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Lysodren

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Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Lysodren?

Lysodren (mitotane) is used by veterinarians to treat Cushing's Disease in dogs. Lysodren requires a prescription from your veterinarian, and is sold per tablet.

For:

Dogs

Benefits:
  • Effective treatment in most cases
How it Works:

Lysodren acts to suppress adrenal gland function by eroding the top layers of the adrenal gland that produce corticosteroid hormones, thereby reducing the production of cortisol.

Cautions:

Side effects include lethargy, weakness, and vomiting. If they occur, stop using the medication and contact your veterinarian. It should not be used in pregnant or nursing animals. Always wear disposable gloves when giving Lysodren to your pet and wash your hands after handling this medication. Pregnant women, or women trying to get pregnant should not handle this medication.

Brand Name:

Lysodren (Bristol-Myers Squibb)

Generic Name:

Mitotane

What is the most important information I should know about Lysodren:

Lysodren, also known as o,p-DDD, is a medication used in dogs for the treatment of Cushing's disease (Hyperadrenocorticism). It is available by prescription as 500mg scored tablets. Use disposable gloves when handling this medication as it is cytotoxic to humans. Wash hands thoroughly if the tablet comes in contact with skin.

What is Lysodren:

Lysodren is used in the treatment of Cushing's disease. Lysodren acts by suppressing adrenal gland function. Lysodren treatment involves two phases, a loading dose phase with higher doses for the first 1 or 2 weeks, then a maintenance dose phase. Lysodren may be used for purposes other than those listed in this medication guide.

What should I discuss with my veterinarian before giving Lysodren to my pet:

Tell your veterinarian if your pet has ever had an allergic reaction to Lysodren. Tell your veterinarian if your pet is pregnant, or lactating. Tell your veterinarian if your pet has kidney or liver disease.

How should this medication be given:

Give this medication exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Your veterinarian will determine the exact dose to be given for the loading phase, and then the maintenance phase. The veterinarian may prescribe glucocorticoids such as prednisone for use in stressful situations such as travel, surgery, or illness. Store this medication at room temperature and protect from light. Keep out of the reach of children and pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

In the event of overdose, contact your veterinarian or veterinary emergency room. Overdose of Lysodren can result in Addison's disease (hypoadrenocorticism), which can be life threatening. Symptoms of Addison's disease may include loss of appetite, vomiting, diarrhea, weakness, depression, drowsiness.

What should I avoid while giving Lysodren to my pet:

Always wear disposable gloves when giving Lysodren to your pet. If the tablet comes in contact with skin, wash thoroughly if the tablet comes in contact with skin. Pregnant women, or women trying to get pregnant should not handle this medication.

What are the possible side effects of Lysodren:

Side effects that may occur when using Lysodren include loss of appetite, nausea, vomiting, or diarrhea. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.

What other drugs will affect Lysodren:

Use caution when giving Lysodren with insulin, spironolactone (Aldactone), Phenobarbital, phenytoin (Dilantin), theophylline (Theo-Dur), warfarin (Coumadin), and drugs that affect the central nervous system, such as acepromazine (PromAce), and amitriptyline (Elavil). Talk to your veterinarian or pharmacist before using Lysodren with any prescription or over the counter medications, including vitamins, minerals and herbal supplements.

Where can I get more information:

Your pharmacist has additional information about Lysodren written for health professionals that you may read.

Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.

How to Use
Directions:
  • Lysodren is a prescription medication used in dogs to treat Cushing's disease.
  • Use disposable gloves when handling this medication as it is cytotoxic to humans.
  • Lysodren should not be used in pregnant or nursing animals. Pregnant women or women trying to get pregnant should not handle this medication.
Tip:

Lysodren is given in an initial, higher dose phase for the first 1 or 2 weeks and then in a maintenance dose phase thereafter.

Dosage:
Dogs:
Weight
Dosage
All weights
Give this medication exactly as directed by the veterinarian. Your veterinarian will determine the correct dose for your pet
Cats:
Do not use!
Horses:
Do not use!
Storage:

Should be stored at room temperature and protected from light.

Ingredients
Lysodren:
Active Ingredients
Mitotane
500 mg
Customer Reviews
Q&A

How long is life expectancy when using this medication?

Asked by: Anonymous
It really depends on your pets particular condition and their response to the medication, Dogs can still live long happy lives. With treatment, some syptomes will disappear quickly while other symptoms may take a while to resolve.
Answered by: Kelly P
Date published: 2015-03-06

is the price for lisodren per tablet or per 100 like you show on your website

Asked by: janneke
Thank you for your question. The price is per tablet.
Answered by: Maureen PetMeds Pro
Date published: 2015-02-04

This must be an error on the price? please tell me price for 30? Also, how does this compare to Veteroyl?

Asked by: DB
The price is correct. Lysodren acts to suppress adrenal gland function by eroding the top layers of the adrenal gland that produce corticosteroid hormones, thereby reducing the production of cortisol. Vetoryl contains a drug that controls the adrenal gland's excess production of cortisol, a hormone released into the bloodstream during times of stress
Answered by: Lilli Pharmacist
Date published: 2014-09-18

Can this pill be crushed?

Asked by: Robyn
It is not advisable to crush the tablet as this medication can be harmful to anyone or any animal to whom it is not prescribed. Crushing the tablet has the potential to leave possible environmental residue and exposing others in your household to the medication.
Answered by: Lilli Pharmacist
Date published: 2014-09-05

What is the usual time frame of giving this drug before starting as a maintenance

Asked by: Dina
The loading dose period is usually one to two weeks. After that, the maintenance dose would begin.
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-02-24

Can you give this medication with vitamin supplements?

ex: Omega 3 pills, glusomine and chondroitin
Asked by: Dina
Yes
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-02-24

Do the benefits outweigh the side effects?

when using this drug to treat Cushings Syndrome?
Asked by: mister
It really depends on your pets condition and which treatment your veterinarian thinks is best for your pet. This is one of the more common treatments used and you can monitor your pet for side effects if you do begin this treatment.
Answered by: Kelly P
Date published: 2012-11-07

will treatment with this drug result in a cure of cushings or is this forever maintenance

Asked by: moc1019
Since there is no cure for Cushing's disease, Lysodren may be used as a maintenance medication.
Answered by: Lisa M
Date published: 2012-10-16
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