Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.
For: Dogs (8 weeks of age and older and weighing at least 5 lbs)
Benefits:
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Begins killing biting fleas within 30 minutes
•
Kills fleas before they can lay eggs
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Prevents heartworm disease
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Treats and controls roundworms, hookworms, and whipworms
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Artificial beef flavor made from pork liver and hydrolyzed soy
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Easy to administer chewable tablet
How it works:
Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.
Cautions:
Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.
More Information:
Brand Name Trifexis (Elanco Animal Health)
Generic Name Spinosad and Milbemycin oxime
What is the most important information I should know about Trifexis: Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.
What is Trifexis: Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.
What should I discuss with my veterinarian before giving Trifexis to my pet: Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).
How should this medication be given: Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77° F). Consult your veterinarian for pregnant or lactating dogs.
What happens if I miss a dose: Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.
What happens if I overdose the pet: Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.
What should I avoid while giving Trifexis: Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.
What are the possible side effects of Trifexis: Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.
What other drugs will affect Trifexis: Talk to your veterinarian before giving any prescription or over the counter medications.
Where can I get more information: Your pharmacist has additional information about Trifexis written for health professionals that you may read.
Directions:
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Please view the chart below for the correct dosage of Trifexis for your dog.
Tip: Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.
Dosage:
Pet
Weight
Dosage
Dogs (Over 8 weeks of age)
5 - 10 lbs
Give one tablet (Pink label box)
10.1 - 20 lbs
Give one tablet (Orange label box)
20.1 - 40 lbs
Give one tablet (Green label box)
40.1 - 60 lbs
Give one tablet (Blue label box)
60.1 - 120 lbs
Give one tablet (Brown label box)
Over 120 lbs
Administer the appropriate combination of tablets
Cats:
Horses:
Storage: Should be stored at room temperature. Keep away from pets and children.
Trifexis for Dogs 5 to 10 lbs:
Active Ingredients per tablet
Amount
Spinosad
140 mg
Milbemycin oxime
2.3 mg
Trifexis for Dogs 10.1 to 20 lbs:
Active Ingredients per tablet
Amount
Spinosad
270 mg
Milbemycin oxime
4.5 mg
Trifexis for Dogs 20.1 to 40 lbs:
Active Ingredients per tablet
Amount
Spinosad
560 mg
Milbemycin oxime
9.3 mg
Trifexis for Dogs 40.1 to 60 lbs:
Active Ingredients per tablet
Amount
Spinosad
810 mg
Milbemycin oxime
13.5 mg
Trifexis for Dogs 60.1 to 120 lbs:
Active Ingredients per tablet
Amount
Spinosad
1620 mg
Milbemycin oxime
27 mg
Trifexis
3.6
5
159
162
Didn't Kill The Eggs
It killed the adult fleas but not the eggs..so I still see young fleas on my dogs..We wanted to try this in replace of Heartgard and Comfortis but so far it is not as good..the dogs did not want to eat this compared to Comfortis. It was quite strange because one of my dogs will eat anything.
05/18/2012
Love this product
Our dogs have been using Trifexis ever since they began heartworm treatment. We love the product!. They are a year and a half old and we have never experienced and problems and they have NEVER had fleas.
05/18/2012
My poor dog has been suffering and worsening over the past two months. Has sores all over him. Completely. Skin is flaking large pieces and he is very itchy. Vet diagnosed him with fungal infection. Said it was contagious. However, I have 2 other dogs and they haven't shown signs of this. He has now started losing hair and his skin is raw in places despite anti fungal cream and an oral medication. Finally clicked yesterday that this started following a switch to Trifexis. Decided to look up reviews. Shame on me for not doing so prior to giving him this medicine. Read same symptoms in some dogs. My big buddy will be coming off this stuff. Might work for some but not my big guy.
05/17/2012
Too many side effects!
After reading all the side effects others have had with their dogs I became a little concerned but tried it on my dog anyway. He absolutely would not eat the pill & I found it had a really strange smell to it. Did not smell like beef! I smashed it into little pieces with a fork and put it in some chicken & still had to force it down his throat. Then for the next 24 hrs. he was lathargic to the point I was getting very concerned. He seems ok this morning but I'm not risking giving it to him again & will stay with his old medication.
05/16/2012
only flea med (i've tried several; both pill and topical) that has stopped the little buggers from eating up my two standard poodles....highly recommend
05/16/2012
There are 6 doses in a package and it does require a prescription from your veterinarian. Prescriptions may be faxed, mailed or verbally given over the phone.
It seems to me that most of the complaints are because of the flea portion of the medication. It would be great to have an alternative to Interceptor (since it is off the market now) without having to worry about the flea med side effects listed here. My Collie Rough (breed cannot take Ivermectin) has taken Interceptor for 5 years and done very well while using Frontline Plus for fleas. With Interceptor off the market, a marketing/sales opportunity may be missed with regard to Collie owners and site hounds.
Trifexis is only made as a combination of the heartworm preventative Milbemycin (Interceptor) and the flea medication Spinosad (Comfortis). Interceptor is not permanently off the market and should be available in the future. Consult your veterinarian for a safe alternative until then.
My dog weighs Just at 10 lbs. I was advised that I could purchase the larger size ( 20 to 40 lbs.) and split them in half to save some money. I have been doing that for a year and have not had any problems. When I called to reorder the girl on the phone said I am not allowed to split them. Do you know of any reason that would prevent me from doing it.
I don't think there is any problem doing it, especially if your dog has not have any problems over a year. We had to get the 10-20 for our 7 lbs dog and the vet said to split it but watch for any side effects..
Splitting the 20-40 Pound tablet for your 10 pound dog is considered administering the medication 'off label'. By doing this, your pet is receiving an additional 10mg of spinosad and an additional 0.15mg of milbemycin per month. These doses exceed what is recommended by the manufacturer for your pets weight. We are unable to provide any guarantee for the product if it is being given for off label use.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.
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