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Glyco-Flex III

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Product Info
How to Use
Customer Reviews
Product Info
What is Glyco-Flex III?

Glyco-Flex III is a nutritional supplement (stage III of the comprehensive Glyco-Flex program for dogs), containing glucosamine as well as Perna Canaliculus (green lipped mussel - which is a good source of protein, minerals, and chondroitin sulfates), and MSM. It is used for maintaining healthy joints, and is recommended for geriatric, and working and sporting breed dogs, as well as a follow-up to orthopedic surgery. Made in the USA. Glyco-Flex III is also available as Glyco-Flex III Soft Chews.



  • Ideal for dogs of all weights
  • Supports joint and connective tissue health
  • Also beneficial in helping dogs recover from orthopedic surgery
  • Natural imitation roast chicken flavor
How it works:

The active ingredients include glucosamine, Perna Canaliculus (green lipped mussel), and MSM. Glucosamine is a natural compound that is found in healthy cartilage in both humans and pets. It helps hydrate healthy joints by increasing the production of molecules that bind and hold water in the cartilage. Healthy cartilage provides cushioning which helps protect a pet's joints while exercising. Many believe that it provides clinical benefit in the synovial fluid by strengthening cartilage and aiding glycosaminoglycan synthesis. Further research on the effectiveness of glucosamine is still needed, but many of our customers find it to be very beneficial to their pets.


Diabetic dogs or dogs that are overweight and have problems with glucose tolerance should have their blood sugars monitored if they are given glucosamine supplements.

Brand Name:

Glyco-Flex III (Vetri-Science)

Active Ingredient(s)

Glyco-Flex III Per tablet: Glucosamine HCl (1000mg), Methysulfonylmethane (1000mg), Brewers Yeast (810mg), Perna canaliculus (Green-Lipped Mussel) (600mg), Dicalcium Phosphate (262mg), Stearic Acid (190mg), Cellulose (190mg), N,N Dimethylglycine HCl (100mg), Manganese Amino Acid Chelate (100mg), Smoke Flavor (57mg), Vitamin E (50 IU), Calcium Ascorbate (30mg), Silicon Dioxide (21mg), Grape Seed Extract (5mg), L-Glutathione (2mg), Selenium (0.002mg).

What is this product used for:

Glyco-Flex III tablets are a nutritional supplement used for maintaining healthy joints. This product represents stage III of the comprehensive Glyco-Flex program for dogs. Glyco-Flex III is recommended for geriatric, and working and sporting breed dogs, as well as a follow up to orthopedic surgery.


Glyco-Flex III tablets are non-prescription (OTC) products.

How should this product be used:

The usual dose of Glyco-Flex III tablets for the first 4-6 weeks in dogs up to 30 lbs is 1/2 tablet. For dogs 31-60 lbs use 1 tablet, for dogs 61-100 lbs use 2 tablets and for dogs over 100 lbs use 2 1/2 tablets. The maintenance dose for dogs up to 30 lbs is 1/2 tablet every other day, for dogs 31-60 lbs is 1/2 tablet, for dogs 61-100 lbs is 1 tablet, for dogs over 100 lbs is 1 1/2 tablets daily.

In the event of overdose:

Contact a veterinarian or veterinary emergency room.

What are the side effects:

There are no reported side effects.

What special precautions are there:

These products are for animal use in dogs only. Glucosamine, in humans, may increase insulin resistance and consequently affect glucose tolerance. Diabetic dogs or dogs that are overweight and have problems with glucose tolerance should have their blood sugars monitored if they are given glucosamine supplements.

How should I store this product:

Store in a cool, dry place. Keep out of the reach of children and animals.

How to Use
  • Glyco-Flex III can be given with or without food.
  • If giving more than 1 tablet daily, divide between AM and PM.

Diabetic dogs should have their blood glucose monitored when taking glucosamine supplements.

