Cyclosporine (Modified) capsules, a generic to Atopica, are used for the treatment of atopic dermatitis in dogs, which is a non-contagious skin disease characterized by chronic inflammation of the skin. While its not approved by the FDA for cats, it is commonly prescribed by veterinarians to treat cats.
Cyclosporine requires a prescription from your veterinarian.
Cats (6 months or older and weighing 4 lbs. or more)
Dogs (6 months or older and weighing 4 lbs. or more)
Cyclosporine treats atopic dermatitis, which can come with any of the following symptoms: scratching, licking, chewing, skin infections, hair loss, bad odors, and sleepless nights
Safe and more affordable alternative to steroid shots
How it works:
Cyclosporine targets cells in the immune system that cause the allergic reaction in your pet. Dosage varies, and can taper off to fewer doses after several weeks. Consult with your veterinarian for specific treatment details.
Consult your veterinarian about possible side effects or drug interactions.
Brand Name Atopica (Novartis Animal Health)
Generic Name Cyclosporine (sy-klo-sporí-een) Modified capsule
What is the most important information I should know about cyclosporine modified: Notify your veterinarian immediately if your pet develops fever (over 103į), painful urination, tiredness, sneezing, coughing, or runny nose. These symptoms could be early signs of dangerous side effects.
What is cyclosporine modified: Cyclosporine modified is an immunosuppressant available by prescription. Cyclosporine modified is FDA approved for use in the treatment of atopic dermatitis in dogs at least 6 months of age and at least 4 pounds. Cyclosporine is available in 30 capsule blister packs in strengths of 25mg for dogs 9.1 to 16 pounds, 50mg for dogs16.1 to 33 pounds and 100mg for dogs 33.1 to 64 lbs. For dogs 64.1 to 79 pounds give a combination of one 100mg capsule and one 50mg capsule as a single dose. For dogs 79.1 to 121 pounds give two 100mg capsules as a single dose. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4 to 8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days.
What should I discuss with my veterinarian before giving cyclosporine modified: Tell your veterinarian if your pet has liver disease, kidney disease, cancer, high blood pressure, a viral, bacterial or fungal infection, or any other serious or chronic condition. Tell your veterinarian if your pet is pregnant or lactating, and if you plan to breed your pet.
How should this medication be given: Give cyclosporine modified exactly as directed by your veterinarian. If you do not understand these directions, ask your veterinarian or pharmacist to explain them to you. Always give cyclosporine modified 2 hours before or 2 hours after a meal. Allow plenty of water for the pet to drink. Do not remove a capsule from the blister pack until required for use. When the capsule is removed from the blister pack there is a characteristic, noticeable smell which is normal. Your veterinarian may want your pet to have regularly scheduled blood tests during treatment to monitor effectiveness and side effects. Store cyclosporine modified at room temperature away from moisture and heat.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and give the next regularly scheduled dose. Do not give a double dose unless otherwise directed by your veterinarian.
What happens if I overdose the pet: Seek emergency veterinary medical treatment.
What should I avoid while giving cyclosporine modified to my pet: The safe use in breeding, pregnant or lactating dogs has not been determined. Do not use cyclosporine modified in dogs with known allergy to the medication. The drug should not be used in dogs with kidney disease, stomach ulcers, and certain blood disorders. Prolonged use of cyclosporine modified can result in bacterial or fungal infection related to a decreased effect of the immune system.
What are the possible side effects of cyclosporine modified: If any of the following serious side effects occur, stop giving cyclosporine modified and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing, swelling of the lips, tongue or face, and hives). Other less serious side effects may occur. Continue giving cyclosporine modified and talk to your veterinarian if your pet develops vomiting, soft stools or diarrhea, muscle cramps, muscle weakness, loss of appetite, and change of hair coat. Other side effects may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect cyclosporine modified: There are many drug/drug interactions that occur when taking cyclosporine modified. Tell your veterinarian what medications your pet is currently using and any new products, including herbal remedies you may start to give. Drug/drug interactions could cause a decrease in effectiveness or an increase in side effects of either cyclosporine modified or the other medication being given. Examples of medications that may cause drug/drug interactions are; SMZ-TMP (Bactrim, Septra), gentamicin, etodolac (EtoGesic), piroxicam (Feldene), ketoconazole (Nizoral), cimetidine (Tagamet), ranitidine (Zantac), itraconazole (Sporanox), methylprednisolone (Medrol), erythromycin, Allopurinol (Zyloprim), metoclopramide (Reglan), prednisOLOne, digoxin (Lanoxin), any type of vaccination.
