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Product Info
How to Use
Customer Reviews
Product Info
What is Percorten-V?

Percorten-V (desoxycorticosterone pivalate) is the only medication approved by the FDA for treating Canine Addison's Disease (hypoadrenocorticism). Percorten-V requires a prescription from your veterinarian.

You will need a syringe to use Percorten-V, but it is not included in the package. Please see 3cc (3ml) luer slip syringe with 3/4" 25 g Needle.



  • Well tolerated
  • Low incidence of side effects
How it Works:

Canine Addison's Disease is a condition where a dog's adrenal glands don't work properly. Normal adrenal glands produce mineralocorticoids that help regulate many bodily functions such as metabolism, blood pressure, and stress response. Percorten-V is a replacement therapy for the mineralocorticoid deficiency in dogs with Addison's disease.


Do not use any preventative vaccines such as Percorten-V without checking with your veterinarian. Talk to your veterinarian about any side effects that seem unusual or bothersome to your pet. Percorten-V should not be stopped suddenly. Percorten-V should not be given to pregnant dogs, or dogs suffering from congestive heart disease, severe renal disease or edema.

Brand Name:

Percorten-V (Novartis)

Generic Name:

Desoxycorticosterone pivalate (DOCP)

What is the most important information I should know about Percorten-V:

Percorten-V is a prescription medication that is commonly used by veterinarians in dogs for the treatment of Addison's disease. Percorten-V is available as a 4 ml multi-dose vial containing 25mg/ml. Percorten-V should not be stopped suddenly. Irritation at the injection site may occur. Percorten-V is administered IM (intramuscularly). Do not administer IV (intravenously). Contact the veterinarian if the pet develops behavior changes, swelling, or unusual weight gain.

What is Percorten-V:

Percorten-V is a corticosteroid used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease. Percorten-V may also be used for purposes other than those listed in this guide.

What should I discuss with my veterinarian before giving Percorten-V to my pet:

Do not give Percorten-V to your pet if the pet has a serious bacterial, viral or fungal infection. Percorten-V weakens the pet's immune response and its ability to fight infections. Tell your veterinarian if your pet has kidney or liver disease, heart disease, stomach ulcers, hypothyroidism, diabetes mellitus or any other medical conditions. Also tell your veterinarian if the pet is pregnant or lactating.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. Do not give more or less than is prescribed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. The usual dose of Percorten-V in dogs is 1mg/pound given by IM injection every 25 days. Store Percorten-V at room temperature away from moisture and heat. Keep this medication away from children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if it almost time for the next dose, skip the dose missed and give only the next regularly scheduled dose. Do not give a double dose of this medication.

What happens if I overdose the pet:

Seek emergency veterinary medical treatment. Symptoms of overdose may include swelling or water retention, high blood pressure, weight gain, low levels of potassium in the blood, and Cushing's disease.

What should I avoid while giving Percorten-V to my pet:

Avoid sources of infection. Do not use any preventative vaccines without checking with the veterinarian.

What are the possible side effects of Percorten-V:

If any of the following serious side effects occur, stop giving Percorten-V and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure or sudden weight gain. Other less serious side effects may occur. Continue giving Percorten-V and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of Percorten-V include thinning of the skin, cataracts, glaucoma, behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Percorten-V:

Do not give any other over the counter or prescription medications, including herbal products, during treatment with Percorten-V without first talking to the veterinarian. Tell your veterinarian if your pet is taking Phenobarbital, furosemide, insulin or glipizide, phenytoin, digoxin, warfarin, or aspirin. Drugs other than those listed may interact with Percorten-V resulting in side effects or altered effectiveness.

Where can I get more information:

Your pharmacist has additional information about Percorten-V written for health professionals that you may read.

