My Account
Errors:

1-800-PetMeds EXCLUSIVEFlea5X Plus - Generic to Frontline Plus

Starts $38.74 $27.89 
Ships in one business day or less
1
Select Pet's Weight:
Dog
04-22 lbs
23-44 lbs
45-88 lbs
89-132 lbs
Cat
All Weights
2
Select a Supply:
3 pack
$38.74
$30.99
$27.89
Price w/coupon TOPTEN
6 pack
$73.23
$58.58
$52.72
Price w/coupon TOPTEN
Free Shipping
Save $3 over 3 pk
12 pack
$138.70
$110.96
$99.86
Price w/coupon TOPTEN
Free Shipping
Save $11 over 3 pk
Starts $38.74 $27.89 
Ships in one business day or less
Please select all product options.
3
Select a Quantity:
Quantity
Please select all product options.
Product Info
How to Use
Ingredients
Customer Reviews
Q&A
Product Info
What is Flea5X Plus - Generic to Frontline Plus?

Flea5X Plus is a monthly topical flea and tick preventative for dogs and cats over 8 weeks of age. It contains the same active ingredients as Frontline Plus. Flea5X Plus contains fipronil to quickly kill adult fleas, ticks and chewing lice on your pet. Flea5X Plus also contains (S)-methoprene, an insect growth regulator that kills flea eggs and larvae to help end the flea life cycle. In addition to killing adult fleas and preventing reinfestation, Flea5X Plus is effective against ticks such as the brown dog tick, the American dog tick, the lone star tick and the deer tick, including those that may transmit Lyme disease. Choose Flea5X Plus for a great savings over leading comparable brands and get the same effective protection for your pet.

For:

Cats/Kittens over 1.5 lbs (8 weeks or older), Dogs/Puppies over 4 lbs (8 weeks or older)

Benefits:
  • Each application protects your pet from multiple pests for a full month
  • Helps control sarcoptic mange infections in dogs
  • Kills fleas that may cause skin allergies
  • Waterproof formula won't wash off during swimming or bathing
  • Kills fleas, flea eggs, flea larvae, ticks (including those that may transmit Lyme disease and other tickborne diseases), and chewing lice
  • Compare to Frontline Plus, containing the same active ingredients
  • Prevents and controls infestations for 30 days
How it Works:

Flea5X Plus contains fipronil, a slow-acting, broad-spectrum insecticide that disrupts the central nervous system of fleas and ticks. It also contains (S)-Methoprene, an insect growth regulator that helps to stop the flea life cycle by killing flea eggs and larvae. The waterproof formula means your pet will be protected even after swimming or bathing.

Please note: This product is not manufactured or distributed by Merial, the makers of FRONTLINE® Plus. FRONTLINE® is a registered trademark of Merial.

Cautions:

Do not use Flea5X Plus for Dogs on cats. Do not use Flea5X Plus for Cats on dogs. Keep pets away from other treated pets for 24 hours. Contact your veterinarian immediately if Flea5X Plus for Dogs is applied to your cat or ingested by your cat, or if Flea5X Plus for Cats is applied to your dog or ingested by your dog. Your pet may experience some temporary irritation at the site of application. If signs persist or become more severe within a few days of application, consult your veterinarian immediately.

Brand Name:

1-800-PetMeds Flea5X Plus

Generic Name:

fipronil & (S)-methoprene

Active Ingredients:

Fipronil & (S)-methoprene

What is Flea5X Plus used for:

Flea5X Plus kills fleas, ticks, and chewing lice, and controls mites that may cause sarcoptic mange in dogs. It is a long-lasting, fast-acting and waterproof formula containing the same active ingredients as Frontline Plus.

Availability of Flea5X Plus:

Flea5X Plus for Dogs is a non-prescription (OTC) product. Flea5X Plus for Cats is a non-prescription (OTC) product.

How should Flea5X Plus be used:

Use Flea5X Plus for Dogs on dogs and puppies weighing over 4 lbs and 8 weeks of age or older. Use Flea5X Plus for Cats on cats and kittens weighing over 1.5 lbs and 8 weeks of age or older. It is available as 0.50 mL applicators for cats, 0.67 mL applicators for dogs 4-22 lbs, 1.34 mL applicators for dogs 23-44 lbs, 2.68 mL applicators for dogs 45-88 lbs and 4.02 mL applicators for dogs 89-132 lbs. Wait 24 hours for product to dry before allowing your pet to go swimming or bathing your pet. Do not reapply for 30 days.

