Treats various internal and external fungal infections
Easy to administer
How it works: Ketoconazole is an antifungal medication that blocks the formation of cortisol in the adrenal glands and for that reason is used in the treatment of Cushing’s disease.
Cautions: Ketoconazole can interact with many other drugs. Fully disclose to your veterinarian any medications your pet is taking before giving ketoconazole. Do not use in pregnant or nursing animals.
Brand Name Nizoral (Janssen)
Generic Name Ketoconazole (keet-ah-cone¿-ah-zole)
What is the most important information I should know about ketoconazole: Do not give this medication if your pet is taking astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Combined with these drugs, ketoconazole could cause serious, even fatal side effects. In rare cases, ketoconazole can cause severe liver damage. Notify your veterinarian immediately if your pet develops nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow eyes, itching, or dark urine. These symptoms may be early signs of liver damage.
What is ketoconazole: Ketoconazole is an antifungal medication. Ketoconazole is a prescription medication that is not FDA approved for use in animals; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats to treat various internal and external fungal infections. Ketoconazole is also used to treat Cushing¿s disease. Ketoconazole is available as 200mg tablets. The usual dose of ketoconazole for dogs and cats is 2.2-13mg/pound every 12 to 24 hours, depending on the disease being treated.
What should I discuss with my veterinarian before giving ketoconazole: Do not give ketoconazole if your pet is being given astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Dangerous or life threatening events may occur. Do not use this medication in animals allergic to it or similar medications. Tell your veterinarian if your pet has liver disease, or if your pet is being given antacids, stomach acid reducers or stomach ulcer medications. Tell your veterinarian if your pet is pregnant or lactating or if you plan to breed your pet.
How should this medication be given: Give ketoconazole exactly as directed by your veterinarian. If you do not understand these directions, ask your pharmacist or veterinarian to explain them to you. Ketoconazole should be given with food. Do not give ketoconazole within 2 hours of an antacid. Allow plenty of drinking water for the pet. Blood tests or other medical evaluations may be required by your veterinarian to monitor progress and side effects. Store ketoconazole at room temperature away from heat and moisture. Keep this medication out of the reach of children and other pets.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication unless directed to by your veterinarian.
What happens if I overdose the pet: Contact your veterinarian or veterinary emergency room. Symptoms of ketoconazole overdose may include dizziness, headache, nausea, vomiting, diarrhea, and abdominal pain.
What should I avoid while giving ketoconazole to my pet: Ketoconazole may cause dizziness. Use caution when given with other medicines that may also cause dizziness.
What are the possible side effects of ketoconazole: If any of the following serious side effects occur, stop giving ketoconazole and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing, swelling of the lips, tongue, or face; hives); or liver damage (yellowish eyes, abdominal pain, unusual fatigue, or dark urine). Other less serious side effects may occur. If any of the following side effects occur, continue to give ketoconazole and talk to your veterinarian; nausea, vomiting, or abdominal pain; diarrhea; headache; dizziness; fatigue; itching. Side effects other than those listed in this guide may occur. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to the pet.
What other drugs will affect ketoconazole: Do not give ketoconazole if your pet is being given astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Dangerous or life threatening events may occur. Before giving ketoconazole, tell your veterinarian about any medications you are giving your pet, especially; cyclosporine (Neoral), methylprednisolone (Medrol), antacids, cimetidine (Tagamet), Nizatidine (Axid), famotidine (pepcid), ranitidine (Zantac), omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), digoxin (Lanoxin), warfarin (Coumadin), phenytoin (Dilantin), glipizide (Glucotrol). Drugs other than those listed in this guide may also interact with ketoconazole. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines, including vitamins, minerals, and herbal products.
Where can I get additional information: Your pharmacist as additional information about ketoconazole written for health professionals that you may read.
Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.
Ketoconazole is a prescription medication used in dogs and cats to treat various internal and external fungal infections. Ketoconazole is also used to treat Cushing’s disease.
Ketoconazole should be given with food. Allow plenty of water for the pet to drink. Do not give Ketoconazole within 2 hours of antacids.
It is very important that you tell your veterinarian or pharmacist about any other medications your pet is taking.
Tip: Results of treatment may not be seen for 1 or 2 weeks and the duration of treatment may last up to several months. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Make sure you complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.
Dosage depends on the particular disease being treated
Storage: Store this product at room temperature.
Secondary yeast and fungal infections are indeed frustrating problems to deal with both for pet and animal guardian. Yeast overgrowths are often secondary to underlying itching and skin allergies, as well as sometimes overuse of oral antibiotics. Guardians and veterinarians will often notice a musty or rotton sock odor often emanating from their pets ears or skin. Sometimes sticky discharge with dark discoloration of the skin can occur. Diagnosis of yeast infection is usually accomplished at a veterinarian's office via exam of the discharge under the microscope. This often forgotten inexpensive diagnostic technique, often leads to misuse of antibiotics in our pets, as well as a worsening of the skin problem. Once diagnosed, I have found ketoconazole a very safe and effective product in helping kill yeast overgrowth on the skin and ears, often leading to much symptomatic relief. However it is important for veterinarians to address the underlying causes of yeast overgrowth such as inhalent/contact allergies, food allergies or hormonal disorders, or the problem will recur. While in the veterinary literature there is caution with this drug in causing liver problems, I have not found this to be much of a problem in my experience and opinion. The biggest side effect I have seen in some pets is vomiting or diarrhea, which I find is usually minimized by giving with small amounts of food. This drug is also often prescribed by veterinarians in allergic dogs who are also prescribed the expensive allergy drug atopica, because it often allows vets to use lower doses of atopica to help control allergic skin symptoms. As for its other use, I have not found ketoconazole helpful in managing dogs with Cushings disease. I give this product an overall rating of a 4 with an ease of use/taste a 4 as well.
Definitely helped with cushings
When my Charlie was diagnosed with Cushings disease I was worried because he'd lost weight and hair in patches here and there. After taking ketoconazole he's back to his normal weight and his hair is coming back and the dandruff is gone. He seems like he feels better too!
My 60 lb shepherd mix was on 100 mg of Atopica daily and would still get occasional ear infections. Vet changed to Ketoconazole (3/4 tablet) and 50 mg Atopica and it made a huge difference. I am now giving this dosage every other day and will try to go to every three days. The Ketoconazole has been a life saver.
Tobbey has taken it for seven years with atopica. They has relieved his allergy symptoms completely in addition to his diet change. He is very healthy. Joyce
Severe liver damage can,t get liver emznye back to normal they were ok before ketoconazole. Dog in serious medical trouble
It seems as though my dog was injured by another dog as they were playing. My dog wasn't bitten but she received a laceration on the right cheek(it's a small circle about 3/4 inch in diameter). It is an opened wound. I have Ketoconazole cream 2%. Did I apply to the wound or no?
I found on a web page a study on anal furunculosis which my dog has had for 2 years he is miserable the study which mentioned ketoconazole as a must when using atopica for treatment why can i not buy this drug in the UK and what are your recommendations for anal furunculosis.America always seems to be way ahead on treatments that work.
The appropriate dose to treat your pet would depend on different things, for example where the infection is and how severe it may be. Please discuss your concerns with your doctor and bring in your pet to be seen if you think she may need to be examined.
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.