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Trifexis

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Trifexis?

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.

For:

Dogs (8 weeks of age and older and weighing at least 5 lbs)

Benefits:
  • Begins killing biting fleas within 30 minutes
  • Kills fleas before they can lay eggs
  • Prevents heartworm disease
  • Treats and controls roundworms, hookworms, and whipworms
  • Artificial beef flavor made from pork liver and hydrolyzed soy
  • Easy-to-administer chewable tablet
How it Works:

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important information I should know about Trifexis:

Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

What is Trifexis:

Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

What should I discuss with my veterinarian before giving Trifexis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should this medication be given:

Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77° F). Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss a dose:

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet:

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis:

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Trifexis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Trifexis:

Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information:

Your pharmacist has additional information about Trifexis written for health professionals that you may read.

How to Use
Directions:
  • Please view the chart below for the correct dosage of Trifexis for your dog.
Tip:

Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.

Dosage:
Dogs (Over 8 weeks of age)
Weight
Dosage
5 - 10 lbs
Give one tablet (Pink label box)
10.1 - 20 lbs
Give one tablet (Orange label box)
20.1 - 40 lbs
Give one tablet (Green label box)
40.1 - 60 lbs
Give one tablet (Blue label box)
60.1 - 120 lbs
Give one tablet (Brown label box)
Over 120 lbs
Administer the appropriate combination of tablets
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature. Keep away from pets and children.

Ingredients
Trifexis for Dogs 5 to 10 lbs:
Active Ingredients per tablet
Amount
Spinosad
140 mg
Milbemycin oxime
2.3 mg
Trifexis for Dogs 10.1 to 20 lbs:
Active Ingredients per tablet
Amount
Spinosad
270 mg
Milbemycin oxime
4.5 mg
Trifexis for Dogs 20.1 to 40 lbs:
Active Ingredients per tablet
Amount
Spinosad
560 mg
Milbemycin oxime
9.3 mg
Trifexis for Dogs 40.1 to 60 lbs:
Active Ingredients per tablet
Amount
Spinosad
810 mg
Milbemycin oxime
13.5 mg
Trifexis for Dogs 60.1 to 120 lbs:
Active Ingredients per tablet
Amount
Spinosad
1620 mg
Milbemycin oxime
27 mg
Customer Reviews
Trifexis is rated 3.792452830188679 out of 5 by 477.
Rated 3 out of 5 by from DOES NOT LAST A FULL 30 DAYS My vet originally had my 5lb Yorkie on Comfortis and I loved it. Comfortis would last a full 30 days plus easily. I notice with using Trifexis it last a good 3 weeks so frustrating! I have a little dog and it just does not last long at all. I live in a neighborhood that is very active with pets (dogs and cats). I need something that is strong and will last 30 days.
Date published: 2016-08-25
Rated 5 out of 5 by from Trifexis 10.1 - 20 lbs The vet gave us a 1 months worth for my two babies. It has worked beautifully. They were chewing themselves up but we couldn't find any fleas, the vetonly found one. She said they were chewing cause they have an allergy to the fleas. There is no infestation of them just a single bite became torture for them. I opened the pill package and it smelled like bleach, it was bad. My dogs wouldn't touch the pill. I crushed it up and mixed it in peanut butter, they knew something was odd about it but heck it was in peanut butter, they wanted that peanut butter so they slowly ate it. They didn't get sick but my smaller baby became just a little lethargic but by the next day he was ok. I will be giving this to them again. Not eagerly because I prefer natural methods but I have tried all the natural methods and they were not working. I can't stand watching them be tortured over flea bites. They were covered in scabs from chewing on themselves in the same spot. I will use it again and again until there is something natural and just as affective, but I don't see that happening.
Date published: 2016-08-25
Rated 5 out of 5 by from Great effective product! Our white terrier mix, had fleas so bad, he was miserable. Our vet recommended this product. I was a little worried as Benji is 10 years old. The pill itself is just a little to large for our 25 lb dog to handle, so we crushed it up into his nightly meal of wet dog food, he had no further problems other, than the pill size. It was amazing to see this product in action, the fleas died off him. Amazing wonderful product.
Date published: 2016-08-25
Rated 5 out of 5 by from Great Results for Many Years on Many Dogs! We have used this product on several dogs that we have had over the years since it first came out and have never had an issue with the dogs getting sick or any negative side effects. 2 of our dogs have severe skin allergies and fleas were making their lives miserable. We have not seen a flea on any of our dogs in years and have had all negative heartworm checks. The trick as many others have said is getting them to eat it. It is not at all what I consider a "chewable dog treat". One of my dogs can detect it in any disguised form and eats the cheese/hot dog/meat/pill pocket and then just drops the trifexis right out of his mouth. I started grinding it with a mortar and pestle and putting it in with some canned dog food and that works. I highly recommend.
Date published: 2016-08-24
Rated 1 out of 5 by from Not going to directly knock this product because so many have had success with it, but our Boston Terrier seems to be fussy about these flea and tick meds. The topicals did not work, and he threw this product up, which is a warning on the product's label.
Date published: 2016-08-21
Rated 2 out of 5 by from Great for fleas but missing Ticks I have been using this medication for my German Pinscher for 3 years and I have come to appreciate the ease of chewable from the topicals. My dog really always hated the taste of this chew and he is not a picky eater. We usually hide it in some cheese or cover it in peanut butter. It is not a small chew even though he is only 35b so it cannot be shoved down the throat like a pill unless you break it into many many small pieces and this sounds like torture to me. We have also experienced an issue with him throwing up several hours later which my vet said can happen from this medication. Lastly, there is NO TICK prevention in this medication. We live in CA and have tick issues anywhere we live or hike. There aren't many preventatives just for ticks for when we need it so we would just use rose geranium oil but I still didn't feel this was the most effective means. We have had to pick ticks off of him after hiking and we finally got tired of him having to suffer tick bites, risking the chance of deer ticks, or even risking the chances of missing a tick on him. We switched his preventative from this Trifexis to Bravecto and using a heart worm preventative additionally. This is much easier than the monthly chew and the impossible task of finding a separate tick only preventative.
Date published: 2016-08-08
Rated 5 out of 5 by from Great Medicine We have two 2 year old Rough Collies and they take them both without peanut butter or anything else. Pill works great and we have had no side effects.
Date published: 2016-08-05
Rated 5 out of 5 by from Trifexis great 1 improvemnet.... The pill is HUGE! Maybe a bit smaller, or coated or with a smell the dogs will not run from. But its effectiveness is second to none. Just wrestling with a 100 # dog every 4 weeks is not my idea of fun. We tried the treat pockets and everything else. Does not work. Just my opinion.
Date published: 2016-08-05
  • 2016-08-28T06:02CST
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Q&A

