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Simple once-a-month tablet that:
  • Kills fleas
  • Prevents heartworm disease
  • Treats & controls adult hookworms, roundworms & whipworms


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    Starts at $107.99 Ships in one business day or less
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      Product Info   How to use   Ingredients   Customer Reviews   Q & A  

    What is Trifexis?

    Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.
    For: Dogs (8 weeks of age and older and weighing at least 5 lbs)
    Begins killing biting fleas within 30 minutes
    Kills fleas before they can lay eggs
    Prevents heartworm disease
    Treats and controls roundworms, hookworms, and whipworms
    Artificial beef flavor made from pork liver and hydrolyzed soy
    Easy to administer chewable tablet

    How it works:
    Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

    Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

    More Information:
    Brand Name
    Trifexis (Elanco Animal Health)
    Generic Name
    Spinosad and Milbemycin oxime
    What is the most important information I should know about Trifexis: Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

    What is Trifexis: Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

    What should I discuss with my veterinarian before giving Trifexis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

    How should this medication be given: Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77į F). Consult your veterinarian for pregnant or lactating dogs.

    What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

    What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

    What should I avoid while giving Trifexis: Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

    What are the possible side effects of Trifexis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

    What other drugs will affect Trifexis: Talk to your veterinarian before giving any prescription or over the counter medications.

    Where can I get more information: Your pharmacist has additional information about Trifexis written for health professionals that you may read.


    Please view the chart below for the correct dosage of Trifexis for your dog.
    Tip: Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.
    Pet Weight Dosage
    (Over 8 weeks of age)
    5 - 10 lbs Give one tablet (Pink label box)
    10.1 - 20 lbs Give one tablet (Orange label box)
    20.1 - 40 lbs Give one tablet (Green label box)
    40.1 - 60 lbs Give one tablet (Blue label box)
    60.1 - 120 lbs Give one tablet (Brown label box)
    Over 120 lbs Administer the appropriate combination of tablets
    Storage: Should be stored at room temperature. Keep away from pets and children.
    Trifexis for Dogs 5 to 10 lbs:
    Active Ingredients per tablet Amount
    Spinosad 140 mg
    Milbemycin oxime 2.3 mg

    Trifexis for Dogs 10.1 to 20 lbs:
    Active Ingredients per tablet Amount
    Spinosad 270 mg
    Milbemycin oxime 4.5 mg

    Trifexis for Dogs 20.1 to 40 lbs:
    Active Ingredients per tablet Amount
    Spinosad 560 mg
    Milbemycin oxime 9.3 mg

    Trifexis for Dogs 40.1 to 60 lbs:
    Active Ingredients per tablet Amount
    Spinosad 810 mg
    Milbemycin oxime 13.5 mg

    Trifexis for Dogs 60.1 to 120 lbs:
    Active Ingredients per tablet Amount
    Spinosad 1620 mg
    Milbemycin oxime 27 mg

    Trifexis 3.7 5 383 387
    trying something new My vet suggested this for my new shih tzu puppy. I was warned that there may be vomiting after the first dose and told not to give another dose/tablet. Although my puppy initially picked the tablet out and dropped next to her bowl, continuing to eat her dinner, I placed it back in the bowl and it disappeared. Awaited the vomiting but my puppy's stomach seemed to digest it just fine. So far, I like the all-in-one dose approach. 06/16/2011
    Great Combination For those of you complaining that your dog was throwing up this pill you need to tell your vet to give your dog Metoclopramide which is an anti-emetic. You give it to your dog an hour before you give Trifexis and your dog will not throw up. I had my dog on Comfortis (spinosad...the flea killing drug in this pill) before and had to give him Metoclopramide so he wouldn't throw up. Not a problem. LOVED the product. On Trifexis my dog doesn't have to take the anti-emetic pill, I just make sure to mix in some chicken with his food after I give him the pill so he will eat. This combination pill saved me money by combining Interceptor with Comfortis. Awesome! My only complaint is that my dog still scratches. He stopped scratching after being on comfortis for an hour. 05/11/2011
    So far so good The reason I give this product a 4 rating is due to the fact that it does not treat ticks. I gave to my Shih Tzus with food and so far I have not seen a flee on them yet. They did not throw it up either. I like the idea that this product prevents heartworms, flea infestations, whipworm, hookworm, and roundworms which is great for the price. I purchased this product from my vet first to see the reaction and if my pets would not get infested with fleas. I check them daily and so far no fleas yet. Before I was using a topical treatment that required me to isolate them for 24 hours after treatment and now I do not have to do that. If I see a tick on my pets, then I will have no other choice but to go back to the topical product until they come out with an effective product that treats ticks as well. 04/27/2011
    Great Product! I was so happy to hear that a combination medication was available to control all internal parasites and kills fleas. The only negative aspects are the cost and it does not help with ticks, however, I am still going to keep all my dogs on Trifexis. I did not have any problems with vomitting with any of my dogs, I followed the directions, mixed the tabs in with some steamed rice and chicken and they chowed down.. :) 04/05/2011
    LOVE IT Feed your pet a normal meal then give this pill. If you do not do this your pet will throw it back up & waste your money. My Bassets are on this and I LOVE IT!!!!! kills fleas within 30 minutes! If you look on the package your pill comes in it clearly states to give with a meal, so follow the directions and you will not have a problem! 03/28/2011
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    220 Questions · 335 Answers

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    Talk to other pet lovers about this product.

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    My dog is 11 lbs in weight, and in good health. Sentinel was suggested at an early age. How is Trifexis different ? She is 5yrs. old (15).
    5 days ago
    Answer this question
    1 week ago
    Answer this question


    Thank you for your question. No, this medication does not kill lice.
    6 days ago
    Maureen PetMeds Pro
    Pompano Beach, FL
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    My dog is currently and has been about 42 pounds. Can she have the 20 to 40 tablet or do we continue with the 40 to 60
    She is full grown . I am currently buy single dose from the vet so really don't know what dose she is getting
    4 weeks, 2 days ago
    Answer this question


    continue with the 40 to 60 lb size
    4 weeks ago
    Linda M 1800petmeds pharmacist
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    1 answer


    This would be my first time ordering. My dogs have been on Trifexus and I want to find a less expensive supplier other than my dog's Vet.
    Do I need a prescription to order?
    1 month ago
    Answer this question


    Trifexis does require a prescription.
    2 weeks ago
    Stephanie Duesler, Pharm. D, MBA
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    Our 12-year old Golden Retriever is here in Mexico with us and I think he has mange. The prescribed cure is mite relief but that seems to come with flea control products.
    He's already on monthly Trifexis, that has flea control. So how do I treat his mange when the products for mites also treat fleas and he's already being treated for fleas? I don't want to overmedicate him. Please help as we are all miserable.
    2 months, 1 week ago
    Currently in Mexico
    Answer this question


    Speak to your veterinarian to determine the most appropriate treatment for your pet. Different products can be used to treat mange.
    2 months, 1 week ago
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    2 3 4 5 ... 9 Next
    2 3 4 5 ... 9 Next
    This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
    Note: Any trademarks are the property of their respective companies.
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