Available in 10mg, 30 mg or 60 mg capsules (based on weight)
How it works:
Vetoryl contains a drug that controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress.
Cautions:
Do not give this medication to dogs with kidney or liver disease. Vetoryl capsules should not be given to dogs taking certain medications or dogs that are pregnant. Speak with your veterinarian about all medications your dog is taking, including over-the-counter medicines.
More Information:
Brand Name Vetoryl
Generic Name Trilostane
What is the most important information I should know about Vetoryl: Vetoryl is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease. Vetoryl is indicated for use in pituitary-dependant hyperadrenocorticism. Vetoryl also has a Minor Use designation for treatment of Cushing's disease caused by adrenal tumors. Vetoryl is available as 10mg capsules, 30 mg capsules and 60 mg capsules. The usual initial starting dose to treat Cushing's disease in dogs is 1.0 to 3.0 mg/pound given once a day based on body weight and capsule size. For dogs at least 3.8 up to 10 lbs give one 10mg capsules once a day. For dogs at least 10 lbs up to 22 lbs give one 30mg capsules once a day. For dogs at least 22 lbs up to 44 lbs give one 60mg capsule. For dogs at least 44 lbs up to 88 lbs give two 60mg capsules. For dogs at least 88 lbs up to 132 lbs give three 60mg capsules. For dogs over 132 lbs give the appropriate combination of capsules. Vetoryl should be given with food. After approximately 10 to 14 days the pet will need to be re-examined and dosage adjustments may be required. Pets may require further re-examination at 30 days, 90 days, and every 3 months thereafter.
What is Vetoryl: Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependant Cushing's disease and Cushing's disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl.
What should I discuss with my veterinarian before giving Vetoryl to my pet: Tell your veterinarian if your pet has kidney or liver disease. Tell your veterinarian about any other medical problems or allergies your dog has now or has had in the past. Tell your veterinarian about any medications your dog is taking including over the counter products and nutritional supplements. Tell your veterinarian if your pet is pregnant, nursing, or if you plan to breed your dog.
How should this medication be given: Give this medication exactly as directed by your veterinarian. Give this medication with food. Do not open capsules and do not attempt to split or divide capsules. Wash your hands after use. Do not handle the capsules if you are pregnant or trying to become pregnant. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Vetoryl at controlled room temperature (77°F) with excursions to 86° F allowed. Keep this medication away from children and other pets.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of Vetoryl overdose may include lethargy, weakness, vomiting, or collapse.
What should I avoid while giving Vetoryl to my pet: Do not give Vetoryl to dogs with kidney or liver disease. Do not give to pregnant or nursing dogs or dogs intended for breeding. Do not touch Vetoryl capsules if you are pregnant or trying to become pregnant.
What are the possible side effects of Vetoryl: If any of the following serious side effects occur, stop giving Vetoryl and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), severe depression, bloody diarrhea, collapse, or other severe reactions. Other less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Vetoryl: Before giving Vetoryl tell your veterinarian if your pet is also taking ACE inhibitors such as enalapril, potassium sparing diuretics such as spironolactone, ketoconazole, or potassium supplements. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines or nutritional supplements.
Where can I get more information: Your pharmacist has additional information about Vetoryl written for health professionals that you may read.
Directions:
•
Vetoryl is used to treat dogs with hyperadrenocorticism, also known as Cushing's Disease.
•
Vetoryl capsules should be given with food.
Tip: Do not open capsules and do not attempt to split or divide capsule.
Dosage:
Pet
Weight
Starting Dosage in mg
Dogs/Puppies:
3.8 to 10 lbs
1 capsule daily (10 mg)
10 to 22 lbs
1 capsule daily (30 mg)
22 to 44 lbs
1 capsule daily (60 mg)
44 to 88 lbs
2 60 mg capsules (120 mg)
88 to 132 lbs
3 60 mg capsules (180 mg)
Over 132 lbs
Administer the appropriate amount of capsules based on dog's weight. Speak with your veterinarian to help you determine the correct dosage for your dog.
Cats/Kittens:
Horses:
Storage: Should be stored at room temperature. Keep out of reach of children.
