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Product Info
What is Selegiline?

Selegiline, also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing's Disease and Canine Cognitive Dysfunction Syndrome (senility). Selegiline requires a prescription from your veterinarian.



  • Easy to administer
  • Typically, once a day dosing
How it Works:

Selegiline increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing's Disease has traditionally been centered on suppressing the adrenal glands production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.


Because Selegiline belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAOI) it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals. If any serious side effects occur (difficulty breathing, hives, agitation, swelling of the lips, tongue or face), stop giving Selegiline and seek emergency veterinary medical attention. Make sure you tell your veterinarian what other medications you are giving your pet.

Brand Name:

Anipryl (Pfizer Animal Health), Eldepryl (Somerset)

Generic Name:

Selegiline (see-ledge'-a-leen)

What is Selegiline:

Selegiline, also known as L-deprenyl, is a monoamine oxidase inhibitor (MAOi) used in dogs for the treatment of Cushing's disease and canine cognitive dysfunction. It is not known specifically how selegiline works. However, it is believed that selegiline prevents the breakdown of dopamine. Selegiline may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving selegiline to my pet:

Selegiline should not be given if the pet is taking meperidine. Tell your veterinarian about any other medical conditions your pet has. Tell your veterinarian if your pet is pregnant or lactating.

What is the most important information I should know about selegiline:

Selegiline is a prescription medication FDA approved for veterinary use in the treatment of Cushing's disease caused by a pituitary tumor in dogs. Selegiline is also used to treat canine cognitive dysfunction. Selegiline is available as 5mg tablets. The usual initial starting dose to treat Cushing's disease in dogs is 0.45mg per pound given once a day in the morning. If no results within 2 months may increase to 0.9mg per pound once a day. If still no response after one month of the increased dose, reevaluate the pet. The dose for canine cognitive dysfunction is 0.2-0.45mg per pound. It may take up to one month or more to see improvement. Do not give more of this medication than is prescribed without consulting your veterinarian. Selegiline may cause drowsiness or dizziness.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store selegiline at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.

What should I avoid while giving Selegiline to my pet:

Selegiline may cause dizziness or drowsiness. Do not give higher doses than those prescribed.

What are the possible side effects of Selegiline:

If any of the following serious side effects occur, stop giving selegiline and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements. Other less serious side effects may occur. Continue giving selegiline and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Selegiline:

Before giving selegiline tell your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.

How to Use
  • Selegiline is a prescription medication used in dogs for the treatment of Cushing's disease caused by a pituitary tumor.
  • Selegiline is also used in dogs to treat canine cognitive dysfunction.

Do not give more of this medication than is prescribed without consulting your veterinarian. Selegiline may cause drowsiness or dizziness.

Dogs: (when used for cognitive dysfunction)
All weights
The starting dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of pets body weight. It may take up to one month or more to see improvement
Dogs: (when used for Cushing's disease)
All weights
The usual starting dose to treat Cushing's disease is 0.45mg per pound of pets body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pets body weight. If still no response after one month of the increased dose, your pet should be reevaluated.
Do not use!
Do not use!

Store this product at room temperature, away from moisture and heat.

Active Ingredient (per tablet):
Selegiline hydrochloride, USP
5 mg
Other Ingredients: Citric Acid, Anhydrous Lactose, Magnesium Stearate, and Microcrystalline Cellulose.
Customer Reviews
Selegiline is rated 3.5 out of 5 by 8.
Rated 3 out of 5 by from Check the facts I originally had started my 15-year-old poodle-bichon on Anipryl. When I tried to get a refill, they were out and have been each time, so I ended up getting the generic. I did not realize until today that the generic was half the mg amount. Benji has done so-so on the generic, but I don't think my vet realizes the difference either, as he has me giving him only 1-1/2 tabs a day when he should probably be taking at least 2 tabs a day. So I am holding my judgment on this for now.
Date published: 2013-04-19
Rated 1 out of 5 by from Do your own homework before you buy When I read the label and realized that the Selegiline was an MAO inhibitor, I decided not to "roll the dice" and possibly compromise my dog. I had relied on the advice of the vet, and should have done my homework before placing the order. The dog is doing better on neurotransmitter enhancing supplements that I acquired.
Date published: 2013-03-18
Rated 1 out of 5 by from Unreasonable Cost My dog needs 30mg daily and has taken anipryl; a single tablet daily makes a 30-day supply cost $95. This generic is a 5mg, meaning she'd need 6 a day; a 60-tablet bottle would be a 10-day supply at $143. I thought generics were supposed to save money...
Date published: 2012-07-01
Rated 5 out of 5 by from excellent sammie is our female Shih-Tzu, she is doing very well, she is white and is 17 lbs she is 12 yrs old and she acts like a puppy, of course she is spoiled but such a good girl she is an indoor dog, the doctor said she does not look like she is 12, all I can say is she is very alert and she knows so much.
Date published: 2009-11-20
Rated 5 out of 5 by from Selegiline So far, Scarlett is doing fine on Selegiline. She seems very active, playful, and is doing well. I am very pleased because she is my baby. She's a 20 lb black an white Shih-Tzu and I love her. She's five years old and was diagnosed with Cushings Disease a couple of months ago.
Date published: 2009-11-16
Rated 5 out of 5 by from Excellent alternative to harsher drugs My Yorkie, Dachshound mix breed was diagnosed with Cushings disease 4 1/2 yrs. ago. I chose Selegiline back then as treatment because I was opposed to anything harsh that might cause other ailments and because I did not want to put her through countless blood tests and vet visits. She is almost 9 yrs old now and is doing amazingly well! She is playful, and happy, and I am so excited that I chose this alternative method of treatment for her. In addition she takes denosyl and marin (OTC vitamins) for liver health. She visits the vet once a yr. for shots and blood work, and I am very happy to report that her "numbers" from her blood work have remained constant :)
Date published: 2009-11-01
Rated 4 out of 5 by from For Cushings My 13 yr old was diagnosed with Cushings (pituitary dependant) over a year ago. I decided against Lysodren, due to its toxic effects, but when her thirst tripled (symptom of Cushings), I started her on Anapryl, although my vet said it works for only 20% of cases. After two months, my dog's thirst had gone back to normal, and i stopped needing to keep her in diapers. Other symptoms still there, but her thirst was affecting our quality of life. I just learned it's available as the generic Selegeline--but only in lower dose tabs. Still, half the cost of Anapryl. If you don't want to destroy your dog's adrenal glands, try selegeline.
Date published: 2009-02-16
Rated 4 out of 5 by from Seems To Be Working My 9 year old Beagle has been on this medication for almost a year for Cushing Syndrome. There was a slight improvement and she seems to be doing well so I am satisfied with this medication, not sure how much the medication is responsible, It did bring her blood work back within the normal ranges. She has hypothiroidism so it's hard to see what is caused by that or the Cushing. She goes back next month for blood work and we will see then how much her levels are. Hopefully they are the same as last time or even better. She has had no symptoms from this medication. However it is very important no days are skipped so always make sure that you have medication for your dog without interruption.
Date published: 2008-08-13
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My vet has suggested giving my senior dog Selegiline for some senility issues he is having. I also give him Novox 25 mg. Can this be given together?