Dogs (tablets) Initial dose
Up to 30 lbs
Give 1/2 tablet daily
31-60 lbs
Give 1 tablet daily
61-100 lbs
Give 2 tablets daily
Over 100 lbs
Give 2 ½ tablets daily
Dogs: Maintenance dose (after 4 to 6 weeks)
Up to 30 lbs
Give 1/2 tablet every other day
31-60 lbs
Give 1/2 tablet daily
61-100 lbs
Give 1 tablets daily
Over 100 lbs
Give 1 ½ tablets daily
Do not use!
Do not use!

Should be stored in a cool, dry place. Keep container tightly closed.

Glyco-Flex III Tablets:
Active Ingredients (per tablet)
Glucosamine HCl (shrimp and crab)
1000 mg
Methylsulfonylmethane (MSM)
1000 mg
Perna Canaliculus (Green Lipped Mussel)
600 mg
N,N-Dimethylglycine HCl (DMG)
100 mg
dl-alpha Tocopheryl Acetate (Vitamin E)
50 IU
Calcium Ascorbate (Vitamin C)
30 mg
Manganese (as Mn Amino Acid Chelate)
10 mg
Grape Seed Extract
5 mg
2 mg
Selenium (as Sodium Selenite)
0.002 mg
Other Ingredients: brewers yeast, cellulose, dicalcium phosphate, natural imitation roast chicken flavor, silicon dioxide, stearic acid.
Customer Reviews
Glyco-Flex III is rated 4.022222222222222 out of 5 by 45.
Rated 5 out of 5 by from Great Product My German Shepard/Husky got loose out our back door about 6 years ago and ran out into the street trying to be playful with my roommate, when a speeding truck slammed into her going 60mph. She is a big girl. She lay on the street for a good 2 minutes while we all ran to her and then she sat up and looked around, as if she was trying to figure out what happened. I of course was screaming in tears and I think she was in shock. Well, we got her to the emergency vet and they did X-rays and urgent surgery. She was down for quite awhile, with casts on her front legs and rear end. The vet prescribed her with Glyco-Flex 3 and other meds. Now she takes 2 Tramadol a day and half a Meloxicam with 1 and a half Glyco-Flex 3 and she runs around and wrestles with my other fur baby and even runs into my kitchen when I call her for a treat. Glyco-Flex 3 really helps her a lot. I swear by it. I just wish I could find a cheaper price on it. =)
Date published: 2015-09-16
Rated 5 out of 5 by from AWESOME !!! This product has made a huge difference in my dog and his arthritis. I would recommend this to anyone without question. It took about a week to see results but when I did they were amazing.
Date published: 2015-04-01
Rated 5 out of 5 by from Keeps our dogs moving I have had many Basset Hounds in my life and started using this product in 1998 when one of our hounds became arthritic. Works like a charm, have used it on 3 hounds since when they became seniors. Had a friend whose German Shorthair broke her back and GlycoflexIII also kept her going another 9 years. We have found the soft chews aren't as effective though. With this product our hounds are able to run-play and hike up to 10 miles at the age 10...awesome!
Date published: 2015-03-27
Rated 4 out of 5 by from THis product really works.MY lab runs and plays like he is 2or 3 years old and he is now 10.Try it you will not be disappointed.
Date published: 2014-07-17
Rated 5 out of 5 by from I think this is a great product! Rebel just turned 2 somewhere around the first of the year. We adopted him so his age is close. He is half Red Heeler and 1/2 Bassett Hound,. He runs like the wind most of the day. He suffered a knee injury, a Vet friend of mine suggested we give him Glyco-Flex III for life and he is better, and still runs like the wind.!
Date published: 2014-05-06
Rated 5 out of 5 by from Glyco Flex 111 I have two dogs and they are both on this med. Taco (Shepherd) is 14 yrs. old and his legs tend to bother him. This med has given him back his agility. Mikey (Shih Tzu) is 12 and has for years limped due to a hip issue. Since going on this med he rarely limps anymore and flies around like he did as a puppy. I highly recommend this product.
Date published: 2013-12-14
Rated 1 out of 5 by from Intolerable Wanted to step-up the joint supplement for our 11 year old Lab mix, however she was unable to tolerate this supplement. Caused yellow emesis and diarrhea. Will return to the classic supplement. She tolerates the Classic Glycoflex very well.
Date published: 2013-08-13
Rated 5 out of 5 by from Is keeping her well and happy Buffy is a 105 lb, 11 year old Great Pyr/Bouvier cross. I inherited her at 2 1/2, when she had been abused and fed junk for food. I changed her diet, took her to the vet, but by 3 1/2 she was in pain, beginning to limp. My vet told me if I would give her Glycoflex III daily she would rebuild her joints and do well. She was absolutely right. Now at almost 12 (which is old for Bouviers) she has slowed down but has no joint problems, is able to run and play--and does not have joint pain at night. This stuff works. Yes, sometimes she doesn't want to eat it, but if I mix up the chews and the tablets I am able to get her to eat the right dosage.
Date published: 2013-07-17
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At what age can you start giving...

