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Trifexis

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Trifexis?

Trifexis is a chewable tablet that kills fleas and prevents infestations, protects against heartworms, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis requires a prescription from your veterinarian.

For:

Dogs (8 weeks of age and older and weighing at least 5 lbs)

Benefits:
  • Begins killing biting fleas within 30 minutes
  • Kills fleas before they can lay eggs
  • Prevents heartworm disease
  • Treats and controls roundworms, hookworms, and whipworms
  • Artificial beef flavor made from pork liver and hydrolyzed soy
  • Easy-to-administer chewable tablet
How Trifexis Works:

Spinosad, an active ingredient in Trifexis, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Trifexis also kills flea eggs before they can mature, which helps to end the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms.

Cautions:

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Consult your veterinarian for pregnant or lactating dogs.

Brand Name:

Trifexis (Elanco Animal Health)

Generic Name:

Spinosad and Milbemycin oxime

What is the most important information I should know about Trifexis:

Trifexis is a prescription medication FDA approved for use in dogs 8 weeks of age or older and 5 lbs of body weight or more. Trifexis contains spinosad and milbemycin oxime and is indicated for the prevention of heartworm disease. Trifexis kills fleas and is indicated for the prevention and treatment of flea infestations, and the treatment and control of adult hookworm, adult roundworm, and adult whipworm infections. Trifexis is available in a pink box for dogs 5 to 10 lbs (140mg/2.3mg)), Orange box for dogs 10.1 to 20 lbs (270mg/4.5mg), Green box for dogs 20.1 to 40 lbs (560mg/9.3mg), Blue box for dogs 40.1 to 60 lbs (810mg/13.5mg), and Brown box for dogs 60.1 to 120 lbs (1620mg/27mg). For dogs over 120 lbs give the appropriate combination of tablets.

What is Trifexis:

Trifexis is a chewable, beef flavored tablet that is made out of pork liver and hydrolyzed soy and given to your dog once month to prevent heartworm, to prevent and treat flea infestations, and to treat and control adult hookworm, roundworm, and whipworm infections. Trifexis chewable tablets are for monthly use in dogs and puppies 8 weeks of age and older and 5 lbs of body weight or more.

What should I discuss with my veterinarian before giving Trifexis to my pet:

Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should this medication be given:

Give Trifexis chewable tablets with food. Give Trifexis chewable tablets once a month. Trifexis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Trifexis at room temperature (68-77° F). Consult your veterinarian for pregnant or lactating dogs.

What happens if I miss a dose:

Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet:

Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Trifexis:

Your pet may maintain normal activities and interactions while being given Trifexis. The safe use of Trifexis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Trifexis:

Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Trifexis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Trifexis:

Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information:

Your pharmacist has additional information about Trifexis written for health professionals that you may read.

How to Use
Directions:
  • Please view the chart below for the correct dosage of Trifexis for your dog.
Tip:

Trifexis does not protect against ticks. To help control ticks, try the Preventic Tick Collar.

Dosage:
Dogs (Over 8 weeks of age)
Weight
Dosage
5 - 10 lbs
Give one tablet (Pink label box)
10.1 - 20 lbs
Give one tablet (Orange label box)
20.1 - 40 lbs
Give one tablet (Green label box)
40.1 - 60 lbs
Give one tablet (Blue label box)
60.1 - 120 lbs
Give one tablet (Brown label box)
Over 120 lbs
Administer the appropriate combination of tablets
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature. Keep away from pets and children.

