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  Product Info   How to use   Ingredients   Customer Reviews   Q & A  

What is Trifexis?

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.
For: Dogs (8 weeks of age and older and weighing at least 5 lbs)
Begins killing biting fleas within 30 minutes
Kills fleas before they can lay eggs
Prevents heartworm disease
Treats and controls roundworms, hookworms, and whipworms
Artificial beef flavor made from pork liver and hydrolyzed soy
Easy to administer chewable tablet

How it works:
Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

More Information:
Brand Name
Trifexis (Elanco Animal Health)
Generic Name
Spinosad and Milbemycin oxime
What is the most important information I should know about Trifexis: Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

What is Trifexis: Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

What should I discuss with my veterinarian before giving Trifexis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should this medication be given: Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77į F). Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis: Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Trifexis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Trifexis: Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information: Your pharmacist has additional information about Trifexis written for health professionals that you may read.


Please view the chart below for the correct dosage of Trifexis for your dog.
Tip: Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.
Pet Weight Dosage
(Over 8 weeks of age)
5 - 10 lbs Give one tablet (Pink label box)
10.1 - 20 lbs Give one tablet (Orange label box)
20.1 - 40 lbs Give one tablet (Green label box)
40.1 - 60 lbs Give one tablet (Blue label box)
60.1 - 120 lbs Give one tablet (Brown label box)
Over 120 lbs Administer the appropriate combination of tablets
Storage: Should be stored at room temperature. Keep away from pets and children.
Trifexis for Dogs 5 to 10 lbs:
Active Ingredients per tablet Amount
Spinosad 140 mg
Milbemycin oxime 2.3 mg

Trifexis for Dogs 10.1 to 20 lbs:
Active Ingredients per tablet Amount
Spinosad 270 mg
Milbemycin oxime 4.5 mg

Trifexis for Dogs 20.1 to 40 lbs:
Active Ingredients per tablet Amount
Spinosad 560 mg
Milbemycin oxime 9.3 mg

Trifexis for Dogs 40.1 to 60 lbs:
Active Ingredients per tablet Amount
Spinosad 810 mg
Milbemycin oxime 13.5 mg

Trifexis for Dogs 60.1 to 120 lbs:
Active Ingredients per tablet Amount
Spinosad 1620 mg
Milbemycin oxime 27 mg

Trifexis 3.6 5 350 354
trying something new My vet suggested this for my new shih tzu puppy. I was warned that there may be vomiting after the first dose and told not to give another dose/tablet. Although my puppy initially picked the tablet out and dropped next to her bowl, continuing to eat her dinner, I placed it back in the bowl and it disappeared. Awaited the vomiting but my puppy's stomach seemed to digest it just fine. So far, I like the all-in-one dose approach. 06/16/2011
Great Combination For those of you complaining that your dog was throwing up this pill you need to tell your vet to give your dog Metoclopramide which is an anti-emetic. You give it to your dog an hour before you give Trifexis and your dog will not throw up. I had my dog on Comfortis (spinosad...the flea killing drug in this pill) before and had to give him Metoclopramide so he wouldn't throw up. Not a problem. LOVED the product. On Trifexis my dog doesn't have to take the anti-emetic pill, I just make sure to mix in some chicken with his food after I give him the pill so he will eat. This combination pill saved me money by combining Interceptor with Comfortis. Awesome! My only complaint is that my dog still scratches. He stopped scratching after being on comfortis for an hour. 05/11/2011
So far so good The reason I give this product a 4 rating is due to the fact that it does not treat ticks. I gave to my Shih Tzus with food and so far I have not seen a flee on them yet. They did not throw it up either. I like the idea that this product prevents heartworms, flea infestations, whipworm, hookworm, and roundworms which is great for the price. I purchased this product from my vet first to see the reaction and if my pets would not get infested with fleas. I check them daily and so far no fleas yet. Before I was using a topical treatment that required me to isolate them for 24 hours after treatment and now I do not have to do that. If I see a tick on my pets, then I will have no other choice but to go back to the topical product until they come out with an effective product that treats ticks as well. 04/27/2011
Great Product! I was so happy to hear that a combination medication was available to control all internal parasites and kills fleas. The only negative aspects are the cost and it does not help with ticks, however, I am still going to keep all my dogs on Trifexis. I did not have any problems with vomitting with any of my dogs, I followed the directions, mixed the tabs in with some steamed rice and chicken and they chowed down.. :) 04/05/2011
LOVE IT Feed your pet a normal meal then give this pill. If you do not do this your pet will throw it back up & waste your money. My Bassets are on this and I LOVE IT!!!!! kills fleas within 30 minutes! If you look on the package your pill comes in it clearly states to give with a meal, so follow the directions and you will not have a problem! 03/28/2011
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194 Questions · 294 Answers

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3 days ago
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Trifexis does not cover ticks.
1 day ago
Pompano beach
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I am trying to identify a pill I found on my dogs bed. I think it may be her trifexis pill but i am afraid to give it to her because i do not know 100 percent that it is. I paid 25 dollars for one trifexis pill for her and i cannot waste it if that is what it is. Please help
5 days ago
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I have been told that many medications that are not bought through a vet office are not as "strong" or do not have the same dose/quatlity as the one they sell. Is that true? I bought my last batch of trifexis from my vet and I am looking to save a little money this time but want the same product. Thank you
1 week, 3 days ago
houston texas
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This is the same product that you would buy from your veterinarian they are made by the same manufacturer.
1 day ago
Pompano beach
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My dog finds a way to leave behind some of the tablet no matter how I crush it and disguise with other food or liquid. I've also tried leaving it open to the air for a while before giving it to him. He is 9 years old and has never done this with any other medication. He's been getting Trifexis for over a year. Do you have anything with a better taste/smell? Otherwise I will go back to giving him the old separate flea, tick, and heart worm meds.
2 weeks, 1 day ago
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try covering it completely in peanut butter ...(cut it in smaller pieces if the pill is too big) This is the ONLY way we can give it to our Husky
2 days ago
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The only thing that worked for our dog is a pill pocket by Greenies. I tried everything else to disguise it from bread to lunch meat and these pill pockets were the only thing that worked.
1 week, 4 days ago
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My dog has been on Trifexis for over a year, but during warm months the fleas always show up and bite before it's time for the next dose. Are there any topical flea products that is okay to use in addition to trifexis?
2 weeks, 6 days ago
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yes , but check with your vet that prescribed the trifexis....what they believe the safest additional
flea medication would be for your pet....considering the health and age of the pet. Capstar can
always be giving safely to get rid of adult fleas.
2 weeks, 2 days ago
Linda M 1800petmeds pharmacist
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This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
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