I have a 7 months old GSD working bloodlines. Can I give it to him just as a supplement/support?
Asked by: miguelart
Your furry friend is young but old enough to take the supplement however you would want to consult your vet and get the proper advice to see if your Furry Friend would need to start this supplement now.
Answered by: James PetMeds Pro
Date published: 2015-10-02

phosphorus level in glycoflex 3 tabs

Asked by: tina
As far as I'm aware there is no Phoshorus in this product. There is an ingredient called dicalcium phosphate which is a form of calcium used to help strengthen bone and there is 262mg in this product. Thanks for your question.
Answered by: Marty, Pharm. D.
Date published: 2015-04-09

What stage do I need Glyco Flex II or III

My dog is a 10 yr. old English Shepherd, and weighs approx. 86 pounds. He has been having difficulty with getting up, getting into vehicles and coming down the stairs. He isn't crying as I read of other reviews, but having difficulty and I want to try GlycoFlex . What stage of Glyco Flex would be best to start him with, II or III. Thank You
Asked by: KountryKate
I would go with III, our Basset's are usually on stage I or II by the time they're 7 then when they start having troubles like you're describing they're on III. We have 2, one of our males is a large hound for his breed (64lbs.) he is on 1 in the am & 1 in the pm, the 52 pounder is only on 1 a day (this is given with food). We swear by this and have seen it help numerous dogs, hope you have luck with it as well!
Answered by: Basset Wrangler
Date published: 2015-03-27

Why are the Glyco-Flex Stage III tablets $80 for 120 while the chews are $54 for 120? Does the medication in one tablet equal one chew?

Is there the same amount of medication in one tablet as there is in one chew? If so, then I don't understand the huge price differential.
Asked by: Marie
The chews aren't as potent, not as many ingredients and in my opinion don't work as well.
Answered by: Basset Wrangler
Date published: 2015-03-27

how long does it take to ship Glycoflex III from 1-800 petmeds to Springfield MO

Asked by: Annie
They have customers answer these questions so i don't know how long ago you asked this question. I always get the free shipping and they are very fast. It usually only takes a couple of days but I also live in Texas.
Answered by: AnimalLover
Date published: 2013-05-07

Can you give Glyco-flex and Rimadyl together?

Asked by: snowy
I am not a vet but I believe you can because this product is just a vitamin supplement.
Answered by: AnimalLover
Date published: 2013-05-07

my poodles fur around all orifices has turned brown since she started taking glyco flex 3 chews and she is white-would the pills cause the same change

Asked by: springer
One of my cats is white and she has no browning from this product.
Answered by: AnimalLover
Date published: 2013-05-07

My dog is on Proin for urine incontenence (2 proin in am and 2 in pm), can she take Glyco Flex III while on Proin?

Asked by: Debra
There are no known interactions between these two medications. So yes she can take Glycoflex III while on Proin.
Answered by: Chris-Pharmacy Intern
Date published: 2013-01-19
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