How to Use
  • Percorten-V is a prescription medication that is commonly used by veterinarians in dogs for the treatment of Addison's disease.
  • Percorten-V is a corticosteroid used to treat conditions, such as Addison's disease, in which the body does not produce enough of its own steroids.
  • Percorten-V is available as a 4 ml multi-dose vial containing 25mg/ml and is administered IM (intramuscularly). Do not administer IV (intravenously).

Percorten-V should not be stopped suddenly. Irritation at the injection site may occur.

All weights
Shake well before using. Give 1mg per pound of body weight by IM (intramuscular) injection every 25 days
Do not use!
Do not use!

Store this product at room temperature, away from moisture and heat.

Active Ingredients (per mL)
Desoxycorticosterone Pivalate
25 mg
10.5 mg
Sodium Carboxymethylcellulose
3 mg
Polysorbate 80
1 mg
Sodium Chloride
8 mg
Thimerosal (a preservative)
Customer Reviews
Percorten-V is rated 4.8571 out of 5 by 35.
Rated 5 out of 5 by from great product My pomeranian/dashaund dog piglet has addison disease and i could not see myself putting him to sleep so i asked our vet if there was something i could give him and he said percortenv and ever since i gave him his injections every month he has been alot better thankyou 1800petmeds for keeping my dog alive
Date published: 2016-02-29
Rated 5 out of 5 by from This product keeps my dog alive! My Boston Terrier dog has Addison's Disease, and he would not be alive if not for monthly Percorten-V injections! At 1-800-PetMeds, I can get this for about a hundred dollar less then at my Vet's office!
Date published: 2015-05-01
Rated 5 out of 5 by from great product/ great price Maggie was diagnosed with Addison's disease and has responded very well to her treatment. She is on Percorten (every 25 days) and Prednisone (daily). It is very helpful to be able to purchase her medications at a better price through PetMeds, especially given that this is a treatment for life. She is a medium dog (30 lbs) so we save about $250 a year when purchasing through PetMeds than through other pharmacies. Thank you!
Date published: 2015-04-19
Rated 5 out of 5 by from Percorten-V Rosco was diagnosed with Addisons about 2 years ago and thanks to the Percorten-V and the Prednisone he's living a happy and healthy life He gets his shot every 30 days and 2.5 mg of Prednisone every morning he is now 7 years old Thanks you PetMeds for making his medication available every month at great price
Date published: 2015-02-15
Rated 5 out of 5 by from My lab was diagnosed at 9 months old with Addison's Disease, he is going to be 9 years old in April. Percoten V along with Prednisone saved his life and has lived a full life so far and still going strong.
Date published: 2014-12-05
Rated 5 out of 5 by from Works Great! This product to has helped save my dog's life. It works well and she is here because of it. Percorten is easy to draw and administer with the proper syringe for the proper dosage.
Date published: 2014-11-15
Rated 5 out of 5 by from This product is a lifesaver My dog Tela was diagnosed with Addison's early last June. Since then I have been giving her monthly injections of Percorten (1 every 28 days). I do have her electrolytes tested once a month and have been lowering her dosage slowly. Percorten has saved her life and I strongly recommend it if your dog has Addison's disease.
Date published: 2013-11-25
Rated 3 out of 5 by from Addisons My Dane was diagnosed with Addison's he is 114 lbs and taking 4.3ml of porcorten does that sound right?
Date published: 2013-11-18
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My dog has Addisons and weighs 85 lbs

My dog weighs 85 lbs. If I get this bottle of 4 ML and she gets 1mg per LB, she will get 3.4 ml per shot correct?
Asked by: Ciera M
Please consult your veterinarian regarding dosing for your pet.
Answered by: Stephanie Duesler, Pharm. D, MBA
Date published: 2015-08-28

Does this drug stimulate hair growth?

