a beautiful coat , and seems to have lots of energy to play. It has been a life changer for her and for our family.
Date published: 2011-11-14
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Can Vetoryl given in the evening with a meal?

Asked by: Dehinebaugh
Vetoryl helps to treat Cushing's disease by decreasing cortisol levels. Cortisol levels are highest in the morning, which is why it is beneficial to give Vetoryl in the morning. It is also important to give it with food, as this increases absorption.
Answered by: Christine
Date published: 2016-10-11

Why can't humans touch this if trying to get pregnant? 

Asked by: MarleyTheBoxer
Vetoryl contains the active ingredient Trilostane, which can reduce the synthesis of progesterone, an important hormone in pregnancy. It is considered a pregnancy category X and should be handled with care in pregnant women or women wishing to become pregnant.
Answered by: Christine
Date published: 2016-10-10

Do you need a prescription? 

Asked by: MarleyTheBoxer
Thank you for your question. Yes it is a prescribed medication.
Answered by: James PetMeds Pro
Date published: 2016-07-21

My dog is taking Denamarin 425 and Furosemide 20 mg She can take Vetoryl?

Asked by: Wanda
yes, the vetoryl can be given with the denamarin and furosemide
Answered by: Linda M 1800petmeds pharmacist
Date published: 2015-07-24

Trilostane 30mg

Is a chewable 30mg or 40mg available. Currently taking 10mg and 30mg. Divots anxious mom.
Asked by: lainie
Trilostane is available in 10mg ,30mg, 60mg,and 120mg strengths.Thanks for your question.
Answered by: Marty, Pharm. D.
Date published: 2015-05-18

Can I order Trilostane 30mg capsules?

I want to order Trilostane capsules the generic for veroryl capsules.
Asked by: Smurfsmomrags
How much for generic 30mg vetoryl
Answered by: Doreen
Date published: 2015-04-08

I need Trilostane 20mg chew tabs chicken flavor

Do you have these available?
Asked by: Buttercup's Mom
Thank you for your question. No, we do not carry this milligram of medication.
Answered by: Maureen PetMeds Pro
Date published: 2015-03-19

will it hurt my dog to miss two doses of Vetoryl

Asked by: brink
Contact your Vet. Mine told me it is better to keep the dosage consistant as it affeccts the production of Cortisol.
Answered by: TJGIRL
Date published: 2015-01-24
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