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Product Info
How to Use
Customer Reviews
Product Info
What is Fluconazole?

Fluconazole is an antifungal medicine in tablet form that is used to treat a variety fungal infections, including yeast infections. It is typically used to treat skin infections, and more intense fungal infections of the lungs and other organs that can occur after your pet inhales fungus from infected soil. Fluconazole is often used in pets who have been unable to tolerate other types of antifungal medication. It is also used for difficult-to-treat fungal infections, such as those that have spread to internal organs. Fluconazole requires a prescription from your veterinarian, and is sold per tablet.


Cats and Dogs

  • Treats a variety of internal and external fungal infections
  • Treats serious fungal infections of the central nervous system (CNS) more effectively than many other antifungals
  • Has fewer side effects than most other antifungals
  • Is effective against ringworm
How it Works:

Fluconazole is related to ketoconazole, but it is more successful in treating infections of the central nervous system (CNS) because it more effectively crosses the blood-brain barrier, allowing the medication to find its way to the infected areas of the body. When your pet takes fluconazole, the active ingredient within the medicine kills the fungus that causes infections by interfering with the cell membranes of the fungus. This inhibits growth of the fungus, which keeps the fungal cells from reproducing, and eventually eradicates the infection.


Fluconazole can interact with many other drugs. It is important to tell your veterinarian about any other medications, vitamins, or supplements your pet is taking before giving fluconazole to your pet. Do not give to pets who have liver disease or impairment. If your pet has kidney disease or kidney failure, discuss the risks versus benefits with your veterinarian before giving fluconazole. Do not give to pregnant animals or animals that are nursing unless your veterinarian says the benefits outweigh the risks. Do not give fluconazole to any pets who are sensitive or allergic to other "azole" antifungal medications, such as ketoconazole. If you have any concerns about this medication, talk with your veterinarian before giving it to your pet.

Brand Name:

Diflucan (Pfizer)

Generic Name:


What is the most important information I should know about fluconazole:

Fluconazole is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. The usual dose of fluconazole in dogs can vary from 5.5mg to 22mg per pound every 12 to 24 hours, depending on the condition being treated. The usual dose in cats is typically 50 mg once a day. The actual dose and duration of treatment depends on the specific condition being treated. Fluconazole should be given to your pet for the entire length of time prescribed by your veterinarian. Treatment with fluconazole may take several months and improvement may not be seen for one or two weeks after treatment begins.

What is Fluconazole:

Fluconazole is an antifungal used to treat systemic fungal infections such as cryptococcal meningitis, blastomycosis, and histoplasmosis. Fluconazole may also be used in treating fungal infections of the skin such as superficial candidiasis, or ringworm. Fluconazole may be used for other purposes than those listed in this guide.

What should I discuss with my veterinarian before giving fluconazole to my pet:

Do not give this medication if your pet is allergic to fluconazole or other azole antifungal agents. Do not use fluconazole if your pet is pregnant unless the benefit outweighs the risk. Tell your veterinarian if your pet is allergic to any medications, or if your pet has liver disease or kidney disease.

How should this medication be given:

Give fluconazole exactly as it was prescribed by your veterinarian. Do not give in larger amounts or use it for longer than recommended by your veterinarian. Follow the instructions on the prescription label. If you do not understand these directions speak to your pharmacist or veterinarian. Your veterinarian may want to perform blood tests on a regular basis to make sure the medication is not causing harmful effects. Store fluconazole at controlled room temperature 68°-77° F.

What happens if I miss giving a dose:

Give the missed dose as soon as you remember. However, if it almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.

What happens if I overdose the pet:

Seek emergency veterinary medical attention if you think you have used too much of this medication. Symptoms of overdose may include loss of appetite, vomiting, jaundice, depression, tiredness, anemia, or a skin rash.

What should I avoid while giving Fluconazole:

Do not use fluconazole in animals with liver disease. Use with caution in animal's with kidney disease. Do not use in pregnant animals unless the benefit outweighs the risk.

What are the possible side effects of Fluconazole:

Seek emergency veterinary medical attention if your pet experiences any signs of an allergic reaction (hives; difficulty breathing; swelling of the face, lips, tongue, or throat). Talk to your veterinarian immediately if your pet develops any of these side effects: jaundice, loss of appetite, vomiting, depression, tiredness, anemia, skin rash. Talk to your veterinarian about any side effect that seems unusual or that is especially bothersome to your pet.

What other medications will affect Fluconazole:

Tell your veterinarian if your pet is using any of the following medications: Buspirone, cisapride, cyclophosphamide, cyclosporine, thiazide diuretics (Dyazide, Diuril), NSAIDS (Rimadyl, Novox), theophylline/aminophylline, tricyclic antidepressants (clomipramine, Clomicalm, amitriptyline), sulfonylurea ant-diabetics (glipizide, glyburide), warfarin (Coumadin). There may be other drugs not listed that can affect fluconazole. Tell your veterinarian about all prescription and non-prescription (OTC) medications, including vitamins, minerals, herbal products, and drugs prescribed by other veterinarians. Do not start using a new medication without telling your veterinarian.

Where can I get more information:

Your pharmacist has information about Fluconazole written for health professionals that you may read. Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.

How to Use
  • Give fluconazole to your pet with food and always make sure your pet has plenty of fresh water to drink while taking this medication.
  • Do not give fluconazole within 2 hours of giving antacids because it could affect the dosage your pet receives.

You may not notice a visible improvement until you've been treating your pet for 1 to 2 weeks, and you may need to treat your pet with fluconazole for several months. Make sure you continue giving the prescription to your pet until the end of the treatment regimen unless your veterinarian specifically directs you to discontinue giving fluconazole. Your pet may feel better, and you may notice an improvement in visible fungal infections before the treatment has ended, but it's important to complete the treatment to prevent a relapse and to prevent the possibility of future resistance to fluconazole or other antifungal medications.

All weights
Dosage and how frequently you will need to administer the medication depends upon the particular infection being treated. Follow your veterinarian's instructions.
Do not use!

Store this product at room temperature in child-proof containers. Keep out of reach of children and pets.

Active Ingredients
100 mg
Customer Reviews
Fluconazole is rated 5.0 out of 5 by 1.
Rated 5 out of 5 by from Works great My 8 mth old puppy has food allergy and developed a secondary yeast infection. Worked great on clearing it right up! Great price too!!!!
Date published: 2011-09-12
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How long approximately will my 20lb. Shitzu need to clear up his severe yeast infection??

I have been fighting this for 8 years in the little boy and little girl. I am at my wits end and am so hoping this is the answer I have been praying for. Have had them on every dog food Vet has suggested along with what friends say. they are now on raw turkey/sardine food. Help!!!! Please!!! Vet is hesitant to prescribe this pill!!!
Asked by: Anonymous
We have a bulldog that is allergic to all the meat based proteins, including duck, buffalo, venison. So we switched to vegetarian dry and canned. There is only one over the counter that we could find but it worked. He is off steroids and antibiotics for the first time in his life. The dermatologist wanted him off the steroids, but left him on the Benadryl. We also had the yeast problems and after 2 months on fluconazole his hair came back in and the ears cleared up too. He gets a bath at least every 10days with coaltar antifungal shampoo. His bedding gets changed frequently too and I wash & dry on allergy cycle. On my GE this is a LONG hot wash. I use vinegar in the rinse water too. We haven't put in the turf type grass in his dog run yet but plan to asap.
Answered by: Dogmom
Date published: 2015-05-13

Yeast Infection

Will this medication treat an Old English Bulldog's Eye Infection, where it weaps down into their folds?
Asked by: Wells1203
You would need to have your pet examined by a veterinarian to see what is causing the weeping. It might be dry eye, or it might be an infection or something else. If it is an infection, your veterinarian will prescribe the appropriate antibiotic.
Answered by: Kelly P
Date published: 2015-03-03

Diflucan (Pfizer)

Can women use this to treat a yeast infection?
Asked by: Anonymous
Thank you for your question. No, this cannot be used on humans.
Answered by: Maureen PetMeds Pro
Date published: 2014-05-27

Human Yeast Infection

Is this product the same Diflucan Fluconazole that is prescribed to females when they have a yeast infection? Can females take this? What is the difference?
Asked by: Anonymous
it is the same active ingredient. It is used in animals to treat systemic fungal infections.
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-04-02

Fluconazole bottled versus compounded

Is there any difference between the bottled fluconazole and the compounded medication? If so, can you tell me the difference?
Asked by: Sue
The compounded fluconazole is made into either a liquid or chewable treats in doses which are not available commercially.
Answered by: Pharmacist
Date published: 2015-01-08


Do you carry this medication in the 200mg tablet
Asked by: Max
Yes, but it is compounded as a chewable tablet.
Answered by: Linda M 1800petmeds pharmacist
Date published: 2014-03-11

Do you sell 400 mg Fluconazole? If so, how much for 90 and 180 day supply?

Asked by: Suzanne
Thank you for your question. Unfortunately, we do not carry that milligram at this time.
Answered by: Maureen PetMeds Pro
Date published: 2014-05-14

Does Fluconazole 50mg make my dog constipated?

She in no other meds, 9 yrs old, 14 lbs.
Asked by: Anonymous
it is very important that your pet drinks lots of fresh water when taking this medication. Please tell your vet about this possible side effect......I think the vet should know right away !! Its inportant that the pet be able to excrete waste as easily as possible and the pet could be in a lot of pain/discomfort.
Answered by: Linda M 1800petmeds pharmacist
Date published: 2013-11-06
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