I have a 7 year old Cocker mix that has developed Cushings. She used to pant uncontrollably, have very dry brittle hair, and was always thirsty and hungry. She was very needy because she seemed to need constant pampering and reassurance. After starting this product, she has become a new dog. She sleeps through the night without having to go out continually, and she doesn't pant all the time. She now has a beautiful coat , and seems to have lots of energy to play. It has been a life changer for her and for our family.
Gizmo my cocapoo has been on 30 mg a day for about 2 months and he's acting like a puppy again! I had no idea, he's 11 so I thought he was just getting old. He'd been to many vets and been misdiagnosed so many times, I had tried everything. He had almost lost all his hair :( so I took him to a doggie dermatologist, and after he administered the proper tests was diagnosed with Cushings, which he had tested negative for previously. It seems there are a few different types of tests and frequently test negative on the regular blood test. His hair hasn't grown back, yet but he sure has more energy, he's running faster, jumping and playing like he used to when he was a pup!
My 10 1/2 year old labrador was diagnosed with adrenal based cushings disease in August '10. Started taking 60mg Vetoryl in September. Noticed marked improvement even in the first week. He is back to his old mischievious behavior. All symptoms have disappeared and appears to be very healthy. It has been a true lifesaver for all of us!
We started our 10 year old wire fox terrier on Vetoryl 60 mg daily. (Our dog weighs 44 pounds) The dose was way too high for him. He became very ill with vomiting and bloody diarrhea. His cortisol dropped too far down. However, as his cortisol levels came back up, we saw glimpses of our precious dog. I feel this product can help him, but at a much smaller dosage. Tell your vet not to prescribe according to the recommendations on the package. There are plenty of studies that suggest starting at a very small dose (1mg per kg of weight) 1kg=2.2 lbs Be careful!!
MacIntosh is a 13 year old Cairn Terrier (Toto) who suffers from Cushings. His symptoms are numerous and all the classics, skin problems, joint aches and pains, thirst, rapid weight gain and big-buddah belly. MacIntosh was diagnosed in January of 2006. The vet suggested putting him down to save him the horrors of this disease. After a second opinion we decided to try steroids and wait a bit. About two years in the steroids were causing horrible skin issues. Our vet suggested trying the Vetoryl and we have a new puppy. MacIntosh has more energy, no symptoms of Cushings and healthy skin. He is chasing the bunnies and squirrels in his back yard and feeling great. We are delighted to report that Cushings is no longer a death sentence, hard evidence of better living through chemicals!
My dog takes Vetoryl 30mg daily so I take the 60mg and cut the capsule in half. I'd like to start ordering from pet meds and told my vet that but he won"t write out the Rx to not have to oder through him and the rx is 20.oo dollars higher through him. Any suggestions? Thank you, Valerie
our Jack R was 24 pds. He is now 17.5 pds. We have just started on the Vetoryl 60mg. His blood sugars are very high 18.2 He was taking Insulin twice daily which we have stopped because there was no improvement in anything. Is there a chance that Vetoryl with the help of SuperGland (which is a natural product used for the Pancrease) will reduce his blood sugar level. He has been diagnosed with Pancreaitis. Your comments are greatly appreciated
I am very concerned that you just stopped the insulin. Vetoryl will not treat diabetes and SuperGland will not either. If your veterinarian has prescribed insulin and your pet is not responding, then you should be in constant communication with your veterinarian making whatever dosage adjustments he/she feels is necessary to get your pet's blood sugar controlled. Cushing's disease, which I assume is what your pet needs Vetoryl for also makes controlling your pet's blood sugar difficult.
My dog is taking Trilostane to treat Cushing's disease, but she also has high blood pressure. My veterinarian just had me start her on Theophylline, but I'm concerned because Theophylline is contraindicated for hypertension.
My veterinarian also wants me to start my dog on Enalapril, but apparently it will conflict with the Trilostane. Could taking all three drugs at once possibly be safe? I wish I knew what to do.
I pop the the pill out into a piece of cheese so, I don't actually touch the pill. I immediatly wash my hands after too. I am 5 months pregnant and have been doing this for atleast 2 months.
I would strongly suggest if you are pregnant that you do not touch the capsule with your bare hands as there may be powder residue on the outside. The safest way to dose your pet is to let someone else do it. If that is not possible, please wear rubber gloves when giving this medication to your pet. Even with wearing gloves, wash your hands with soap and water after taking the gloves off.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.
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