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Trifexis

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Starts $138.74 $99.89 
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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Trifexis?

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.

For:

Dogs (8 weeks of age and older and weighing at least 5 lbs)

Benefits:
  • Begins killing biting fleas within 30 minutes
  • Kills fleas before they can lay eggs
  • Prevents heartworm disease
  • Treats and controls roundworms, hookworms, and whipworms
  • Artificial beef flavor made from pork liver and hydrolyzed soy
  • Easy-to-administer chewable tablet
How Trifexis Works:

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important information I should know about Trifexis:

Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

What is Trifexis:

Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

What should I discuss with my veterinarian before giving Trifexis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should this medication be given:

Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77° F). Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss a dose:

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet:

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis:

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Trifexis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Trifexis:

Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information:

Your pharmacist has additional information about Trifexis written for health professionals that you may read.

How to Use
Directions:
  • Please view the chart below for the correct dosage of Trifexis for your dog.
Tip:

Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.

Dosage:
Dogs (Over 8 weeks of age)
Weight
Dosage
5 - 10 lbs
Give one tablet (Pink label box)
10.1 - 20 lbs
Give one tablet (Orange label box)
20.1 - 40 lbs
Give one tablet (Green label box)
40.1 - 60 lbs
Give one tablet (Blue label box)
60.1 - 120 lbs
Give one tablet (Brown label box)
Over 120 lbs
Administer the appropriate combination of tablets
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature. Keep away from pets and children.

Ingredients
Trifexis for Dogs 5 to 10 lbs:
Active Ingredients per tablet
Amount
Spinosad
140 mg
Milbemycin oxime
2.3 mg
Trifexis for Dogs 10.1 to 20 lbs:
Active Ingredients per tablet
Amount
Spinosad
270 mg
Milbemycin oxime
4.5 mg
Trifexis for Dogs 20.1 to 40 lbs:
Active Ingredients per tablet
Amount
Spinosad
560 mg
Milbemycin oxime
9.3 mg
Trifexis for Dogs 40.1 to 60 lbs:
Active Ingredients per tablet
Amount
Spinosad
810 mg
Milbemycin oxime
13.5 mg
Trifexis for Dogs 60.1 to 120 lbs:
Active Ingredients per tablet
Amount
Spinosad
1620 mg
Milbemycin oxime
27 mg
Customer Reviews
Trifexis is rated 3.8357 out of 5 by 499.
Rated 5 out of 5 by from Really good product I have been using Trifexis for both my dogs for a long time and it seems to be keeping them safe and happy. They don't eat it the way they are suppose to but their not stupid either. They know a pill coming when they see one. I really like working with 1-800-petmeds they are reasonably priced and very quick. Howeve my dogs are Cardigan Corgis and they should have a picture of that instead of a Pembroke representing them. That should be a question in the initial interview. See attached.
Date published: 2016-11-21
Rated 5 out of 5 by from Trifexis Been using it over a year. It's the best I have ever used
Date published: 2016-11-13
Rated 5 out of 5 by from Thank u! Omg we had a horrible problem with fleas when we moved into our new home. I was at my wits end trying dog dips and yard sprays. Finally, I got the Triflexis and omg It worked miracles. The dogs were flea free and after a pest place came and sprayed the yard I was finally flea free! I'm so happy! Thanks pet meds for your fast shipping and good communication!!
Date published: 2016-11-12
Rated 5 out of 5 by from I love this product ! I am thrilled with my purchasing experience with 1800petmeds.com . I received the Trifexis quickly and both of my dogs do great with it. My German Shepherd will take it easily. I wait at least 30 minutes after she eats a meal. My finicky Boston Terrier has to be have it in peanut butter. I highly recommend this company and this option for keeping fleas and ticks away and as heartworm monthly preventative.
Date published: 2016-11-08
Rated 5 out of 5 by from I have used Trifexis for 5+ years now and am completely satisfied with it. Nothing else has controlled the fleas like it does.
Date published: 2016-11-07
Rated 5 out of 5 by from Excellent Product! My vet recommended this product when we first got our Zoey! Have had great results and no side effects. Effective and easy to use.
Date published: 2016-11-07
Rated 5 out of 5 by from Great product !!! I choked on the price but my baby had bad allergic reactions to flea bites so I had to try it. She has been flea free for 6 months now.. LOVE IT !!! Money well spent !!
Date published: 2016-11-04
Rated 5 out of 5 by from trifexis Donnie and his owners love love trifexis absoultly the best for your pet. can not beat pet meds for the price . worth your money to keep your pet safe if you love your pet like we do thanks pet meds.
Date published: 2016-11-03
  • 2016-12-03T06:02CST
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Q&A

How often can I bathe my dog while she is on Trifextis?

Asked by: Angela
You can bathe your dog as often as needed as the product is internal, not topical and won't wash off.
Answered by: SuzyCVT
Date published: 2016-11-29

Do you need a prescription from vet for trifexis?

Asked by: Rocky
Trifexis requires a prescription from a veterinarian.
Answered by: Lisa M
Date published: 2016-11-25

Do you take coupons and which coupons do you accept?

Asked by: Debbie
Please contact our sales department for pricing and special offers.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

Does trifexis help with any tick prevention

Asked by: shell
Trifexis does not cover ticks. You may chose to add a tick collar for added tick prevention for your pet
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

I have 3 dogs, 2 that would require the 60-120 lbs tablet. My 3rd dog would need a 5-10lb . Is there anyway I could give the small dog just a portion of the large dogs tablet?

Asked by: Jvturner
No.
Answered by: Lilli Pharmacist
Date published: 2016-11-10

If I purchase frifexis from your company and my dog happens to get heartworm,will you help pay for the treatment?

Asked by: Heidi 40
If your dog was prescribed Trifexis by a licensed veterinarian, has the proper testing, and you have proof that you have been purchasing USDA approved product and administering it properly every month, it would be the manufacturer of Trifexis (Elanco) that would be financially responsible should your dog still become infected with heartworms, not the pharmacy that sold you the product.
Answered by: SuzyCVT
Date published: 2016-11-01

Is there a generic for trifexis?

Asked by: Nina
Not yet.
Answered by: SuzyCVT
Date published: 2016-11-01

Should I have my dog checked for heartworms before giving Trifexis? He was tested a couple months ago and it came back negative, but I've heard if he has heartworms that the medication will hurt him, is this true?

Asked by: Beth
There is a potential for an adverse reaction when many heartworm preventatives are given to a dog with adult heartworms in the heart. However, if your dog tested negative a couple of months ago, it is safe to start heartworm prevention now but your dog should be tested again in 6 months. It takes 6 months from the day of infection for the test to show a positive result since it tests for adults, not immature heartworms. Your dog may have become infected since the last test and starting the Trifexis.
Answered by: SuzyCVT
Date published: 2016-11-01
  • 2016-12-03T06:07CST
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