To apply Flea5X Plus:

Remove tubes from packaging and separate one tube from the rest of the pack. Hold with the notched end pointing up and away from your face. Cut off the end at the notch along the lines. With one hand, spread the fur on your pet's back between the shoulder blades and invert the tube over your pet. Use the open end of the tube to part the fur completely and squeeze the tube firmly to apply all the contents onto that one spot. Wash hands after application.

What are the side effects of Flea5X Plus:

Pets may experience some temporary irritation at the site of product application. If signs persist, consult a veterinarian immediately.

What special precautions are there with Flea5X Plus:

DO NOT USE FLEA5X FOR DOGS ON CATS. DO NOT USE FLEA5X FOR CATS ON DOGS. Do not use on cats or kittens under 1.5 lbs or under 8 weeks of age. Do not use on dogs or puppies under 4 lbs or under 8 weeks of age. Use the entire contents on each pet. Do not split one tube between pets. Do not use multiple tubes on one pet. Weigh your dog to ensure you are applying the right dose formulated for the weight of your dog. Consult your vet before using on debilitated, aged, or medicated pets. Also consult your vet before using on pregnant or nursing dogs. Flea5X Plus for Cats can be used on breeding, pregnant, or lactating cats. Consult a veterinarian before using on pets with known organ dysfunction. Pets may experience temporary irritation at application site. Certain medications can interact with pesticides. Sensitivities may occur after using ANY pesticide product on pets. If signs of sensitivity occur, bathe your pet with soap and rinse with large amounts of water. If signs continue, contact your veterinarian immediately. Do not allow children to apply this product.

Harmful if swallowed. Causes eye irritation. Avoid contact with skin, eyes, or clothing. Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.

If swallowed:

Call a poison control center or a doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person.

If in eyes:

Flush eyes with plenty of water. Call a doctor if irritation persists.

If on skin:

Wash with plenty of soap and water. Get medical attention if irritation persists.

Hot Line Number:

Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may also contact 1-866-307-9795 for emergency medical treatment information.

In the event of overdose:

Contact your veterinarian or veterinary emergency room.

How should I store Flea5X Plus:

Keep out of reach of children. Do not remove the tube from the package until you are ready to use it. Store in a cool (below 77°F/25°C) dry place inaccessible to children and pets. Do not refrigerate. Protect from direct sunlight.

How to Use
Directions:
  • Remove the Flea5X Plus product tubes from the package. Separate one tube from the others.
  • Hold the Flea5X Plus tube with notched end pointing up and away from your face and body. Use scissors to cut off the narrow end at the notches along the line.
  • Invert the tube over the back of your pet's neck and use the open end to part your pet's hair.
  • Squeeze the tube firmly to apply all of the solution to your pet's skin, as a spot to your pet's back between the shoulder blades.
  • Do not apply more often than once every 30 days.
Tip:

Wait until application site is fully dry (usually 24 hours) before bathing your pet or letting your pet go swimming.