I have a Yorkie he is 2 and weight is 4.3 can he take trifexis

Asked by: Shardee
Yes, you can. My Yorkie was 4lbs when prescribed to this. 
Answered by: Wisco
Date published: 2016-08-22

Does Trifexis prevent Mosquito's from biting? It's my understanding that mosquito bites are the leading cause of heart-worms.... But the product packaging and info makes no reference to preventing them.

Asked by: Vicky
Trifexis does not prevent mosquitos from biting, it works by killing microfilariae and larvae from maturing into adult heartworms.
Answered by: paulpharmacistintern
Date published: 2016-08-18

My dog weighs around 135 lb. Will the highest dose (60-120 lb) be satisfactory for him?

Asked by: Timsmom
Talk to your veterinarian. He may start your dog on that dose or they may want to give him a combo of the tablets.
Answered by: paulpharmacistintern
Date published: 2016-08-18

I have 2 dogs.  One is 8 lbs the other 22lbs.  Do I need to get 2 packages or can I give the 22lb one the same as the 8lb one? 

Asked by: Whytedove
You'll need 2 packages. Each with the appropriate dose for your sized pets.
Answered by: paulpharmacistintern
Date published: 2016-08-11

Does Trifexis cover tick protection for dogs?

Asked by: Ricardo63
Trifexis does not cover tick protection.
Answered by: paulpharmacistintern
Date published: 2016-08-06

Does trifexis prevent ticks

Asked by: Mary
Trifexis both kills and protects against fleas.
Answered by: paulpharmacistintern
Date published: 2016-08-06

I have a 130 lb golden retriever, which trifexus do I need for him?  Do you offer discounts if I order for all three of my pets? My other two are 75 - 80lbs.

Asked by: Christine
For your golden retiever, you'll need a combo of pills. Talk to your veterinarian about the finding the appropriate dose for your retriever and other dogs.
Answered by: paulpharmacistintern
Date published: 2016-08-05

My dog is over 120 pounds. Does he really need the extra dose?

Asked by: Steph
You can always discuss your concern with your veterinarian but they will most likely want you to use the extra dose.
Answered by: paulpharmacistintern
Date published: 2016-08-04
  • 2016-08-28T06:08CST
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