Clomipramine is used to treat separation anxiety. It is also used sometimes to treat obsessive compulsive disorders and aggression. Clomipramine requires a prescription from your veterinarian, and is sold per capsule.
For: Dogs & Cats
Treats separation anxiety in pets
Helps reduce symptoms caused by separation anxiety such as, excessive barking, inappropriate elimination, and other destructive tendencies
Can sometimes be used to treat obsessive compulsive disorders and aggression
It is not a tranquilizer or a sedative, and should not affect your pet's personality or memory
How it works:
Clomipramine is a tricyclic antidepressant and affects chemicals in the brain (serotonin) that may become unbalanced leading to behavioral problems in pets. Clomipramine treats separation anxiety in pets. Separation anxiety is in many cases the root cause of behaviors such as excessive barking, inappropriate elimination, and other destructive tendencies. When used in conjunction with a training program, Clomipramine may be used to help decrease or eliminate these behaviors by helping treat the root cause. In addition, it is sometimes used to treat obsessive compulsive disorders and aggression
Don't use Clomipramine if your pet is taking a monoamine oxidase inhibitor (MAOI) such as Anipryl, or selegiline, or has been using a Preventic Collar in the last 14 days. Clomipramine may increase the effects of other drugs and may cause drowsiness. Stop giving your pet Clomipramine and contact your vet if the pet displays any of the following reactions: difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.
Brand Name Anafranil (Novartis), Clomicalm (Novartis)
Generic Name Clomipramine (klo-mipí-ra-meen)
What is the most important information I should know about clomipramine: Clomipramine is a prescription medication FDA approved for veterinary use. Clomipramine is available as 20mg, 40mg and 80mg tablets. Clomipramine , FDA approved for human use, is also used in veterinary medicine and is available as 25mg, 50mg and 75mg capsules. The usual dose of clomipramine in dogs is 0.5-1.8mg per pound every 24 hours depending on the condition and the response to therapy. Clomipramine may also be useful in cats, but cats tend to be more sensitive to tricyclic antidepressant drugs. Dosing of cats may be difficult with the commercially available products. Clomipramine may not help symptoms right away. It may take a number of days before symptoms begin to lessen. Contact your veterinarian if symptoms get worse or if new symptoms develop while the pet is on this medication. Clomipramine may cause drowsiness or dizziness.
What is Clomipramine: Clomipramine is a Tricyclic antidepressant. Clomipramine affects chemicals in the brain that may become unbalanced leading to behavioral problems in pets. Clomipramine is used to treat separation anxiety. Clomipramine (Anafranil) is sometimes used to treat aggression and obsessive-compulsive disorders such as tail chasing. Clomipramine may also be used for purposes other than those listed in this guide.
What should I discuss with my veterinarian before giving clomipramine to my pet: Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Tell your veterinarian if your pet has liver or kidney disease; asthma; thyroid disease; diabetes; stomach or intestinal problems; high blood pressure or heart disease; difficulty urinating, seizures, or glaucoma. Tell your veterinarian if the pet is pregnant or lactating.
How should this medication be given: Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store clomipramine at room temperature away from moisture and heat. Keep this medication away from children and pets.
What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of clomipramine overdose include seizures, confusion, drowsiness, agitation, hallucinations and low blood pressure (dizziness, fatigue, fainting).
What should I avoid while giving Clomipramine to my pet: Clomipramine may cause dizziness or drowsiness. Do not stop giving clomipramine suddenly. This could cause symptoms such as nausea and malaise.
What are the possible side effects of Clomipramine: If any of the following serious side effects occur, stop giving clomipramine and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face, or hives); seizures; a fast or irregular heartbeat; high blood pressure; difficulty urinating; or fever with increased panting, muscle stiffness or muscle weakness. Other less serious side effects may occur. Continue giving clomipramine and talk to your veterinarian if your pet has drowsiness or dizziness; dry mouth and eyes; constipation; panting; mild agitation, weakness or headache; nausea or loss of weight or appetite. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
What other drugs will affect Clomipramine: Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Clomipramine may increase the effects of other drugs that may cause drowsiness, including other antidepressants, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants. Drugs other than those listed may also interact with clomipramine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines including herbal products.
Where can I get more information: Your pharmacist has additional information about clomipramine written for health professionals that you may read.
Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.
Clomipramine capsules are a prescription medication used in dogs and cats to treat separation anxiety. It is also sometimes used to treat obsessive compulsive disorders and aggression.
Clomipramine capsules are FDA approved for human use. However, it is not uncommon for veterinarians to prescribe clomipramine capsules for use in dogs and cats.
Clomipramine capsules are classified as tricyclic antidepressants. Clomipramine capsules affect chemicals in the ;brain that may become unbalanced leading to behavioral problems in dogs and cats.