Dosage:
Dogs/Puppies (8 weeks of age or older):
Weight
Dosage
4 to 22 lbs
Apply contents of 1 applicator once a month (0.67 mL)
23-44 lbs
Apply contents of 1 applicator once a month (1.34 mL)
45-88 lbs
Apply contents of 1 applicator once a month (2.68 mL)
89-132 lbs
Apply contents of 1 applicator once a month (4.02 mL)
Cats/Kittens (8 weeks of age or older):
Weight
Dosage
Over 1.5 lbs
Apply contents of 1 applicator once a month (0.50 mL)
Horses:
Do not use!
Ingredients
Flea5X Plus for Dogs & Puppies 8 weeks or older, 4 to 22 lbs:
Active ingredients (per 0.67 ml applicator)
Amount
Fipronil
9.80%
(S)-methoprene
8.80%
Other ingredients
81.40%
Flea5X Plus for Dogs & Puppies 8 weeks or older, 23-44 lbs:
Active ingredients (per 1.34 ml applicator)
Amount
Fipronil
9.80%
(S)-methoprene
8.80%
Other ingredients
81.40%
Flea5X Plus for Dogs & Puppies 8 weeks or older, 45-88 lbs:
Active ingredients (per 2.68 ml applicator)
Amount
Fipronil
9.80%
(S)-methoprene
8.80%
Other ingredients
81.40%
Flea5X Plus for Dogs & Puppies 8 weeks or older, 89-132 lbs:
Active ingredients (per 4.02 ml applicator)
Amount
Fipronil
9.80%
(S)-methoprene
8.80%
Other ingredients
81.40%
Flea5X Plus for Cats & Kittens 8 weeks or older, over 1.5 lbs:
Active ingredients (per 0.50 ml applicator)
Amount
Fipronil
9.80%
(S)-methoprene
11.80%
Other ingredients
78.40%
Customer Reviews
Flea5X Plus - Generic to Frontline Plus is rated 2.963917525773196 out of 5 by 194.
Rated 5 out of 5 by from No problems whatsoever! I've been using this on my cat for 3 months now and have had NO issues with fleas or ticks. It has been just as effective as the more expensive name-brand version. My cat spends a lot of time outdoors and has never had a problem, no fleas, no ticks.
Date published: 2016-08-21
Rated 1 out of 5 by from does'nt work very good I bought this almost a month ago and it started working right but then the fleas came back after two weeks now I have to wait till this wears off my cats and I am getting fleas all over my house as a ruslt of this
Date published: 2016-08-19
Rated 1 out of 5 by from Does not work My kitty was full of flea's in two weeks! I applied correctly, my animals using Frontline did not have fleas..
Date published: 2016-08-16
Rated 1 out of 5 by from Use with Caution This product is NOT a pill - it is a liquid. The label states that this product is dangerous to humans. If you choose to purchase, use gloves when applying. You have to avoid touching your dog in the medicated area for 3 hours after application, as well as discourage the dog from touching it. To avoid this hassle and potential danger to you and your dog, my advice would be to purchase a pill product instead. On the plus side, 1800petmeds customer service and medical emergency hotline were very helpful, attentive, and kind. That was the silver lining to my otherwise bad experience.
Date published: 2016-08-15
Rated 1 out of 5 by from spend the extra After a couple months using this I noticed my dog itching/scratching rubbing his hind end against furniture to the extent of losing fur, so I have trashed it and ordered K9 Advantix which I KNOW works
Date published: 2016-08-14
Rated 1 out of 5 by from Returned I sent back this generic brand because it doesn't work. I do want it replaced with the original frontline plus.
Date published: 2016-08-13
Rated 1 out of 5 by from Doesn't work! I iwll stick with Frontline.. My poor little dogs has fleas1 I used this product on her twice in 50 days and she still has fleas!
Date published: 2016-08-12
Rated 1 out of 5 by from Not effective I applied product as directed and my dog got whoozy but never and I mean never stopped scratching . Product did not have any effect except for making my dog seem drunk. Do not waste your money.
Date published: 2016-08-11
  • 2016-08-23T06:05CST
  • bvseo_cps, prod_bvrr, vn_cps_3.3.0
  • cp_1, bvpage1
  • co_hasreviews, tv_4, tr_190
  • loc_en_US, sid_prod11480, PRD, sort_mostRecent
  • clientName_1800petmeds
Q&A

Do you have to get a vet prescribe products to give or apply on pet, to prevent fleas?

Asked by: Kevin 53
For Flea5X Plus you do not need a prescription from a veterinarian.
Answered by: paulpharmacistintern
Date published: 2016-08-11

Can they be broken in half

Asked by: Jean
Hi there, you would need to get the exact weight size for this medication to work properly.
Answered by: James PetMeds Pro
Date published: 2016-07-20

I have a flea infestation that has been going on for 7 months now. I have tried several different topical medications (Flea 5x plus, and PetAction plus all generic for Frontline,plus others) none of which have had any affect.Is there a better alternative?

Asked by: saltlife1313
Hi there, you will need to treat the flea infestation in the house, treating the pets alone will not resolve the issue. So you would need to use foggers to take care of the infestation in the house. If the issue is outside they also have treatments for outdoors as well. Unfortunately no medication is going to resolve the issue on your pets if the infestation is not treated properly.
Answered by: James PetMeds Pro
Date published: 2016-07-20

We have always used frontline, but it isn't working anymore. Is this product killing the fleas? I live in California.

Asked by: LilJJ
Hi, this a great product however this medication has the same exact ingredients as frontline plus.
Answered by: James PetMeds Pro
Date published: 2016-07-20

is a prescription required

Asked by: nancy
Hi there, this does not require a prescription.
Answered by: James PetMeds Pro
Date published: 2016-07-20

Can I put this on my pregnant cat?

Asked by: jessid1
Please consult with your veterinarian before doing so.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-21

Where is this manufactured?  Where does it ship from?  

Asked by: Twiggy Z
This product is manufactured in the U.S.A and ships from Florida.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-14

Do u take care credit card?

Asked by: Llowdmac
I'm so sorry, we do not accept care credit.
Answered by: Cherley Petmeds Pro
Date published: 2016-06-09
  • 2016-08-23T06:05CST
  • bvseo_cps, prod_bvqa, vn_cps_3.3.0
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_41
  • loc_en_US, sid_prod11480, PRD, sort_recentAnswersFirst
  • clientName_1800petmeds
Close
Live Chat Share Website Feedback
Name:
Email:
Phone:
Feedback: