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  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Vetoryl?

Vetoryl Capsules are used to treat dogs with hyperadrenocorticism (Cushing's Disease). Vetoryl requires a prescription from your veterinarian.
Alternate photos:
  Vetoryl (10 mg)
  Vetoryl (30 mg)
  Vetoryl (60 mg)
  Vetoryl (120 mg)
For: Dogs

Improvement may be seen within several weeks
Available in 10 mg, 30 mg, 60 mg or 120 mg capsules (based on weight)

How it works:
Vetoryl contains a drug that controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress.

Do not give this medication to dogs with kidney or liver disease. Vetoryl capsules should not be given to dogs taking certain medications or dogs that are pregnant. Speak with your veterinarian about all medications your dog is taking, including over-the-counter medicines.

More Information:
Brand Name
Generic Name
What is the most important information I should know about Vetoryl:
Vetoryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's Disease. Vetoryl is indicated for use in pituitary-dependant hyperadrenocorticism. Vetoryl also has a Minor Use designation for treatment of Cushing's Disease caused by adrenal tumors. Vetoryl is available as 10mg capsules, 30 mg capsules, 60 mg capsules and 120 mg capsules. The usual initial starting dose to treat Cushing's Disease in dogs is 1.0 to 3.0 mg/pound given once a day based on body weight and capsule size. For dogs at least 3.8 up to 10 lbs give one 10 mg capsules once a day. For dogs at least 10 lbs up to 22 lbs give one 30 mg capsules once a day. For dogs at least 22 lbs up to 44 lbs give one 60 mg capsule. For dogs at least 44 lbs up to 88 lbs give one 120 mg capsule. For dogs at least 88 lbs up to 132 lbs give one 120 mg capsule and one 60 mg capsule, totaling 180 mg. For dogs over 132 lbs give the appropriate combination of capsules. Vetoryl should be given with food. After approximately 10 to 14 days the pet will need to be re-examined and dosage adjustments may be required. Pets may require further re-examination at 30 days, 90 days, and every 3 months thereafter.
What is Vetoryl:
Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependant Cushing's Disease and Cushing's Disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl.
What should I discuss with my veterinarian before giving Vetoryl to my pet:
Tell your veterinarian if your pet has kidney or liver disease. Tell your veterinarian about any other medical problems or allergies your dog has now or has had in the past. Tell your veterinarian about any medications your dog is taking including over the counter products and nutritional supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your dog.
How should this medication be given:
Give this medication exactly as directed by your veterinarian. Give this medication with food. Do not open capsules and do not attempt to split or divide capsules. Wash your hands after use. Do not handle the capsules if you are pregnant or trying to become pregnant. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Vetoryl at controlled room temperature (77įF) with excursions to 86į F allowed. Keep this medication away from children and other pets.
What happens if I miss giving a dose:
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet:
Seek emergency veterinary medical treatment. Symptoms of Vetoryl overdose may include lethargy, weakness, vomiting, or collapse.
What should I avoid while giving Vetoryl to my pet:
Do not give Vetoryl to dogs with kidney or liver disease. Do not give to pregnant or nursing dogs or dogs intended for breeding. Do not touch Vetoryl capsules if you are pregnant or trying to become pregnant.
What are the possible side effects of Vetoryl:
If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Vetoryl:
Before giving Vetoryl tell your veterinarian if your pet is also taking ACE inhibitors such as enalapril, potassium sparing diuretics such as spironolactone, ketoconazole, or potassium supplements. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines or nutritional supplements.
Where can I get more information:
Your pharmacist has additional information about Vetoryl written for health professionals that you may read.


Vetoryl is used to treat dogs with hyperadrenocorticism, also known as Cushing's Disease.
Vetoryl capsules should be given with food.
Tip: Do not open capsules and do not attempt to split or divide capsule.
Pet Weight Starting Dosage in mg
Dogs/Puppies: 3.8 to 10 lbs 1 capsule of 10 mg daily
10 to 22 lbs 1 capsule of 30 mg daily
22 to 44 lbs 1 capsule of 60 mg daily
44 to 88 lbs 1 capsule of 120 mg daily
88 to 132 lbs 1 capsule of 120 mg plus 1 60 mg capsule daily (180 mg total)
Over 132 lbs Administer the appropriate amount of capsules based on dog's weight. Speak with your veterinarian to help you determine the correct dosage for your dog.
Storage: Should be stored at room temperature. Keep out of reach of children.
Vetoryl Capsules (10 mg)
Active Ingredients Amount
Trilostane 10 mg