Percorten-V Since our dog has received this medication she is doing much better. The question I have is does it cause hair growth? She has grown hair on her belly that she has never had before and other places. Thank you.
Asked by: Gregoreee
No, no more than before the starting Percorten.
Answered by: marti
Date published: 2015-05-01

How does percorten compare to flurodrocortizone

What is the difference in these two drugs for dogs with Addisons?
Asked by: Anonymous
They both are used to treat Addisons. The main difference is that the Percorten is injectable and given at intervals that can range from 3 to 4 weeks while the fludrocortisone is an oral tablet that is usually given daily or a few days each week.
Answered by: Kelly P
Date published: 2015-04-09


How much comes in a bottle of percorten? And how many doses?
Asked by: Sandy
4 mL comes in one bottle. My dog originally got a shot of 2.4 mL when she was first diagnosed. Now I have her electrolytes tested every month and her dose is now at 1.6 mL. My vet has been dropping it by approximately .2mL a month. However, I will keep testing her electrolytes until I find out her ideal, low dosage.
Answered by: Colleen
Date published: 2013-11-25

Once percorten-v is opened how many doses can I give him

I was told by Novartis that after two months (I give the Percorten-v every 28 days) I must get a new bottle. Please help.
Asked by: none
My dog's a Min Pin who's been on .57 of it for 6 yrs & his vet is one of my best friends. I get 5 doses give or take (due to drawing wrong occasionally & losing a little to squirting) The last dose of the bottle (5 mos) shows the very obvious boost & that little "fountain of youth" effect I see if he's been especially stressed after the 25 day post dose, then I know the signs that it's time early or not to give him his shot on the 25th day. But that is just what my Friend/Vet told me to do. He also said if he shows none of what are his clear signs, HE (MY DOG) can even go a day or two past 30th day (perhaps because of his size. I know exactly when I have no more than two days to give him that shot based on quite a few signs. It varies with how much stress or excitement he's had when close to the regular 30 day mark. If I see the "signs" I'll give it to him even if it's only been 23 days since last dose. *This is what my Vet has supervised for many years but my kid like all is not like any other so always make sure your Vet agrees. Of course a drug company would say that. One thing my friend/Vet was always fastidious about when he was doing the injection was he shakes the bottle for a really long time, at least a minute or two. (Make sure there's no sign of powder at the bottom when you turn the vial over) I keep it in the fridge & find that it's easier to shake if you take it out 15 mins or so & let it get to room temperature *following the drugs included leaflet instructions as to the temperatures which are safe for it to be stored at. It's OK up to 80 degrees I believe - but don't rely on me.
Answered by: Scooch Senior
Date published: 2013-09-17


Since our dog has received this medication she is doing much better. The question I have is does it cause hair growth? She has grown hair on her belly that she has never had before and other places. Thank you.
Asked by: Gregoreee
Hair growth is not a known side effect of this drug, you may obtain more information from the manufacturer to see if they have had similar reports from other people. Otherwise you should check with your veterinarian to see if there may be any other causes for the hair growth.
Answered by: Janine M./Pharmacist
Date published: 2013-09-10

my dog has been on percorten for 1 year now. she is experiencing dry skin and hair loss. could thsi be attributed to the percoten? if so what can b

Asked by: lilo
Have your dogs thyroid checked, too. My Maltese has Addison's and then developed a thyroid issue that wasn't recognized until we insisted on bloodwork, so be proactive and ask for tests-don't wait for Dr to suggest. She's been on Thyroid meds since and her hair has gotten thicker, her skin healthier and her weight as well
Answered by: jjm
Date published: 2013-05-16

My vet says his Percorten cost keeps increasing?

I have a 25lb Beagle and about 2 yrs ago he started to receive a Percorten injection once/month. I paid around $80/month. Six months ago the cots increase to $105. My latest visit was $150. Is it normal to have it increase this much?
Asked by: Steve
purchase your own vial with a script from a nice vet, not one taking you for all your $$, learn how much to give and give the shot every 26 days. our dog weighs about 20 lbs and we give her .8ml your might need .9ml. ask your vet to be sure
Answered by: Greg
Date published: 2013-05-06
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