Lysodren (mitotane) is used by veterinarians to treat Cushing's Disease in dogs. Lysodren requires a prescription from your veterinarian, and is sold per tablet.
Effective treatment in most cases
How it works: Lysodren acts to suppress adrenal gland function by eroding the top layers of the adrenal gland that produce corticosteroid hormones, thereby reducing the production of cortisol.
Cautions: Side effects include lethargy, weakness, and vomiting. If they occur, stop using the medication and contact your veterinarian. It should not be used in pregnant or nursing animals. Always wear disposable gloves when giving Lysodren to your pet and wash your hands after handling this medication. Pregnant women, or women trying to get pregnant should not handle this medication.
Brand Name Lysodren (Bristol-Myers Squibb)
Generic Name Mitotane
What is the most important information I should know about Lysodren: Lysodren, also known as o,p-DDD, is a medication used in dogs for the treatment of Cushing¿s disease (Hyperadrenocorticism). It is available by prescription as 500mg scored tablets. Use disposable gloves when handling this medication as it is cytotoxic to humans. Wash hands thoroughly if the tablet comes in contact with skin.
What is Lysodren: Lysodren is used in the treatment of Cushing¿s disease. Lysodren acts by suppressing adrenal gland function. Lysodren treatment involves two phases, a loading dose phase with higher doses for the first 1 or 2 weeks, then a maintenance dose phase. Lysodren may be used for purposes other than those listed in this medication guide.
What should I discuss with my veterinarian before giving Lysodren to my pet: Tell your veterinarian if your pet has ever had an allergic reaction to Lysodren. Tell your veterinarian if your pet is pregnant, or lactating. Tell your veterinarian if your pet has kidney or liver disease.
How should this medication be given: Give this medication exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Your veterinarian will determine the exact dose to be given for the loading phase, and then the maintenance phase. The veterinarian may prescribe glucocorticoids such as prednisone for use in stressful situations such as travel, surgery, or illness. Store this medication at room temperature and protect from light. Keep out of the reach of children and pets.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet: In the event of overdose, contact your veterinarian or veterinary emergency room. Overdose of Lysodren can result in Addison¿s disease (hypoadrenocorticism), which can be life threatening. Symptoms of Addison¿s disease may include loss of appetite, vomiting, diarrhea, weakness, depression, drowsiness.
What should I avoid while giving Lysodren to my pet: Always wear disposable gloves when giving Lysodren to your pet. If the tablet comes in contact with skin, wash thoroughly if the tablet comes in contact with skin. Pregnant women, or women trying to get pregnant should not handle this medication.
What are the possible side effects of Lysodren: Side effects that may occur when using Lysodren include loss of appetite, nausea, vomiting, or diarrhea. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Lysodren: Use caution when giving Lysodren with insulin, spironolactone (Aldactone), Phenobarbital, phenytoin (Dilantin), theophylline (Theo-Dur), warfarin (Coumadin), and drugs that affect the central nervous system, such as acepromazine (PromAce), and amitriptyline (Elavil). Talk to your veterinarian or pharmacist before using Lysodren with any prescription or over the counter medications, including vitamins, minerals and herbal supplements.
Where can I get more information: Your pharmacist has additional information about Lysodren written for health professionals that you may read.
Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.
Lysodren is a prescription medication used in dogs to treat Cushing’s disease.
Use disposable gloves when handling this medication as it is cytotoxic to humans.
Lysodren should not be used in pregnant or nursing animals. Pregnant women or women trying to get pregnant should not handle this medication.
Tip: Lysodren is given in an initial, higher dose phase for the first 1 or 2 weeks and then in a maintenance dose phase thereafter.
Give this medication exactly as directed by the veterinarian. Your veterinarian will determine the correct dose for your pet
Storage: Should be stored at room temperature and protected from light.
It really depends on your pets condition and which treatment your veterinarian thinks is best for your pet. This is one of the more common treatments used and you can monitor your pet for side effects if you do begin this treatment.
The side effects of Lysodren should not be cumulative. The presence of liver disease could affect the metabolism of the medication thereby causing the levels of the drug to accumulate in the body. Higher blood levels could cause more side effects.
The most-common side-effects include lethargy, gastritis, anorexia, vomiting and diarrhea. In rare instances, dogs may experience central nervous system (CNS) signs, ataxia, weakness and seizures. Please discuss any adverse effects or unusual reactions with your veterinarian.
I would strongly suggest if there's someone else in the household who can give the dose of medicine that they be the one to do so. If it has to be you, I highly recommend, in an abundance of caution, that you wear rubber gloves when handling this medication, even if you don't actually touch the tablet. Wash your hands after giving each dose.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.