Vetoryl Capsules (30 mg)
Active Ingredients Amount
Trilostane 30 mg

Vetoryl Capsules (60 mg)
Active Ingredients Amount
Trilostane 60 mg

Vetoryl Capsules (120 mg)
Active Ingredients Amount
Trilostane 120 mg
Vetoryl 4.5 5 14 14
The product has helped my dog greatly. The product is excellent. The price on this website is outrageous. I can get it for much less at my vet's office. 03/07/2014
Wonderful for Cushings Syndrome Our girl, Molly, an Australian Cattle Dog, was drinking water and eating all the time. She would even eat rocks as she was thinking she was thirsty and hungry all the time. She got so fat and we were cleaning up "accidents" all the time. I found what I thought was her problem on the internet and advised our Vet of what I thought it was. We did all the "tests" and nothing was conclusive. But convinced Vet to put her on a Cushings Medication. She choose Vetoryl 120 mg. It took a couple of weeks before we noticed a difference. It has been 5 months and Molly is back to herself! Her eyes were bulging as she has the Pituitary Cushings, her stomach was huge and she had no energy, her fur was falling out and she had no muscle tone. She is now acting like a pup again and she is 11 years old. Amazing stuff! Thank you God! 07/20/2013
Careful of Diagnosis and Dose Vet determined our German Shorthair had Cushings. Prescribed 60mg dose for 60# dog. Caused her to pace uncontrollably and lose balance. Backed off to 30mg dose with similar results in about 5 days of drug. Have backed her off of Vetoryl completely - she was much healthier and happier without this prescription. Not clear why it didn't work for our dog. 02/06/2013
vetoryl Wow, We too have a 14 year old cocker spaniel and she had uncontrollable shakes and panting. drinking water non stop and urinating wife diagnosed using internet. Vet prescribed Vetoryl capsules and it saved her life, shes old but is back to normal, if we miss a day on the pill she gets symptoms right back so we give it to her every other day and shes just fine. Thanks, Tony 02/03/2012
Life changer I have a 7 year old Cocker mix that has developed Cushings. She used to pant uncontrollably, have very dry brittle hair, and was always thirsty and hungry. She was very needy because she seemed to need constant pampering and reassurance. After starting this product, she has become a new dog. She sleeps through the night without having to go out continually, and she doesn't pant all the time. She now has a beautiful coat , and seems to have lots of energy to play. It has been a life changer for her and for our family. 11/14/2011
15 Questions · 17 Answers

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1 month, 2 weeks ago
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She wants to sit with us now. She has become needy. She is a Lhasa Apso. Please help
9 months ago
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The behavior changes your dog is experiencing are not known to occur with Vetoryl. Please consult with your veterinarian regarding all of your dog's current medications, vitamins, or changes in food.
9 months ago
Pharmacy Intern
Pompano beach
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Will the calcium from cheese causing calcium deposite (calcinosis) within his skin?

Can the Vetoryl capsules be open and sprinlke to food to be administered?
1 year, 2 months ago
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Paul, We give our dog, Molly, hot dog, cheese slices, and also sprinkle on the food. It is always a problem to administer pills to her as she is smart, but if there are other dogs in the house - I give them the same as she is getting only without the pill, and she instinctively eats it so quick she doesn't know it is in there. As for sprinkling, she doesn't like the taste - so she won't eat here food ---

You will just have to try different things and see what works. The Calcium is probably not enough to hurt him, but I am not a Vet. So ask him/her instead.
1 year ago
Coulee Girl
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The Vetroyl capsules should be given with food; however the capsules should NOT be opened they must be given whole. You will need to ask your veterinarian if it is ok to give cheese to your dog.
1 year, 1 month ago
Janine M./Pharmacist
Pompano beach
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My dog has cushing we do have the prescription from a panamanian vet would be possible to mail that over to you guys to order?
1 year, 9 months ago
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Florida pharmacy laws allow us to accept original prescriptions from International veterinarians as long as there is a valid veterinarian to patient relationship.
1 year, 9 months ago
Lilli Pharmacist
Pompano Beach, FL
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I have 11 pills and she goes back to get in 30 days for recheck to c if dosage will b lowered
1 year, 11 months ago
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Unfortunately, we only sell stock bottles of the 30 count Vetoryl. Thank you.
1 year, 11 months ago
Rich - Student Pharmacist
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
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