Where can I get more information: Your pharmacist has additional information about cyclosporine modified written for health professionals that you can read.
Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.
Cyclosporine (modified) is a selective immunomodulator used for the treatment of atopic dermatitis in dogs and cats 6 months and older and at least 4.5 lbs.
Cyclosporine (modified) is available as 25mg, 50mg, and 100mg blister packs, each containing 30 capsules.
Tip: Do not remove capsule from blister pack until required for use. When the capsule is removed from the blister pack there is a characteristic, noticeable smell which is normal.
Dogs/Puppies: (6 months and older)
Over 4 lbs
Give 2.5mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink
Cats/Kittens:(6 months and older)
Over 4 lbs
Give 2.3-3.1mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink
Storage: Store this product at room temperature. Some variation in the color of the powder may occur from batch to batch.
Cyclosporine (Modified) Generic To Atopica
Helped bring down liver enzymes
My vet prescribed this medication to bring down my dog's very high liver enzymes. She has no symptoms but tests showed chronic liver disease. It appears to be working because, while not normal, the liver enzymes have come down a lot. It's expensive, but if it keeps her alive longer (she's 14) it's worth it.
It works :-)
My dogson Reef has suffered from really bad skin and food allergies for most of his life. We tried everything, shots, cortisone, Benadryl, different prescription foods, shampoos, dips, the works. We changed vets a couple of times as well in hopes of finding someone or something who could help him manage. It would break my heart to see him scratch and bite himself while helplessly whimpering. He looked like a zombie beagle, with multiple pruritus and almost hairless until his current vet prescribed him atopica. It immediately worked like magic!Then a friend suggested getting cyclosporine from this website as it is more affordable. We tried it, it works just as atopica did and he has been on it ever since. So happy to see him be able to enjoy life and not scratch and bite himself incessantly. His hair grew back and now he's back to being the most handsome beagle I've ever seen. :-)
My Bella Mia has suffered from allergies most of her life. So bad that she has a prescription plan at Walgreens - was on allergy shots every 10 days - hydroxizine 3x a day, prescription dog food and other medicines from time to time; she suffered badly CONSTANTLY biting & scratching, didn't sleep well. Ever since I started her on Cyclosporine 2 months ago she doesn't need her allergy shots or hydrox. or other medications. She may still need prescription dog food but that's still under "process of elimination". She's comfortable. Every pet is different, if it doesn't work for one doesn't mean it won't work for others! I recommend giving it a try.
I had to give Logan shots for over 5 years. He did somewhat better, but, it was painful for me. His allergies continued to persist while on shots. Finally, the vet prescribed Atopica and it was successful. Cyclosporine was less expensive so I tried it and Logan has done extreemly well over the years. It did inflame his gums so the dosage was decreased as well as the swelling. He is 14 years old and has congestive hear failor but his alergies to mold and fungus are under control. Try it. It works!
Reaction to the Generic Atopica
I gave this product a poor rating because my furbaby Squire had a horrible reaction to the generic Atopica. Moments after taking, he itched more than ever and the itch continued for hours. I should not have tried to save a little cash as it resulted in a miserable little guy. Going back to Atopica as my vet prescribed. Guess I just wasted a $100.00.
Most over the counter allergy medications ( diphenhydramine, clemastine ) are not in the form of a treat. Diphenhydramine is available as an over the counter liquid. If you are inquiring about cyclosporine modified specifically, there is a new liquid version available formulated for cats called Atopica liquid for cats that requires a prescription.
Thank-you for your question. A compounded cyclosporine is not the same as "modified". Modified cyclosporine is a manufactured doseform available for better absorption (versus unmodified). Pharmacies will compound cyclosporine in order to obtain a different form such as eye drops, oral solution, etc. It's important to always be aware of the type of cyclosporine your dog is taking and to make sure you always get the same product (unmodified vs. modified) as again, they do absorb differently. We want to make sure they are getting consistent doses. Hope this helps!
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.