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Product Info
How to Use
Customer Reviews
Product Info
What is Ketoconazole?

Ketoconazole is used to treat fungal infections. It is also used to treat Cushing's disease. Ketoconazole, available as 200mg scored tablets (sold per tablet), requires a prescription from your veterinarian.


Cats and Dogs

  • Treats various internal and external fungal infections
  • Easy to administer
How it Works:

Ketoconazole is an antifungal medication that blocks the formation of cortisol in the adrenal glands and for that reason is used in the treatment of Cushing's disease.


Ketoconazole can interact with many other drugs. Fully disclose to your veterinarian any medications your pet is taking before giving ketoconazole. Do not use in pregnant or nursing animals.

Brand Name:

Nizoral (Janssen)

Generic Name:

Ketoconazole (keet-ah-cone'-ah-zole)

What should I discuss with my veterinarian before giving ketoconazole:

Do not give ketoconazole if your pet is being given astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Dangerous or life threatening events may occur. Do not use this medication in animals allergic to it or similar medications. Tell your veterinarian if your pet has liver disease, or if your pet is being given antacids, stomach acid reducers or stomach ulcer medications. Tell your veterinarian if your pet is pregnant or lactating or if you plan to breed your pet.

What is the most important information I should know about ketoconazole:

Do not give this medication if your pet is taking astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Combined with these drugs, ketoconazole could cause serious, even fatal side effects. In rare cases, ketoconazole can cause severe liver damage. Notify your veterinarian immediately if your pet develops nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow eyes, itching, or dark urine. These symptoms may be early signs of liver damage.

How should this medication be given:

Give ketoconazole exactly as directed by your veterinarian. If you do not understand these directions, ask your pharmacist or veterinarian to explain them to you. Ketoconazole should be given with food. Do not give ketoconazole within 2 hours of an antacid. Allow plenty of drinking water for the pet. Blood tests or other medical evaluations may be required by your veterinarian to monitor progress and side effects. Store ketoconazole at room temperature away from heat and moisture. Keep this medication out of the reach of children and other pets.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication unless directed to by your veterinarian.

What should I avoid while giving ketoconazole to my pet:

Ketoconazole may cause dizziness. Use caution when given with other medicines that may also cause dizziness.

What are the possible side effects of ketoconazole:

If any of the following serious side effects occur, stop giving ketoconazole and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing, swelling of the lips, tongue, or face; hives); or liver damage (yellowish eyes, abdominal pain, unusual fatigue, or dark urine). Other less serious side effects may occur. If any of the following side effects occur, continue to give ketoconazole and talk to your veterinarian; nausea, vomiting, or abdominal pain; diarrhea; headache; dizziness; fatigue; itching. Side effects other than those listed in this guide may occur. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to the pet.

What other drugs will affect ketoconazole:

Do not give ketoconazole if your pet is being given astemizole (Hismanal), cisapride (Propulsid) or triazolam (Halcion). Dangerous or life threatening events may occur. Before giving ketoconazole, tell your veterinarian about any medications you are giving your pet, especially; cyclosporine (Neoral), methylprednisolone (Medrol), antacids, cimetidine (Tagamet), Nizatidine (Axid), famotidine (pepcid), ranitidine (Zantac), omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), digoxin (Lanoxin), warfarin (Coumadin), phenytoin (Dilantin), glipizide (Glucotrol). Drugs other than those listed in this guide may also interact with ketoconazole. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines, including vitamins, minerals, and herbal products.

How to Use
  • Ketoconazole is a prescription medication used in dogs and cats to treat various internal and external fungal infections. Ketoconazole is also used to treat Cushing's disease.
  • Ketoconazole should be given with food. Allow plenty of water for the pet to drink. Do not give Ketoconazole within 2 hours of antacids.
  • It is very important that you tell your veterinarian or pharmacist about any other medications your pet is taking.

Results of treatment may not be seen for 1 or 2 weeks and the duration of treatment may last up to several months. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Make sure you complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

All weights
Dosage depends on the particular disease being treated
Do not use!

Store this product at room temperature.