He is almost 15 yrs old, 15 lb Papillon
Asked by: Leslie
My 14yrs old aussie takes 75mg No vox and 5mg Selegiline for her senility, arthritis, and back degeneration.  The Selegiline has been a miracle drug for us!!!  She was so out of it, she barely ate, she peed eveywhere, she walked aimlessly, she constantly bit when bumbed by a dog, or when I had to give meds.  Now she is happy, comes when called, and is back "with it"!!  Back to no aggression and all love, no mental problems, and happy and cuddly!!!  
Answered by: Ancient Aussie Lover
Date published: 2017-01-09

Side effects 

Asked by: Sue47
Common side effects include dizziness, drowsiness, nausea, abdominal pain or diarrhea.
Answered by: S Duesler PharmD MBA
Date published: 2016-11-17

My 9 year old boxer has been taking this medication (30mg) for almost 4 weeks now with not much improvement. How long should it be before we see a change?

Asked by: Mreiff23
It may take anywhere from 2-6 weeks to see clinical improvement in your boxer.
Answered by: Christine
Date published: 2016-10-10

My 23 pound Boston Terrier has been on Selegiline 5 mg for 2 1/2 weeks. He is displaying many adverse symptoms (trembling of the body, weakness in the legs, loss of appetite, "lost" stance, pupillary dysfunction, etc). Should I discontinue t

Asked by: Kelbran
Speak with your vet about these side effects your Terrier is experiencing. The vet may want to adjust the dose or discontinue the medication and start something else.
Answered by: Christine
Date published: 2016-09-29


Does the Selegline come in a smaller dose? My vet wants me to give 2mg to my dog a day.
Asked by: Jo
The smallest strength we carry is 5 mg.
Answered by: Linda petmeds pharmacist
Date published: 2015-07-10

would i have to increase the number of pills at 5mg selegiline to equal 15mg of Anipryl

Asked by: AMG
AMG, Thank-you for your question. Yes, you would have to increase the number of selegiline tablets from 1 to 3 in order to equal 15mg of Anipryl. Anipryl is currently out of stock. Hope this helps! Jessica A. Pharmacy Intern 1800Petmeds
Answered by: Dulcineas17
Date published: 2013-03-21

Is it ok to crush selegiline pills before giving to my dog?

Asked by: Eric
Yes, it can be crushed. Make sure to wear gloves and wash hands well. If adding to food, just add to a small amount of food to ensure that your pet will get the entire dose.
Answered by: Kelly P
Date published: 2013-03-04

Selegiline interaction with Rimadyl?

My 16 year old Jack Russell has been on Selegiline for about 7 months now to control canine cognitive dysfunction. He is also in the middle stages of renal failure -- kidney values are ok but protein leaking in the urine. He is also on spironolactone, thyroxine, amlodipine and enalapril. Recently he went off his food and lost a good bit of weight. We switched his food and he is eating & gaining weight again, but when he lost the weight he began losing the use of his hind legs. Our vet has recommended Rimadyl for this situation even though there is a contraindication with Selegiline--a judgment made as a quality of life call. My question is, what damage is this potentially going to do to him and what should we be watching for if/when the impact of this manifests itself?
Asked by: GPB
Hello, Great question; in regards to drug interactions between Rimadyl and Selegiline, there is a magnified risk of behavioral fluctuations, including lethargy, hallucinations, disorientations, irritability, and sleep disturbances. You should also be observant for an increased incidence of gastrointestinal side effects, which include nausea/vomiting, diarrhea and constipation. Good luck and I hope this was beneficial for you.
Answered by: Rich - Student Pharmacist
Date published: 2012-07-28
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