Ingredients
Trifexis for Dogs 5 to 10 lbs:
Active Ingredients per tablet
Amount
Spinosad
140 mg
Milbemycin oxime
2.3 mg
Trifexis for Dogs 10.1 to 20 lbs:
Active Ingredients per tablet
Amount
Spinosad
270 mg
Milbemycin oxime
4.5 mg
Trifexis for Dogs 20.1 to 40 lbs:
Active Ingredients per tablet
Amount
Spinosad
560 mg
Milbemycin oxime
9.3 mg
Trifexis for Dogs 40.1 to 60 lbs:
Active Ingredients per tablet
Amount
Spinosad
810 mg
Milbemycin oxime
13.5 mg
Trifexis for Dogs 60.1 to 120 lbs:
Active Ingredients per tablet
Amount
Spinosad
1620 mg
Milbemycin oxime
27 mg
Customer Reviews
Trifexis is rated 3.8511 out of 5 by 517.
Rated 4 out of 5 by from Great product Great product but remember this is not for tick preventative! Works great on flea prevent & worms but my dog got into a nest of seed ticks & they stuck like glue! Treated this at the vet & picked them off for days! :(
Date published: 2017-01-18
Rated 5 out of 5 by from Convenient air tight packaging ensuring freshness. Have used Trifexis for many years with perfect reaults.
Date published: 2017-01-17
Rated 3 out of 5 by from The smell and the taste of this "chewable tablet" are so bad that my golden retriever won't take them. We have tried covering them with spray cheese or peanut butter, but it doesn't hide the smell. We have resorted to putting small pieces of it down her throat and making her swallow them. I hate doing it this way!
Date published: 2017-01-15
Rated 4 out of 5 by from Quite effective Rescued Niya 3 years ago. She has been on Triflexis ever since. Appears to be working very well. After the first 2 months we were having trouble getting her to take the pills. So we coated it in butter (to seal the smell) then wrapped it in soft bread. This worked for 3 months. Now spits it out. We're looking for a new solution besides shoving it down her throat. She acts like we are punishing her.
Date published: 2017-01-14
Rated 5 out of 5 by from Love it!! All 3 of our furkids are on it Furkids been on Trifexis for years. Living in the south with sandfleas, hardly ever find a flea on them.
Date published: 2017-01-14
Rated 5 out of 5 by from I have been using trifectis for six months !! It's been great no fleas in sight! If I do see a flea it is dead in a short time.
Date published: 2017-01-14
Rated 5 out of 5 by from Awesome product I have had no trouble with this product. I would recommend this product for any pet owner
Date published: 2017-01-09
Rated 5 out of 5 by from My Katie is on Trifexis for about 2 years. It is the best flea tick and heartworm medication on the market.
Date published: 2017-01-08
  • 2017-01-20T06:07CST
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Q&A

My dog's weight ranges from 9.8-10.4 lbs and he may loose/gain a few ounces depending on his daily activity level. Would it be better to have him on the 5-10 lb pill, or the 10.1-20 lb pill. I want him to have the correct dosage without having too much. 

Asked by: Benedict
I recommend you use the 5-10 pound dose on your dog. The heartworm part of Trifexis is very safe to use at the higher dose, but the flea control part may make your dog nauseous at the higher dose.
Answered by: SuzyCVT
Date published: 2017-01-06

What's the off brand for trifexis at the store

Asked by: Gigi
There is no generic equivalent for Trifexis available at this time.
Answered by: SuzyCVT
Date published: 2017-01-06

How recent must a heartworm test be in order to get Trifexus? Can I wait a month or two to get Trifexus after she has been tested for heartworm? 

Asked by: Lilyanne0823
Your pet should be on consistent heartworm prevention every 30 days. A lapse longer than 45 days is not recommended.
Answered by: S Duesler PharmD MBA
Date published: 2016-12-30

Can it cause heart trouble 

Asked by: Sugar
No studies have shown that this medication can increase the occurrence of cardiac issues in your pet.
Answered by: S Duesler PharmD MBA
Date published: 2016-12-30

Does Trifexis cover for ticks, too?

Asked by: Lynn 8710
Trifexis does not cover for ticks. Many people have had great success combining this product with a tick collar.
Answered by: 1800Petmeds Pharmacist
Date published: 2016-12-30

I'm not sure if it's been exactly 30 days. Somewhere between 28-30. Is it okay to give to my dog?

Asked by: Cand4
It is okay to give the next dose if you're at 28 days or more. It is best to now mark the calendar and maintain the schedule going forward. This will not only insure that the days are correct but it will also serve as a reminder each month. I use the calendar on my cell phone to remind me to give my dog his medication and that has been very helpful and has freed me up from having to constantly be concerned about the schedule. Most phones have these type of reminders built in and there are also many apps that can help you set up a schedule for medication.
Answered by: 1800Petmeds Pharmacist
Date published: 2016-12-21

may I fax my dog's Rx?  what is your fax #? Thanks

Asked by: jdbjd123
We do need the original written prescription mailed into us. If you need the medication immediately we can attempt to contact your veterinarian for further authorization. Our Mailing Address: 420 S. Congress Suite 100 Delray Beach, FL 33445
Answered by: Pharmacy Manager
Date published: 2016-12-20

Can I give my puppy a dose. A week earlier. If he has fleas?

Asked by: Amanda
If your puppy was already given a Trifexis tablet, there should be no need to give another dose early as it is still working. However, if your puppy has not been given Trifexis before, but rather another heartworm prevention and perhaps a topical flea control, it is safe to give the Trifexis a week early to get the fleas under control. You may instead try a Capstar tablet for the fleas which will kill all the fleas for 24 hours if you are concerned about giving the Trifexis early.
Answered by: SuzyCVT
Date published: 2016-12-13
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