Tip: Clomicalm tablets may not help alleviate symptoms right away. It may take a number of days before symptoms begin to lessen.
Give 0.9-1.8mg per pound of pets body weight once daily with food. Allow pet to have plenty of water to drink. Actual dosage depends on the condition being treated and the pets response to therapy
Give 0.5mg per pound of pets body weight once daily with food. Allow pet to have plenty of water to drink. Actual dosage depends on the condition being treated and the pets response to therapy
Storage: Store Clomipramine at room temperature away from moisture and heat.
Active Ingredient (per capsule)
Active Ingredient (per capsule)
Active Ingredient (per capsule)
Our dog had been to 3 homes and the shelter before we got him. He was super high strung and could never relax. He paced the halls at night and constantly licked his paws. He would have accidents in the kitchen and vomit every time we left. I am a dog trainer and I had tried everything to sooth him, my other dogs have never had any problems. He has only been taking it for a week, but it has been a major difference, there has been no accidents or vomit in the house for 4 days! He has been sleeping through the night. I am so happy the poor guy can finally relax.
This Medication May Have Saved My Dogs Life
My Weimaraner has had severe separation anxiety ever since he was a puppy. He would constantly bark when we would leave the house to the point that the neighbors would call the police. We were given tranquilizers by a veterinarian to give to the dog before we would leave the house. The dog would fight through the tranquilizers to the point where he was running into the walls, because he was so high. My dog was used to being at home with my disabled mother for years. She died 6 months ago leaving my dog a nervous wreck. My dog started urinating on the floor every time I would leave the house even for a few minutes. The veterinarian recommended that i take my dog to a behavior specialist at a University. This was not an option for me. I finally told the veterinarian that something had to be done, or I would have to give my dog up for adoption. He started my dog on Clomipramine 50mg which I noticed changes within just a few days. He was on the 50 mg twice a day for a month. Towards the end of the month, I noticed that he was once again becoming more neurotic and had a few eliminations in the house. I asked the veterinarian to increase his medication to 75 mg twice a day. My dog has been on that now for only a few days. He is doing great. His barking has seemed to settle down, and his eliminations in the house have since stopped all together. If you think your dog has an obsessive compulsive disorder or severe separation anxiety, I would recommend talking to your veterinarian about this medication. It may save your dog‚Äôs sanity and yours.
Very pleased with the PetMeds service. The medication is great and does not over sedate, or take the fun out of my Weimaraner. She plays hard, has lots of energy, but is not hysterical anymore.
For the first ten days or so, it seemed she was over sedated, but the vet said to hang in there, and we did and it evened out nicely.
She's a very happy pooch and so are we and her companion Weimie.
Great long term
I have a large 2 yr. old weimeraner. He has separation anxiety and has been secreting anal glands to the point of infection. Once he started this medication it has stopped and done wonders.
Our 3 year old maltese had very bad separation anxiety. He would go to the bathroom (both #1 and #2) in his cage (even if we only left him alone for an hour or so), bark all day, etc. This went on for a bout a year with us trying EVERYTHING to fix it and not wanting to put him on meds because we didn't want it to change his personality.
Finally, I went to the vet and talked to him and he prescribed this medicine to Gibbs. Since Gibbs is a smaller dog I actually have to split the pills up into 4 smaller empty gel capsules in order to ensure he gets the correct dosage. It's a little extra work but the vet said the only other anxiety med he really trusts wasn't be made anymore. I'm okay with it.
Anyway... IT WORKS! He doesn't bark as much when we leave (just a couple of little barks, not wailing anymore) and he has not gone to the bathroom in his cage in over a month and a half (since the second day he was on the meds).
Also - it hasn't affected his behavior at all. He is still his playful self and always happy to see us come home. I feel so much better that he is happier now.
My two bulldogs (56 and 60 pounds) have been attacking eachother at least 2 times daily which has lead to many emergency vet visits. Our vet suggested this product. Based on their weight, how much should I be giving them per day and how many a day?
The usual dose for Clomiramine is 0.9-1.8mg per pound of body weight 1 time a day with food. Therefore, the doses for your 56 and 60 pound dogs respectively would be 44.8-100.8mg and 54-108mg. Your vet may even recommend even lower doses than these to start to prevent side effects and to slowly titrate the dose upwards.
He's a toy fox terrier weighing about 11 pounds and is currently taking 5mg of Clomicalm once a day and his current vet has recommended the Clomipramine but don't know what the right dosage is for my dog. They only had large doses at the vet.
Thank-you for your question. For a dog weighing 11 pounds it is safe to take up to 20mg per day of Clomicalm (clomipramine). Dogs weighing 5.6-10.9 pounds (since you stated the dog weighs ABOUT 11 pounds) may take up to 10mg per day. Hope this helps!
This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.