Active Ingredient:
200 mg
Customer Reviews
Ketoconazole is rated 4.0 out of 5 by 15.
Rated 5 out of 5 by from Allergies I have used this for my Zoe and it worked so good for her.
Date published: 2016-03-22
Rated 5 out of 5 by from Definitely helped with cushings When my Charlie was diagnosed with Cushings disease I was worried because he'd lost weight and hair in patches here and there. After taking ketoconazole he's back to his normal weight and his hair is coming back and the dandruff is gone. He seems like he feels better too!
Date published: 2014-11-19
Rated 5 out of 5 by from Wonderful! My 60 lb shepherd mix was on 100 mg of Atopica daily and would still get occasional ear infections. Vet changed to Ketoconazole (3/4 tablet) and 50 mg Atopica and it made a huge difference. I am now giving this dosage every other day and will try to go to every three days. The Ketoconazole has been a life saver.
Date published: 2014-11-15
Rated 5 out of 5 by from Tobbey has taken it for seven years with atopica. They has relieved his allergy symptoms completely in addition to his diet change. He is very healthy. Joyce
Date published: 2014-09-13
Rated 1 out of 5 by from Severe liver damage can,t get liver emznye back to normal they were ok before ketoconazole. Dog in serious medical trouble
Date published: 2011-12-30
Rated 4 out of 5 by from My Doberman Pinscher was lactating and cleaning her new borns all the time. She develop blisters outside under her mouth and we tried a topical lotion first. It wasn't quite doing the job. Once the puppies got to 5 weeks, we weaned them off her so she could take this medicine prescribed for 21 days. It has done a better job getting rid of the skin problem but she will vomit at least once a day, mostly the early evening dose she would do this. My vet recommended to stop taking them because she was also taking an antibiotic for a different kind of insect bite infection and see if the vomiting will cease. She has recovered from the blisters and the puppies are well worth the job done for a good mom she is.
Date published: 2010-08-19
Rated 5 out of 5 by from Cleared up the skin problem very quickly.
Date published: 2010-03-09
Rated 5 out of 5 by from All Over Yeast Infection My lab, Bo, who is now 11, has been battling yeast infections for a couple of years now. A few summers back, after spending most of his time swimming in our pool, Bo became very, very stinky. Like old gym socks. The vet put him on this product and within a few weeks, the infection began to clear and the smell started going away. I use it year round, but reduce the dose down to 1x a week, or not at all in the winter. Because he likes the water so much, and his coat is dense, he is prone to this type of infection, so by summer, I am usually using it 3x's to 4x's a week. Last summer, because I was proactive, he never broke out into an all over body infection and what little there was, never got out of control.
Date published: 2010-01-26
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Took my dog to the vet for ear infection gave her a shot for the infection and ketoconazole told me to stop her apoquel pills for 10 days I would like to know if it is safe to give her ketoconazole with her apoquel because she is getting a ear infection

Asked by: Sandyfeet70
I would consult your vet before restarting the Apoquel.
Answered by: Ben B
Date published: 2017-02-21

Second half to my question Is it safe to give my dog Apoquel with ketoconazole because she has been off of Apoquel for. 2 weeks

Asked by: Sandyfeet70
I would consult your veterinarian before use, but I would not recommend the two together.
Answered by: Ben B
Date published: 2017-02-21

I have a Bulldog/Pitbull mix and he has sensitive skin, and flakes a lot. Lately he has been getting ringworm a from the dog parks, home remedies doesn't cure it cause it comes back. Does this med help for it? 

Asked by: Issy
Yes, ketoconazole can help to treat ringworm. However, this medication requires a prescription from your veterinarian.
Answered by: Christine
Date published: 2016-10-12

Should I give tablet once or twice daily - 65# dog

Asked by: lynne
The dosage depends on the particular disease being treated, so it is hard to say how many tablets you should give to your 65 lb dog. If you are unsure, speak with your veterinarian to confirm the correct dose. Doses can be anywhere from 1.1-4.5 mg/lb (71.5-292.5 mg for a 65 lb dog).
Answered by: Christine
Date published: 2016-10-10

What can i use for ear infection  yeast small dog

Asked by: jackabbey22
Typically, for an ear infection, you would use antibiotic ear drops. These require a prescription from your veterinarian.
Answered by: Christine
Date published: 2016-10-05

For the oral medication, how many tablets should be administered for a mild ringworm infection in a 55lb female lab mix

Asked by: evacranford
Typically for fungal infections, like ringworm, the dosage of ketoconazole is 2.3-4.6 mg/lb orally every 12-24 hours. For a 55 lb lab, this ranges from 126.5 mg - 253 mg orally every 12-24 hours. Treatment duration can vary, but generally should be continued for atleast 1 month after complete resolution of clinical signs. This medication requires a prescription from your veterinarian, and they may have more specific directions for you.
Answered by: Christine
Date published: 2016-10-04

My vet told me to give to my dog for server itching but also put her on antacids and prednilsolone 5mg tablets all at once?It states do not give with antacids or prednilsolone tablets? Is it safe to be giving her all at once? Shes a Chinese crested dog 

Asked by: Trish
You'll want to give the ketoconazole 1 hour before or 2 hours after giving the antacid.The prednisolone could have a higher effect while your dog is on ketoconazole too. Speak to your vet if you still have concerns.
Answered by: paulpharmacistintern
Date published: 2016-09-14

May I apply Ketoconazole Cream to open wound?

It seems as though my dog was injured by another dog as they were playing. My dog wasn't bitten but she received a laceration on the right cheek(it's a small circle about 3/4 inch in diameter). It is an opened wound. I have Ketoconazole cream 2%. Did I apply to the wound or no?
Asked by: Anonymous
I would recommend that you contact your veterinarian prior to using something on your dogs open wound. Your veterinarian may want to examine your pet to see if antibiotics are necessary. Ketoconazole is an antifungal and may not be appropriate.
Answered by: Anonymous
Date published: 2016-09-14
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